| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting ADAR in acute myeloid leukemia cell THP-1 cell line (Study accession: SRP293637) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_729_KD_ADAR_SRP293637 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TKTL1 | transketolase-like 1 | 5.46295 |
| COL6A5 | collagen, type VI, alpha 5 | 4.94729 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 4.8452 |
| TXNIP | thioredoxin interacting protein | 4.459 |
| PCLO | piccolo presynaptic cytomatrix protein | 4.12654 |
| COL15A1 | collagen, type XV, alpha 1 | 3.92706 |
| MUC19 | mucin 19, oligomeric | 3.88628 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 3.85238 |
| N4BP2 | NEDD4 binding protein 2 | 3.85238 |
| MEF2C | myocyte enhancer factor 2C | 3.83587 |
| TNFRSF9 | tumor necrosis factor receptor superfamily, member 9 | 3.70256 |
| MYO18B | myosin XVIIIB | 3.62249 |
| SLC26A1 | solute carrier family 26 (anion exchanger), member 1 | 3.58564 |
| TTC28 | tetratricopeptide repeat domain 28 | 3.57485 |
| RYR2 | ryanodine receptor 2 (cardiac) | 3.32611 |
| SLC38A10 | solute carrier family 38, member 10 | 3.24981 |
| APH1B | APH1B gamma secretase subunit | 3.23171 |
| GMPPA | GDP-mannose pyrophosphorylase A | 3.2226 |
| CELF2 | CUGBP, Elav-like family member 2 | 3.16252 |
| COLGALT2 | collagen beta(1-O)galactosyltransferase 2 | 3.12267 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 3.11855 |
| POTEE | POTE ankyrin domain family, member E | 3.08939 |
| PPM1E | protein phosphatase, Mg2+/Mn2+ dependent, 1E | 3.08825 |
| IQSEC2 | IQ motif and Sec7 domain 2 | 3.03092 |
| MRC2 | mannose receptor, C type 2 | 2.9938 |
| CPEB1 | cytoplasmic polyadenylation element binding protein 1 | 2.90777 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 2.90448 |
| RNF213 | ring finger protein 213 | 2.88745 |
| HIP1 | huntingtin interacting protein 1 | 2.88677 |
| ESYT1 | extended synaptotagmin-like protein 1 | 2.79232 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 2.792 |
| BCAS3 | breast carcinoma amplified sequence 3 | 2.66818 |
| ZFHX3 | zinc finger homeobox 3 | 2.66258 |
| PIM2 | Pim-2 proto-oncogene, serine/threonine kinase | 2.65841 |
| NECAP2 | NECAP endocytosis associated 2 | 2.62718 |
| ATXN3L | ataxin 3-like | 2.62453 |
| LRRC56 | leucine rich repeat containing 56 | 2.60735 |
| RELN | reelin | 2.54554 |
| SNX19 | sorting nexin 19 | 2.5256 |
| SH3TC1 | SH3 domain and tetratricopeptide repeats 1 | 2.49067 |
| TMEM2 | transmembrane protein 2 | 2.46345 |
| POU2F2 | POU class 2 homeobox 2 | 2.45685 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 2.43631 |
| RETSAT | retinol saturase (all-trans-retinol 13,14-reductase) | 2.43631 |
| CFAP70 | cilia and flagella associated protein 70 | 2.41844 |
| SZT2 | seizure threshold 2 homolog (mouse) | 2.41513 |
| TRIM69 | tripartite motif containing 69 | 2.41191 |
| MESDC2 | mesoderm development candidate 2 | 2.39412 |
| SSR1 | signal sequence receptor, alpha | 2.387 |
| TLR8 | toll-like receptor 8 | 2.36822 |
| ARHGAP6 | Rho GTPase activating protein 6 | 2.36291 |
| WDYHV1 | WDYHV motif containing 1 | 2.36291 |
| MLLT4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 2.35145 |
| ZDHHC9 | zinc finger, DHHC-type containing 9 | 2.34957 |
| ANKRD31 | ankyrin repeat domain 31 | 2.34275 |
| NCOA1 | nuclear receptor coactivator 1 | 2.34275 |
| PTPRH | protein tyrosine phosphatase, receptor type, H | 2.34275 |
| CD80 | CD80 molecule | 2.34275 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | 2.33552 |
| IL10RA | interleukin 10 receptor, alpha | 2.32671 |
| AMOTL1 | angiomotin like 1 | 2.32479 |
| CCDC97 | coiled-coil domain containing 97 | 2.29964 |
| NEBL | nebulette | 2.29964 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 2.29964 |
| C15ORF26 | chromosome 15 open reading frame 26 | 2.29964 |
| CCDC154 | coiled-coil domain containing 154 | 2.29964 |
| PHYKPL | 5-phosphohydroxy-L-lysine phospho-lyase | 2.27791 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | 2.2757 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 2.27411 |
| MUC4 | mucin 4, cell surface associated | 2.26254 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 2.25438 |
| EPAS1 | endothelial PAS domain protein 1 | 2.25418 |
| GAB2 | GRB2-associated binding protein 2 | 2.25418 |
| SOX5 | SRY (sex determining region Y)-box 5 | 2.25418 |
| PTPN9 | protein tyrosine phosphatase, non-receptor type 9 | 2.25086 |
| FNDC3B | fibronectin type III domain containing 3B | 2.24182 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 2.23101 |
| ESRRB | estrogen-related receptor beta | 2.23101 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | 2.2076 |
| UBXN2B | UBX domain protein 2B | 2.2076 |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | 2.20683 |
| GGCX | gamma-glutamyl carboxylase | 2.20335 |
| TMEM194B | transmembrane protein 194B | 2.2017 |
| ZNF780B | zinc finger protein 780B | 2.19667 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 2.19592 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | 2.19379 |
| COL6A3 | collagen, type VI, alpha 3 | 2.17765 |
| ANKRD24 | ankyrin repeat domain 24 | 2.1775 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 2.1775 |
| CPZ | carboxypeptidase Z | 2.17394 |
| GALC | galactosylceramidase | 2.16394 |
| ARSG | arylsulfatase G | 2.15725 |
| COL9A2 | collagen, type IX, alpha 2 | 2.14036 |
| FAM129A | family with sequence similarity 129, member A | 2.12191 |
| PHOX2A | paired-like homeobox 2a | 2.11962 |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | 2.11263 |
| FHAD1 | forkhead-associated (FHA) phosphopeptide binding domain 1 | 2.1027 |
| SMAD3 | SMAD family member 3 | 2.10118 |
| NCOA3 | nuclear receptor coactivator 3 | 2.09696 |
| C10ORF54 | chromosome 10 open reading frame 54 | 2.09696 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADAR | adenosine deaminase, RNA-specific | -12.1784 |
| ALDOC | aldolase C, fructose-bisphosphate | -12.096 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -10.5123 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -8.05754 |
| TDG | thymine-DNA glycosylase | -7.38826 |
| ABHD5 | abhydrolase domain containing 5 | -7.0675 |
| KLHL15 | kelch-like family member 15 | -6.91447 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | -6.71571 |
| HSPA1A | heat shock 70kDa protein 1A | -6.20909 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | -6.01496 |
| CYP26A1 | cytochrome P450, family 26, subfamily A, polypeptide 1 | -5.7794 |
| ZBTB43 | zinc finger and BTB domain containing 43 | -5.75617 |
| PGK1 | phosphoglycerate kinase 1 | -5.63301 |
| FEM1C | fem-1 homolog c (C. elegans) | -5.45629 |
| MSMO1 | methylsterol monooxygenase 1 | -5.45629 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -5.45629 |
| SLFN14 | schlafen family member 14 | -5.30316 |
| INSIG1 | insulin induced gene 1 | -5.12068 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.84634 |
| YOD1 | YOD1 deubiquitinase | -4.62649 |
| MME | membrane metallo-endopeptidase | -4.604 |
| NCOA4 | nuclear receptor coactivator 4 | -4.59576 |
| SMCR8 | Smith-Magenis syndrome chromosome region, candidate 8 | -4.59576 |
| KLHL28 | kelch-like family member 28 | -4.04187 |
| CPOX | coproporphyrinogen oxidase | -4.04187 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | -4.04187 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -4.02051 |
| ENO2 | enolase 2 (gamma, neuronal) | -3.95266 |
| TMC8 | transmembrane channel-like 8 | -3.94029 |
| TPI1 | triosephosphate isomerase 1 | -3.92706 |
| HMGB2 | high mobility group box 2 | -3.92706 |
| OAT | ornithine aminotransferase | -3.90877 |
| ALDOA | aldolase A, fructose-bisphosphate | -3.90648 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -3.90648 |
| HSPA1B | heat shock 70kDa protein 1B | -3.90648 |
| CWC22 | CWC22 spliceosome-associated protein | -3.85886 |
| BCLAF1 | BCL2-associated transcription factor 1 | -3.85238 |
| MORF4L2 | mortality factor 4 like 2 | -3.85238 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -3.85238 |
| SQLE | squalene epoxidase | -3.83359 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -3.73845 |
| HIST1H2BH | histone cluster 1, H2bh | -3.72865 |
| INSL3 | insulin-like 3 (Leydig cell) | -3.71628 |
| HEMGN | hemogen | -3.67717 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | -3.64531 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -3.64531 |
| LGMN | legumain | -3.62878 |
| FSD1 | fibronectin type III and SPRY domain containing 1 | -3.60417 |
| ANKRD50 | ankyrin repeat domain 50 | -3.60389 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -3.58564 |
| HILPDA | hypoxia inducible lipid droplet-associated | -3.53982 |
| MAGEA3 | melanoma antigen family A3 | -3.45029 |
| APLNR | apelin receptor | -3.44495 |
| TMEM135 | transmembrane protein 135 | -3.37748 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -3.37748 |
| LDHA | lactate dehydrogenase A | -3.36189 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -3.32611 |
| FZD4 | frizzled class receptor 4 | -3.32611 |
| FAM83D | family with sequence similarity 83, member D | -3.27899 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -3.2226 |
| ZNF330 | zinc finger protein 330 | -3.12898 |
| MRGBP | MRG/MORF4L binding protein | -3.11039 |
| NEK2 | NIMA-related kinase 2 | -3.11039 |
| RARS | arginyl-tRNA synthetase | -3.09232 |
| SRSF4 | serine/arginine-rich splicing factor 4 | -3.05259 |
| C5ORF15 | chromosome 5 open reading frame 15 | -3.04716 |
| CRYM | crystallin, mu | -3.01904 |
| YTHDC1 | YTH domain containing 1 | -3.01371 |
| CCDC94 | coiled-coil domain containing 94 | -2.9826 |
| CALR | calreticulin | -2.9702 |
| LFNG | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -2.9702 |
| NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | -2.9159 |
| PPIH | peptidylprolyl isomerase H (cyclophilin H) | -2.91001 |
| PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | -2.91001 |
| HSPA8 | heat shock 70kDa protein 8 | -2.8984 |
| ATP6V1E1 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 | -2.88819 |
| SOCS6 | suppressor of cytokine signaling 6 | -2.88819 |
| ZBTB5 | zinc finger and BTB domain containing 5 | -2.83797 |
| DRG1 | developmentally regulated GTP binding protein 1 | -2.8376 |
| CCSAP | centriole, cilia and spindle-associated protein | -2.82315 |
| PRDX1 | peroxiredoxin 1 | -2.81912 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -2.80034 |
| HIST1H3A | histone cluster 1, H3a | -2.79709 |
| DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 | -2.79232 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -2.79232 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -2.77471 |
| GPKOW | G patch domain and KOW motifs | -2.76721 |
| ZBTB10 | zinc finger and BTB domain containing 10 | -2.76332 |
| MAGED2 | melanoma antigen family D2 | -2.76332 |
| HIST1H2AE | histone cluster 1, H2ae | -2.74458 |
| VRK1 | vaccinia related kinase 1 | -2.73605 |
| SLU7 | SLU7 splicing factor homolog (S. cerevisiae) | -2.73605 |
| PTTG1 | pituitary tumor-transforming 1 | -2.73519 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -2.69826 |
| CRYAB | crystallin, alpha B | -2.6808 |
| HBP1 | HMG-box transcription factor 1 | -2.66258 |
| TXNDC16 | thioredoxin domain containing 16 | -2.65964 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | -2.63144 |
| NIPSNAP1 | nipsnap homolog 1 (C. elegans) | -2.61982 |
| TBC1D23 | TBC1 domain family, member 23 | -2.61939 |
