Perturb_8731_KD_HERV_SRP343980 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting HERV in HSF cell line were purchased from CTCC cell line (Study accession: SRP343980) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_8731_KD_HERV_SRP343980 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
PRSS23 protease, serine, 23 20.0
TPM3 tropomyosin 3 20.0
UBE2Z ubiquitin-conjugating enzyme E2Z 20.0
PGAM1 phosphoglycerate mutase 1 (brain) 20.0
TFPI2 tissue factor pathway inhibitor 2 20.0
CCL5 chemokine (C-C motif) ligand 5 20.0
SCARB2 scavenger receptor class B, member 2 20.0
LIMA1 LIM domain and actin binding 1 20.0
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 20.0
DCBLD2 discoidin, CUB and LCCL domain containing 2 20.0
CD164 CD164 molecule, sialomucin 20.0
TPM4 tropomyosin 4 20.0
ALCAM activated leukocyte cell adhesion molecule 20.0
GANAB glucosidase, alpha; neutral AB 20.0
GRN granulin 20.0
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 20.0
MYO10 myosin X 20.0
ZFP36L1 ZFP36 ring finger protein-like 1 20.0
NT5E 5'-nucleotidase, ecto (CD73) 20.0
IGFBP6 insulin-like growth factor binding protein 6 20.0
IFI6 interferon, alpha-inducible protein 6 20.0
MX2 MX dynamin-like GTPase 2 20.0
MX1 MX dynamin-like GTPase 1 20.0
PARP14 poly (ADP-ribose) polymerase family, member 14 20.0
IFITM3 interferon induced transmembrane protein 3 20.0
RNF213 ring finger protein 213 20.0
RRBP1 ribosome binding protein 1 20.0
TRIP12 thyroid hormone receptor interactor 12 20.0
SAMD9L sterile alpha motif domain containing 9-like 20.0
LY6E lymphocyte antigen 6 complex, locus E 20.0
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 20.0
CXCL10 chemokine (C-X-C motif) ligand 10 20.0
GBP1 guanylate binding protein 1, interferon-inducible 20.0
GBP4 guanylate binding protein 4 20.0
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 20.0
STAT2 signal transducer and activator of transcription 2, 113kDa 20.0
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 20.0
ADAR adenosine deaminase, RNA-specific 20.0
CXCL11 chemokine (C-X-C motif) ligand 11 20.0
NFE2L1 nuclear factor, erythroid 2-like 1 20.0
LDHA lactate dehydrogenase A 20.0
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 20.0
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 20.0
OASL 2'-5'-oligoadenylate synthetase-like 20.0
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 20.0
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 20.0
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 20.0
ISG15 ISG15 ubiquitin-like modifier 20.0
CD44 CD44 molecule (Indian blood group) 20.0
STAT1 signal transducer and activator of transcription 1, 91kDa 20.0
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 20.0
TMBIM1 transmembrane BAX inhibitor motif containing 1 20.0
HM13 histocompatibility (minor) 13 20.0
CKAP4 cytoskeleton-associated protein 4 20.0
ITM2B integral membrane protein 2B 20.0
LAPTM4A lysosomal protein transmembrane 4 alpha 20.0
CXCR4 chemokine (C-X-C motif) receptor 4 20.0
MT2A metallothionein 2A 20.0
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 20.0
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 20.0
B2M beta-2-microglobulin 20.0
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 20.0
SFRP1 secreted frizzled-related protein 1 20.0
SAMD9 sterile alpha motif domain containing 9 20.0
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 20.0
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 20.0
MCL1 myeloid cell leukemia 1 20.0
ADAM19 ADAM metallopeptidase domain 19 20.0
TIMP1 TIMP metallopeptidase inhibitor 1 20.0
OPTN optineurin 20.0
HLA-B major histocompatibility complex, class I, B 20.0
HLA-A major histocompatibility complex, class I, A 20.0
LGMN legumain 20.0
CTSL cathepsin L 20.0
IGFBP3 insulin-like growth factor binding protein 3 20.0
IGFBP4 insulin-like growth factor binding protein 4 20.0
HLA-C major histocompatibility complex, class I, C 20.0
HLA-E major histocompatibility complex, class I, E 20.0
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 20.0
WARS tryptophanyl-tRNA synthetase 20.0
UBR4 ubiquitin protein ligase E3 component n-recognin 4 20.0
GPRC5A G protein-coupled receptor, class C, group 5, member A 20.0
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 20.0
ANPEP alanyl (membrane) aminopeptidase 20.0
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 20.0
SLFN5 schlafen family member 5 20.0
IFI16 interferon, gamma-inducible protein 16 20.0
TRIM22 tripartite motif containing 22 20.0
TMSB10 thymosin beta 10 20.0
TXNIP thioredoxin interacting protein 20.0
CLIC4 chloride intracellular channel 4 20.0
RSAD2 radical S-adenosyl methionine domain containing 2 20.0
H3F3A H3 histone, family 3A 20.0
SULF1 sulfatase 1 20.0
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 20.0
ZNFX1 zinc finger, NFX1-type containing 1 20.0
ECE1 endothelin converting enzyme 1 20.0
PRNP prion protein 20.0
IFIH1 interferon induced with helicase C domain 1 20.0
HELZ2 helicase with zinc finger 2, transcriptional coactivator 20.0

decreased expression

Symbol Name Standardized Value
C16ORF45 chromosome 16 open reading frame 45 -20.0
NUDT16L1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 -20.0
TTLL7 tubulin tyrosine ligase-like family member 7 -20.0
GLIS3 GLIS family zinc finger 3 -20.0
KCNIP3 Kv channel interacting protein 3, calsenilin -20.0
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -20.0
ANKRD34A ankyrin repeat domain 34A -20.0
CC2D2A coiled-coil and C2 domain containing 2A -20.0
DIRAS1 DIRAS family, GTP-binding RAS-like 1 -20.0
CNN1 calponin 1, basic, smooth muscle -20.0
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -20.0
TMEM35 transmembrane protein 35 -20.0
CDK15 cyclin-dependent kinase 15 -20.0
ACAT1 acetyl-CoA acetyltransferase 1 -20.0
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 -20.0
RHOD ras homolog family member D -20.0
POLR1E polymerase (RNA) I polypeptide E, 53kDa -20.0
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 -20.0
SLC38A4 solute carrier family 38, member 4 -20.0
SH3GL2 SH3-domain GRB2-like 2 -20.0
CLCN5 chloride channel, voltage-sensitive 5 -20.0
CHML choroideremia-like (Rab escort protein 2) -20.0
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -20.0
BCAT2 branched chain amino-acid transaminase 2, mitochondrial -20.0
PITPNM3 PITPNM family member 3 -20.0
TMEM120B transmembrane protein 120B -20.0
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 -20.0
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -20.0
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -20.0
SOCS7 suppressor of cytokine signaling 7 -20.0
PNPLA3 patatin-like phospholipase domain containing 3 -20.0
DPY19L3 dpy-19-like 3 (C. elegans) -20.0
LOC728392 uncharacterized LOC728392 -20.0
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -20.0
JADE1 jade family PHD finger 1 -20.0
OTUD3 OTU deubiquitinase 3 -20.0
HMCN1 hemicentin 1 -20.0
ZSWIM7 zinc finger, SWIM-type containing 7 -20.0
GCAT glycine C-acetyltransferase -20.0
NPM3 nucleophosmin/nucleoplasmin 3 -20.0
MAP3K7CL MAP3K7 C-terminal like -20.0
RASL10B RAS-like, family 10, member B -20.0
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 -20.0
AKAP6 A kinase (PRKA) anchor protein 6 -20.0
ANOS1 anosmin 1 -20.0
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) -20.0
STAC SH3 and cysteine rich domain -20.0
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog -20.0
RHOBTB1 Rho-related BTB domain containing 1 -20.0
SLC7A14 solute carrier family 7, member 14 -20.0
FAM212B family with sequence similarity 212, member B -20.0
GATSL2 GATS protein-like 2 -20.0
SLC38A2 solute carrier family 38, member 2 -20.0
PYGO1 pygopus family PHD finger 1 -20.0
GSTA4 glutathione S-transferase alpha 4 -20.0
PLA2G12A phospholipase A2, group XIIA -20.0
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -20.0
ARL3 ADP-ribosylation factor-like 3 -20.0
PIDD1 p53-induced death domain protein 1 -20.0
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -20.0
TMEM178B transmembrane protein 178B -20.0
FAT3 FAT atypical cadherin 3 -20.0
RGS5 regulator of G-protein signaling 5 -20.0
CSDC2 cold shock domain containing C2, RNA binding -20.0
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -20.0
TMEM168 transmembrane protein 168 -20.0
SUGCT succinyl-CoA:glutarate-CoA transferase -20.0
KRTAP1-5 keratin associated protein 1-5 -20.0
CEND1 cell cycle exit and neuronal differentiation 1 -20.0
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -20.0
FAM172A family with sequence similarity 172, member A -20.0
IGIP IgA-inducing protein -20.0
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -20.0
HSPA4L heat shock 70kDa protein 4-like -20.0
LMOD1 leiomodin 1 (smooth muscle) -20.0
PCDHGA7 protocadherin gamma subfamily A, 7 -20.0
FITM2 fat storage-inducing transmembrane protein 2 -20.0
ARMCX4 armadillo repeat containing, X-linked 4 -20.0
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -20.0
REEP2 receptor accessory protein 2 -20.0
SYTL5 synaptotagmin-like 5 -20.0
GPATCH11 G patch domain containing 11 -20.0
KCTD7 potassium channel tetramerization domain containing 7 -20.0
TNS2 tensin 2 -20.0
WRB tryptophan rich basic protein -20.0
TMEM8B transmembrane protein 8B -20.0
CEP78 centrosomal protein 78kDa -20.0
NAP1L3 nucleosome assembly protein 1-like 3 -20.0
KIAA1462 KIAA1462 -20.0
NREP neuronal regeneration related protein -20.0
NMT2 N-myristoyltransferase 2 -20.0
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 -20.0
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -20.0
SYNC syncoilin, intermediate filament protein -20.0
RAB40B RAB40B, member RAS oncogene family -20.0
NOV nephroblastoma overexpressed -20.0
FNDC4 fibronectin type III domain containing 4 -20.0
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 -20.0
HSPB3 heat shock 27kDa protein 3 -20.0
ARL4C ADP-ribosylation factor-like 4C -20.0