| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting CNOT1 in HEK293T cell line (Study accession: SRP285534) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_7243_KD_CNOT1_SRP285534 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSD17B1 | hydroxysteroid (17-beta) dehydrogenase 1 | 14.4023 |
| NMT2 | N-myristoyltransferase 2 | 11.9113 |
| ICAM3 | intercellular adhesion molecule 3 | 10.7144 |
| CYB561D2 | cytochrome b561 family, member D2 | 10.5623 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 10.4148 |
| ZNF224 | zinc finger protein 224 | 10.3477 |
| ERCC4 | excision repair cross-complementation group 4 | 9.4802 |
| CENPT | centromere protein T | 8.91261 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 8.4309 |
| MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | 8.25741 |
| GLOD4 | glyoxalase domain containing 4 | 7.99127 |
| HSPA1A | heat shock 70kDa protein 1A | 7.58991 |
| SARM1 | sterile alpha and TIR motif containing 1 | 7.54373 |
| SRRD | SRR1 domain containing | 7.51087 |
| ALPK1 | alpha-kinase 1 | 7.45948 |
| METTL25 | methyltransferase like 25 | 7.37952 |
| FKBP15 | FK506 binding protein 15, 133kDa | 7.36743 |
| KIAA0586 | KIAA0586 | 7.31237 |
| FGF2 | fibroblast growth factor 2 (basic) | 7.19108 |
| C1ORF122 | chromosome 1 open reading frame 122 | 7.17209 |
| ZNF593OS | ZNF593 opposite strand | 6.74879 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 6.67783 |
| LONP2 | lon peptidase 2, peroxisomal | 6.58004 |
| CIRBP | cold inducible RNA binding protein | 5.9824 |
| SCLT1 | sodium channel and clathrin linker 1 | 5.64405 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 5.51891 |
| HEATR4 | HEAT repeat containing 4 | 5.50775 |
| CEBPZOS | CEBPZ opposite strand | 5.24746 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 5.14817 |
| MAK16 | MAK16 homolog (S. cerevisiae) | 5.14817 |
| HPS4 | Hermansky-Pudlak syndrome 4 | 5.14817 |
| RFXANK | regulatory factor X-associated ankyrin-containing protein | 5.14817 |
| BAG2 | BCL2-associated athanogene 2 | 5.14357 |
| GFAP | glial fibrillary acidic protein | 5.08992 |
| MITD1 | MIT, microtubule interacting and transport, domain containing 1 | 4.99186 |
| BCCIP | BRCA2 and CDKN1A interacting protein | 4.99186 |
| TFIP11 | tuftelin interacting protein 11 | 4.89215 |
| PSMC3IP | PSMC3 interacting protein | 4.87397 |
| FAM117A | family with sequence similarity 117, member A | 4.75963 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | 4.68866 |
| GPN3 | GPN-loop GTPase 3 | 4.67081 |
| SNRNP35 | small nuclear ribonucleoprotein 35kDa (U11/U12) | 4.55178 |
| ARL10 | ADP-ribosylation factor-like 10 | 4.51527 |
| SPATA9 | spermatogenesis associated 9 | 4.45225 |
| BRD2 | bromodomain containing 2 | 4.39125 |
| SLC4A1AP | solute carrier family 4 (anion exchanger), member 1, adaptor protein | 4.34769 |
| GPR37L1 | G protein-coupled receptor 37 like 1 | 4.32888 |
| MPDU1 | mannose-P-dolichol utilization defect 1 | 4.32888 |
| MMP21 | matrix metallopeptidase 21 | 4.29944 |
| NEK8 | NIMA-related kinase 8 | 4.26091 |
| NUDC | nudC nuclear distribution protein | 4.26091 |
| THRA | thyroid hormone receptor, alpha | 4.18657 |
| ELP4 | elongator acetyltransferase complex subunit 4 | 4.18657 |
| CENPP | centromere protein P | 4.17309 |
| ATF5 | activating transcription factor 5 | 4.01561 |
| FAM104A | family with sequence similarity 104, member A | 3.90568 |
| TMEM263 | transmembrane protein 263 | 3.8311 |
| LINS | lines homolog (Drosophila) | 3.73832 |
| WDR43 | WD repeat domain 43 | 3.72993 |
| BRIX1 | BRX1, biogenesis of ribosomes | 3.72141 |
| RPS27A | ribosomal protein S27a | 3.71447 |
| UTP15 | UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) | 3.71305 |
| SNAP47 | synaptosomal-associated protein, 47kDa | 3.61085 |
| TMEM120B | transmembrane protein 120B | 3.60143 |
| PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | 3.57488 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 3.55239 |
| ENDOG | endonuclease G | 3.49318 |
| KRT17 | keratin 17, type I | 3.48718 |
| ATG9B | autophagy related 9B | 3.46068 |
| TTI2 | TELO2 interacting protein 2 | 3.45419 |
| ERCC1 | excision repair cross-complementation group 1 | 3.45298 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 3.42947 |
| TMEM184A | transmembrane protein 184A | 3.40895 |
| ATP8B4 | ATPase, class I, type 8B, member 4 | 3.36069 |
| SLC38A2 | solute carrier family 38, member 2 | 3.35665 |
| NCAPH2 | non-SMC condensin II complex, subunit H2 | 3.34589 |
| ZBTB11 | zinc finger and BTB domain containing 11 | 3.31485 |
| COG5 | component of oligomeric golgi complex 5 | 3.31266 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 3.27396 |
| EXOC3 | exocyst complex component 3 | 3.26433 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 3.2454 |
| NPC1 | Niemann-Pick disease, type C1 | 3.24241 |
| LAMTOR4 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 | 3.21413 |
| PRCC | papillary renal cell carcinoma (translocation-associated) | 3.20168 |
| POMGNT1 | protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | 3.15964 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 3.11622 |
| USP10 | ubiquitin specific peptidase 10 | 3.10199 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 3.09863 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | 3.07558 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | 3.0524 |
| IFT22 | intraflagellar transport 22 | 3.0223 |
| LNX1 | ligand of numb-protein X 1, E3 ubiquitin protein ligase | 2.99449 |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | 2.99138 |
| WBSCR22 | Williams Beuren syndrome chromosome region 22 | 2.98332 |
| TREH | trehalase (brush-border membrane glycoprotein) | 2.97848 |
| CXCR5 | chemokine (C-X-C motif) receptor 5 | 2.95109 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | 2.94903 |
| MOCS2 | molybdenum cofactor synthesis 2 | 2.92656 |
| C1ORF56 | chromosome 1 open reading frame 56 | 2.92656 |
| KCNE2 | potassium channel, voltage gated subfamily E regulatory beta subunit 2 | 2.90922 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SETD6 | SET domain containing 6 | -20.0 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -8.50854 |
| ADAT2 | adenosine deaminase, tRNA-specific 2 | -7.51087 |
| STAB1 | stabilin 1 | -6.59354 |
| TTC19 | tetratricopeptide repeat domain 19 | -6.55802 |
| CCNC | cyclin C | -5.95558 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | -5.84079 |
| RBPMS | RNA binding protein with multiple splicing | -4.931 |
| PLS3 | plastin 3 | -4.76086 |
| GCC1 | GRIP and coiled-coil domain containing 1 | -4.5765 |
| FAM73A | family with sequence similarity 73, member A | -4.55723 |
| PLXNC1 | plexin C1 | -4.51068 |
| PPP6R2 | protein phosphatase 6, regulatory subunit 2 | -4.36737 |
| CENPV | centromere protein V | -4.28407 |
| LRRC75A | leucine rich repeat containing 75A | -4.21762 |
| PEX5L | peroxisomal biogenesis factor 5-like | -4.2139 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -4.17309 |
| RNF32 | ring finger protein 32 | -4.10559 |
| AP5Z1 | adaptor-related protein complex 5, zeta 1 subunit | -4.10113 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | -3.99953 |
| CCDC28B | coiled-coil domain containing 28B | -3.96565 |
| SLC7A10 | solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 | -3.86022 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | -3.86022 |
| AP1G2 | adaptor-related protein complex 1, gamma 2 subunit | -3.8199 |
| SDCBP | syndecan binding protein (syntenin) | -3.73832 |
| SETD7 | SET domain containing (lysine methyltransferase) 7 | -3.71305 |
| BOC | BOC cell adhesion associated, oncogene regulated | -3.69003 |
| HBP1 | HMG-box transcription factor 1 | -3.64026 |
| C14ORF166 | chromosome 14 open reading frame 166 | -3.63016 |
| MCMDC2 | minichromosome maintenance domain containing 2 | -3.61085 |
| ARG2 | arginase 2 | -3.60047 |
| MYL5 | myosin, light chain 5, regulatory | -3.51338 |
| AGBL5 | ATP/GTP binding protein-like 5 | -3.509 |
| MXD3 | MAX dimerization protein 3 | -3.45274 |
| C5ORF63 | chromosome 5 open reading frame 63 | -3.45274 |
| ZNF546 | zinc finger protein 546 | -3.43535 |
| ZBTB37 | zinc finger and BTB domain containing 37 | -3.43007 |
| CDHR5 | cadherin-related family member 5 | -3.41806 |
| SLC16A4 | solute carrier family 16, member 4 | -3.38953 |
| RGL4 | ral guanine nucleotide dissociation stimulator-like 4 | -3.36069 |
| TGFB3 | transforming growth factor, beta 3 | -3.35432 |
| USP49 | ubiquitin specific peptidase 49 | -3.35432 |
| ZC2HC1C | zinc finger, C2HC-type containing 1C | -3.35432 |
| MMP24 | matrix metallopeptidase 24 (membrane-inserted) | -3.35432 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | -3.32949 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -3.27921 |
| HYI | hydroxypyruvate isomerase (putative) | -3.27921 |
| NOSTRIN | nitric oxide synthase trafficking | -3.27887 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -3.27396 |
| TXLNA | taxilin alpha | -3.26266 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -3.25315 |
| RAB24 | RAB24, member RAS oncogene family | -3.23968 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | -3.19491 |
| LIPI | lipase, member I | -3.19322 |
| FAM184B | family with sequence similarity 184, member B | -3.15964 |
| SMYD2 | SET and MYND domain containing 2 | -3.15714 |
| DUSP16 | dual specificity phosphatase 16 | -3.15714 |
| MMRN2 | multimerin 2 | -3.13423 |
| SLC46A1 | solute carrier family 46 (folate transporter), member 1 | -3.10958 |
| BEST1 | bestrophin 1 | -3.10797 |
| PDE5A | phosphodiesterase 5A, cGMP-specific | -3.08632 |
| GRIN2C | glutamate receptor, ionotropic, N-methyl D-aspartate 2C | -3.04448 |
| ZNF101 | zinc finger protein 101 | -3.02981 |
| STK24 | serine/threonine kinase 24 | -3.01341 |
| FBXO25 | F-box protein 25 | -2.99353 |
| TNC | tenascin C | -2.97848 |
| COLGALT2 | collagen beta(1-O)galactosyltransferase 2 | -2.96736 |
| JAK1 | Janus kinase 1 | -2.96403 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -2.93876 |
| RMND5B | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | -2.91876 |
| PRICKLE1 | prickle homolog 1 (Drosophila) | -2.88798 |
| MASP2 | mannan-binding lectin serine peptidase 2 | -2.86945 |
| TM6SF1 | transmembrane 6 superfamily member 1 | -2.86945 |
| KCTD18 | potassium channel tetramerization domain containing 18 | -2.86219 |
| CNOT7 | CCR4-NOT transcription complex, subunit 7 | -2.8578 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -2.85625 |
| PAX6 | paired box 6 | -2.84823 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -2.84061 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.8356 |
| PTOV1 | prostate tumor overexpressed 1 | -2.82144 |
| TRMT13 | tRNA methyltransferase 13 homolog (S. cerevisiae) | -2.78584 |
| C2ORF88 | chromosome 2 open reading frame 88 | -2.76218 |
| RHOQ | ras homolog family member Q | -2.74897 |
| LRCH4 | leucine-rich repeats and calponin homology (CH) domain containing 4 | -2.74406 |
| COA5 | cytochrome c oxidase assembly factor 5 | -2.72665 |
| TTBK2 | tau tubulin kinase 2 | -2.72366 |
| NUMB | numb homolog (Drosophila) | -2.72366 |
| ADCY5 | adenylate cyclase 5 | -2.71234 |
| XPA | xeroderma pigmentosum, complementation group A | -2.69877 |
| POM121 | POM121 transmembrane nucleoporin | -2.69341 |
| AGK | acylglycerol kinase | -2.693 |
| ZNF24 | zinc finger protein 24 | -2.69238 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | -2.66661 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -2.66543 |
| ICA1L | islet cell autoantigen 1,69kDa-like | -2.66538 |
| SPATA21 | spermatogenesis associated 21 | -2.65536 |
| PGF | placental growth factor | -2.65302 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -2.63943 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | -2.61043 |
| GSE1 | Gse1 coiled-coil protein | -2.57761 |
