Perturb_7847_KD_PUM2_SRP166185 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting PUM2 in HeLa cell line (Study accession: SRP166185) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_7847_KD_PUM2_SRP166185 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 20.0
CTGF connective tissue growth factor 20.0
PID1 phosphotyrosine interaction domain containing 1 20.0
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 20.0
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 20.0
IER3 immediate early response 3 20.0
DCBLD2 discoidin, CUB and LCCL domain containing 2 20.0
PTGES prostaglandin E synthase 20.0
HIST1H2AC histone cluster 1, H2ac 20.0
EPAS1 endothelial PAS domain protein 1 20.0
CSRP1 cysteine and glycine-rich protein 1 20.0
TES testin LIM domain protein 20.0
CNN2 calponin 2 20.0
LBH limb bud and heart development 20.0
NT5E 5'-nucleotidase, ecto (CD73) 20.0
LUM lumican 20.0
PLK2 polo-like kinase 2 20.0
STC2 stanniocalcin 2 20.0
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 20.0
AOX1 aldehyde oxidase 1 20.0
TPM4 tropomyosin 4 20.0
TPM1 tropomyosin 1 (alpha) 20.0
ZNF185 zinc finger protein 185 (LIM domain) 20.0
MFAP5 microfibrillar associated protein 5 20.0
BCAR3 breast cancer anti-estrogen resistance 3 20.0
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 20.0
C3 complement component 3 20.0
IL7R interleukin 7 receptor 20.0
PICALM phosphatidylinositol binding clathrin assembly protein 20.0
TBC1D2 TBC1 domain family, member 2 20.0
CCND1 cyclin D1 20.0
THBS1 thrombospondin 1 20.0
KRT80 keratin 80, type II 20.0
DUSP4 dual specificity phosphatase 4 20.0
DUSP1 dual specificity phosphatase 1 20.0
ADGRG6 adhesion G protein-coupled receptor G6 20.0
PHLDB2 pleckstrin homology-like domain, family B, member 2 20.0
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 20.0
S100P S100 calcium binding protein P 20.0
FOLR1 folate receptor 1 (adult) 20.0
FRMD6 FERM domain containing 6 20.0
ISG15 ISG15 ubiquitin-like modifier 20.0
CLDN1 claudin 1 20.0
SLPI secretory leukocyte peptidase inhibitor 20.0
NPNT nephronectin 20.0
CDK6 cyclin-dependent kinase 6 20.0
SAT1 spermidine/spermine N1-acetyltransferase 1 20.0
ERRFI1 ERBB receptor feedback inhibitor 1 20.0
TMEM2 transmembrane protein 2 20.0
KIAA0040 KIAA0040 20.0
ITGAV integrin, alpha V 20.0
DAAM1 dishevelled associated activator of morphogenesis 1 20.0
IL18 interleukin 18 20.0
NUPR1 nuclear protein, transcriptional regulator, 1 20.0
EMP1 epithelial membrane protein 1 20.0
AMOTL2 angiomotin like 2 20.0
AMIGO2 adhesion molecule with Ig-like domain 2 20.0
IGFBP7 insulin-like growth factor binding protein 7 20.0
CLIC4 chloride intracellular channel 4 20.0
CLIC3 chloride intracellular channel 3 20.0
DMD dystrophin 20.0
MAP2 microtubule-associated protein 2 20.0
GADD45A growth arrest and DNA-damage-inducible, alpha 20.0
ITGB4 integrin, beta 4 20.0
TAGLN transgelin 20.0
SH3KBP1 SH3-domain kinase binding protein 1 20.0
CCNA2 cyclin A2 20.0
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 20.0
OPTN optineurin 20.0
GLIPR1 GLI pathogenesis-related 1 20.0
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 20.0
CD24 CD24 molecule 20.0
HIST1H1C histone cluster 1, H1c 20.0
EPHA2 EPH receptor A2 20.0
KRT7 keratin 7, type II 20.0
NEK7 NIMA-related kinase 7 20.0
WNT5A wingless-type MMTV integration site family, member 5A 20.0
SLFN5 schlafen family member 5 20.0
PRSS23 protease, serine, 23 20.0
CCDC80 coiled-coil domain containing 80 20.0
SDC2 syndecan 2 20.0
SDC4 syndecan 4 20.0
ENC1 ectodermal-neural cortex 1 (with BTB domain) 20.0
MYL9 myosin, light chain 9, regulatory 20.0
NCEH1 neutral cholesterol ester hydrolase 1 20.0
THSD4 thrombospondin, type I, domain containing 4 20.0
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 20.0
FLNB filamin B, beta 20.0
IL32 interleukin 32 20.0
CAV1 caveolin 1, caveolae protein, 22kDa 20.0
CPE carboxypeptidase E 20.0
KRT17 keratin 17, type I 20.0
JUN jun proto-oncogene 20.0
FSTL1 follistatin-like 1 20.0
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 20.0
TGM2 transglutaminase 2 20.0
ANXA1 annexin A1 20.0
ANXA3 annexin A3 20.0
GPRC5A G protein-coupled receptor, class C, group 5, member A 20.0
DIO2 deiodinase, iodothyronine, type II 20.0

decreased expression

Symbol Name Standardized Value
RHOV ras homolog family member V -20.0
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) -20.0
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -20.0
CRABP2 cellular retinoic acid binding protein 2 -20.0
TNS1 tensin 1 -20.0
PEG10 paternally expressed 10 -20.0
IGFBP5 insulin-like growth factor binding protein 5 -20.0
CA9 carbonic anhydrase IX -20.0
RAPSN receptor-associated protein of the synapse -20.0
SCD stearoyl-CoA desaturase (delta-9-desaturase) -20.0
FADS1 fatty acid desaturase 1 -20.0
DLG2 discs, large homolog 2 (Drosophila) -20.0
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -20.0
NR2F1 nuclear receptor subfamily 2, group F, member 1 -20.0
SREBF2 sterol regulatory element binding transcription factor 2 -20.0
FOXO4 forkhead box O4 -20.0
FGFR4 fibroblast growth factor receptor 4 -20.0
SREBF1 sterol regulatory element binding transcription factor 1 -20.0
CA12 carbonic anhydrase XII -20.0
RAB26 RAB26, member RAS oncogene family -20.0
STARD4 StAR-related lipid transfer (START) domain containing 4 -20.0
ECEL1 endothelin converting enzyme-like 1 -20.0
METTL7A methyltransferase like 7A -20.0
CSDC2 cold shock domain containing C2, RNA binding -20.0
GYLTL1B glycosyltransferase-like 1B -20.0
STAC2 SH3 and cysteine rich domain 2 -20.0
LPIN1 lipin 1 -20.0
SYNGAP1 synaptic Ras GTPase activating protein 1 -20.0
PCSK9 proprotein convertase subtilisin/kexin type 9 -20.0
UNC5D unc-5 homolog D (C. elegans) -20.0
MAP1A microtubule-associated protein 1A -20.0
ADRA2A adrenoceptor alpha 2A -20.0
PRG4 proteoglycan 4 -20.0
DHCR7 7-dehydrocholesterol reductase -20.0
FAM46A family with sequence similarity 46, member A -20.0
DNM1 dynamin 1 -20.0
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 -20.0
MCF2L MCF.2 cell line derived transforming sequence-like -20.0
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -20.0
PCOLCE procollagen C-endopeptidase enhancer -20.0
RHBDL3 rhomboid, veinlet-like 3 (Drosophila) -20.0
COL9A3 collagen, type IX, alpha 3 -20.0
INSIG1 insulin induced gene 1 -20.0
SV2A synaptic vesicle glycoprotein 2A -20.0
ALPI alkaline phosphatase, intestinal -19.699
RARG retinoic acid receptor, gamma -19.301
HPDL 4-hydroxyphenylpyruvate dioxygenase-like -18.699
NIPSNAP1 nipsnap homolog 1 (C. elegans) -18.6198
TNC tenascin C -18.4949
ACACA acetyl-CoA carboxylase alpha -18.4437
EHMT2 euchromatic histone-lysine N-methyltransferase 2 -18.3979
MEIS1 Meis homeobox 1 -18.0506
FAM13C family with sequence similarity 13, member C -17.8539
IQGAP2 IQ motif containing GTPase activating protein 2 -17.0696
FOXO6 forkhead box O6 -16.7703
CSPG4 chondroitin sulfate proteoglycan 4 -16.5658
IL1R1 interleukin 1 receptor, type I -16.4652
CCNG1 cyclin G1 -16.2069
PRKCB protein kinase C, beta -16.0411
SQLE squalene epoxidase -15.8736
AMER1 APC membrane recruitment protein 1 -15.8314
CD276 CD276 molecule -15.7862
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -15.6112
PDE3B phosphodiesterase 3B, cGMP-inhibited -15.3678
VARS valyl-tRNA synthetase -15.366
VAV3 vav 3 guanine nucleotide exchange factor -15.2328
MTUS1 microtubule associated tumor suppressor 1 -15.2176
DHCR24 24-dehydrocholesterol reductase -15.1446
ENO2 enolase 2 (gamma, neuronal) -15.0531
TPPP3 tubulin polymerization-promoting protein family member 3 -15.023
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 -14.8722
LDLR low density lipoprotein receptor -14.7328
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 -14.5493
RNF182 ring finger protein 182 -14.4827
CRLF1 cytokine receptor-like factor 1 -14.3998
LAMA1 laminin, alpha 1 -14.3457
DDN dendrin -14.288
KCNIP3 Kv channel interacting protein 3, calsenilin -14.2497
QPCTL glutaminyl-peptide cyclotransferase-like -14.2233
PCDH17 protocadherin 17 -14.2114
CREB3L2 cAMP responsive element binding protein 3-like 2 -14.1904
TSPYL4 TSPY-like 4 -14.1821
NIPAL4 NIPA-like domain containing 4 -14.1593
GOLIM4 golgi integral membrane protein 4 -14.1532
MVK mevalonate kinase -14.0126
FLNC filamin C, gamma -14.0104
RNF150 ring finger protein 150 -13.916
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -13.8863
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -13.799
ARPIN actin-related protein 2/3 complex inhibitor -13.7613
IRX3 iroquois homeobox 3 -13.6655
JUND jun D proto-oncogene -13.5648
ALDOC aldolase C, fructose-bisphosphate -13.5152
TUB tubby bipartite transcription factor -13.4554
NAT14 N-acetyltransferase 14 (GCN5-related, putative) -13.4206
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -13.3122
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -13.2118
FAM189B family with sequence similarity 189, member B -13.0569
LRRC58 leucine rich repeat containing 58 -13.056
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -12.9723