Perturb_6470_KD_PDRG1_SRP314383 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting PDRG1 in glioblastoma cell U118 cell line (Study accession: SRP314383) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_6470_KD_PDRG1_SRP314383 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 20.0
IRS1 insulin receptor substrate 1 20.0
VAMP3 vesicle-associated membrane protein 3 20.0
TGFBI transforming growth factor, beta-induced, 68kDa 20.0
PGAM1 phosphoglycerate mutase 1 (brain) 20.0
MLEC malectin 20.0
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 20.0
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 20.0
IRAK1 interleukin-1 receptor-associated kinase 1 20.0
QKI QKI, KH domain containing, RNA binding 20.0
EHD2 EH-domain containing 2 20.0
GAPDH glyceraldehyde-3-phosphate dehydrogenase 20.0
TGFBR1 transforming growth factor, beta receptor 1 20.0
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 20.0
GRN granulin 20.0
DPYSL3 dihydropyrimidinase-like 3 20.0
MLF2 myeloid leukemia factor 2 20.0
CHD3 chromodomain helicase DNA binding protein 3 20.0
GNAS GNAS complex locus 20.0
TFRC transferrin receptor 20.0
STC2 stanniocalcin 2 20.0
GANAB glucosidase, alpha; neutral AB 20.0
ALCAM activated leukocyte cell adhesion molecule 20.0
TPM1 tropomyosin 1 (alpha) 20.0
PDIA6 protein disulfide isomerase family A, member 6 20.0
PDIA3 protein disulfide isomerase family A, member 3 20.0
COL1A1 collagen, type I, alpha 1 20.0
CD47 CD47 molecule 20.0
MTMR4 myotubularin related protein 4 20.0
EID1 EP300 interacting inhibitor of differentiation 1 20.0
BBX bobby sox homolog (Drosophila) 20.0
MRC2 mannose receptor, C type 2 20.0
TAPBP TAP binding protein (tapasin) 20.0
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 20.0
HTRA1 HtrA serine peptidase 1 20.0
AHCYL1 adenosylhomocysteinase-like 1 20.0
AP2M1 adaptor-related protein complex 2, mu 1 subunit 20.0
FOSL2 FOS-like antigen 2 20.0
RPS18 ribosomal protein S18 20.0
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 20.0
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 20.0
CSRP1 cysteine and glycine-rich protein 1 20.0
COL7A1 collagen, type VII, alpha 1 20.0
GJA1 gap junction protein, alpha 1, 43kDa 20.0
MBNL1 muscleblind-like splicing regulator 1 20.0
NDRG1 N-myc downstream regulated 1 20.0
SRSF5 serine/arginine-rich splicing factor 5 20.0
PTGFRN prostaglandin F2 receptor inhibitor 20.0
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 20.0
SPTAN1 spectrin, alpha, non-erythrocytic 1 20.0
ITGAV integrin, alpha V 20.0
MXRA7 matrix-remodelling associated 7 20.0
ENO2 enolase 2 (gamma, neuronal) 20.0
PGK1 phosphoglycerate kinase 1 20.0
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 20.0
SERINC1 serine incorporator 1 20.0
SERINC3 serine incorporator 3 20.0
ZMIZ1 zinc finger, MIZ-type containing 1 20.0
PRKCSH protein kinase C substrate 80K-H 20.0
PLBD2 phospholipase B domain containing 2 20.0
PTTG1IP pituitary tumor-transforming 1 interacting protein 20.0
SRSF11 serine/arginine-rich splicing factor 11 20.0
ANKRD52 ankyrin repeat domain 52 20.0
PLD3 phospholipase D family, member 3 20.0
ENO1 enolase 1, (alpha) 20.0
HLA-B major histocompatibility complex, class I, B 20.0
HLA-A major histocompatibility complex, class I, A 20.0
CALR calreticulin 20.0
PAM peptidylglycine alpha-amidating monooxygenase 20.0
ERO1L ERO1-like (S. cerevisiae) 20.0
TPI1 triosephosphate isomerase 1 20.0
CTSA cathepsin A 20.0
AFF4 AF4/FMR2 family, member 4 20.0
FERMT2 fermitin family member 2 20.0
B2M beta-2-microglobulin 20.0
PEG10 paternally expressed 10 20.0
COL5A1 collagen, type V, alpha 1 20.0
LAMP1 lysosomal-associated membrane protein 1 20.0
CALD1 caldesmon 1 20.0
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 20.0
ARL4C ADP-ribosylation factor-like 4C 20.0
WDR26 WD repeat domain 26 20.0
SNAI2 snail family zinc finger 2 20.0
CCDC80 coiled-coil domain containing 80 20.0
VEGFA vascular endothelial growth factor A 20.0
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 20.0
COL5A2 collagen, type V, alpha 2 20.0
PKM pyruvate kinase, muscle 20.0
FSTL1 follistatin-like 1 20.0
EDIL3 EGF-like repeats and discoidin I-like domains 3 20.0
ACADVL acyl-CoA dehydrogenase, very long chain 20.0
TM9SF2 transmembrane 9 superfamily member 2 20.0
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 20.0
QSOX1 quiescin Q6 sulfhydryl oxidase 1 20.0
CANX calnexin 20.0
HLA-C major histocompatibility complex, class I, C 20.0
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 20.0
CERCAM cerebral endothelial cell adhesion molecule 20.0
MMP2 matrix metallopeptidase 2 20.0
SURF4 surfeit 4 20.0

decreased expression

Symbol Name Standardized Value
GAP43 growth associated protein 43 -20.0
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -20.0
CCL2 chemokine (C-C motif) ligand 2 -20.0
AIF1L allograft inflammatory factor 1-like -20.0
ADTRP androgen-dependent TFPI-regulating protein -20.0
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -20.0
SLC16A14 solute carrier family 16, member 14 -20.0
PPARG peroxisome proliferator-activated receptor gamma -20.0
IGFL3 IGF-like family member 3 -20.0
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B -20.0
LDOC1 leucine zipper, down-regulated in cancer 1 -20.0
KSR1 kinase suppressor of ras 1 -20.0
DIRAS1 DIRAS family, GTP-binding RAS-like 1 -20.0
FSD1 fibronectin type III and SPRY domain containing 1 -20.0
NRXN3 neurexin 3 -20.0
SYNDIG1 synapse differentiation inducing 1 -20.0
FAM49A family with sequence similarity 49, member A -20.0
BFSP1 beaded filament structural protein 1, filensin -20.0
KRT75 keratin 75, type II -20.0
CRIP2 cysteine-rich protein 2 -20.0
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -20.0
TDRKH tudor and KH domain containing -20.0
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -20.0
MYEF2 myelin expression factor 2 -20.0
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -20.0
COL4A2 collagen, type IV, alpha 2 -20.0
AP3B2 adaptor-related protein complex 3, beta 2 subunit -20.0
PCDHGC5 protocadherin gamma subfamily C, 5 -20.0
SYT14 synaptotagmin XIV -20.0
KDR kinase insert domain receptor -20.0
SCAMP5 secretory carrier membrane protein 5 -20.0
RAB3D RAB3D, member RAS oncogene family -20.0
PPP2R2B protein phosphatase 2, regulatory subunit B, beta -20.0
AKNA AT-hook transcription factor -20.0
PNLIPRP3 pancreatic lipase-related protein 3 -20.0
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) -20.0
CCDC125 coiled-coil domain containing 125 -20.0
MRS2 MRS2 magnesium transporter -20.0
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -20.0
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -20.0
QPRT quinolinate phosphoribosyltransferase -20.0
FER1L6 fer-1-like family member 6 -20.0
CRYM crystallin, mu -20.0
CD40 CD40 molecule, TNF receptor superfamily member 5 -20.0
FAR2 fatty acyl CoA reductase 2 -20.0
GOLGA7B golgin A7 family, member B -20.0
ACP5 acid phosphatase 5, tartrate resistant -20.0
MTMR1 myotubularin related protein 1 -20.0
GDF15 growth differentiation factor 15 -20.0
BEND7 BEN domain containing 7 -20.0
ITGA6 integrin, alpha 6 -20.0
MAML3 mastermind-like 3 (Drosophila) -20.0
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 -20.0
SLC45A1 solute carrier family 45, member 1 -20.0
HOPX HOP homeobox -20.0
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -20.0
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -20.0
ALOXE3 arachidonate lipoxygenase 3 -20.0
ZNF219 zinc finger protein 219 -20.0
CALB2 calbindin 2 -20.0
KLF4 Kruppel-like factor 4 (gut) -20.0
FCRLA Fc receptor-like A -20.0
NLGN1 neuroligin 1 -20.0
DAW1 dynein assembly factor with WDR repeat domains 1 -20.0
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -20.0
FOXS1 forkhead box S1 -20.0
MACROD1 MACRO domain containing 1 -20.0
SYT1 synaptotagmin I -20.0
IGSF9B immunoglobulin superfamily, member 9B -20.0
VGF VGF nerve growth factor inducible -20.0
WNT3 wingless-type MMTV integration site family, member 3 -20.0
FAM196A family with sequence similarity 196, member A -20.0
LRRC37A3 leucine rich repeat containing 37, member A3 -20.0
CSDC2 cold shock domain containing C2, RNA binding -20.0
TNXB tenascin XB -20.0
GRB14 growth factor receptor-bound protein 14 -20.0
PPL periplakin -20.0
LAT2 linker for activation of T cells family, member 2 -20.0
DGAT2 diacylglycerol O-acyltransferase 2 -20.0
BAMBI BMP and activin membrane-bound inhibitor -20.0
IL33 interleukin 33 -20.0
NRG2 neuregulin 2 -20.0
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 -20.0
FAM81A family with sequence similarity 81, member A -20.0
ELMOD1 ELMO/CED-12 domain containing 1 -20.0
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -20.0
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -20.0
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 -20.0
C5AR1 complement component 5a receptor 1 -20.0
STXBP5L syntaxin binding protein 5-like -20.0
RGS10 regulator of G-protein signaling 10 -20.0
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) -20.0
ACOX2 acyl-CoA oxidase 2, branched chain -20.0
TMCC3 transmembrane and coiled-coil domain family 3 -20.0
NGF nerve growth factor (beta polypeptide) -20.0
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -20.0
FAM84A family with sequence similarity 84, member A -20.0
MAPK10 mitogen-activated protein kinase 10 -20.0
MAPK12 mitogen-activated protein kinase 12 -20.0
RPP25 ribonuclease P/MRP 25kDa subunit -20.0