Perturb_6791_KD_CDK12_SRP042402 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting CDK12 in HCT116 cell line (Study accession: SRP042402) (PerturbAtlas)
Similar Terms
Downloads & Tools

Genes

139 genes differentially expressed following the Perturb_6791_KD_CDK12_SRP042402 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
IFNE interferon, epsilon 7.31772
COL12A1 collagen, type XII, alpha 1 6.76829
WWC3 WWC family member 3 3.26281
ZNF804A zinc finger protein 804A 2.5795
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 2.5609
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.53705
MAP2 microtubule-associated protein 2 2.48095
ZBTB18 zinc finger and BTB domain containing 18 2.17219
IL1RAP interleukin 1 receptor accessory protein 2.09553
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 2.08985
FAT4 FAT atypical cadherin 4 2.08985
PHLDA1 pleckstrin homology-like domain, family A, member 1 2.02766
HMCN1 hemicentin 1 2.02766
DDX26B DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B 2.02068
RIMS2 regulating synaptic membrane exocytosis 2 1.93894
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 1.93894
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 1.91281
ITGB8 integrin, beta 8 1.91281
C10ORF54 chromosome 10 open reading frame 54 1.71224
ONECUT2 one cut homeobox 2 1.71224
XXYLT1 xyloside xylosyltransferase 1 1.63424
ARHGAP23 Rho GTPase activating protein 23 1.63096
RAB15 RAB15, member RAS oncogene family 1.63005
RBM24 RNA binding motif protein 24 1.62371
KBTBD8 kelch repeat and BTB (POZ) domain containing 8 1.62371
TNRC6C trinucleotide repeat containing 6C 1.62371
ZMAT3 zinc finger, matrin-type 3 1.61574
ZFHX4 zinc finger homeobox 4 1.5811
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase 1.52601
ACER2 alkaline ceramidase 2 1.51779
BTG2 BTG family, member 2 1.50428
TET2 tet methylcytosine dioxygenase 2 1.50428
CNTN1 contactin 1 1.49484
OSTM1 osteopetrosis associated transmembrane protein 1 1.47743
IGF2R insulin-like growth factor 2 receptor 1.47743
FNIP2 folliculin interacting protein 2 1.46165
FAM120C family with sequence similarity 120C 1.45249
MED12L mediator complex subunit 12-like 1.43419
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 1.43096
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.42438
COL4A5 collagen, type IV, alpha 5 1.41754
NAV2 neuron navigator 2 1.41694
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 1.41077
HSPA4L heat shock 70kDa protein 4-like 1.41077
RHOD ras homolog family member D 1.37814
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 1.3652
ANK2 ankyrin 2, neuronal 1.36229
MEIS2 Meis homeobox 2 1.34463
AMOTL2 angiomotin like 2 1.34463
FAM214A family with sequence similarity 214, member A 1.34463
MBD5 methyl-CpG binding domain protein 5 1.34463
XYLT1 xylosyltransferase I 1.34463
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 1.34463
KIF26B kinesin family member 26B 1.34463
NCEH1 neutral cholesterol ester hydrolase 1 1.34463
HEG1 heart development protein with EGF-like domains 1 1.32846
GLCCI1 glucocorticoid induced 1 1.32139
ANTXR2 anthrax toxin receptor 2 1.31048

decreased expression

Symbol Name Standardized Value
SFR1 SWI5-dependent recombination repair 1 -4.84532
CORIN corin, serine peptidase -4.27172
TMEM256 transmembrane protein 256 -4.22515
HIST2H2BF histone cluster 2, H2bf -4.22515
HIST1H4I histone cluster 1, H4i -4.02529
RPS27 ribosomal protein S27 -3.43598
MRPS27 mitochondrial ribosomal protein S27 -3.39449
TAS2R4 taste receptor, type 2, member 4 -3.29559
HIST3H2BB histone cluster 3, H2bb -3.28748
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -3.28748
BRCA1 breast cancer 1, early onset -3.10279
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -3.01867
DDIT4 DNA-damage-inducible transcript 4 -2.93703
RPL7 ribosomal protein L7 -2.86282
RAB26 RAB26, member RAS oncogene family -2.5609
MRPL45 mitochondrial ribosomal protein L45 -2.31484
ADM adrenomedullin -2.29002
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 -2.18215
FLOT1 flotillin 1 -2.14269
INSIG1 insulin induced gene 1 -2.05908
THOC6 THO complex 6 -2.02766
TATDN1 TatD DNase domain containing 1 -2.02766
SLC39A11 solute carrier family 39, member 11 -2.02068
NLRP14 NLR family, pyrin domain containing 14 -2.01374
GMPR2 guanosine monophosphate reductase 2 -2.00948
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like -1.93894
HIST1H2BD histone cluster 1, H2bd -1.93894
PCSK9 proprotein convertase subtilisin/kexin type 9 -1.93894
RPL36AL ribosomal protein L36a-like -1.93894
ZMYM1 zinc finger, MYM-type 1 -1.93894
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -1.93894
FADS1 fatty acid desaturase 1 -1.93894
ARHGAP19 Rho GTPase activating protein 19 -1.93894
GINS1 GINS complex subunit 1 (Psf1 homolog) -1.93894
WNT16 wingless-type MMTV integration site family, member 16 -1.91494
PRIM1 primase, DNA, polypeptide 1 (49kDa) -1.83138
H1F0 H1 histone family, member 0 -1.75892
DHRS3 dehydrogenase/reductase (SDR family) member 3 -1.71224
HIST1H2AK histone cluster 1, H2ak -1.71224
PMFBP1 polyamine modulated factor 1 binding protein 1 -1.71224
PLAC8L1 PLAC8-like 1 -1.70253
AK7 adenylate kinase 7 -1.68563
RPS17 ribosomal protein S17 -1.65317
NELFE negative elongation factor complex member E -1.63005
EME1 essential meiotic structure-specific endonuclease 1 -1.63005
HIST1H2AC histone cluster 1, H2ac -1.61574
VMP1 vacuole membrane protein 1 -1.6112
HIST1H2AI histone cluster 1, H2ai -1.6112
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) -1.60205
METTL2B methyltransferase like 2B -1.60205
IQCG IQ motif containing G -1.60205
DEPDC1 DEP domain containing 1 -1.58413
GINS4 GINS complex subunit 4 (Sld5 homolog) -1.57912
TMEM141 transmembrane protein 141 -1.57702
COMMD8 COMM domain containing 8 -1.57702
LRRC75A leucine rich repeat containing 75A -1.56112
HIST3H2A histone cluster 3, H2a -1.55284
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -1.54313
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) -1.51464
RIBC2 RIB43A domain with coiled-coils 2 -1.47312
CDK12 cyclin-dependent kinase 12 -1.43096
RING1 ring finger protein 1 -1.42221
LACTB2 lactamase, beta 2 -1.40815
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -1.36431
HIST1H3A histone cluster 1, H3a -1.36229
CHMP2A charged multivesicular body protein 2A -1.34463
C8ORF33 chromosome 8 open reading frame 33 -1.34463
PNPO pyridoxamine 5'-phosphate oxidase -1.34463
RPS26 ribosomal protein S26 -1.34463
MSH5 mutS homolog 5 -1.34463
LINC00998 long intergenic non-protein coding RNA 998 -1.34463
SLC38A2 solute carrier family 38, member 2 -1.34463
RPGRIP1L RPGRIP1-like -1.34463
KRT7 keratin 7, type II -1.34463
PPCS phosphopantothenoylcysteine synthetase -1.34463
FBXO32 F-box protein 32 -1.34463
H2AFX H2A histone family, member X -1.34463
ZMAT2 zinc finger, matrin-type 2 -1.34463
KIAA1407 KIAA1407 -1.33612
GCAT glycine C-acetyltransferase -1.32846
LRRC69 leucine rich repeat containing 69 -1.31238