| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KO perturbation targeting AGO1 in HeLa cell line (Study accession: SRP136692) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_7838_KO_AGO1_SRP136692 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CEL | carboxyl ester lipase | 20.0 |
| IGFL2 | IGF-like family member 2 | 20.0 |
| FSIP1 | fibrous sheath interacting protein 1 | 20.0 |
| PHKA2 | phosphorylase kinase, alpha 2 (liver) | 20.0 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | 20.0 |
| ACO1 | aconitase 1, soluble | 20.0 |
| MED12L | mediator complex subunit 12-like | 19.3979 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | 15.8063 |
| HARS2 | histidyl-tRNA synthetase 2, mitochondrial | 13.9441 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 13.9421 |
| UBXN11 | UBX domain protein 11 | 13.8831 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 10.9298 |
| FKBP15 | FK506 binding protein 15, 133kDa | 8.9228 |
| C11ORF68 | chromosome 11 open reading frame 68 | 8.9074 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 8.44429 |
| C12ORF73 | chromosome 12 open reading frame 73 | 8.42555 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 8.24583 |
| LOC400499 | uncharacterized LOC400499 | 6.94676 |
| ERCC1 | excision repair cross-complementation group 1 | 6.79678 |
| FGFR1 | fibroblast growth factor receptor 1 | 6.65058 |
| FAM166A | family with sequence similarity 166, member A | 6.49175 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 6.10621 |
| GRPR | gastrin-releasing peptide receptor | 6.07102 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 5.81368 |
| NOXO1 | NADPH oxidase organizer 1 | 5.33185 |
| PEX1 | peroxisomal biogenesis factor 1 | 5.25211 |
| DAZAP2 | DAZ associated protein 2 | 5.20677 |
| KIAA0895 | KIAA0895 | 5.09128 |
| RHOBTB2 | Rho-related BTB domain containing 2 | 5.08689 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 5.04444 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | 4.70334 |
| FZD4 | frizzled class receptor 4 | 4.63498 |
| TATDN2 | TatD DNase domain containing 2 | 4.54488 |
| KRT8 | keratin 8, type II | 4.35776 |
| NCL | nucleolin | 4.33026 |
| MROH1 | maestro heat-like repeat family member 1 | 4.32244 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | 4.20539 |
| VPS9D1 | VPS9 domain containing 1 | 4.19446 |
| ORAOV1 | oral cancer overexpressed 1 | 4.11668 |
| IFIH1 | interferon induced with helicase C domain 1 | 4.01398 |
| TRRAP | transformation/transcription domain-associated protein | 3.98672 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 3.97737 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 3.95602 |
| PRICKLE3 | prickle homolog 3 (Drosophila) | 3.95602 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 3.83394 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 3.70993 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 3.70304 |
| RSL1D1 | ribosomal L1 domain containing 1 | 3.56565 |
| TUBB2A | tubulin, beta 2A class IIa | 3.52662 |
| STK16 | serine/threonine kinase 16 | 3.50249 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 3.48473 |
| SZT2 | seizure threshold 2 homolog (mouse) | 3.48224 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 3.46229 |
| PSORS1C1 | psoriasis susceptibility 1 candidate 1 | 3.42082 |
| PAQR3 | progestin and adipoQ receptor family member III | 3.4031 |
| IGSF10 | immunoglobulin superfamily, member 10 | 3.39534 |
| DDX31 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 | 3.34707 |
| AHNAK | AHNAK nucleoprotein | 3.3297 |
| HSPA8 | heat shock 70kDa protein 8 | 3.31161 |
| PLCD4 | phospholipase C, delta 4 | 3.28809 |
| ACTG1 | actin gamma 1 | 3.27483 |
| C12ORF10 | chromosome 12 open reading frame 10 | 3.13933 |
| CFAP57 | cilia and flagella associated protein 57 | 3.10477 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 3.10477 |
| NDUFC1 | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa | 3.09567 |
| RBM25 | RNA binding motif protein 25 | 3.08684 |
| C5ORF45 | chromosome 5 open reading frame 45 | 3.06238 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 3.03997 |
| EPHA1 | EPH receptor A1 | 2.98317 |
| MUC13 | mucin 13, cell surface associated | 2.93363 |
| OGFRL1 | opioid growth factor receptor-like 1 | 2.91747 |
| PKD2L2 | polycystic kidney disease 2-like 2 | 2.91747 |
| SH3PXD2A | SH3 and PX domains 2A | 2.90181 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 2.865 |
| RHD | Rh blood group, D antigen | 2.80487 |
| ADCY9 | adenylate cyclase 9 | 2.68396 |
| CEP126 | centrosomal protein 126kDa | 2.67866 |
| SFT2D3 | SFT2 domain containing 3 | 2.66628 |
| LIMA1 | LIM domain and actin binding 1 | 2.65748 |
| SRR | serine racemase | 2.64648 |
| KIF2A | kinesin heavy chain member 2A | 2.63911 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | 2.63729 |
| COG8 | component of oligomeric golgi complex 8 | 2.56783 |
| FLNA | filamin A, alpha | 2.54617 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 2.52169 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 2.52169 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 2.51561 |
| STK3 | serine/threonine kinase 3 | 2.48667 |
| NNAT | neuronatin | 2.4742 |
| ZFC3H1 | zinc finger, C3H1-type containing | 2.44165 |
| SNX32 | sorting nexin 32 | 2.39034 |
| SRRD | SRR1 domain containing | 2.37071 |
| SEMA6D | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D | 2.3487 |
| SBF2 | SET binding factor 2 | 2.3487 |
| CXCR5 | chemokine (C-X-C motif) receptor 5 | 2.32182 |
| MPRIP | myosin phosphatase Rho interacting protein | 2.28468 |
| BRD9 | bromodomain containing 9 | 2.25554 |
| NUP62 | nucleoporin 62kDa | 2.18706 |
| BBS2 | Bardet-Biedl syndrome 2 | 2.14183 |
| BIRC3 | baculoviral IAP repeat containing 3 | 2.13278 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SRPX2 | sushi-repeat containing protein, X-linked 2 | -20.0 |
| NOC2L | nucleolar complex associated 2 homolog (S. cerevisiae) | -20.0 |
| ELP2 | elongator acetyltransferase complex subunit 2 | -20.0 |
| MMP24-AS1 | MMP24 antisense RNA 1 | -17.1013 |
| COG5 | component of oligomeric golgi complex 5 | -16.3611 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -16.2527 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -14.7885 |
| PM20D1 | peptidase M20 domain containing 1 | -14.2637 |
| ZNF831 | zinc finger protein 831 | -12.4109 |
| PANK2 | pantothenate kinase 2 | -11.3855 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | -11.0562 |
| PZP | pregnancy-zone protein | -10.6273 |
| SRFBP1 | serum response factor binding protein 1 | -10.5202 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | -10.2604 |
| DNAJC17 | DnaJ (Hsp40) homolog, subfamily C, member 17 | -10.191 |
| DUSP16 | dual specificity phosphatase 16 | -10.1299 |
| ATPIF1 | ATPase inhibitory factor 1 | -10.0676 |
| SIK2 | salt-inducible kinase 2 | -9.9484 |
| SMPD3 | sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) | -9.07463 |
| STK24 | serine/threonine kinase 24 | -8.84202 |
| TSTD2 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 | -8.21713 |
| ASS1 | argininosuccinate synthase 1 | -7.83325 |
| MINA | MYC induced nuclear antigen | -7.77832 |
| BBIP1 | BBSome interacting protein 1 | -7.43272 |
| TRIM24 | tripartite motif containing 24 | -7.34562 |
| NCBP2L | nuclear cap binding protein subunit 2-like | -7.12991 |
| EIF4B | eukaryotic translation initiation factor 4B | -7.06955 |
| CCDC176 | coiled-coil domain containing 176 | -6.86064 |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | -6.79345 |
| STAG3 | stromal antigen 3 | -6.70992 |
| SESN3 | sestrin 3 | -6.58613 |
| THEM5 | thioesterase superfamily member 5 | -6.33682 |
| SMCR8 | Smith-Magenis syndrome chromosome region, candidate 8 | -6.09932 |
| RIMS1 | regulating synaptic membrane exocytosis 1 | -5.99311 |
| FMNL1 | formin-like 1 | -5.71167 |
| RCE1 | Ras converting CAAX endopeptidase 1 | -5.62472 |
| MTERF4 | mitochondrial transcription termination factor 4 | -5.58726 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -5.46009 |
| FGF7 | fibroblast growth factor 7 | -5.23564 |
| KAT5 | K(lysine) acetyltransferase 5 | -5.15941 |
| SAMD14 | sterile alpha motif domain containing 14 | -4.99779 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | -4.94003 |
| RANGRF | RAN guanine nucleotide release factor | -4.90248 |
| CACTIN | cactin, spliceosome C complex subunit | -4.82317 |
| VIPR2 | vasoactive intestinal peptide receptor 2 | -4.81764 |
| BAIAP2 | BAI1-associated protein 2 | -4.72251 |
| EML2 | echinoderm microtubule associated protein like 2 | -4.53738 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | -4.4508 |
| H2AFY | H2A histone family, member Y | -4.33891 |
| CCR7 | chemokine (C-C motif) receptor 7 | -4.32435 |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | -4.22662 |
| NELFCD | negative elongation factor complex member C/D | -4.19855 |
| CDON | cell adhesion associated, oncogene regulated | -4.13986 |
| EYS | eyes shut homolog (Drosophila) | -4.10205 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -4.09656 |
| SCAND1 | SCAN domain containing 1 | -4.09228 |
| BID | BH3 interacting domain death agonist | -4.08137 |
| PCGF3 | polycomb group ring finger 3 | -4.01394 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -3.97359 |
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | -3.84399 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -3.83229 |
| DENND4C | DENN/MADD domain containing 4C | -3.76756 |
| UFSP2 | UFM1-specific peptidase 2 | -3.73977 |
| RASD2 | RASD family, member 2 | -3.72515 |
| PEG10 | paternally expressed 10 | -3.68295 |
| CHAD | chondroadherin | -3.51889 |
| PHKG1 | phosphorylase kinase, gamma 1 (muscle) | -3.39534 |
| SIX5 | SIX homeobox 5 | -3.39286 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -3.38129 |
| MPI | mannose phosphate isomerase | -3.3672 |
| C22ORF15 | chromosome 22 open reading frame 15 | -3.34013 |
| TPR | translocated promoter region, nuclear basket protein | -3.27483 |
| PPM1N | protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) | -3.24636 |
| PGF | placental growth factor | -3.14423 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | -3.104 |
| BRD7 | bromodomain containing 7 | -3.09059 |
| NEMF | nuclear export mediator factor | -2.87804 |
| CDK4 | cyclin-dependent kinase 4 | -2.85671 |
| TSEN54 | TSEN54 tRNA splicing endonuclease subunit | -2.85265 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -2.82785 |
| GGACT | gamma-glutamylamine cyclotransferase | -2.79125 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -2.79122 |
| TRABD2B | TraB domain containing 2B | -2.77405 |
| TCP1 | t-complex 1 | -2.76779 |
| MCM3AP | minichromosome maintenance complex component 3 associated protein | -2.73083 |
| KCNAB1 | potassium channel, voltage gated subfamily A regulatory beta subunit 1 | -2.62126 |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | -2.58677 |
| GMPPB | GDP-mannose pyrophosphorylase B | -2.57567 |
| A2M | alpha-2-macroglobulin | -2.56755 |
| PON2 | paraoxonase 2 | -2.55735 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -2.55735 |
| DPF2 | D4, zinc and double PHD fingers family 2 | -2.5569 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -2.52837 |
| TKFC | triokinase/FMN cyclase | -2.49281 |
| CSDC2 | cold shock domain containing C2, RNA binding | -2.47937 |
| KBTBD4 | kelch repeat and BTB (POZ) domain containing 4 | -2.47011 |
| TSSK3 | testis-specific serine kinase 3 | -2.46493 |
| KRT23 | keratin 23, type I | -2.45821 |
| SPTB | spectrin, beta, erythrocytic | -2.44089 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -2.4293 |
