Perturb_677_KO_SLC15A4_SRP212091 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KO perturbation targeting SLC15A4 in acute myeloid leukemia cell THP-1 (TLR9-overexpression) cell line (Study accession: SRP212091) (PerturbAtlas)
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Genes

50 genes differentially expressed following the Perturb_677_KO_SLC15A4_SRP212091 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
NME7 NME/NM23 family member 7 10.4569
C5ORF45 chromosome 5 open reading frame 45 7.10994
CSNK1D casein kinase 1, delta 5.0602
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.98174
MRPL37 mitochondrial ribosomal protein L37 2.78752
AATK apoptosis-associated tyrosine kinase 2.52484
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.18676
KIF1B kinesin family member 1B 1.87377
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 1.81432
CTBP2 C-terminal binding protein 2 1.77352
MCM9 minichromosome maintenance complex component 9 1.30869
BBIP1 BBSome interacting protein 1 1.30869
STK11 serine/threonine kinase 11 1.30869

decreased expression

Symbol Name Standardized Value
C1ORF74 chromosome 1 open reading frame 74 -20.0
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa -18.0969
PARP9 poly (ADP-ribose) polymerase family, member 9 -14.5039
HPS4 Hermansky-Pudlak syndrome 4 -10.1704
TCP1 t-complex 1 -7.10994
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 -6.91217
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -6.26084
CCNA2 cyclin A2 -5.82593
FXYD6 FXYD domain containing ion transport regulator 6 -5.42662
CAPN12 calpain 12 -5.0602
IFI6 interferon, alpha-inducible protein 6 -4.11477
GFM2 G elongation factor, mitochondrial 2 -3.79513
FKBP15 FK506 binding protein 15, 133kDa -3.5385
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) -3.43169
ARG2 arginase 2 -2.93383
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 -2.74574
WDR86 WD repeat domain 86 -2.64665
PRICKLE3 prickle homolog 3 (Drosophila) -2.50183
IL16 interleukin 16 -2.40586
VRK2 vaccinia related kinase 2 -2.03192
ANGPTL6 angiopoietin-like 6 -1.94203
SPATA21 spermatogenesis associated 21 -1.90975
ACOT13 acyl-CoA thioesterase 13 -1.89607
PAQR3 progestin and adipoQ receptor family member III -1.87377
ADGRL1 adhesion G protein-coupled receptor L1 -1.87377
TFB1M transcription factor B1, mitochondrial -1.81432
C18ORF8 chromosome 18 open reading frame 8 -1.81432
NKIRAS1 NFKB inhibitor interacting Ras-like 1 -1.81432
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) -1.81432
ZNF740 zinc finger protein 740 -1.73506
ZNF276 zinc finger protein 276 -1.63337
DDTL D-dopachrome tautomerase-like -1.54393
GDF9 growth differentiation factor 9 -1.47849
TMTC3 transmembrane and tetratricopeptide repeat containing 3 -1.44654
ORAOV1 oral cancer overexpressed 1 -1.44157
ACO1 aconitase 1, soluble -1.43972
ACSS3 acyl-CoA synthetase short-chain family member 3 -1.39626