| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting RC3H1/RC3H2 in HEK293T cell line (Study accession: SRP058191) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_7426_KD_RC3H1/RC3H2_SRP058191 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF185 | zinc finger protein 185 (LIM domain) | 20.0 |
| FGFR1OP | FGFR1 oncogene partner | 20.0 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 15.774 |
| FAM84B | family with sequence similarity 84, member B | 14.982 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 14.2828 |
| SOX4 | SRY (sex determining region Y)-box 4 | 13.7805 |
| GAS1 | growth arrest-specific 1 | 13.6127 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 11.9424 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 11.3821 |
| POLR1C | polymerase (RNA) I polypeptide C, 30kDa | 10.2643 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 10.0027 |
| SLIT2 | slit homolog 2 (Drosophila) | 9.8109 |
| CLSTN2 | calsyntenin 2 | 8.36793 |
| HMGA2 | high mobility group AT-hook 2 | 8.01399 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 7.50807 |
| TUBA1A | tubulin, alpha 1a | 7.4963 |
| TM2D3 | TM2 domain containing 3 | 6.93559 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 6.71254 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor | 6.6743 |
| BAX | BCL2-associated X protein | 6.37506 |
| UNC5B | unc-5 homolog B (C. elegans) | 6.36186 |
| DPCD | deleted in primary ciliary dyskinesia homolog (mouse) | 6.29397 |
| CENPA | centromere protein A | 6.14323 |
| EFNB2 | ephrin-B2 | 5.80841 |
| PTBP2 | polypyrimidine tract binding protein 2 | 5.68934 |
| WBP4 | WW domain binding protein 4 | 5.66335 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 5.63794 |
| LZTFL1 | leucine zipper transcription factor-like 1 | 5.44104 |
| MPHOSPH6 | M-phase phosphoprotein 6 | 5.38909 |
| HLA-C | major histocompatibility complex, class I, C | 5.2432 |
| PLXNA4 | plexin A4 | 5.23988 |
| LRRC4 | leucine rich repeat containing 4 | 5.21521 |
| SOX9 | SRY (sex determining region Y)-box 9 | 5.12993 |
| CETN2 | centrin, EF-hand protein, 2 | 5.08613 |
| TFRC | transferrin receptor | 5.04352 |
| IFT27 | intraflagellar transport 27 | 5.02134 |
| MOK | MOK protein kinase | 4.9211 |
| DYRK1B | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B | 4.91083 |
| ZDHHC12 | zinc finger, DHHC-type containing 12 | 4.89939 |
| UBE2Q2 | ubiquitin-conjugating enzyme E2Q family member 2 | 4.88414 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 4.83412 |
| UBXN11 | UBX domain protein 11 | 4.74576 |
| FN1 | fibronectin 1 | 4.74576 |
| GPX3 | glutathione peroxidase 3 | 4.74038 |
| C7ORF60 | chromosome 7 open reading frame 60 | 4.66037 |
| RWDD1 | RWD domain containing 1 | 4.63737 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | 4.4806 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 4.46639 |
| SOCS2 | suppressor of cytokine signaling 2 | 4.4341 |
| HLA-B | major histocompatibility complex, class I, B | 4.4341 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 4.37778 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 4.35823 |
| TMEM165 | transmembrane protein 165 | 4.32768 |
| TLE4 | transducin-like enhancer of split 4 | 4.31399 |
| LHFPL4 | lipoma HMGIC fusion partner-like 4 | 4.30695 |
| MAGED2 | melanoma antigen family D2 | 4.17739 |
| CCDC117 | coiled-coil domain containing 117 | 4.07423 |
| CD164 | CD164 molecule, sialomucin | 3.99716 |
| TMEM248 | transmembrane protein 248 | 3.93422 |
| RPL22L1 | ribosomal protein L22-like 1 | 3.89503 |
| BARX2 | BARX homeobox 2 | 3.89233 |
| ACTB | actin, beta | 3.79495 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | 3.79495 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 3.77511 |
| CDKN2B | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 3.6879 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | 3.68466 |
| EPHB4 | EPH receptor B4 | 3.53185 |
| CDH20 | cadherin 20, type 2 | 3.51119 |
| C9ORF116 | chromosome 9 open reading frame 116 | 3.45117 |
| KIN | Kin17 DNA and RNA binding protein | 3.4132 |
| RFX6 | regulatory factor X, 6 | 3.37888 |
| FOXP4 | forkhead box P4 | 3.30858 |
| WTIP | Wilms tumor 1 interacting protein | 3.30673 |
| GPC3 | glypican 3 | 3.29723 |
| MAGEC2 | melanoma antigen family C2 | 3.25539 |
| FOXG1 | forkhead box G1 | 3.14669 |
| PAK4 | p21 protein (Cdc42/Rac)-activated kinase 4 | 3.13093 |
| RYBP | RING1 and YY1 binding protein | 3.05532 |
| LIMD2 | LIM domain containing 2 | 3.0483 |
| YAP1 | Yes-associated protein 1 | 3.04388 |
| SEC61A2 | Sec61 alpha 2 subunit (S. cerevisiae) | 3.03513 |
| MARCKSL1 | MARCKS-like 1 | 3.00703 |
| KIF5C | kinesin family member 5C | 2.9924 |
| CCDC40 | coiled-coil domain containing 40 | 2.95399 |
| LSM2 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 2.93777 |
| SDK1 | sidekick cell adhesion molecule 1 | 2.93777 |
| ITGA9 | integrin, alpha 9 | 2.93777 |
| DBNL | drebrin-like | 2.92288 |
| FOXD1 | forkhead box D1 | 2.91284 |
| MSL3 | male-specific lethal 3 homolog (Drosophila) | 2.91281 |
| GRN | granulin | 2.9007 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 2.79209 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 2.74673 |
| CPOX | coproporphyrinogen oxidase | 2.72166 |
| TUBD1 | tubulin, delta 1 | 2.70925 |
| AMD1 | adenosylmethionine decarboxylase 1 | 2.70562 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 2.68813 |
| CCNB1 | cyclin B1 | 2.67116 |
| MBIP | MAP3K12 binding inhibitory protein 1 | 2.67116 |
| SCIN | scinderin | 2.60874 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC16A14 | solute carrier family 16, member 14 | -20.0 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -20.0 |
| TSC22D3 | TSC22 domain family, member 3 | -20.0 |
| NDRG1 | N-myc downstream regulated 1 | -20.0 |
| RC3H2 | ring finger and CCCH-type domains 2 | -17.0731 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -16.1294 |
| MCM6 | minichromosome maintenance complex component 6 | -15.654 |
| ADD2 | adducin 2 (beta) | -13.7805 |
| NUP50 | nucleoporin 50kDa | -12.7004 |
| ADAM9 | ADAM metallopeptidase domain 9 | -11.6349 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -11.473 |
| ALDH1L2 | aldehyde dehydrogenase 1 family, member L2 | -11.4565 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -11.1403 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | -10.2547 |
| JAG2 | jagged 2 | -10.0027 |
| CADM1 | cell adhesion molecule 1 | -9.88684 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -9.8109 |
| ASS1 | argininosuccinate synthase 1 | -9.47416 |
| MDK | midkine (neurite growth-promoting factor 2) | -8.53993 |
| FADS1 | fatty acid desaturase 1 | -8.31439 |
| PSAT1 | phosphoserine aminotransferase 1 | -8.27258 |
| SNX4 | sorting nexin 4 | -7.97649 |
| GDF7 | growth differentiation factor 7 | -7.72294 |
| ANLN | anillin, actin binding protein | -7.61726 |
| EPDR1 | ependymin related 1 | -7.37136 |
| ZCCHC12 | zinc finger, CCHC domain containing 12 | -7.35778 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | -7.06477 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -6.97503 |
| DMKN | dermokine | -6.81662 |
| FSCN1 | fascin actin-bundling protein 1 | -6.78504 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -6.71254 |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | -6.68371 |
| KLHL15 | kelch-like family member 15 | -6.57963 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -6.55783 |
| FLT4 | fms-related tyrosine kinase 4 | -6.54673 |
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma | -6.52529 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | -6.35486 |
| SMIM13 | small integral membrane protein 13 | -6.29397 |
| NUPL1 | nucleoporin like 1 | -6.10772 |
| STC2 | stanniocalcin 2 | -6.04267 |
| INSIG1 | insulin induced gene 1 | -5.94725 |
| TONSL | tonsoku-like, DNA repair protein | -5.81995 |
| KAT2B | K(lysine) acetyltransferase 2B | -5.60237 |
| ATAD2 | ATPase family, AAA domain containing 2 | -5.46248 |
| ATXN7L3B | ataxin 7-like 3B | -5.46248 |
| DSTYK | dual serine/threonine and tyrosine protein kinase | -5.30843 |
| ZNF711 | zinc finger protein 711 | -5.2432 |
| PKN3 | protein kinase N3 | -5.04616 |
| MBNL1 | muscleblind-like splicing regulator 1 | -4.97714 |
| NARS | asparaginyl-tRNA synthetase | -4.93316 |
| KLHL8 | kelch-like family member 8 | -4.74763 |
| CANX | calnexin | -4.74576 |
| NUP133 | nucleoporin 133kDa | -4.72129 |
| RNF169 | ring finger protein 169 | -4.6771 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -4.64069 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | -4.60492 |
| CCND1 | cyclin D1 | -4.5656 |
| ZNF621 | zinc finger protein 621 | -4.51338 |
| HSPA1B | heat shock 70kDa protein 1B | -4.4341 |
| INIP | INTS3 and NABP interacting protein | -4.32768 |
| RRM2 | ribonucleotide reductase M2 | -4.17739 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | -4.12033 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -4.12011 |
| FOXN2 | forkhead box N2 | -4.10084 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -4.05196 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -3.91734 |
| TDP1 | tyrosyl-DNA phosphodiesterase 1 | -3.91133 |
| ARF6 | ADP-ribosylation factor 6 | -3.85006 |
| TUB | tubby bipartite transcription factor | -3.84425 |
| RAD51D | RAD51 paralog D | -3.82646 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | -3.8257 |
| IARS | isoleucyl-tRNA synthetase | -3.76168 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -3.74364 |
| SLC6A15 | solute carrier family 6 (neutral amino acid transporter), member 15 | -3.70498 |
| DNM1 | dynamin 1 | -3.68466 |
| FAM132B | family with sequence similarity 132, member B | -3.68466 |
| ZNF121 | zinc finger protein 121 | -3.64686 |
| MYOM2 | myomesin 2 | -3.64022 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | -3.62799 |
| TMPO | thymopoietin | -3.56348 |
| RASEF | RAS and EF-hand domain containing | -3.52583 |
| ANOS1 | anosmin 1 | -3.34797 |
| MGEA5 | meningioma expressed antigen 5 (hyaluronidase) | -3.32565 |
| YEATS4 | YEATS domain containing 4 | -3.27652 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | -3.27386 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | -3.24476 |
| CAPN2 | calpain 2, (m/II) large subunit | -3.24257 |
| PLEKHG4 | pleckstrin homology domain containing, family G (with RhoGef domain) member 4 | -3.23996 |
| AARS | alanyl-tRNA synthetase | -3.23856 |
| SLC16A9 | solute carrier family 16, member 9 | -3.10856 |
| HIST3H2A | histone cluster 3, H2a | -3.04388 |
| SLC38A1 | solute carrier family 38, member 1 | -3.04388 |
| GCK | glucokinase (hexokinase 4) | -3.00232 |
| CKAP2 | cytoskeleton associated protein 2 | -2.99353 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -2.98535 |
| EIF2B1 | eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa | -2.96972 |
| BRI3BP | BRI3 binding protein | -2.96594 |
| CD46 | CD46 molecule, complement regulatory protein | -2.95399 |
| GLA | galactosidase, alpha | -2.88779 |
| EXO1 | exonuclease 1 | -2.88456 |
