Perturb_8365_KD_MACROH2A1/MACROH2A2_SRP293364 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting MACROH2A1/MACROH2A2 in hepatoblastoma cell HepG2 cell line (Study accession: SRP293364) (PerturbAtlas)
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Genes

41 genes differentially expressed following the Perturb_8365_KD_MACROH2A1/MACROH2A2_SRP293364 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
MED28 mediator complex subunit 28 8.84848
ADGRG5 adhesion G protein-coupled receptor G5 8.81962
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 7.38747
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 7.14719
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 6.52436
TRO trophinin 6.26371
SRFBP1 serum response factor binding protein 1 5.87195
KLKB1 kallikrein B, plasma (Fletcher factor) 1 4.56951
OIT3 oncoprotein induced transcript 3 3.9574
DMGDH dimethylglycine dehydrogenase 3.49473
RBBP4 retinoblastoma binding protein 4 3.49473
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 3.28806
PCGF1 polycomb group ring finger 1 3.26034
LBX2 ladybird homeobox 2 3.25586
HSF1 heat shock transcription factor 1 3.19923
KLHL14 kelch-like family member 14 3.15848
PRSS23 protease, serine, 23 3.00939
SPATA6L spermatogenesis associated 6-like 3.00939
TRIM46 tripartite motif containing 46 2.93433
SZRD1 SUZ RNA binding domain containing 1 2.87629
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 2.69198
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2.61844
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 2.60887
FGG fibrinogen gamma chain 2.51832
WDR13 WD repeat domain 13 2.51069
CHMP1A charged multivesicular body protein 1A 2.48432
FANCF Fanconi anemia, complementation group F 2.41122
MZF1 myeloid zinc finger 1 2.41122
SCTR secretin receptor 2.21401
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.18482
CRMP1 collapsin response mediator protein 1 2.16915
PEX6 peroxisomal biogenesis factor 6 1.87951
ACOT8 acyl-CoA thioesterase 8 1.80443
PSIP1 PC4 and SFRS1 interacting protein 1 1.78865
MXRA7 matrix-remodelling associated 7 1.31558

decreased expression

Symbol Name Standardized Value
PACRGL PARK2 co-regulated-like -20.0
PLK5 polo-like kinase 5 -7.02808
STRA13 stimulated by retinoic acid 13 -5.22073
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -3.91555
NME7 NME/NM23 family member 7 -1.87496
SCMH1 sex comb on midleg homolog 1 (Drosophila) -1.82686