Perturb_78_KD_BAP18_SRP074464 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting BAP18 in 22Rv1 cell line (Study accession: SRP074464) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_78_KD_BAP18_SRP074464 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
WNT4 wingless-type MMTV integration site family, member 4 8.76782
AQP3 aquaporin 3 (Gill blood group) 8.09741
MYOF myoferlin 7.24169
TNS3 tensin 3 6.88828
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 5.80516
GPRC5A G protein-coupled receptor, class C, group 5, member A 4.69829
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 4.65331
FREM2 FRAS1 related extracellular matrix protein 2 4.62277
BEND4 BEN domain containing 4 4.25342
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 4.14609
BASP1 brain abundant, membrane attached signal protein 1 4.02334
AIM1 absent in melanoma 1 4.00766
CAPN2 calpain 2, (m/II) large subunit 3.99744
LAMB3 laminin, beta 3 3.73532
CD44 CD44 molecule (Indian blood group) 3.67035
ATOH8 atonal homolog 8 (Drosophila) 3.63982
AUTS2 autism susceptibility candidate 2 3.58591
KCNK17 potassium channel, two pore domain subfamily K, member 17 3.56242
EPHB3 EPH receptor B3 3.53443
SCARA3 scavenger receptor class A, member 3 3.53158
LHFP lipoma HMGIC fusion partner 3.47253
ARHGAP6 Rho GTPase activating protein 6 3.36086
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 3.34831
DOCK10 dedicator of cytokinesis 10 3.10808
SDC2 syndecan 2 3.10455
AMOTL1 angiomotin like 1 3.07852
LAMB1 laminin, beta 1 3.06864
FLNA filamin A, alpha 2.98056
TRNP1 TMF1-regulated nuclear protein 1 2.81558
ZNF532 zinc finger protein 532 2.79722
CREB5 cAMP responsive element binding protein 5 2.75865
TEX15 testis expressed 15 2.69906
THBS1 thrombospondin 1 2.69906
TGFB2 transforming growth factor, beta 2 2.69487
TBX2 T-box 2 2.68256
TFPI2 tissue factor pathway inhibitor 2 2.66323
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2.64712
ANXA2 annexin A2 2.63802
EDN1 endothelin 1 2.61237
THRB thyroid hormone receptor, beta 2.57796
KRT9 keratin 9, type I 2.57796
HSPB8 heat shock 22kDa protein 8 2.55427
LITAF lipopolysaccharide-induced TNF factor 2.54821
CNN2 calponin 2 2.4835
FAM83G family with sequence similarity 83, member G 2.32714
CCNA2 cyclin A2 2.32714
TSPAN15 tetraspanin 15 2.31172
C2CD2 C2 calcium-dependent domain containing 2 2.23265
RASD1 RAS, dexamethasone-induced 1 2.22383
P3H2 prolyl 3-hydroxylase 2 2.22383
KALRN kalirin, RhoGEF kinase 2.19391
TPM4 tropomyosin 4 2.1902
FZD8 frizzled class receptor 8 2.18814
WWC3 WWC family member 3 2.18814
MISP mitotic spindle positioning 2.17277
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 2.16079
FRMD3 FERM domain containing 3 2.16034
SPG20 spastic paraplegia 20 (Troyer syndrome) 2.15246
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 2.13488
MYL9 myosin, light chain 9, regulatory 2.10657
LBH limb bud and heart development 2.10657
TMCO4 transmembrane and coiled-coil domains 4 2.06511
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 2.06511
SUSD5 sushi domain containing 5 2.02297
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 2.02175
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 2.01953
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 2.0175
PRKCA protein kinase C, alpha 2.01565
COL2A1 collagen, type II, alpha 1 2.01419
PALLD palladin, cytoskeletal associated protein 1.98808
ALOXE3 arachidonate lipoxygenase 3 1.98765
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.98298
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 1.96915
RAB7B RAB7B, member RAS oncogene family 1.96887
DNMBP dynamin binding protein 1.96674
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 1.96345
KDELC2 KDEL (Lys-Asp-Glu-Leu) containing 2 1.95611
ZYX zyxin 1.94759
PTPN14 protein tyrosine phosphatase, non-receptor type 14 1.92403
SIPA1L2 signal-induced proliferation-associated 1 like 2 1.91233
DAPK2 death-associated protein kinase 2 1.89684
TMEM30B transmembrane protein 30B 1.89399
WTIP Wilms tumor 1 interacting protein 1.88814
ZNF853 zinc finger protein 853 1.88654
SNAI1 snail family zinc finger 1 1.88654
KIRREL kin of IRRE like (Drosophila) 1.87694
KPNA7 karyopherin alpha 7 (importin alpha 8) 1.86707
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 1.85695
LAD1 ladinin 1 1.84523
SHC4 SHC (Src homology 2 domain containing) family, member 4 1.83709
FAM102A family with sequence similarity 102, member A 1.83709
BMP2 bone morphogenetic protein 2 1.83709
ADGRF4 adhesion G protein-coupled receptor F4 1.81903
LUM lumican 1.81903
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 1.81903
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 1.81903
CERK ceramide kinase 1.81903
MSRB3 methionine sulfoxide reductase B3 1.81881
ACTG1 actin gamma 1 1.81097
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 1.80106

decreased expression

Symbol Name Standardized Value
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -20.0
CHGB chromogranin B -20.0
CPLX2 complexin 2 -17.0255
NEFH neurofilament, heavy polypeptide -14.9846
XKR7 XK, Kell blood group complex subunit-related family, member 7 -11.1601
UNC79 unc-79 homolog (C. elegans) -9.92025
VSTM2A V-set and transmembrane domain containing 2A -9.83664
SCGN secretagogin, EF-hand calcium binding protein -9.06419
CELF4 CUGBP, Elav-like family member 4 -8.79824
SEZ6 seizure related 6 homolog (mouse) -8.79824
DNER delta/notch-like EGF repeat containing -8.22199
TMEM198 transmembrane protein 198 -8.19907
RAB3C RAB3C, member RAS oncogene family -7.86936
AP3B2 adaptor-related protein complex 3, beta 2 subunit -7.74996
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -7.53103
SNAP25 synaptosomal-associated protein, 25kDa -7.1138
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 -6.93704
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -6.67855
SYT4 synaptotagmin IV -6.18805
SYP synaptophysin -6.01807
SLC35F1 solute carrier family 35, member F1 -5.98835
UNC80 unc-80 homolog (C. elegans) -5.26822
SCAMP5 secretory carrier membrane protein 5 -5.21142
SYT14 synaptotagmin XIV -5.19606
BSN bassoon presynaptic cytomatrix protein -5.18614
GPR158 G protein-coupled receptor 158 -5.01607
GRIA2 glutamate receptor, ionotropic, AMPA 2 -4.73905
MMP24 matrix metallopeptidase 24 (membrane-inserted) -4.26046
GDAP1 ganglioside induced differentiation associated protein 1 -4.24517
RAB39A RAB39A, member RAS oncogene family -4.07739
RUNX1 runt-related transcription factor 1 -4.03675
GNG4 guanine nucleotide binding protein (G protein), gamma 4 -4.00766
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -3.63982
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) -3.62403
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.5398
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 -3.32057
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 -3.2849
RUNDC3A RUN domain containing 3A -3.22613
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled -3.16637
GSTM4 glutathione S-transferase mu 4 -3.03289
STXBP5L syntaxin binding protein 5-like -2.88567
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -2.85941
EPHA3 EPH receptor A3 -2.81558
SVOP SV2 related protein homolog (rat) -2.76817
HRH3 histamine receptor H3 -2.75865
SEPT9 septin 9 -2.75865
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.75865
LOC101928991 coiled-coil domain-containing protein 92-like -2.73749
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -2.73358
GMDS GDP-mannose 4,6-dehydratase -2.72214
TMEM145 transmembrane protein 145 -2.69906
MPZL2 myelin protein zero-like 2 -2.69602
PCLO piccolo presynaptic cytomatrix protein -2.67803
GOLGA7B golgin A7 family, member B -2.64712
RHOU ras homolog family member U -2.61237
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 -2.55427
SLITRK1 SLIT and NTRK-like family, member 1 -2.53683
AMER3 APC membrane recruitment protein 3 -2.52375
ANK1 ankyrin 1, erythrocytic -2.51304
KDM5D lysine (K)-specific demethylase 5D -2.42425
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 -2.40852
SYN1 synapsin I -2.29444
CA12 carbonic anhydrase XII -2.19617
USP9Y ubiquitin specific peptidase 9, Y-linked -2.19617
CPLX1 complexin 1 -2.19614
SCRT1 scratch family zinc finger 1 -2.18814
DPYSL4 dihydropyrimidinase-like 4 -2.18814
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 -2.16079
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -2.16079
RORC RAR-related orphan receptor C -2.16034
FAM105A family with sequence similarity 105, member A -2.15291
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -2.15246
ACTL6B actin-like 6B -2.10681
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 -2.10609
SRRM4 serine/arginine repetitive matrix 4 -2.06511
NRSN1 neurensin 1 -2.04931
GSR glutathione reductase -2.04466
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 -2.0175
CALCB calcitonin-related polypeptide beta -1.98765
C3ORF14 chromosome 3 open reading frame 14 -1.98298
SLFN11 schlafen family member 11 -1.95611
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 -1.94761
SLC39A6 solute carrier family 39 (zinc transporter), member 6 -1.92383
CECR6 cat eye syndrome chromosome region, candidate 6 -1.91233
SLFN13 schlafen family member 13 -1.86707
CNTNAP5 contactin associated protein-like 5 -1.84988
TMEM180 transmembrane protein 180 -1.84988
DISP2 dispatched homolog 2 (Drosophila) -1.81416
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 -1.80988
PSD pleckstrin and Sec7 domain containing -1.80988
SYPL2 synaptophysin-like 2 -1.80988
SBSPON somatomedin B and thrombospondin, type 1 domain containing -1.80823
CPNE9 copine family member IX -1.80823
CKMT1B creatine kinase, mitochondrial 1B -1.73321
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -1.72997
INSM2 insulinoma-associated 2 -1.71202
UNC13A unc-13 homolog A (C. elegans) -1.68669
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit -1.68614
VGF VGF nerve growth factor inducible -1.6626
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -1.61839