| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KO perturbation targeting KEAP1 in H358 cell line (Study accession: ERP124775) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_6607_KO_KEAP1_ERP124775 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| G6PD | glucose-6-phosphate dehydrogenase | 20.0 |
| GPX2 | glutathione peroxidase 2 | 20.0 |
| PANX2 | pannexin 2 | 20.0 |
| UGDH | UDP-glucose 6-dehydrogenase | 20.0 |
| ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic | 19.699 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 18.2218 |
| TSPAN7 | tetraspanin 7 | 16.3744 |
| RAB15 | RAB15, member RAS oncogene family | 16.347 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 15.3005 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 14.3139 |
| PGD | phosphogluconate dehydrogenase | 13.6625 |
| NAMPT | nicotinamide phosphoribosyltransferase | 13.2949 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 12.6163 |
| RAP1GAP | RAP1 GTPase activating protein | 12.1426 |
| DOCK10 | dedicator of cytokinesis 10 | 12.1426 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 11.8298 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 11.5 |
| FHOD1 | formin homology 2 domain containing 1 | 11.403 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 10.8715 |
| GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) | 10.8715 |
| DPP4 | dipeptidyl-peptidase 4 | 10.8715 |
| SLC22A31 | solute carrier family 22, member 31 | 10.5212 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 10.5027 |
| WFS1 | Wolfram syndrome 1 (wolframin) | 10.4774 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 10.4399 |
| B4GALNT1 | beta-1,4-N-acetyl-galactosaminyl transferase 1 | 10.0831 |
| SMIM14 | small integral membrane protein 14 | 9.9617 |
| COL9A3 | collagen, type IX, alpha 3 | 9.94919 |
| SLC12A8 | solute carrier family 12, member 8 | 9.41901 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 9.26105 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 9.1719 |
| PADI4 | peptidyl arginine deiminase, type IV | 8.80391 |
| HMOX1 | heme oxygenase 1 | 8.72625 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 | 8.70005 |
| TALDO1 | transaldolase 1 | 8.36043 |
| JDP2 | Jun dimerization protein 2 | 8.08845 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 8.03333 |
| HIP1 | huntingtin interacting protein 1 | 7.39901 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | 7.34284 |
| KCNV1 | potassium channel, voltage gated modifier subfamily V, member 1 | 7.32161 |
| PRDX1 | peroxiredoxin 1 | 7.17089 |
| FECH | ferrochelatase | 7.09406 |
| EGF | epidermal growth factor | 7.03506 |
| ELMO3 | engulfment and cell motility 3 | 6.85134 |
| CACNA1H | calcium channel, voltage-dependent, T type, alpha 1H subunit | 6.81741 |
| SQLE | squalene epoxidase | 6.81136 |
| SCARB1 | scavenger receptor class B, member 1 | 6.77665 |
| TXNRD1 | thioredoxin reductase 1 | 6.53686 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 6.39553 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | 6.34938 |
| WNK2 | WNK lysine deficient protein kinase 2 | 6.29265 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 6.28198 |
| LGMN | legumain | 6.18977 |
| TRIM54 | tripartite motif containing 54 | 6.06363 |
| MGST1 | microsomal glutathione S-transferase 1 | 6.03465 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 5.99508 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 5.9585 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | 5.94683 |
| ZBTB46 | zinc finger and BTB domain containing 46 | 5.87833 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | 5.86001 |
| CTH | cystathionine gamma-lyase | 5.84786 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | 5.66082 |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 5.57656 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 5.55436 |
| SLC47A2 | solute carrier family 47 (multidrug and toxin extrusion), member 2 | 5.55391 |
| CH25H | cholesterol 25-hydroxylase | 5.52347 |
| KCNQ3 | potassium channel, voltage gated KQT-like subfamily Q, member 3 | 5.34389 |
| SYTL2 | synaptotagmin-like 2 | 5.33944 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 5.30927 |
| GFAP | glial fibrillary acidic protein | 5.30927 |
| FHL1 | four and a half LIM domains 1 | 5.22625 |
| ASIC1 | acid sensing (proton gated) ion channel 1 | 5.17873 |
| PNMA2 | paraneoplastic Ma antigen 2 | 5.16125 |
| LOC102723996 | ICOS ligand | 5.1477 |
| GSR | glutathione reductase | 5.137 |
| AKR1B15 | aldo-keto reductase family 1, member B15 | 5.08308 |
| NAPSA | napsin A aspartic peptidase | 5.07588 |
| NPR3 | natriuretic peptide receptor 3 | 5.07453 |
| PIR | pirin (iron-binding nuclear protein) | 5.03942 |
| EXPH5 | exophilin 5 | 4.97445 |
| FAM178B | family with sequence similarity 178, member B | 4.88489 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 4.81881 |
| PRR15L | proline rich 15-like | 4.7854 |
| VSTM2L | V-set and transmembrane domain containing 2 like | 4.74582 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | 4.74417 |
| GATA2 | GATA binding protein 2 | 4.73316 |
| TBC1D4 | TBC1 domain family, member 4 | 4.65964 |
| NUAK2 | NUAK family, SNF1-like kinase, 2 | 4.65294 |
| GATSL2 | GATS protein-like 2 | 4.63632 |
| FAM46C | family with sequence similarity 46, member C | 4.61822 |
| MAP2 | microtubule-associated protein 2 | 4.54765 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | 4.53584 |
| PCDH19 | protocadherin 19 | 4.50908 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 4.50668 |
| AQP3 | aquaporin 3 (Gill blood group) | 4.4807 |
| ACOXL | acyl-CoA oxidase-like | 4.43092 |
| RLTPR | RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing | 4.41138 |
| EPB41 | erythrocyte membrane protein band 4.1 | 4.41138 |
| KLHL36 | kelch-like family member 36 | 4.40043 |
| NAT8L | N-acetyltransferase 8-like (GCN5-related, putative) | 4.38331 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ARHGAP30 | Rho GTPase activating protein 30 | -13.7427 |
| C15ORF52 | chromosome 15 open reading frame 52 | -13.3978 |
| SRPX | sushi-repeat containing protein, X-linked | -12.7815 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -12.2051 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -11.9867 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -11.7527 |
| TNC | tenascin C | -11.5231 |
| NTNG1 | netrin G1 | -10.5886 |
| PRICKLE1 | prickle homolog 1 (Drosophila) | -10.4774 |
| KLF13 | Kruppel-like factor 13 | -10.3564 |
| WFDC2 | WAP four-disulfide core domain 2 | -9.07982 |
| WIPF1 | WAS/WASL interacting protein family, member 1 | -8.72434 |
| EPHA3 | EPH receptor A3 | -8.36128 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -8.21793 |
| PDLIM7 | PDZ and LIM domain 7 (enigma) | -8.21516 |
| GLIPR1 | GLI pathogenesis-related 1 | -7.66271 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | -7.36934 |
| ZNF608 | zinc finger protein 608 | -7.34284 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | -7.30254 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -7.18106 |
| UTS2 | urotensin 2 | -7.0671 |
| SOCS2 | suppressor of cytokine signaling 2 | -6.82487 |
| VIM | vimentin | -6.80092 |
| ARL4C | ADP-ribosylation factor-like 4C | -6.77148 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -6.67081 |
| PKP2 | plakophilin 2 | -6.59742 |
| DNER | delta/notch-like EGF repeat containing | -6.59742 |
| MGAT5B | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B | -6.59742 |
| SMIM3 | small integral membrane protein 3 | -6.17818 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -6.14104 |
| MME | membrane metallo-endopeptidase | -6.03465 |
| TLN2 | talin 2 | -6.03465 |
| PLEK2 | pleckstrin 2 | -5.88061 |
| GAP43 | growth associated protein 43 | -5.87505 |
| TENM3 | teneurin transmembrane protein 3 | -5.79827 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -5.56819 |
| UNC13D | unc-13 homolog D (C. elegans) | -5.55753 |
| S100A2 | S100 calcium binding protein A2 | -5.50945 |
| EPHA5 | EPH receptor A5 | -5.41877 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -5.33371 |
| MUM1L1 | melanoma associated antigen (mutated) 1-like 1 | -5.33371 |
| PADI3 | peptidyl arginine deiminase, type III | -5.31853 |
| CPA4 | carboxypeptidase A4 | -5.30927 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -5.29484 |
| DTX3 | deltex 3, E3 ubiquitin ligase | -5.17873 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -5.15635 |
| XK | X-linked Kx blood group | -5.14961 |
| WNT9A | wingless-type MMTV integration site family, member 9A | -5.14961 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -4.96807 |
| UGT8 | UDP glycosyltransferase 8 | -4.87527 |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | -4.86444 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -4.84367 |
| GJB2 | gap junction protein, beta 2, 26kDa | -4.81881 |
| IL23A | interleukin 23, alpha subunit p19 | -4.81738 |
| LUZP2 | leucine zipper protein 2 | -4.79918 |
| ANKMY2 | ankyrin repeat and MYND domain containing 2 | -4.76185 |
| ISPD | isoprenoid synthase domain containing | -4.72405 |
| ME3 | malic enzyme 3, NADP(+)-dependent, mitochondrial | -4.67774 |
| EPAS1 | endothelial PAS domain protein 1 | -4.66781 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -4.61822 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -4.58555 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -4.56927 |
| PDCD1LG2 | programmed cell death 1 ligand 2 | -4.55934 |
| DSE | dermatan sulfate epimerase | -4.55811 |
| IFI27L2 | interferon, alpha-inducible protein 27-like 2 | -4.54564 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -4.53125 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | -4.4418 |
| SCIN | scinderin | -4.40659 |
| VILL | villin-like | -4.39466 |
| RUNX2 | runt-related transcription factor 2 | -4.3658 |
| FOXJ1 | forkhead box J1 | -4.29379 |
| CAPRIN2 | caprin family member 2 | -4.2862 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | -4.27219 |
| HAS2 | hyaluronan synthase 2 | -4.19415 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -4.19415 |
| PCDHGB7 | protocadherin gamma subfamily B, 7 | -4.18713 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | -4.13621 |
| CITED4 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 | -4.11529 |
| PCDHGA11 | protocadherin gamma subfamily A, 11 | -4.08245 |
| ANKFN1 | ankyrin-repeat and fibronectin type III domain containing 1 | -4.02841 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -3.98177 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -3.97124 |
| P2RY2 | purinergic receptor P2Y, G-protein coupled, 2 | -3.9216 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -3.87875 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -3.86747 |
| E2F7 | E2F transcription factor 7 | -3.85625 |
| MECOM | MDS1 and EVI1 complex locus | -3.84019 |
| SOX5 | SRY (sex determining region Y)-box 5 | -3.83588 |
| NDST3 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 | -3.82423 |
| RGS1 | regulator of G-protein signaling 1 | -3.80495 |
| SP140 | SP140 nuclear body protein | -3.80104 |
| MILR1 | mast cell immunoglobulin-like receptor 1 | -3.79444 |
| MASP1 | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | -3.76632 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | -3.75966 |
| PCDH1 | protocadherin 1 | -3.75294 |
| BNC2 | basonuclin 2 | -3.73935 |
| ARL14 | ADP-ribosylation factor-like 14 | -3.73078 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -3.70441 |
| IL11 | interleukin 11 | -3.68129 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | -3.66901 |
