Perturb_721_KO_INTS6_SRP299240 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KO perturbation targeting INTS6 in acute myeloid leukemia cell THP-1 cell line (Study accession: SRP299240) (PerturbAtlas)
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Genes

14 genes differentially expressed following the Perturb_721_KO_INTS6_SRP299240 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
PRICKLE3 prickle homolog 3 (Drosophila) 5.8322
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 3.89173
GFM2 G elongation factor, mitochondrial 2 3.33369
MAN1B1 mannosidase, alpha, class 1B, member 1 2.6442
UBXN11 UBX domain protein 11 2.35396
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 2.06345
TCP1 t-complex 1 1.81905
TATDN2 TatD DNase domain containing 2 1.80361
PDIA6 protein disulfide isomerase family A, member 6 1.47617
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 1.38872

decreased expression

Symbol Name Standardized Value
COX20 COX20 cytochrome c oxidase assembly factor -2.35396
BBIP1 BBSome interacting protein 1 -2.06345
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 -1.68363
ZFP36L2 ZFP36 ring finger protein-like 2 -1.61178