Perturb_8206_KD_PRPF6_SRP013565 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting PRPF6 in hepatoblastoma cell HepG2 cell line (Study accession: SRP013565) (PerturbAtlas)
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Genes

85 genes differentially expressed following the Perturb_8206_KD_PRPF6_SRP013565 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
LIN7A lin-7 homolog A (C. elegans) 9.68436
PCGF1 polycomb group ring finger 1 4.62502
BEST1 bestrophin 1 4.2925
TMEM186 transmembrane protein 186 3.96274
PHF10 PHD finger protein 10 3.71967
PRCD progressive rod-cone degeneration 3.68578
MNS1 meiosis-specific nuclear structural 1 3.19645
ZBTB46 zinc finger and BTB domain containing 46 3.00968
FSIP1 fibrous sheath interacting protein 1 2.90891
C14ORF93 chromosome 14 open reading frame 93 2.52898
SGPP2 sphingosine-1-phosphate phosphatase 2 2.41987
CPM carboxypeptidase M 2.41987
SPRYD4 SPRY domain containing 4 2.27563
BAG2 BCL2-associated athanogene 2 2.15199
TCP1 t-complex 1 2.10944
TLDC2 TBC/LysM-associated domain containing 2 2.01442
AKAP13 A kinase (PRKA) anchor protein 13 1.86614
ACO2 aconitase 2, mitochondrial 1.86078
DDIT3 DNA-damage-inducible transcript 3 1.85229
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 1.79639
FAM63A family with sequence similarity 63, member A 1.78511
ABI1 abl-interactor 1 1.74128
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 1.72852
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 1.71324
PGF placental growth factor 1.69851
SLC46A1 solute carrier family 46 (folate transporter), member 1 1.64318
WTAP Wilms tumor 1 associated protein 1.57329
UBXN11 UBX domain protein 11 1.4694
RECQL RecQ helicase-like 1.45849
DXO decapping exoribonuclease 1.37708
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 1.34371
AIG1 androgen-induced 1 1.31252

decreased expression

Symbol Name Standardized Value
SRFBP1 serum response factor binding protein 1 -20.0
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -20.0
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit -17.9547
MROH8 maestro heat-like repeat family member 8 -16.3757
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -10.8915
CCDC152 coiled-coil domain containing 152 -9.68436
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -7.83836
COA3 cytochrome c oxidase assembly factor 3 -7.21618
PNCK pregnancy up-regulated nonubiquitous CaM kinase -5.58653
C6ORF47 chromosome 6 open reading frame 47 -5.41056
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 -5.22141
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -4.99436
C17ORF100 chromosome 17 open reading frame 100 -3.9682
HPS3 Hermansky-Pudlak syndrome 3 -3.95013
TACC3 transforming, acidic coiled-coil containing protein 3 -3.49445
COG5 component of oligomeric golgi complex 5 -3.47414
CKAP5 cytoskeleton associated protein 5 -3.05695
TRIM31 tripartite motif containing 31 -2.90891
COX20 COX20 cytochrome c oxidase assembly factor -2.61176
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -2.52329
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -2.38675
SCTR secretin receptor -2.21756
PANK2 pantothenate kinase 2 -2.15232
PCYT1A phosphate cytidylyltransferase 1, choline, alpha -2.14936
CCDC84 coiled-coil domain containing 84 -2.14553
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -1.99983
BCAR3 breast cancer anti-estrogen resistance 3 -1.99742
GTPBP1 GTP binding protein 1 -1.99661
SERP1 stress-associated endoplasmic reticulum protein 1 -1.98331
C18ORF8 chromosome 18 open reading frame 8 -1.98331
GABPA GA binding protein transcription factor, alpha subunit 60kDa -1.91576
TMEM50B transmembrane protein 50B -1.86683
LRRK1 leucine-rich repeat kinase 1 -1.86614
INO80D INO80 complex subunit D -1.86614
LINC00094 long intergenic non-protein coding RNA 94 -1.86352
SPAG1 sperm associated antigen 1 -1.82666
UFSP2 UFM1-specific peptidase 2 -1.8102
SPC24 SPC24, NDC80 kinetochore complex component -1.80384
APOM apolipoprotein M -1.79961
PCGF2 polycomb group ring finger 2 -1.79639
ACTN4 actinin, alpha 4 -1.78397
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -1.73067
CYB561A3 cytochrome b561 family, member A3 -1.67019
HEPACAM hepatic and glial cell adhesion molecule -1.64318
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -1.57873
PECAM1 platelet/endothelial cell adhesion molecule 1 -1.52825
KRT18 keratin 18, type I -1.45773
ATG10 autophagy related 10 -1.45773
C12ORF73 chromosome 12 open reading frame 73 -1.45546
CLDN22 claudin 22 -1.41419
RMDN1 regulator of microtubule dynamics 1 -1.39336
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -1.38056
UGP2 UDP-glucose pyrophosphorylase 2 -1.3413