Perturb_6459_KD_LKB1_SRP094725 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting LKB1 in glioblastoma cell T98 cell line (Study accession: SRP094725) (PerturbAtlas)
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Genes

172 genes differentially expressed following the Perturb_6459_KD_LKB1_SRP094725 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
CEND1 cell cycle exit and neuronal differentiation 1 20.0
CHPF chondroitin polymerizing factor 14.3386
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 9.33722
STEAP3 STEAP family member 3, metalloreductase 8.43032
TOP1MT topoisomerase (DNA) I, mitochondrial 7.80469
HIPK3 homeodomain interacting protein kinase 3 6.60123
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 6.38322
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 6.22525
EMP2 epithelial membrane protein 2 6.22525
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 5.95489
GDF15 growth differentiation factor 15 4.28682
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.99098
RNF152 ring finger protein 152 3.86104
IL6ST interleukin 6 signal transducer 3.83146
KRT4 keratin 4, type II 3.73925
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 3.645
PLXNA2 plexin A2 3.56309
MEN1 multiple endocrine neoplasia I 3.54396
DISP2 dispatched homolog 2 (Drosophila) 3.54396
GDF11 growth differentiation factor 11 3.36559
SYP synaptophysin 3.3461
LOC728392 uncharacterized LOC728392 3.3461
ANO10 anoctamin 10 3.28518
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 3.27036
NKAIN1 Na+/K+ transporting ATPase interacting 1 3.25891
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) 3.16533
FAIM2 Fas apoptotic inhibitory molecule 2 3.16533
OSGIN2 oxidative stress induced growth inhibitor family member 2 3.14984
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 3.14938
RAB39B RAB39B, member RAS oncogene family 3.14938
SYNGR3 synaptogyrin 3 2.99887
TLN1 talin 1 2.80193
XYLT1 xylosyltransferase I 2.80193
RBM38 RNA binding motif protein 38 2.7914
OLFML2A olfactomedin-like 2A 2.6387
ISM1 isthmin 1, angiogenesis inhibitor 2.63724
ALCAM activated leukocyte cell adhesion molecule 2.56808
KIF5C kinesin family member 5C 2.53507
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 2.44792
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.41216
PDE4B phosphodiesterase 4B, cAMP-specific 2.39822
MYEOV myeloma overexpressed 2.39496
RBM15B RNA binding motif protein 15B 2.39496
IQSEC1 IQ motif and Sec7 domain 1 2.37415
NT5DC2 5'-nucleotidase domain containing 2 2.34504
SAR1B secretion associated, Ras related GTPase 1B 2.34287
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 2.33676
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 2.335
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2.32698
CNIH4 cornichon family AMPA receptor auxiliary protein 4 2.31604
THY1 Thy-1 cell surface antigen 2.2873
TMEM115 transmembrane protein 115 2.2873
MOGS mannosyl-oligosaccharide glucosidase 2.25687
PDGFRL platelet-derived growth factor receptor-like 2.25556
ELAVL2 ELAV like neuron-specific RNA binding protein 2 2.25068
UCK1 uridine-cytidine kinase 1 2.14957
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 2.11582
CPNE2 copine II 2.04249
DUSP5 dual specificity phosphatase 5 2.04249
ADRA1D adrenoceptor alpha 1D 2.00762
MTPN myotrophin 1.99819
ZNF366 zinc finger protein 366 1.99806
ASPHD1 aspartate beta-hydroxylase domain containing 1 1.97648
SS18 synovial sarcoma translocation, chromosome 18 1.92708
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 1.82661
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 1.82661
NID1 nidogen 1 1.75174
LMNB2 lamin B2 1.73364
SPOPL speckle-type POZ protein-like 1.73296
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 1.72271
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1 1.7127
VGF VGF nerve growth factor inducible 1.69736
ZCCHC3 zinc finger, CCHC domain containing 3 1.69736
PANK3 pantothenate kinase 3 1.69562
PPAPDC1A phosphatidic acid phosphatase type 2 domain containing 1A 1.67663
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 1.63113
TMEM145 transmembrane protein 145 1.61077
HPS6 Hermansky-Pudlak syndrome 6 1.60943
SCN1B sodium channel, voltage gated, type I beta subunit 1.60943
ZDHHC20 zinc finger, DHHC-type containing 20 1.58701
TRIB2 tribbles pseudokinase 2 1.57235
DRD2 dopamine receptor D2 1.571
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 1.571
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 1.571
PIANP PILR alpha associated neural protein 1.56405
ZNF28 zinc finger protein 28 1.5555
ZDHHC22 zinc finger, DHHC-type containing 22 1.46207
RBM24 RNA binding motif protein 24 1.45831
RAB11FIP4 RAB11 family interacting protein 4 (class II) 1.45831
RIT1 Ras-like without CAAX 1 1.45831
C16ORF45 chromosome 16 open reading frame 45 1.44587
C1QL1 complement component 1, q subcomponent-like 1 1.44367
RAB36 RAB36, member RAS oncogene family 1.43856
PGRMC2 progesterone receptor membrane component 2 1.43796
BRSK1 BR serine/threonine kinase 1 1.42168
CHRM2 cholinergic receptor, muscarinic 2 1.42168
HERPUD2 HERPUD family member 2 1.40534
SATB2 SATB homeobox 2 1.39678
TRIM62 tripartite motif containing 62 1.39284
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 1.35294

decreased expression

Symbol Name Standardized Value
LIPC lipase, hepatic -5.31994
CLDN12 claudin 12 -5.0582
MAP2 microtubule-associated protein 2 -4.91279
VCL vinculin -4.32835
STK11 serine/threonine kinase 11 -4.09176
KIF21A kinesin family member 21A -3.74416
SCCPDH saccharopine dehydrogenase (putative) -3.645
TTL tubulin tyrosine ligase -3.54509
RAB31 RAB31, member RAS oncogene family -3.10484
SCML2 sex comb on midleg-like 2 (Drosophila) -2.95458
SGMS1 sphingomyelin synthase 1 -2.64799
SPDL1 spindle apparatus coiled-coil protein 1 -2.59305
SNAP23 synaptosomal-associated protein, 23kDa -2.46723
ESYT2 extended synaptotagmin-like protein 2 -2.34287
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -2.32698
POC1B POC1 centriolar protein B -2.2873
RASA2 RAS p21 protein activator 2 -2.22921
FERMT2 fermitin family member 2 -2.15782
SMIM14 small integral membrane protein 14 -2.11226
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 -2.07272
ADAM17 ADAM metallopeptidase domain 17 -2.06466
CARD6 caspase recruitment domain family, member 6 -2.04249
CCDC50 coiled-coil domain containing 50 -2.04249
COL4A1 collagen, type IV, alpha 1 -2.04249
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -2.04249
GBE1 glucan (1,4-alpha-), branching enzyme 1 -2.04249
TNIP3 TNFAIP3 interacting protein 3 -2.02805
PTPRJ protein tyrosine phosphatase, receptor type, J -2.00762
SPRYD3 SPRY domain containing 3 -2.00762
FBXO45 F-box protein 45 -1.85478
RNF19B ring finger protein 19B -1.85114
UNKL unkempt family zinc finger-like -1.84231
SPG20 spastic paraplegia 20 (Troyer syndrome) -1.84231
DPYSL3 dihydropyrimidinase-like 3 -1.83208
CHIC1 cysteine-rich hydrophobic domain 1 -1.81059
METAP2 methionyl aminopeptidase 2 -1.81059
GXYLT1 glucoside xylosyltransferase 1 -1.74223
IL1RAP interleukin 1 receptor accessory protein -1.73296
HMMR hyaluronan-mediated motility receptor (RHAMM) -1.70842
NRG4 neuregulin 4 -1.70842
FGD6 FYVE, RhoGEF and PH domain containing 6 -1.70725
C3 complement component 3 -1.69562
CDPF1 cysteine-rich, DPF motif domain containing 1 -1.61372
RTN3 reticulon 3 -1.60943
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -1.60943
TMEM154 transmembrane protein 154 -1.60943
TLR1 toll-like receptor 1 -1.60943
ZFP62 ZFP62 zinc finger protein -1.60943
ZSWIM4 zinc finger, SWIM-type containing 4 -1.57235
GEMIN2 gem (nuclear organelle) associated protein 2 -1.56405
SRXN1 sulfiredoxin 1 -1.55893
DERA deoxyribose-phosphate aldolase (putative) -1.55893
OPTN optineurin -1.5555
KIAA1147 KIAA1147 -1.52611
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 -1.52108
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -1.51671
SPTA1 spectrin, alpha, erythrocytic 1 -1.50256
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -1.46269
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -1.45831
CD22 CD22 molecule -1.45831
F2RL2 coagulation factor II (thrombin) receptor-like 2 -1.45831
KIAA0319 KIAA0319 -1.45299
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae) -1.4463
NR1D2 nuclear receptor subfamily 1, group D, member 2 -1.43796
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase -1.42529
PANX2 pannexin 2 -1.40046
MYCBP MYC binding protein -1.39551
LMLN leishmanolysin-like (metallopeptidase M8 family) -1.38074
UBA6 ubiquitin-like modifier activating enzyme 6 -1.37785
STX18 syntaxin 18 -1.35294
VTI1B vesicle transport through interaction with t-SNAREs 1B -1.35294
MTMR9 myotubularin related protein 9 -1.3034