| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KO perturbation targeting METTL3 in HCT116 cell line (Study accession: SRP193002) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_6836_KO_METTL3_SRP193002 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAPK15 | mitogen-activated protein kinase 15 | 20.0 |
| IGLON5 | IgLON family member 5 | 19.0969 |
| TTYH1 | tweety family member 1 | 18.8539 |
| ZNF740 | zinc finger protein 740 | 15.4397 |
| NDUFB9 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa | 13.2061 |
| PLK1 | polo-like kinase 1 | 11.725 |
| RRBP1 | ribosome binding protein 1 | 11.3124 |
| THBS1 | thrombospondin 1 | 10.5292 |
| ARSG | arylsulfatase G | 10.3066 |
| TECPR1 | tectonin beta-propeller repeat containing 1 | 10.2744 |
| IGFL2 | IGF-like family member 2 | 10.2485 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | 10.0353 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 9.29428 |
| RGS11 | regulator of G-protein signaling 11 | 9.05125 |
| C1ORF122 | chromosome 1 open reading frame 122 | 9.0247 |
| CCDC151 | coiled-coil domain containing 151 | 8.55357 |
| SIGLEC12 | sialic acid binding Ig-like lectin 12 (gene/pseudogene) | 8.47299 |
| PLXNB3 | plexin B3 | 8.39635 |
| NCBP2L | nuclear cap binding protein subunit 2-like | 8.29357 |
| RECQL5 | RecQ protein-like 5 | 8.00663 |
| MXRA8 | matrix-remodelling associated 8 | 7.94131 |
| PRRT2 | proline-rich transmembrane protein 2 | 7.78929 |
| REEP5 | receptor accessory protein 5 | 7.68865 |
| STK25 | serine/threonine kinase 25 | 7.47603 |
| AP1G2 | adaptor-related protein complex 1, gamma 2 subunit | 7.35128 |
| THEM5 | thioesterase superfamily member 5 | 6.9592 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 6.72772 |
| PXDN | peroxidasin | 6.69862 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | 6.61235 |
| JRK | Jrk homolog (mouse) | 6.39026 |
| ASPDH | aspartate dehydrogenase domain containing | 6.36716 |
| FAM227B | family with sequence similarity 227, member B | 6.18558 |
| CDC14B | cell division cycle 14B | 6.143 |
| FBXL19 | F-box and leucine-rich repeat protein 19 | 5.9812 |
| SLC25A22 | solute carrier family 25 (mitochondrial carrier: glutamate), member 22 | 5.96521 |
| ADAMTSL4 | ADAMTS-like 4 | 5.59836 |
| CCDC152 | coiled-coil domain containing 152 | 5.59494 |
| POLR3H | polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) | 5.59494 |
| PDE7A | phosphodiesterase 7A | 5.56523 |
| FZD4 | frizzled class receptor 4 | 5.50995 |
| AFAP1L2 | actin filament associated protein 1-like 2 | 5.50042 |
| C2 | complement component 2 | 5.48338 |
| E4F1 | E4F transcription factor 1 | 5.40959 |
| ITGB7 | integrin, beta 7 | 5.37694 |
| COL4A3BP | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | 5.16536 |
| DOPEY1 | dopey family member 1 | 5.1578 |
| CEP72 | centrosomal protein 72kDa | 5.10502 |
| IRS1 | insulin receptor substrate 1 | 5.10266 |
| ARRDC1 | arrestin domain containing 1 | 5.05505 |
| SOX15 | SRY (sex determining region Y)-box 15 | 5.03837 |
| UBE2D4 | ubiquitin-conjugating enzyme E2D 4 (putative) | 5.00927 |
| LOC100130705 | uncharacterized LOC100130705 | 4.97623 |
| SIK2 | salt-inducible kinase 2 | 4.95231 |
| TMEM120B | transmembrane protein 120B | 4.78977 |
| GCSAM | germinal center-associated, signaling and motility | 4.78977 |
| FSIP1 | fibrous sheath interacting protein 1 | 4.7047 |
| BNIP2 | BCL2/adenovirus E1B 19kDa interacting protein 2 | 4.69199 |
| NFRKB | nuclear factor related to kappaB binding protein | 4.67167 |
| DNASE1L2 | deoxyribonuclease I-like 2 | 4.65231 |
| HIST1H4I | histone cluster 1, H4i | 4.54789 |
| RUVBL1 | RuvB-like AAA ATPase 1 | 4.54789 |
| FXR2 | fragile X mental retardation, autosomal homolog 2 | 4.53032 |
| MIPOL1 | mirror-image polydactyly 1 | 4.50462 |
| RELL1 | RELT-like 1 | 4.47595 |
| SDR39U1 | short chain dehydrogenase/reductase family 39U, member 1 | 4.4759 |
| ROGDI | rogdi homolog (Drosophila) | 4.40693 |
| PHF3 | PHD finger protein 3 | 4.31234 |
| BOP1 | block of proliferation 1 | 4.23904 |
| MRTO4 | mRNA turnover 4 homolog (S. cerevisiae) | 4.21271 |
| CD3EAP | CD3e molecule, epsilon associated protein | 4.09718 |
| HPS3 | Hermansky-Pudlak syndrome 3 | 4.07921 |
| GPR20 | G protein-coupled receptor 20 | 4.05055 |
| MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) | 4.01184 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 4.00432 |
| MTERF2 | mitochondrial transcription termination factor 2 | 3.95823 |
| BRI3 | brain protein I3 | 3.92632 |
| LRRC4B | leucine rich repeat containing 4B | 3.90081 |
| CD37 | CD37 molecule | 3.85897 |
| HABP4 | hyaluronan binding protein 4 | 3.83728 |
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | 3.71873 |
| MBNL1 | muscleblind-like splicing regulator 1 | 3.70711 |
| GJD3 | gap junction protein, delta 3, 31.9kDa | 3.59877 |
| MPC2 | mitochondrial pyruvate carrier 2 | 3.57497 |
| RNF39 | ring finger protein 39 | 3.55112 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 3.54986 |
| MUC15 | mucin 15, cell surface associated | 3.52723 |
| FAM118B | family with sequence similarity 118, member B | 3.46093 |
| SORT1 | sortilin 1 | 3.44671 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | 3.4165 |
| PRMT7 | protein arginine methyltransferase 7 | 3.36773 |
| DAZAP2 | DAZ associated protein 2 | 3.34824 |
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 | 3.32167 |
| MAF1 | MAF1 homolog (S. cerevisiae) | 3.29922 |
| PAGR1 | PAXIP1 associated glutamate-rich protein 1 | 3.26991 |
| PNCK | pregnancy up-regulated nonubiquitous CaM kinase | 3.25426 |
| SOX30 | SRY (sex determining region Y)-box 30 | 3.19877 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 3.19877 |
| ADGRG5 | adhesion G protein-coupled receptor G5 | 3.16707 |
| ANKRD13A | ankyrin repeat domain 13A | 3.16272 |
| ERAP1 | endoplasmic reticulum aminopeptidase 1 | 3.16272 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TOX4 | TOX high mobility group box family member 4 | -20.0 |
| ENOSF1 | enolase superfamily member 1 | -14.8 |
| TICRR | TOPBP1-interacting checkpoint and replication regulator | -13.6202 |
| COX20 | COX20 cytochrome c oxidase assembly factor | -13.5422 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | -12.4283 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | -11.9969 |
| SH3D21 | SH3 domain containing 21 | -11.3945 |
| RECQL | RecQ helicase-like | -9.74344 |
| CMTM7 | CKLF-like MARVEL transmembrane domain containing 7 | -8.39635 |
| USP34 | ubiquitin specific peptidase 34 | -7.33785 |
| SPRYD4 | SPRY domain containing 4 | -7.2112 |
| RIC1 | RAB6A GEF complex partner 1 | -7.12364 |
| WDR33 | WD repeat domain 33 | -7.01079 |
| C8ORF59 | chromosome 8 open reading frame 59 | -6.97255 |
| TSNAXIP1 | translin-associated factor X interacting protein 1 | -6.82522 |
| GPLD1 | glycosylphosphatidylinositol specific phospholipase D1 | -6.75595 |
| SRR | serine racemase | -6.72772 |
| SLC16A4 | solute carrier family 16, member 4 | -6.60415 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -6.2999 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -6.18558 |
| PLLP | plasmolipin | -5.93361 |
| MARCH7 | membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase | -5.9244 |
| JAM3 | junctional adhesion molecule 3 | -5.80999 |
| PPIL2 | peptidylprolyl isomerase (cyclophilin)-like 2 | -5.78267 |
| FANCD2OS | FANCD2 opposite strand | -5.55709 |
| PLEKHG4B | pleckstrin homology domain containing, family G (with RhoGef domain) member 4B | -5.50042 |
| LOX | lysyl oxidase | -5.48632 |
| SLC18A2 | solute carrier family 18 (vesicular monoamine transporter), member 2 | -5.06346 |
| NIPA2 | non imprinted in Prader-Willi/Angelman syndrome 2 | -5.04775 |
| PYROXD1 | pyridine nucleotide-disulphide oxidoreductase domain 1 | -5.00291 |
| C14ORF79 | chromosome 14 open reading frame 79 | -4.88746 |
| SRSF9 | serine/arginine-rich splicing factor 9 | -4.54863 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -4.48477 |
| JMJD4 | jumonji domain containing 4 | -4.33809 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -4.3315 |
| FN1 | fibronectin 1 | -4.31481 |
| TYMS | thymidylate synthetase | -4.31147 |
| POLG | polymerase (DNA directed), gamma | -4.28728 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | -4.27025 |
| ANKRD61 | ankyrin repeat domain 61 | -4.23318 |
| LHFPL3 | lipoma HMGIC fusion partner-like 3 | -4.21941 |
| PRELID1 | PRELI domain containing 1 | -4.21376 |
| KCNIP4 | Kv channel interacting protein 4 | -4.16476 |
| RER1 | retention in endoplasmic reticulum sorting receptor 1 | -4.01363 |
| VPRBP | Vpr (HIV-1) binding protein | -3.98047 |
| TSPAN31 | tetraspanin 31 | -3.85837 |
| MLX | MLX, MAX dimerization protein | -3.78732 |
| TNRC6C | trinucleotide repeat containing 6C | -3.77822 |
| TRIM59 | tripartite motif containing 59 | -3.71873 |
| FAM57A | family with sequence similarity 57, member A | -3.70848 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | -3.52058 |
| SPDYE6 | speedy/RINGO cell cycle regulator family member E6 | -3.39894 |
| PAQR4 | progestin and adipoQ receptor family member IV | -3.32711 |
| WDR5B | WD repeat domain 5B | -3.22625 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | -3.18761 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -3.17236 |
| DNM2 | dynamin 2 | -3.16707 |
| RNF214 | ring finger protein 214 | -3.11739 |
| TMPRSS9 | transmembrane protease, serine 9 | -3.10974 |
| DBNL | drebrin-like | -3.06687 |
| EVL | Enah/Vasp-like | -3.05512 |
| MIA3 | melanoma inhibitory activity family, member 3 | -3.05224 |
| ZNF276 | zinc finger protein 276 | -3.05124 |
| TSC2 | tuberous sclerosis 2 | -3.04595 |
| ABCB8 | ATP-binding cassette, sub-family B (MDR/TAP), member 8 | -3.02115 |
| SLC38A10 | solute carrier family 38, member 10 | -3.01874 |
| CAPN2 | calpain 2, (m/II) large subunit | -2.99211 |
| KIF7 | kinesin family member 7 | -2.97279 |
| WDR90 | WD repeat domain 90 | -2.9698 |
| KLC1 | kinesin light chain 1 | -2.93689 |
| RAB3GAP2 | RAB3 GTPase activating protein subunit 2 (non-catalytic) | -2.93689 |
| HEATR5A | HEAT repeat containing 5A | -2.92219 |
| MRPS18C | mitochondrial ribosomal protein S18C | -2.8968 |
| MYO1E | myosin IE | -2.8956 |
| ZNF337 | zinc finger protein 337 | -2.85491 |
| GATA2 | GATA binding protein 2 | -2.85386 |
| TMEM80 | transmembrane protein 80 | -2.83973 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -2.83024 |
| CEPT1 | choline/ethanolamine phosphotransferase 1 | -2.82162 |
| WBP2 | WW domain binding protein 2 | -2.79883 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -2.78778 |
| WDR6 | WD repeat domain 6 | -2.78174 |
| NOSTRIN | nitric oxide synthase trafficking | -2.77668 |
| CHRNA3 | cholinergic receptor, nicotinic, alpha 3 (neuronal) | -2.77099 |
| C2ORF88 | chromosome 2 open reading frame 88 | -2.75079 |
| DIS3L | DIS3 like exosome 3'-5' exoribonuclease | -2.74074 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | -2.70749 |
| DNAJC17 | DnaJ (Hsp40) homolog, subfamily C, member 17 | -2.6488 |
| SPDYE3 | speedy/RINGO cell cycle regulator family member E3 | -2.64778 |
| TBL3 | transducin (beta)-like 3 | -2.64375 |
| ZNF710 | zinc finger protein 710 | -2.63192 |
| EML5 | echinoderm microtubule associated protein like 5 | -2.60095 |
| CD302 | CD302 molecule | -2.58731 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -2.57987 |
| FUT2 | fucosyltransferase 2 (secretor status included) | -2.57274 |
| GON4L | gon-4-like (C. elegans) | -2.57157 |
| CEMP1 | cementum protein 1 | -2.57 |
| CIZ1 | CDKN1A interacting zinc finger protein 1 | -2.56634 |
| GPRC5D | G protein-coupled receptor, class C, group 5, member D | -2.55654 |
| ZNF711 | zinc finger protein 711 | -2.55614 |
