Perturb_6867_OE_CRLM1_SRP309080 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description OE perturbation targeting CRLM1 in HCT116 cell line (Study accession: SRP309080) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_6867_OE_CRLM1_SRP309080 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 20.0
HES4 hes family bHLH transcription factor 4 20.0
RRAS related RAS viral (r-ras) oncogene homolog 20.0
MED15 mediator complex subunit 15 20.0
FLII flightless I homolog (Drosophila) 20.0
UBE2S ubiquitin-conjugating enzyme E2S 20.0
FGFR1 fibroblast growth factor receptor 1 20.0
IRS2 insulin receptor substrate 2 20.0
FSCN1 fascin actin-bundling protein 1 20.0
SREBF2 sterol regulatory element binding transcription factor 2 20.0
INSIG1 insulin induced gene 1 20.0
HMG20B high mobility group 20B 20.0
NR4A1 nuclear receptor subfamily 4, group A, member 1 20.0
TRIB1 tribbles pseudokinase 1 20.0
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 20.0
CDC20 cell division cycle 20 20.0
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 20.0
TMEM158 transmembrane protein 158 (gene/pseudogene) 20.0
IER5 immediate early response 5 20.0
FAM46B family with sequence similarity 46, member B 20.0
ALDOC aldolase C, fructose-bisphosphate 20.0
DUSP2 dual specificity phosphatase 2 20.0
DUSP1 dual specificity phosphatase 1 20.0
FAM195B family with sequence similarity 195, member B 20.0
RPS27A ribosomal protein S27a 20.0
SPC24 SPC24, NDC80 kinetochore complex component 20.0
COL13A1 collagen, type XIII, alpha 1 20.0
PNPLA2 patatin-like phospholipase domain containing 2 20.0
DHCR7 7-dehydrocholesterol reductase 20.0
C1ORF167 chromosome 1 open reading frame 167 20.0
DHCR24 24-dehydrocholesterol reductase 20.0
CLDN4 claudin 4 20.0
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 20.0
PPP1R15A protein phosphatase 1, regulatory subunit 15A 20.0
NDRG1 N-myc downstream regulated 1 20.0
MVD mevalonate (diphospho) decarboxylase 20.0
CLU clusterin 20.0
CIB1 calcium and integrin binding 1 (calmyrin) 20.0
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 20.0
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 20.0
HMOX1 heme oxygenase 1 20.0
KRT19 keratin 19, type I 20.0
KRT15 keratin 15, type I 20.0
FDFT1 farnesyl-diphosphate farnesyltransferase 1 20.0
MBOAT2 membrane bound O-acyltransferase domain containing 2 20.0
FOS FBJ murine osteosarcoma viral oncogene homolog 20.0
LDLR low density lipoprotein receptor 20.0
SCD stearoyl-CoA desaturase (delta-9-desaturase) 20.0
CPA4 carboxypeptidase A4 20.0
HSPA1B heat shock 70kDa protein 1B 20.0
FASN fatty acid synthase 20.0
GADD45B growth arrest and DNA-damage-inducible, beta 20.0
BLVRB biliverdin reductase B 20.0
JUN jun proto-oncogene 20.0
JUP junction plakoglobin 20.0
VGF VGF nerve growth factor inducible 20.0
TIMP2 TIMP metallopeptidase inhibitor 2 20.0
KRTAP2-4 keratin associated protein 2-4 20.0
CCNA2 cyclin A2 20.0
FTL ferritin, light polypeptide 20.0
GOLGA2 golgin A2 19.5229
H1FX H1 histone family, member X 19.301
DHDH dihydrodiol dehydrogenase (dimeric) 19.2218
ICAM5 intercellular adhesion molecule 5, telencephalin 19.0969
GDPGP1 GDP-D-glucose phosphorylase 1 18.9586
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 18.9586
AMOTL2 angiomotin like 2 18.4318
WDR45B WD repeat domain 45B 18.3768
HSPG2 heparan sulfate proteoglycan 2 17.8182
MFSD10 major facilitator superfamily domain containing 10 17.4763
LDLRAD2 low density lipoprotein receptor class A domain containing 2 17.4698
CD81 CD81 molecule 17.4622
PTPRU protein tyrosine phosphatase, receptor type, U 17.4559
BAG3 BCL2-associated athanogene 3 17.3799
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 17.2055
POLRMT polymerase (RNA) mitochondrial (DNA directed) 17.1643
LTBP4 latent transforming growth factor beta binding protein 4 17.0835
PLEC plectin 16.9367
AATK apoptosis-associated tyrosine kinase 16.7807
PTRF polymerase I and transcript release factor 16.712
BANP BTG3 associated nuclear protein 16.6751
PRKD2 protein kinase D2 16.6457
PNPLA6 patatin-like phospholipase domain containing 6 16.6012
DAGLB diacylglycerol lipase, beta 16.3982
BAIAP2 BAI1-associated protein 2 16.1524
HDAC5 histone deacetylase 5 16.0432
PCSK9 proprotein convertase subtilisin/kexin type 9 16.0192
NPW neuropeptide W 16.0059
ELOVL1 ELOVL fatty acid elongase 1 15.8537
F2RL1 coagulation factor II (thrombin) receptor-like 1 15.6901
DUSP4 dual specificity phosphatase 4 15.5389
LGALS1 lectin, galactoside-binding, soluble, 1 15.5389
MFSD12 major facilitator superfamily domain containing 12 15.5374
ACTG1 actin gamma 1 15.4242
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 15.3066
PGAM1 phosphoglycerate mutase 1 (brain) 15.1761
NAPRT nicotinate phosphoribosyltransferase 15.1558
FOXK2 forkhead box K2 15.0871
ACADVL acyl-CoA dehydrogenase, very long chain 14.5877
CYC1 cytochrome c-1 14.5554

decreased expression

Symbol Name Standardized Value
FAM149B1 family with sequence similarity 149, member B1 -20.0
PDIA4 protein disulfide isomerase family A, member 4 -20.0
DCBLD2 discoidin, CUB and LCCL domain containing 2 -20.0
RPE65 retinal pigment epithelium-specific protein 65kDa -20.0
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -20.0
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -20.0
C12ORF73 chromosome 12 open reading frame 73 -20.0
STC2 stanniocalcin 2 -20.0
RUVBL1 RuvB-like AAA ATPase 1 -20.0
CDCP1 CUB domain containing protein 1 -20.0
HYOU1 hypoxia up-regulated 1 -20.0
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 -20.0
WARS tryptophanyl-tRNA synthetase -20.0
MT1E metallothionein 1E -20.0
FAM83H family with sequence similarity 83, member H -20.0
AKAP12 A kinase (PRKA) anchor protein 12 -20.0
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -20.0
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -20.0
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -20.0
TRIOBP TRIO and F-actin binding protein -20.0
SFPQ splicing factor proline/glutamine-rich -20.0
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -20.0
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -20.0
GJD3 gap junction protein, delta 3, 31.9kDa -20.0
GDF15 growth differentiation factor 15 -20.0
ENOSF1 enolase superfamily member 1 -20.0
SNX22 sorting nexin 22 -20.0
OASL 2'-5'-oligoadenylate synthetase-like -20.0
ZACN zinc activated ligand-gated ion channel -20.0
VPS9D1 VPS9 domain containing 1 -20.0
NTSR1 neurotensin receptor 1 (high affinity) -20.0
FAT1 FAT atypical cadherin 1 -20.0
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -20.0
SDF2L1 stromal cell-derived factor 2-like 1 -20.0
ITGB4 integrin, beta 4 -20.0
ERCC1 excision repair cross-complementation group 1 -20.0
SYNC syncoilin, intermediate filament protein -20.0
EREG epiregulin -20.0
PHLDA1 pleckstrin homology-like domain, family A, member 1 -20.0
PLAU plasminogen activator, urokinase -20.0
EFHD2 EF-hand domain family, member D2 -20.0
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -20.0
MFSD11 major facilitator superfamily domain containing 11 -20.0
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -20.0
CALR calreticulin -20.0
IER5L immediate early response 5-like -20.0
FUS FUS RNA binding protein -20.0
KRT18 keratin 18, type I -20.0
TMEM50B transmembrane protein 50B -20.0
SLC38A1 solute carrier family 38, member 1 -20.0
KRT8 keratin 8, type II -20.0
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -20.0
KRT7 keratin 7, type II -20.0
WRAP53 WD repeat containing, antisense to TP53 -19.699
MYOF myoferlin -19.699
PTPRB protein tyrosine phosphatase, receptor type, B -19.699
CANX calnexin -19.5229
FAM69B family with sequence similarity 69, member B -19.3979
NCL nucleolin -19.301
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -18.9208
HMGA2 high mobility group AT-hook 2 -18.2291
HNRNPM heterogeneous nuclear ribonucleoprotein M -18.1367
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -18.0177
PLAUR plasminogen activator, urokinase receptor -17.8447
SLC38A2 solute carrier family 38, member 2 -17.6737
S100A4 S100 calcium binding protein A4 -17.3316
PDIA3 protein disulfide isomerase family A, member 3 -17.2472
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -16.9622
IARS isoleucyl-tRNA synthetase -16.8099
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -16.7044
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -16.6751
TRIB3 tribbles pseudokinase 3 -16.5589
SDC4 syndecan 4 -15.9794
IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) -15.9313
EIF6 eukaryotic translation initiation factor 6 -15.5285
TXNRD1 thioredoxin reductase 1 -15.2152
XBP1 X-box binding protein 1 -14.7396
ZC3H7B zinc finger CCCH-type containing 7B -14.6341
FKRP fukutin related protein -14.1313
MCM4 minichromosome maintenance complex component 4 -14.1186
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -13.9058
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -13.8543
SEPT2 septin 2 -13.8179
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -13.6727
PYGB phosphorylase, glycogen; brain -13.5874
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -13.5673
PHGDH phosphoglycerate dehydrogenase -13.4723
RBMX RNA binding motif protein, X-linked -13.2562
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 -13.2482
PDGFB platelet-derived growth factor beta polypeptide -13.2121
TFRC transferrin receptor -12.9059
U2AF2 U2 small nuclear RNA auxiliary factor 2 -12.7582
ZNF469 zinc finger protein 469 -12.7501
TSC22D1 TSC22 domain family, member 1 -12.6024
SRRM5 serine/arginine repetitive matrix 5 -12.5597
ZNF771 zinc finger protein 771 -12.4354
LCN2 lipocalin 2 -12.415
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -12.2537
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -12.201
CDKN2A cyclin-dependent kinase inhibitor 2A -12.0612