| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KO perturbation targeting DNMT3A/DNMT3B in HUES64(ESCs) cell line (Study accession: SRP186642) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_8781_KO_DNMT3A/DNMT3B_SRP186642 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TUBA1C | tubulin, alpha 1c | 20.0 |
| GRPR | gastrin-releasing peptide receptor | 20.0 |
| MAGEB17 | melanoma antigen family B17 | 20.0 |
| MME | membrane metallo-endopeptidase | 20.0 |
| SSC4D | scavenger receptor cysteine rich family, 4 domains | 20.0 |
| CRYAB | crystallin, alpha B | 20.0 |
| ZNF827 | zinc finger protein 827 | 20.0 |
| NDUFV3 | NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa | 20.0 |
| SLC7A6OS | solute carrier family 7, member 6 opposite strand | 19.699 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | 19.699 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | 19.0458 |
| CCDC74B | coiled-coil domain containing 74B | 18.8239 |
| MIEN1 | migration and invasion enhancer 1 | 18.6778 |
| PAX8 | paired box 8 | 17.9101 |
| AKAP7 | A kinase (PRKA) anchor protein 7 | 15.624 |
| SGCE | sarcoglycan, epsilon | 15.3284 |
| FADS1 | fatty acid desaturase 1 | 15.1678 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 14.3583 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 14.1613 |
| RAB26 | RAB26, member RAS oncogene family | 14.1025 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | 13.6393 |
| NME7 | NME/NM23 family member 7 | 13.3614 |
| COL4A3BP | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | 12.9317 |
| ACAD8 | acyl-CoA dehydrogenase family, member 8 | 10.9384 |
| MCMDC2 | minichromosome maintenance domain containing 2 | 10.7707 |
| SAMHD1 | SAM domain and HD domain 1 | 10.6886 |
| PTOV1 | prostate tumor overexpressed 1 | 10.6163 |
| CCDC106 | coiled-coil domain containing 106 | 10.6083 |
| LYRM5 | LYR motif containing 5 | 10.2098 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | 9.9626 |
| ERCC1 | excision repair cross-complementation group 1 | 9.90334 |
| ACBD6 | acyl-CoA binding domain containing 6 | 9.76826 |
| THBS3 | thrombospondin 3 | 9.70895 |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | 9.52001 |
| MFSD11 | major facilitator superfamily domain containing 11 | 9.31041 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 9.1709 |
| CTSA | cathepsin A | 9.13627 |
| ITGA7 | integrin, alpha 7 | 9.1041 |
| PIWIL4 | piwi-like RNA-mediated gene silencing 4 | 8.94135 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 8.92612 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 8.65067 |
| ZNF771 | zinc finger protein 771 | 8.58451 |
| MRPS18C | mitochondrial ribosomal protein S18C | 8.53048 |
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | 8.52149 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 8.49228 |
| TMED1 | transmembrane emp24 protein transport domain containing 1 | 8.48959 |
| IFT20 | intraflagellar transport 20 | 8.46341 |
| RUVBL1 | RuvB-like AAA ATPase 1 | 8.41469 |
| NPAP1 | nuclear pore associated protein 1 | 8.41294 |
| ABHD8 | abhydrolase domain containing 8 | 8.3681 |
| FAM71E1 | family with sequence similarity 71, member E1 | 8.36488 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | 8.3362 |
| NPEPL1 | aminopeptidase-like 1 | 8.20026 |
| PINK1 | PTEN induced putative kinase 1 | 7.8785 |
| PRSS12 | protease, serine, 12 (neurotrypsin, motopsin) | 7.7467 |
| HEXB | hexosaminidase B (beta polypeptide) | 7.74626 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | 7.70574 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | 7.68463 |
| ACPT | acid phosphatase, testicular | 7.5943 |
| HIST1H2BN | histone cluster 1, H2bn | 7.40744 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 7.29213 |
| HIST1H4I | histone cluster 1, H4i | 7.22742 |
| PDPR | pyruvate dehydrogenase phosphatase regulatory subunit | 7.21192 |
| LAMA5 | laminin, alpha 5 | 7.17556 |
| C8ORF59 | chromosome 8 open reading frame 59 | 7.14715 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 7.14098 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 7.10159 |
| PHYKPL | 5-phosphohydroxy-L-lysine phospho-lyase | 6.8615 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 6.8615 |
| P2RY11 | purinergic receptor P2Y, G-protein coupled, 11 | 6.86094 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | 6.81559 |
| CLVS1 | clavesin 1 | 6.79901 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | 6.55329 |
| LAMA3 | laminin, alpha 3 | 6.48173 |
| NOXO1 | NADPH oxidase organizer 1 | 6.44673 |
| KRT8 | keratin 8, type II | 6.44201 |
| EFR3B | EFR3 homolog B (S. cerevisiae) | 6.37885 |
| SPON2 | spondin 2, extracellular matrix protein | 6.36393 |
| CLU | clusterin | 6.35406 |
| RNF123 | ring finger protein 123 | 6.26275 |
| FSIP2 | fibrous sheath interacting protein 2 | 6.21256 |
| SLC15A3 | solute carrier family 15 (oligopeptide transporter), member 3 | 6.1784 |
| PNPLA2 | patatin-like phospholipase domain containing 2 | 6.08457 |
| OTUD4 | OTU deubiquitinase 4 | 6.0665 |
| BTLA | B and T lymphocyte associated | 6.01322 |
| CASKIN1 | CASK interacting protein 1 | 6.01322 |
| UTS2 | urotensin 2 | 5.85265 |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | 5.79577 |
| CD37 | CD37 molecule | 5.77294 |
| EFHC1 | EF-hand domain (C-terminal) containing 1 | 5.63538 |
| MXD3 | MAX dimerization protein 3 | 5.58708 |
| WDR55 | WD repeat domain 55 | 5.58686 |
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 5.54874 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 5.53479 |
| SLC46A1 | solute carrier family 46 (folate transporter), member 1 | 5.44593 |
| FEZF1 | FEZ family zinc finger 1 | 5.43632 |
| MROH1 | maestro heat-like repeat family member 1 | 5.43143 |
| C12ORF65 | chromosome 12 open reading frame 65 | 5.41819 |
| TSPAN31 | tetraspanin 31 | 5.3358 |
| FUZ | fuzzy planar cell polarity protein | 5.26585 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPSG1 | tryptase gamma 1 | -20.0 |
| SEPP1 | selenoprotein P, plasma, 1 | -20.0 |
| CDHR5 | cadherin-related family member 5 | -20.0 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | -20.0 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | -20.0 |
| NME6 | NME/NM23 nucleoside diphosphate kinase 6 | -20.0 |
| ALPPL2 | alkaline phosphatase, placental-like 2 | -20.0 |
| IL3RA | interleukin 3 receptor, alpha (low affinity) | -20.0 |
| ALPP | alkaline phosphatase, placental | -20.0 |
| CSNK1D | casein kinase 1, delta | -18.7447 |
| ERVH48-1 | endogenous retrovirus group 48, member 1 | -18.0269 |
| NDUFS7 | NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) | -18.0177 |
| MYL9 | myosin, light chain 9, regulatory | -16.8413 |
| KNDC1 | kinase non-catalytic C-lobe domain (KIND) containing 1 | -16.7857 |
| IRF7 | interferon regulatory factor 7 | -16.5585 |
| SLC26A1 | solute carrier family 26 (anion exchanger), member 1 | -15.9909 |
| TTN | titin | -15.8418 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -15.1596 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -14.9234 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | -14.3508 |
| BMP8A | bone morphogenetic protein 8a | -14.0504 |
| SLC9A3 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 | -14.0028 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -13.262 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | -12.7475 |
| BRAT1 | BRCA1-associated ATM activator 1 | -12.6622 |
| FSIP1 | fibrous sheath interacting protein 1 | -12.0919 |
| SIK2 | salt-inducible kinase 2 | -12.0635 |
| BLCAP | bladder cancer associated protein | -11.9538 |
| TMEM80 | transmembrane protein 80 | -11.2997 |
| FXYD1 | FXYD domain containing ion transport regulator 1 | -11.2706 |
| CYP19A1 | cytochrome P450, family 19, subfamily A, polypeptide 1 | -11.0757 |
| MTMR10 | myotubularin related protein 10 | -10.7827 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | -10.5324 |
| JAKMIP2 | janus kinase and microtubule interacting protein 2 | -10.2668 |
| LMNTD2 | lamin tail domain containing 2 | -10.1186 |
| C6ORF10 | chromosome 6 open reading frame 10 | -9.59636 |
| MYH16 | myosin, heavy chain 16 pseudogene | -9.5956 |
| CDK15 | cyclin-dependent kinase 15 | -9.59344 |
| MMP24-AS1 | MMP24 antisense RNA 1 | -9.47805 |
| CRHR2 | corticotropin releasing hormone receptor 2 | -9.47248 |
| TNFRSF25 | tumor necrosis factor receptor superfamily, member 25 | -9.36227 |
| LRRN3 | leucine rich repeat neuronal 3 | -8.81845 |
| SCGB3A2 | secretoglobin, family 3A, member 2 | -8.53048 |
| SETMAR | SET domain and mariner transposase fusion gene | -8.3282 |
| ANKFY1 | ankyrin repeat and FYVE domain containing 1 | -8.2209 |
| MROH5 | maestro heat-like repeat family member 5 | -8.17647 |
| SPINK8 | serine peptidase inhibitor, Kazal type 8 (putative) | -8.14577 |
| ZNF562 | zinc finger protein 562 | -7.9319 |
| KCNT1 | potassium channel, sodium activated subfamily T, member 1 | -7.52468 |
| COL20A1 | collagen, type XX, alpha 1 | -7.43675 |
| COMMD9 | COMM domain containing 9 | -7.39558 |
| FLNB | filamin B, beta | -7.28461 |
| FSCN1 | fascin actin-bundling protein 1 | -7.27537 |
| SERINC4 | serine incorporator 4 | -7.22107 |
| C9ORF84 | chromosome 9 open reading frame 84 | -7.1315 |
| COL6A1 | collagen, type VI, alpha 1 | -7.11009 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | -7.11009 |
| MTA3 | metastasis associated 1 family, member 3 | -7.04468 |
| PLXNB3 | plexin B3 | -7.03899 |
| EPAS1 | endothelial PAS domain protein 1 | -6.93469 |
| ANO8 | anoctamin 8 | -6.77624 |
| PERM1 | PPARGC1 and ESRR induced regulator, muscle 1 | -6.62447 |
| FAM20A | family with sequence similarity 20, member A | -6.56606 |
| TNFAIP8L3 | tumor necrosis factor, alpha-induced protein 8-like 3 | -6.55124 |
| KIAA1614 | KIAA1614 | -6.44673 |
| MSH2 | mutS homolog 2 | -6.38869 |
| TMEM255B | transmembrane protein 255B | -6.29674 |
| LRRTM3 | leucine rich repeat transmembrane neuronal 3 | -6.25156 |
| KLHDC4 | kelch domain containing 4 | -6.20162 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -6.06003 |
| FILIP1L | filamin A interacting protein 1-like | -6.0525 |
| FRMD5 | FERM domain containing 5 | -5.99865 |
| ADRA2C | adrenoceptor alpha 2C | -5.96191 |
| TSPAN11 | tetraspanin 11 | -5.95874 |
| HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | -5.8108 |
| FAM160B2 | family with sequence similarity 160, member B2 | -5.69798 |
| PALLD | palladin, cytoskeletal associated protein | -5.69481 |
| DNAJC17 | DnaJ (Hsp40) homolog, subfamily C, member 17 | -5.68818 |
| COL10A1 | collagen, type X, alpha 1 | -5.59296 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | -5.48645 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -5.48201 |
| COL9A3 | collagen, type IX, alpha 3 | -5.47694 |
| FAM65A | family with sequence similarity 65, member A | -5.43632 |
| PLXDC1 | plexin domain containing 1 | -5.42498 |
| PCDHA4 | protocadherin alpha 4 | -5.29294 |
| ZNF391 | zinc finger protein 391 | -5.23871 |
| SLC26A9 | solute carrier family 26 (anion exchanger), member 9 | -5.2058 |
| ASPN | asporin | -5.20282 |
| MLF2 | myeloid leukemia factor 2 | -5.20043 |
| KCTD2 | potassium channel tetramerization domain containing 2 | -5.18507 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -5.15615 |
| GRM6 | glutamate receptor, metabotropic 6 | -5.11373 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | -5.11086 |
| RUNX2 | runt-related transcription factor 2 | -5.07579 |
| DENND3 | DENN/MADD domain containing 3 | -5.04122 |
| CYP4A22 | cytochrome P450, family 4, subfamily A, polypeptide 22 | -4.96596 |
| GPR155 | G protein-coupled receptor 155 | -4.96479 |
| A2M | alpha-2-macroglobulin | -4.96228 |
| ERVW-1 | endogenous retrovirus group W, member 1 | -4.93267 |
| FAM196A | family with sequence similarity 196, member A | -4.93115 |
