| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting CCNF/E2F7/E2F8 in HeLa cell line (Study accession: SRP212181) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_7854_KD_CCNF/E2F7/E2F8_SRP212181 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PAQR3 | progestin and adipoQ receptor family member III | 20.0 |
| INTS8 | integrator complex subunit 8 | 20.0 |
| PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1 | 20.0 |
| PRICKLE3 | prickle homolog 3 (Drosophila) | 20.0 |
| ENOSF1 | enolase superfamily member 1 | 20.0 |
| POLG | polymerase (DNA directed), gamma | 20.0 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | 20.0 |
| SYNC | syncoilin, intermediate filament protein | 20.0 |
| FSIP1 | fibrous sheath interacting protein 1 | 20.0 |
| KIAA0895 | KIAA0895 | 20.0 |
| PAQR4 | progestin and adipoQ receptor family member IV | 20.0 |
| BAG2 | BCL2-associated athanogene 2 | 20.0 |
| PMEL | premelanosome protein | 20.0 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 20.0 |
| CCDC107 | coiled-coil domain containing 107 | 20.0 |
| GTPBP1 | GTP binding protein 1 | 20.0 |
| ABI2 | abl-interactor 2 | 20.0 |
| ADCY3 | adenylate cyclase 3 | 19.5229 |
| CLCC1 | chloride channel CLIC-like 1 | 18.6778 |
| C14ORF79 | chromosome 14 open reading frame 79 | 18.1938 |
| MLX | MLX, MAX dimerization protein | 17.5186 |
| TSPAN31 | tetraspanin 31 | 16.8901 |
| TMPO | thymopoietin | 16.7683 |
| FAM149B1 | family with sequence similarity 149, member B1 | 16.5847 |
| FBXO11 | F-box protein 11 | 15.005 |
| B3GNT4 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 | 14.3621 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 14.2064 |
| PFKM | phosphofructokinase, muscle | 13.8067 |
| MYH11 | myosin, heavy chain 11, smooth muscle | 13.4447 |
| FAS | Fas cell surface death receptor | 13.376 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | 13.2833 |
| CD37 | CD37 molecule | 12.7516 |
| CAPN12 | calpain 12 | 12.5293 |
| LRRC41 | leucine rich repeat containing 41 | 12.4928 |
| VIL1 | villin 1 | 12.2183 |
| GYG1 | glycogenin 1 | 11.8702 |
| SDR39U1 | short chain dehydrogenase/reductase family 39U, member 1 | 10.9285 |
| TRIM59 | tripartite motif containing 59 | 8.85386 |
| GSE1 | Gse1 coiled-coil protein | 8.83458 |
| CTBP2 | C-terminal binding protein 2 | 8.63875 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 8.07966 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 7.84338 |
| PAQR5 | progestin and adipoQ receptor family member V | 7.78162 |
| FAM166A | family with sequence similarity 166, member A | 7.54334 |
| PRPF40B | PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) | 7.52842 |
| TRAPPC4 | trafficking protein particle complex 4 | 7.47232 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 7.42358 |
| GNB3 | guanine nucleotide binding protein (G protein), beta polypeptide 3 | 7.32079 |
| TLDC2 | TBC/LysM-associated domain containing 2 | 7.17228 |
| NNT | nicotinamide nucleotide transhydrogenase | 7.14116 |
| NPRL2 | nitrogen permease regulator-like 2 (S. cerevisiae) | 7.12213 |
| TP53BP1 | tumor protein p53 binding protein 1 | 7.03284 |
| DNAJC17 | DnaJ (Hsp40) homolog, subfamily C, member 17 | 6.96305 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | 6.92383 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 6.88694 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | 6.85858 |
| FANCD2OS | FANCD2 opposite strand | 6.76022 |
| FAM122C | family with sequence similarity 122C | 6.38599 |
| MCF2L2 | MCF.2 cell line derived transforming sequence-like 2 | 6.34925 |
| NT5DC4 | 5'-nucleotidase domain containing 4 | 6.01682 |
| HMGB2 | high mobility group box 2 | 5.89573 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 5.8529 |
| ELP5 | elongator acetyltransferase complex subunit 5 | 5.84455 |
| CTRL | chymotrypsin-like | 5.83393 |
| DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | 5.72746 |
| CPSF3L | cleavage and polyadenylation specific factor 3-like | 5.7206 |
| MBNL1 | muscleblind-like splicing regulator 1 | 5.625 |
| EDN1 | endothelin 1 | 5.57828 |
| EPB41 | erythrocyte membrane protein band 4.1 | 5.54 |
| NUP153 | nucleoporin 153kDa | 5.50048 |
| HOOK2 | hook microtubule-tethering protein 2 | 5.45193 |
| BOP1 | block of proliferation 1 | 5.42741 |
| PRIMPOL | primase and polymerase (DNA-directed) | 5.41604 |
| SIDT2 | SID1 transmembrane family, member 2 | 5.35883 |
| RNF214 | ring finger protein 214 | 5.28627 |
| NOSTRIN | nitric oxide synthase trafficking | 5.25174 |
| KREMEN2 | kringle containing transmembrane protein 2 | 5.24026 |
| TKFC | triokinase/FMN cyclase | 5.23447 |
| IAH1 | isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) | 5.1483 |
| KLC1 | kinesin light chain 1 | 5.13557 |
| DNAH11 | dynein, axonemal, heavy chain 11 | 5.11239 |
| PTOV1 | prostate tumor overexpressed 1 | 5.07959 |
| GUCD1 | guanylyl cyclase domain containing 1 | 5.07597 |
| MTMR2 | myotubularin related protein 2 | 5.05852 |
| HIRIP3 | HIRA interacting protein 3 | 5.03573 |
| ACSM3 | acyl-CoA synthetase medium-chain family member 3 | 5.0008 |
| CISD3 | CDGSH iron sulfur domain 3 | 4.95726 |
| ELP4 | elongator acetyltransferase complex subunit 4 | 4.81617 |
| UBXN6 | UBX domain protein 6 | 4.80623 |
| SNX32 | sorting nexin 32 | 4.79715 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | 4.73973 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 4.63043 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 4.59084 |
| SYNGR2 | synaptogyrin 2 | 4.45408 |
| HSD17B6 | hydroxysteroid (17-beta) dehydrogenase 6 | 4.40273 |
| GCDH | glutaryl-CoA dehydrogenase | 4.39777 |
| CDC23 | cell division cycle 23 | 4.33973 |
| IFT80 | intraflagellar transport 80 | 4.30542 |
| MPHOSPH8 | M-phase phosphoprotein 8 | 4.25554 |
| SMIM19 | small integral membrane protein 19 | 4.17146 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RECQL | RecQ helicase-like | -20.0 |
| SLC7A6OS | solute carrier family 7, member 6 opposite strand | -20.0 |
| HIST1H4I | histone cluster 1, H4i | -20.0 |
| TMEM120B | transmembrane protein 120B | -20.0 |
| ATP8B4 | ATPase, class I, type 8B, member 4 | -20.0 |
| RER1 | retention in endoplasmic reticulum sorting receptor 1 | -20.0 |
| PGF | placental growth factor | -20.0 |
| PZP | pregnancy-zone protein | -20.0 |
| KRT8 | keratin 8, type II | -20.0 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | -20.0 |
| BEST1 | bestrophin 1 | -18.8539 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -18.4685 |
| C8ORF59 | chromosome 8 open reading frame 59 | -18.0969 |
| SARM1 | sterile alpha and TIR motif containing 1 | -17.4413 |
| C5ORF45 | chromosome 5 open reading frame 45 | -17.2388 |
| CXCR5 | chemokine (C-X-C motif) receptor 5 | -17.1046 |
| C12ORF65 | chromosome 12 open reading frame 65 | -16.8901 |
| YIF1B | Yip1 interacting factor homolog B (S. cerevisiae) | -15.9376 |
| DHX32 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | -15.9376 |
| TBCE | tubulin folding cofactor E | -15.9376 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -14.5634 |
| ERAP1 | endoplasmic reticulum aminopeptidase 1 | -13.616 |
| TMEM79 | transmembrane protein 79 | -13.3842 |
| CSNK1D | casein kinase 1, delta | -13.1698 |
| MMP24-AS1 | MMP24 antisense RNA 1 | -12.9291 |
| EXOSC9 | exosome component 9 | -12.9158 |
| SRR | serine racemase | -12.9157 |
| TMEM223 | transmembrane protein 223 | -12.4372 |
| CNP | 2',3'-cyclic nucleotide 3' phosphodiesterase | -12.2683 |
| ARG2 | arginase 2 | -12.2016 |
| RBBP4 | retinoblastoma binding protein 4 | -11.7427 |
| CRYZ | crystallin, zeta (quinone reductase) | -11.5279 |
| THAP3 | THAP domain containing, apoptosis associated protein 3 | -11.4886 |
| ATG7 | autophagy related 7 | -11.0006 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | -10.9285 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -10.7907 |
| PRPF39 | pre-mRNA processing factor 39 | -10.5341 |
| TOX4 | TOX high mobility group box family member 4 | -10.3079 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | -10.1113 |
| GADD45GIP1 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 | -9.75713 |
| MTHFD1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | -9.67723 |
| COG5 | component of oligomeric golgi complex 5 | -8.84955 |
| ERCC4 | excision repair cross-complementation group 4 | -8.76921 |
| SULF2 | sulfatase 2 | -8.64641 |
| USP20 | ubiquitin specific peptidase 20 | -8.63875 |
| DIMT1 | DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) | -8.61174 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -8.41294 |
| CDK4 | cyclin-dependent kinase 4 | -8.40059 |
| SNAP47 | synaptosomal-associated protein, 47kDa | -8.05578 |
| FAM118B | family with sequence similarity 118, member B | -7.75512 |
| SPAG17 | sperm associated antigen 17 | -7.74494 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | -7.72299 |
| AKTIP | AKT interacting protein | -7.49487 |
| BBS2 | Bardet-Biedl syndrome 2 | -7.4667 |
| DLEC1 | deleted in lung and esophageal cancer 1 | -7.39896 |
| PPP2R5D | protein phosphatase 2, regulatory subunit B', delta | -7.22921 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | -7.15191 |
| GGCX | gamma-glutamyl carboxylase | -7.12411 |
| AFG3L2 | AFG3-like AAA ATPase 2 | -6.98928 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | -6.98896 |
| NOC2L | nucleolar complex associated 2 homolog (S. cerevisiae) | -6.89318 |
| ZBTB25 | zinc finger and BTB domain containing 25 | -6.83376 |
| TMEM50B | transmembrane protein 50B | -6.69919 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -6.57862 |
| UBN1 | ubinuclein 1 | -6.10873 |
| EML5 | echinoderm microtubule associated protein like 5 | -6.04576 |
| NAPEPLD | N-acyl phosphatidylethanolamine phospholipase D | -5.79686 |
| DDTL | D-dopachrome tautomerase-like | -5.78408 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -5.75597 |
| NKIRAS2 | NFKB inhibitor interacting Ras-like 2 | -5.7226 |
| PMPCB | peptidase (mitochondrial processing) beta | -5.7206 |
| C14ORF166 | chromosome 14 open reading frame 166 | -5.63675 |
| TMEM97 | transmembrane protein 97 | -5.60994 |
| NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae) | -5.58198 |
| CP | ceruloplasmin (ferroxidase) | -5.58029 |
| TMEM184A | transmembrane protein 184A | -5.57639 |
| NKIRAS1 | NFKB inhibitor interacting Ras-like 1 | -5.5506 |
| SNX22 | sorting nexin 22 | -5.47611 |
| DLD | dihydrolipoamide dehydrogenase | -5.35213 |
| SH3PXD2A | SH3 and PX domains 2A | -5.24026 |
| B9D1 | B9 protein domain 1 | -5.2166 |
| CFAP126 | cilia and flagella associated protein 126 | -5.06943 |
| ARSG | arylsulfatase G | -5.04088 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -4.9515 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | -4.93232 |
| ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | -4.88309 |
| JSRP1 | junctional sarcoplasmic reticulum protein 1 | -4.85422 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -4.80246 |
| NCOA4 | nuclear receptor coactivator 4 | -4.7187 |
| GTF3A | general transcription factor IIIA | -4.65088 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -4.40313 |
| VCL | vinculin | -4.36453 |
| MED12L | mediator complex subunit 12-like | -4.28264 |
| LYSMD4 | LysM, putative peptidoglycan-binding, domain containing 4 | -4.22454 |
| ARL10 | ADP-ribosylation factor-like 10 | -4.2109 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | -4.21056 |
| GRIP2 | glutamate receptor interacting protein 2 | -4.17889 |
| TUBB1 | tubulin, beta 1 class VI | -4.17889 |
| BTG3 | BTG family, member 3 | -4.13166 |
| PI4K2A | phosphatidylinositol 4-kinase type 2 alpha | -4.12954 |
