Perturb_772_KD_SRRM2_SRP366559 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting SRRM2 in acute myeloid leukemia cell THP-1 cell line (Study accession: SRP366559) (PerturbAtlas)
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Genes

117 genes differentially expressed following the Perturb_772_KD_SRRM2_SRP366559 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
AVPR2 arginine vasopressin receptor 2 19.699
UBE2L3 ubiquitin-conjugating enzyme E2L 3 10.1974
COX6B2 cytochrome c oxidase subunit VIb polypeptide 2 (testis) 6.74714
SH2D2A SH2 domain containing 2A 5.26974
MAN1B1 mannosidase, alpha, class 1B, member 1 4.86681
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 3.89831
NOXO1 NADPH oxidase organizer 1 3.63271
SGSM2 small G protein signaling modulator 2 3.61561
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 3.42083
NARFL nuclear prelamin A recognition factor-like 3.16308
GPR55 G protein-coupled receptor 55 3.13352
MYO15B myosin XVB 2.99889
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 2.8786
TTC9B tetratricopeptide repeat domain 9B 2.83185
RRAS related RAS viral (r-ras) oncogene homolog 2.62137
FEN1 flap structure-specific endonuclease 1 2.52409
VSIG2 V-set and immunoglobulin domain containing 2 2.43376
AHNAK2 AHNAK nucleoprotein 2 2.30046
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 2.27939
CACFD1 calcium channel flower domain containing 1 2.27799
TMC4 transmembrane channel-like 4 2.24556
CPTP ceramide-1-phosphate transfer protein 2.22293
POR P450 (cytochrome) oxidoreductase 2.22293
C21ORF2 chromosome 21 open reading frame 2 2.11898
NNAT neuronatin 1.8769
ESAM endothelial cell adhesion molecule 1.82841
CIRBP cold inducible RNA binding protein 1.78319
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1.73579
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 1.70898
NLRP9 NLR family, pyrin domain containing 9 1.70898
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 1.70898
CCDC107 coiled-coil domain containing 107 1.70487
KIF17 kinesin family member 17 1.66775
TBC1D20 TBC1 domain family, member 20 1.66556
GPRC5B G protein-coupled receptor, class C, group 5, member B 1.64655
GFAP glial fibrillary acidic protein 1.47906
LTA4H leukotriene A4 hydrolase 1.47906
FPGS folylpolyglutamate synthase 1.41754
HDDC3 HD domain containing 3 1.35206
NSD1 nuclear receptor binding SET domain protein 1 1.32976
METRN meteorin, glial cell differentiation regulator 1.32588

decreased expression

Symbol Name Standardized Value
TEX28 testis expressed 28 -20.0
ABHD14A abhydrolase domain containing 14A -6.74714
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing -6.16698
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 -6.06968
RECQL4 RecQ protein-like 4 -5.65971
C11ORF21 chromosome 11 open reading frame 21 -4.71388
MMP24 matrix metallopeptidase 24 (membrane-inserted) -4.45224
SLC25A35 solute carrier family 25, member 35 -4.22128
POM121 POM121 transmembrane nucleoporin -4.21917
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -4.08038
TRAPPC4 trafficking protein particle complex 4 -4.05573
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -3.58859
ZDHHC8 zinc finger, DHHC-type containing 8 -3.42501
PRICKLE3 prickle homolog 3 (Drosophila) -3.0772
ENTHD2 ENTH domain containing 2 -3.06678
ASMTL acetylserotonin O-methyltransferase-like -2.7377
SRPK3 SRSF protein kinase 3 -2.70745
CORO1A coronin, actin binding protein, 1A -2.61692
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 -2.52583
AZU1 azurocidin 1 -2.4189
LRRC75A leucine rich repeat containing 75A -2.40186
MYH7B myosin, heavy chain 7B, cardiac muscle, beta -2.35091
PER3 period circadian clock 3 -2.34741
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) -2.33687
NUP62 nucleoporin 62kDa -2.33016
BAIAP2L2 BAI1-associated protein 2-like 2 -2.19628
NCR3 natural cytotoxicity triggering receptor 3 -2.17254
NEUROG3 neurogenin 3 -2.07647
L3MBTL2 l(3)mbt-like 2 (Drosophila) -2.05764
FAM69B family with sequence similarity 69, member B -2.00351
MPI mannose phosphate isomerase -1.99958
IRF2BPL interferon regulatory factor 2 binding protein-like -1.97689
DCDC2B doublecortin domain containing 2B -1.97689
ERBB2 erb-b2 receptor tyrosine kinase 2 -1.92985
NUPR1 nuclear protein, transcriptional regulator, 1 -1.85518
ACTN4 actinin, alpha 4 -1.85052
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -1.85052
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) -1.84912
DMPK dystrophia myotonica-protein kinase -1.84455
WDR13 WD repeat domain 13 -1.84455
GAS6 growth arrest-specific 6 -1.84455
ENKD1 enkurin domain containing 1 -1.84455
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) -1.84455
SRRM5 serine/arginine repetitive matrix 5 -1.81463
NOP16 NOP16 nucleolar protein -1.80153
CCDC154 coiled-coil domain containing 154 -1.80153
SH3D21 SH3 domain containing 21 -1.79849
CATIP ciliogenesis associated TTC17 interacting protein -1.79482
LRRC46 leucine rich repeat containing 46 -1.79245
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -1.79245
LENG9 leukocyte receptor cluster (LRC) member 9 -1.76634
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -1.7309
BSG basigin (Ok blood group) -1.70898
TRABD TraB domain containing -1.66775
ATG10 autophagy related 10 -1.66775
ZNF433 zinc finger protein 433 -1.66775
BCL7A B-cell CLL/lymphoma 7A -1.63726
PHKG2 phosphorylase kinase, gamma 2 (testis) -1.63726
WDR90 WD repeat domain 90 -1.62218
SH3D19 SH3 domain containing 19 -1.61764
PHKG1 phosphorylase kinase, gamma 1 (muscle) -1.57
MPRIP myosin phosphatase Rho interacting protein -1.5063
ANKMY1 ankyrin repeat and MYND domain containing 1 -1.49947
LMNTD2 lamin tail domain containing 2 -1.49847
MMP19 matrix metallopeptidase 19 -1.49035
HDGFRP3 hepatoma-derived growth factor, related protein 3 -1.47906
KHNYN KH and NYN domain containing -1.47906
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 -1.46332
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -1.46332
DTX4 deltex 4, E3 ubiquitin ligase -1.41069
TSSK3 testis-specific serine kinase 3 -1.39241
ZNF273 zinc finger protein 273 -1.39148
RUNX2 runt-related transcription factor 2 -1.39148
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -1.39148
COL9A3 collagen, type IX, alpha 3 -1.38585
SZT2 seizure threshold 2 homolog (mouse) -1.35356