Perturb_8472_Mut|KD_IDH1_SRP099826 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description Mut|KD perturbation targeting IDH1 in hESC derived NSCs cell line (Study accession: SRP099826) (PerturbAtlas)
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Genes

63 genes differentially expressed following the Perturb_8472_Mut|KD_IDH1_SRP099826 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
PLD4 phospholipase D family, member 4 10.8021
FSIP1 fibrous sheath interacting protein 1 3.39101
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 3.37269
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 3.20029
PCSK7 proprotein convertase subtilisin/kexin type 7 2.97205
SZT2 seizure threshold 2 homolog (mouse) 2.81804
GJB5 gap junction protein, beta 5, 31.1kDa 2.55982
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.55196
ADA adenosine deaminase 2.51516
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 2.33162
C14ORF166 chromosome 14 open reading frame 166 2.25384
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 2.21487
VEPH1 ventricular zone expressed PH domain-containing 1 2.16048
PKDREJ polycystin (PKD) family receptor for egg jelly 2.0858
PLXNA4 plexin A4 2.07719
PARK2 parkin RBR E3 ubiquitin protein ligase 2.07719
TENM2 teneurin transmembrane protein 2 1.49467
RAB40A RAB40A, member RAS oncogene family 1.47464
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 1.47464
C2ORF16 chromosome 2 open reading frame 16 1.4307
SUMF1 sulfatase modifying factor 1 1.4307
BMP8A bone morphogenetic protein 8a 1.41952
KIAA1549L KIAA1549-like 1.3273

decreased expression

Symbol Name Standardized Value
C12ORF60 chromosome 12 open reading frame 60 -16.1988
CCDC152 coiled-coil domain containing 152 -7.47952
COL6A2 collagen, type VI, alpha 2 -6.84259
ZFP36L2 ZFP36 ring finger protein-like 2 -4.8365
DLX1 distal-less homeobox 1 -4.7733
H1F0 H1 histone family, member 0 -4.52616
ORAOV1 oral cancer overexpressed 1 -4.47029
MOCS1 molybdenum cofactor synthesis 1 -3.74274
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 -3.71152
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -3.33234
COL6A3 collagen, type VI, alpha 3 -3.29115
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -3.29115
LMO2 LIM domain only 2 (rhombotin-like 1) -3.22801
CRABP1 cellular retinoic acid binding protein 1 -3.22801
LYST lysosomal trafficking regulator -3.1613
MOXD1 monooxygenase, DBH-like 1 -2.86867
NEFM neurofilament, medium polypeptide -2.72283
PRRX1 paired related homeobox 1 -2.62979
TGFBI transforming growth factor, beta-induced, 68kDa -2.55272
FANCL Fanconi anemia, complementation group L -2.51516
INF2 inverted formin, FH2 and WH2 domain containing -2.20722
COL6A1 collagen, type VI, alpha 1 -2.15675
PRICKLE3 prickle homolog 3 (Drosophila) -2.1531
C1QL4 complement component 1, q subcomponent-like 4 -2.08117
MAPK7 mitogen-activated protein kinase 7 -2.04606
IL17RD interleukin 17 receptor D -2.02672
COL2A1 collagen, type II, alpha 1 -2.00068
STRA6 stimulated by retinoic acid 6 -1.81196
SPAG8 sperm associated antigen 8 -1.79769
TBX2 T-box 2 -1.79328
SCUBE1 signal peptide, CUB domain, EGF-like 1 -1.72315
FZD1 frizzled class receptor 1 -1.55203
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta -1.48983
LOC338667 V-set and immunoglobulin domain-containing protein 10-like -1.48463
SLC19A1 solute carrier family 19 (folate transporter), member 1 -1.45967
NREP neuronal regeneration related protein -1.4574
CCND1 cyclin D1 -1.456
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 -1.3914
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -1.37681
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 -1.34759