| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting FIP1L1 in hepatoblastoma cell HepG2 cell line (Study accession: SRP013565) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_8107_KD_FIP1L1_SRP013565 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ORAOV1 | oral cancer overexpressed 1 | 20.0 |
| TUBA1C | tubulin, alpha 1c | 20.0 |
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | 20.0 |
| RNF24 | ring finger protein 24 | 20.0 |
| VTI1B | vesicle transport through interaction with t-SNAREs 1B | 20.0 |
| PCSK7 | proprotein convertase subtilisin/kexin type 7 | 20.0 |
| ADCY7 | adenylate cyclase 7 | 20.0 |
| OR2I1P | olfactory receptor, family 2, subfamily I, member 1 pseudogene | 19.5229 |
| UBXN11 | UBX domain protein 11 | 19.3979 |
| CTU2 | cytosolic thiouridylase subunit 2 homolog (S. pombe) | 18.5686 |
| CXCR5 | chemokine (C-X-C motif) receptor 5 | 18.3768 |
| BOP1 | block of proliferation 1 | 16.4143 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | 15.5945 |
| SUN2 | Sad1 and UNC84 domain containing 2 | 14.0542 |
| KRT8 | keratin 8, type II | 13.1309 |
| LDLRAD2 | low density lipoprotein receptor class A domain containing 2 | 12.6639 |
| TMEM184A | transmembrane protein 184A | 12.6639 |
| PGF | placental growth factor | 12.4293 |
| STRA13 | stimulated by retinoic acid 13 | 12.0459 |
| MYH11 | myosin, heavy chain 11, smooth muscle | 11.6012 |
| ATG7 | autophagy related 7 | 11.1421 |
| BTBD2 | BTB (POZ) domain containing 2 | 11.0049 |
| RHOBTB2 | Rho-related BTB domain containing 2 | 10.4697 |
| ADRM1 | adhesion regulating molecule 1 | 10.3698 |
| XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 3 | 9.95002 |
| BCAN | brevican | 9.85864 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 9.78253 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 9.69398 |
| EPHA1 | EPH receptor A1 | 9.64776 |
| DHRS12 | dehydrogenase/reductase (SDR family) member 12 | 9.45926 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 9.38359 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | 9.267 |
| ERAP1 | endoplasmic reticulum aminopeptidase 1 | 9.24859 |
| OSBP2 | oxysterol binding protein 2 | 9.2384 |
| ATG16L2 | autophagy related 16-like 2 (S. cerevisiae) | 9.23441 |
| TRO | trophinin | 9.23327 |
| TCTEX1D4 | Tctex1 domain containing 4 | 9.21834 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 9.03404 |
| ATG9B | autophagy related 9B | 9.02372 |
| DLD | dihydrolipoamide dehydrogenase | 9.02372 |
| CTNS | cystinosin, lysosomal cystine transporter | 9.0092 |
| FBXW8 | F-box and WD repeat domain containing 8 | 8.73255 |
| MFSD12 | major facilitator superfamily domain containing 12 | 8.36838 |
| TNRC6C | trinucleotide repeat containing 6C | 8.28742 |
| BRI3 | brain protein I3 | 8.26557 |
| CLVS1 | clavesin 1 | 8.07308 |
| TRRAP | transformation/transcription domain-associated protein | 7.95745 |
| HRNR | hornerin | 7.9553 |
| FGF22 | fibroblast growth factor 22 | 7.71173 |
| UQCC2 | ubiquinol-cytochrome c reductase complex assembly factor 2 | 7.63446 |
| IGLON5 | IgLON family member 5 | 7.18209 |
| SYTL4 | synaptotagmin-like 4 | 6.83026 |
| SLC4A2 | solute carrier family 4 (anion exchanger), member 2 | 6.78172 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 6.62682 |
| SLC2A12 | solute carrier family 2 (facilitated glucose transporter), member 12 | 6.59459 |
| YIF1B | Yip1 interacting factor homolog B (S. cerevisiae) | 6.34208 |
| CCDC78 | coiled-coil domain containing 78 | 6.34208 |
| C5ORF45 | chromosome 5 open reading frame 45 | 6.27946 |
| GOLM1 | golgi membrane protein 1 | 6.20554 |
| FRMD4A | FERM domain containing 4A | 6.04771 |
| REV1 | REV1, polymerase (DNA directed) | 5.98824 |
| PTOV1 | prostate tumor overexpressed 1 | 5.96594 |
| ZFAND1 | zinc finger, AN1-type domain 1 | 5.94029 |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) | 5.90811 |
| TFPT | TCF3 (E2A) fusion partner (in childhood Leukemia) | 5.78337 |
| HOOK2 | hook microtubule-tethering protein 2 | 5.69593 |
| WFS1 | Wolfram syndrome 1 (wolframin) | 5.54204 |
| NRD1 | nardilysin (N-arginine dibasic convertase) | 5.50543 |
| DXO | decapping exoribonuclease | 5.44465 |
| SLC26A1 | solute carrier family 26 (anion exchanger), member 1 | 5.11976 |
| C19ORF60 | chromosome 19 open reading frame 60 | 5.04682 |
| PROZ | protein Z, vitamin K-dependent plasma glycoprotein | 5.03732 |
| TMEM186 | transmembrane protein 186 | 5.00675 |
| GJD3 | gap junction protein, delta 3, 31.9kDa | 4.97173 |
| RPL31 | ribosomal protein L31 | 4.92272 |
| ZHX3 | zinc fingers and homeoboxes 3 | 4.74841 |
| SPATA7 | spermatogenesis associated 7 | 4.65137 |
| KRT17 | keratin 17, type I | 4.63484 |
| ENG | endoglin | 4.63484 |
| CAPN12 | calpain 12 | 4.60764 |
| ACO1 | aconitase 1, soluble | 4.58903 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 4.57966 |
| GMPR2 | guanosine monophosphate reductase 2 | 4.56 |
| RBPMS | RNA binding protein with multiple splicing | 4.55838 |
| PLIN4 | perilipin 4 | 4.53358 |
| CARD14 | caspase recruitment domain family, member 14 | 4.52467 |
| TYW1 | tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) | 4.50386 |
| MPP5 | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) | 4.49463 |
| SPATA21 | spermatogenesis associated 21 | 4.46058 |
| CCR7 | chemokine (C-C motif) receptor 7 | 4.36369 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 4.28886 |
| LSAMP | limbic system-associated membrane protein | 4.2854 |
| PLTP | phospholipid transfer protein | 4.26715 |
| CTSH | cathepsin H | 4.24516 |
| ARHGAP5 | Rho GTPase activating protein 5 | 4.22972 |
| MACROD1 | MACRO domain containing 1 | 4.2118 |
| KCNB1 | potassium channel, voltage gated Shab related subfamily B, member 1 | 4.20641 |
| GCSAM | germinal center-associated, signaling and motility | 4.19918 |
| RABL6 | RAB, member RAS oncogene family-like 6 | 4.16841 |
| DMAP1 | DNA methyltransferase 1 associated protein 1 | 4.13354 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP5E | ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit | -20.0 |
| MARCH7 | membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase | -20.0 |
| SRFBP1 | serum response factor binding protein 1 | -20.0 |
| TCP1 | t-complex 1 | -20.0 |
| DNAJC16 | DnaJ (Hsp40) homolog, subfamily C, member 16 | -20.0 |
| PRSS23 | protease, serine, 23 | -20.0 |
| ASAH2B | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B | -20.0 |
| C17ORF100 | chromosome 17 open reading frame 100 | -20.0 |
| CCDC152 | coiled-coil domain containing 152 | -20.0 |
| FAM35A | family with sequence similarity 35, member A | -20.0 |
| SERPINA12 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 | -20.0 |
| LTB4R2 | leukotriene B4 receptor 2 | -20.0 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -20.0 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | -20.0 |
| AFF4 | AF4/FMR2 family, member 4 | -20.0 |
| CGREF1 | cell growth regulator with EF-hand domain 1 | -20.0 |
| HPS3 | Hermansky-Pudlak syndrome 3 | -20.0 |
| C6ORF47 | chromosome 6 open reading frame 47 | -20.0 |
| HEPACAM | hepatic and glial cell adhesion molecule | -18.2757 |
| FADS1 | fatty acid desaturase 1 | -18.1805 |
| HCN3 | hyperpolarization activated cyclic nucleotide gated potassium channel 3 | -16.9508 |
| THUMPD1 | THUMP domain containing 1 | -16.8579 |
| PCYT1A | phosphate cytidylyltransferase 1, choline, alpha | -16.7572 |
| BEST1 | bestrophin 1 | -16.0944 |
| MRPL43 | mitochondrial ribosomal protein L43 | -16.0944 |
| DLEC1 | deleted in lung and esophageal cancer 1 | -15.9968 |
| DDB1 | damage-specific DNA binding protein 1, 127kDa | -15.9858 |
| ZNF517 | zinc finger protein 517 | -15.0009 |
| LINC00854 | long intergenic non-protein coding RNA 854 | -14.5968 |
| ACTN4 | actinin, alpha 4 | -13.8518 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -13.3221 |
| CROCC2 | ciliary rootlet coiled-coil, rootletin family member 2 | -13.289 |
| RAPSN | receptor-associated protein of the synapse | -13.1323 |
| USP37 | ubiquitin specific peptidase 37 | -13.0629 |
| B3GALT6 | UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 | -12.4941 |
| SIVA1 | SIVA1, apoptosis-inducing factor | -12.093 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | -10.6197 |
| COA3 | cytochrome c oxidase assembly factor 3 | -10.4788 |
| RRBP1 | ribosome binding protein 1 | -10.2009 |
| FSIP2 | fibrous sheath interacting protein 2 | -9.69398 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | -9.68103 |
| ERI2 | ERI1 exoribonuclease family member 2 | -9.54324 |
| SGCE | sarcoglycan, epsilon | -9.4921 |
| KAZN | kazrin, periplakin interacting protein | -9.1612 |
| IGSF3 | immunoglobulin superfamily, member 3 | -9.15671 |
| TRIM31 | tripartite motif containing 31 | -9.01502 |
| SARM1 | sterile alpha and TIR motif containing 1 | -8.96553 |
| SLC18A2 | solute carrier family 18 (vesicular monoamine transporter), member 2 | -8.7121 |
| COQ6 | coenzyme Q6 monooxygenase | -8.69319 |
| DHX8 | DEAH (Asp-Glu-Ala-His) box polypeptide 8 | -8.52617 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -8.40049 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -8.37454 |
| LOC122455342 | testis-specific serine/proline-rich protein | -8.27279 |
| C14ORF80 | chromosome 14 open reading frame 80 | -7.89937 |
| CEMP1 | cementum protein 1 | -7.86946 |
| EMG1 | EMG1 N1-specific pseudouridine methyltransferase | -7.84109 |
| CHAD | chondroadherin | -7.80668 |
| KLHL14 | kelch-like family member 14 | -7.74886 |
| MVK | mevalonate kinase | -7.64557 |
| LRRC47 | leucine rich repeat containing 47 | -7.56939 |
| TRAPPC4 | trafficking protein particle complex 4 | -7.519 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -7.51777 |
| DBH | dopamine beta-hydroxylase (dopamine beta-monooxygenase) | -7.24408 |
| CKAP5 | cytoskeleton associated protein 5 | -7.03269 |
| NPB | neuropeptide B | -6.89219 |
| CYB561A3 | cytochrome b561 family, member A3 | -6.75203 |
| TNFRSF25 | tumor necrosis factor receptor superfamily, member 25 | -6.71211 |
| SCTR | secretin receptor | -6.6298 |
| ACSF2 | acyl-CoA synthetase family member 2 | -6.60687 |
| MAT2A | methionine adenosyltransferase II, alpha | -6.44996 |
| C12ORF73 | chromosome 12 open reading frame 73 | -6.44475 |
| COL4A3BP | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | -6.29479 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | -6.26661 |
| CCDC176 | coiled-coil domain containing 176 | -6.2503 |
| PNPLA7 | patatin-like phospholipase domain containing 7 | -6.19103 |
| FAM132A | family with sequence similarity 132, member A | -6.13451 |
| CSNK1D | casein kinase 1, delta | -6.00929 |
| DHX38 | DEAH (Asp-Glu-Ala-His) box polypeptide 38 | -5.96224 |
| MTBP | MDM2 binding protein | -5.8309 |
| MDH2 | malate dehydrogenase 2, NAD (mitochondrial) | -5.77094 |
| LRRC41 | leucine rich repeat containing 41 | -5.7429 |
| ANO3 | anoctamin 3 | -5.60074 |
| FAM134C | family with sequence similarity 134, member C | -5.59987 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | -5.51917 |
| TRIM14 | tripartite motif containing 14 | -5.37728 |
| C12ORF76 | chromosome 12 open reading frame 76 | -5.32542 |
| C1ORF159 | chromosome 1 open reading frame 159 | -5.323 |
| PNCK | pregnancy up-regulated nonubiquitous CaM kinase | -5.20177 |
| SPTLC2 | serine palmitoyltransferase, long chain base subunit 2 | -5.1259 |
| MXD3 | MAX dimerization protein 3 | -5.0957 |
| FBLIM1 | filamin binding LIM protein 1 | -5.08379 |
| ALOX12B | arachidonate 12-lipoxygenase, 12R type | -5.04073 |
| HDLBP | high density lipoprotein binding protein | -5.02356 |
| LNX1 | ligand of numb-protein X 1, E3 ubiquitin protein ligase | -4.89905 |
| SYT15 | synaptotagmin XV | -4.8559 |
| DOPEY1 | dopey family member 1 | -4.79897 |
| C7ORF49 | chromosome 7 open reading frame 49 | -4.7228 |
| SSTR5 | somatostatin receptor 5 | -4.63861 |
| APOB | apolipoprotein B | -4.43752 |
| SPAG4 | sperm associated antigen 4 | -4.4328 |
