| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting FXR1 in H358 cell line (Study accession: SRP113319) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_6611_KD_FXR1_SRP113319 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAGP | small cell adhesion glycoprotein | 20.0 |
| GPA33 | glycoprotein A33 (transmembrane) | 20.0 |
| PRDM8 | PR domain containing 8 | 20.0 |
| SPHK1 | sphingosine kinase 1 | 20.0 |
| TMC8 | transmembrane channel-like 8 | 20.0 |
| LEMD1 | LEM domain containing 1 | 20.0 |
| FOXJ1 | forkhead box J1 | 20.0 |
| PAEP | progestagen-associated endometrial protein | 20.0 |
| PER1 | period circadian clock 1 | 20.0 |
| NKD2 | naked cuticle homolog 2 (Drosophila) | 20.0 |
| LCK | LCK proto-oncogene, Src family tyrosine kinase | 20.0 |
| PRSS22 | protease, serine, 22 | 20.0 |
| PYGB | phosphorylase, glycogen; brain | 20.0 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 20.0 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 20.0 |
| ARL4D | ADP-ribosylation factor-like 4D | 20.0 |
| CDK15 | cyclin-dependent kinase 15 | 20.0 |
| AREG | amphiregulin | 20.0 |
| CD22 | CD22 molecule | 20.0 |
| TRAF1 | TNF receptor-associated factor 1 | 20.0 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | 20.0 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 20.0 |
| FOSL1 | FOS-like antigen 1 | 20.0 |
| FAM43A | family with sequence similarity 43, member A | 20.0 |
| GDF15 | growth differentiation factor 15 | 20.0 |
| BARX2 | BARX homeobox 2 | 20.0 |
| VSIG10 | V-set and immunoglobulin domain containing 10 | 20.0 |
| KRT81 | keratin 81, type II | 20.0 |
| STMN3 | stathmin-like 3 | 20.0 |
| DUSP5 | dual specificity phosphatase 5 | 20.0 |
| MLPH | melanophilin | 20.0 |
| SOX21 | SRY (sex determining region Y)-box 21 | 20.0 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 20.0 |
| TM4SF1 | transmembrane 4 L six family member 1 | 20.0 |
| METTL7B | methyltransferase like 7B | 20.0 |
| EHD2 | EH-domain containing 2 | 20.0 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | 20.0 |
| PLIN2 | perilipin 2 | 20.0 |
| FAM83A | family with sequence similarity 83, member A | 20.0 |
| MED20 | mediator complex subunit 20 | 20.0 |
| LURAP1L | leucine rich adaptor protein 1-like | 20.0 |
| GPR35 | G protein-coupled receptor 35 | 20.0 |
| NOS3 | nitric oxide synthase 3 (endothelial cell) | 20.0 |
| KCNK6 | potassium channel, two pore domain subfamily K, member 6 | 20.0 |
| HOPX | HOP homeobox | 20.0 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 20.0 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 20.0 |
| PLAU | plasminogen activator, urokinase | 20.0 |
| WNT7A | wingless-type MMTV integration site family, member 7A | 20.0 |
| MRAP | melanocortin 2 receptor accessory protein | 20.0 |
| CPA4 | carboxypeptidase A4 | 20.0 |
| KCNF1 | potassium channel, voltage gated modifier subfamily F, member 1 | 20.0 |
| CALB2 | calbindin 2 | 20.0 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 20.0 |
| IL20RB | interleukin 20 receptor beta | 20.0 |
| KLK6 | kallikrein-related peptidase 6 | 20.0 |
| G0S2 | G0/G1 switch 2 | 20.0 |
| KLF2 | Kruppel-like factor 2 | 20.0 |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | 20.0 |
| PRR5L | proline rich 5 like | 20.0 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 20.0 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 20.0 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | 20.0 |
| KRT15 | keratin 15, type I | 20.0 |
| PSG3 | pregnancy specific beta-1-glycoprotein 3 | 20.0 |
| THEMIS2 | thymocyte selection associated family member 2 | 20.0 |
| ME3 | malic enzyme 3, NADP(+)-dependent, mitochondrial | 20.0 |
| AXL | AXL receptor tyrosine kinase | 20.0 |
| KRT86 | keratin 86, type II | 19.699 |
| ADAM8 | ADAM metallopeptidase domain 8 | 19.5229 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | 19.301 |
| TMEM173 | transmembrane protein 173 | 18.699 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 18.5086 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 18.2676 |
| HIST1H1C | histone cluster 1, H1c | 18.2441 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 18.2147 |
| CARD10 | caspase recruitment domain family, member 10 | 17.8416 |
| IL4R | interleukin 4 receptor | 17.8069 |
| RNF10 | ring finger protein 10 | 17.7212 |
| THEM5 | thioesterase superfamily member 5 | 17.6383 |
| MYADM | myeloid-associated differentiation marker | 17.6234 |
| WFDC3 | WAP four-disulfide core domain 3 | 17.5768 |
| ITGA10 | integrin, alpha 10 | 17.5467 |
| KLF4 | Kruppel-like factor 4 (gut) | 17.2147 |
| MYEOV | myeloma overexpressed | 17.1209 |
| CARD11 | caspase recruitment domain family, member 11 | 16.9952 |
| MAPKAPK3 | mitogen-activated protein kinase-activated protein kinase 3 | 16.9496 |
| MMP17 | matrix metallopeptidase 17 (membrane-inserted) | 16.9389 |
| TPM2 | tropomyosin 2 (beta) | 16.9344 |
| RARG | retinoic acid receptor, gamma | 16.8921 |
| IFI27 | interferon, alpha-inducible protein 27 | 16.8844 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 16.765 |
| PPARD | peroxisome proliferator-activated receptor delta | 16.634 |
| C11ORF68 | chromosome 11 open reading frame 68 | 16.6185 |
| HMGA1 | high mobility group AT-hook 1 | 16.4603 |
| FAM167A | family with sequence similarity 167, member A | 16.3837 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 16.3801 |
| KRT17 | keratin 17, type I | 16.313 |
| SYTL3 | synaptotagmin-like 3 | 16.0415 |
| C1ORF116 | chromosome 1 open reading frame 116 | 15.8647 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NXPH4 | neurexophilin 4 | -20.0 |
| FN1 | fibronectin 1 | -20.0 |
| ATOH8 | atonal homolog 8 (Drosophila) | -20.0 |
| NLN | neurolysin (metallopeptidase M3 family) | -20.0 |
| PIPOX | pipecolic acid oxidase | -20.0 |
| RAVER2 | ribonucleoprotein, PTB-binding 2 | -20.0 |
| SLPI | secretory leukocyte peptidase inhibitor | -20.0 |
| ADAM28 | ADAM metallopeptidase domain 28 | -20.0 |
| GPNMB | glycoprotein (transmembrane) nmb | -20.0 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | -20.0 |
| LAMP3 | lysosomal-associated membrane protein 3 | -20.0 |
| PLXND1 | plexin D1 | -20.0 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -20.0 |
| DMBX1 | diencephalon/mesencephalon homeobox 1 | -20.0 |
| TFRC | transferrin receptor | -20.0 |
| COL7A1 | collagen, type VII, alpha 1 | -20.0 |
| DNM1 | dynamin 1 | -20.0 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | -20.0 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -20.0 |
| CACNA1H | calcium channel, voltage-dependent, T type, alpha 1H subunit | -20.0 |
| SARAF | store-operated calcium entry-associated regulatory factor | -20.0 |
| LYNX1 | Ly6/neurotoxin 1 | -20.0 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -20.0 |
| SUSD2 | sushi domain containing 2 | -20.0 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -20.0 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -20.0 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -20.0 |
| SUCLA2 | succinate-CoA ligase, ADP-forming, beta subunit | -20.0 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -20.0 |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | -20.0 |
| DTX4 | deltex 4, E3 ubiquitin ligase | -20.0 |
| ACKR3 | atypical chemokine receptor 3 | -20.0 |
| LY6D | lymphocyte antigen 6 complex, locus D | -20.0 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -20.0 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -20.0 |
| CEL | carboxyl ester lipase | -20.0 |
| ZC3H12A | zinc finger CCCH-type containing 12A | -20.0 |
| COL9A2 | collagen, type IX, alpha 2 | -20.0 |
| BEND3 | BEN domain containing 3 | -20.0 |
| CYP4X1 | cytochrome P450, family 4, subfamily X, polypeptide 1 | -20.0 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -20.0 |
| NRCAM | neuronal cell adhesion molecule | -20.0 |
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | -20.0 |
| GCGR | glucagon receptor | -20.0 |
| SRP9 | signal recognition particle 9kDa | -20.0 |
| LCN2 | lipocalin 2 | -20.0 |
| CANX | calnexin | -20.0 |
| MYH10 | myosin, heavy chain 10, non-muscle | -20.0 |
| CPE | carboxypeptidase E | -20.0 |
| TTYH3 | tweety family member 3 | -20.0 |
| CCL20 | chemokine (C-C motif) ligand 20 | -20.0 |
| C3 | complement component 3 | -20.0 |
| CP | ceruloplasmin (ferroxidase) | -20.0 |
| ZNF704 | zinc finger protein 704 | -20.0 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -20.0 |
| EHF | ets homologous factor | -19.699 |
| CNN2 | calponin 2 | -19.0458 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -18.699 |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | -18.6383 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -18.585 |
| LYPD6B | LY6/PLAUR domain containing 6B | -18.5528 |
| SYNPO | synaptopodin | -18.5376 |
| ITGAV | integrin, alpha V | -18.4318 |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | -18.3468 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -17.9281 |
| RALBP1 | ralA binding protein 1 | -17.4976 |
| KIAA1644 | KIAA1644 | -17.1273 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | -17.1221 |
| FGFR3 | fibroblast growth factor receptor 3 | -16.6379 |
| HDAC4 | histone deacetylase 4 | -16.4638 |
| AFG3L2 | AFG3-like AAA ATPase 2 | -16.4504 |
| G6PD | glucose-6-phosphate dehydrogenase | -16.2146 |
| SMAD6 | SMAD family member 6 | -16.0974 |
| CIITA | class II, major histocompatibility complex, transactivator | -16.0025 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -15.9388 |
| METTL7A | methyltransferase like 7A | -15.8485 |
| ZMPSTE24 | zinc metallopeptidase STE24 | -15.7273 |
| PARVB | parvin, beta | -15.6795 |
| NPNT | nephronectin | -15.6206 |
| IL7R | interleukin 7 receptor | -15.5415 |
| FTH1 | ferritin, heavy polypeptide 1 | -15.1738 |
| DCLK1 | doublecortin-like kinase 1 | -14.8877 |
| CAPN13 | calpain 13 | -14.7517 |
| MAPK9 | mitogen-activated protein kinase 9 | -14.735 |
| GJB2 | gap junction protein, beta 2, 26kDa | -14.6479 |
| PANX2 | pannexin 2 | -14.2579 |
| THBS1 | thrombospondin 1 | -14.1545 |
| CDCA7 | cell division cycle associated 7 | -13.8346 |
| KIAA1715 | KIAA1715 | -13.7317 |
| HS6ST1 | heparan sulfate 6-O-sulfotransferase 1 | -13.7164 |
| PRMT6 | protein arginine methyltransferase 6 | -13.6678 |
| MMP13 | matrix metallopeptidase 13 | -13.576 |
| USP40 | ubiquitin specific peptidase 40 | -13.4619 |
| TMEM132A | transmembrane protein 132A | -13.4051 |
| ZNF664 | zinc finger protein 664 | -13.2851 |
| MPG | N-methylpurine-DNA glycosylase | -13.229 |
| ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 | -13.0725 |
| PARN | poly(A)-specific ribonuclease | -13.0299 |
| B4GALT4 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | -12.7808 |
| SPDEF | SAM pointed domain containing ETS transcription factor | -12.5175 |
