| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KO perturbation targeting HNF6 in HUES8 cell line (Study accession: SRP217514) (PerturbAtlas) |
| Similar Terms | |
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200 genes differentially expressed following the Perturb_8787_KO_HNF6_SRP217514 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| WDR72 | WD repeat domain 72 | 20.0 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 16.3047 |
| KRT8 | keratin 8, type II | 11.4213 |
| IGF2 | insulin-like growth factor 2 | 11.2238 |
| WDR41 | WD repeat domain 41 | 10.9909 |
| ASMTL | acetylserotonin O-methyltransferase-like | 9.82692 |
| ZNF224 | zinc finger protein 224 | 9.23001 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 7.42335 |
| DENND1A | DENN/MADD domain containing 1A | 6.83299 |
| MAPK10 | mitogen-activated protein kinase 10 | 6.04976 |
| CCNYL1 | cyclin Y-like 1 | 5.51011 |
| C12ORF43 | chromosome 12 open reading frame 43 | 5.04836 |
| TMEM258 | transmembrane protein 258 | 4.96986 |
| CXCR5 | chemokine (C-X-C motif) receptor 5 | 4.9125 |
| TMEM184A | transmembrane protein 184A | 4.89689 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | 4.6484 |
| OR2I1P | olfactory receptor, family 2, subfamily I, member 1 pseudogene | 4.56556 |
| PDK2 | pyruvate dehydrogenase kinase, isozyme 2 | 4.46664 |
| ENO3 | enolase 3 (beta, muscle) | 4.36953 |
| TMEM120B | transmembrane protein 120B | 4.17477 |
| C5ORF45 | chromosome 5 open reading frame 45 | 4.11944 |
| SPTB | spectrin, beta, erythrocytic | 3.80559 |
| PDAP1 | PDGFA associated protein 1 | 3.65636 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 3.57579 |
| UQCC2 | ubiquinol-cytochrome c reductase complex assembly factor 2 | 3.46223 |
| GPR137 | G protein-coupled receptor 137 | 3.44005 |
| MMEL1 | membrane metallo-endopeptidase-like 1 | 3.34917 |
| RHOF | ras homolog family member F (in filopodia) | 3.33557 |
| SH3PXD2A | SH3 and PX domains 2A | 3.32361 |
| FBXO44 | F-box protein 44 | 3.31706 |
| CTSA | cathepsin A | 3.2614 |
| CCDC42B | coiled-coil domain containing 42B | 3.07911 |
| FAM71E1 | family with sequence similarity 71, member E1 | 3.02998 |
| ZFAND1 | zinc finger, AN1-type domain 1 | 3.00589 |
| EME1 | essential meiotic structure-specific endonuclease 1 | 3.00299 |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | 2.95433 |
| CD99 | CD99 molecule | 2.95399 |
| SLC25A45 | solute carrier family 25, member 45 | 2.94923 |
| CYB5R2 | cytochrome b5 reductase 2 | 2.81764 |
| ZNF593OS | ZNF593 opposite strand | 2.7577 |
| MMP24-AS1 | MMP24 antisense RNA 1 | 2.74616 |
| ANKRD37 | ankyrin repeat domain 37 | 2.72358 |
| TP53I11 | tumor protein p53 inducible protein 11 | 2.61975 |
| YIPF2 | Yip1 domain family, member 2 | 2.60377 |
| ARG2 | arginase 2 | 2.56214 |
| GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 2.46076 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 2.40863 |
| DPYSL3 | dihydropyrimidinase-like 3 | 2.40863 |
| DDTL | D-dopachrome tautomerase-like | 2.3989 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 2.36034 |
| NCAPH2 | non-SMC condensin II complex, subunit H2 | 2.3344 |
| SH3D21 | SH3 domain containing 21 | 2.32795 |
| ADAMTS18 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | 2.31487 |
| C1ORF54 | chromosome 1 open reading frame 54 | 2.29999 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 2.25771 |
| SMPD4 | sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) | 2.22832 |
| C19ORF57 | chromosome 19 open reading frame 57 | 2.22266 |
| MXD3 | MAX dimerization protein 3 | 2.16607 |
| NKX6-2 | NK6 homeobox 2 | 2.07922 |
| UBXN11 | UBX domain protein 11 | 2.06793 |
| LOC122455342 | testis-specific serine/proline-rich protein | 2.04723 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 2.0255 |
| SLC47A2 | solute carrier family 47 (multidrug and toxin extrusion), member 2 | 1.95045 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | 1.91164 |
| FBXL6 | F-box and leucine-rich repeat protein 6 | 1.90648 |
| ZNF135 | zinc finger protein 135 | 1.84337 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | 1.82332 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 1.82184 |
| EPHA1 | EPH receptor A1 | 1.80543 |
| ISYNA1 | inositol-3-phosphate synthase 1 | 1.79817 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | 1.77129 |
| EME2 | essential meiotic structure-specific endonuclease subunit 2 | 1.73733 |
| LYPD1 | LY6/PLAUR domain containing 1 | 1.7262 |
| ACAP3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 | 1.65582 |
| BEST1 | bestrophin 1 | 1.61758 |
| NPRL3 | nitrogen permease regulator-like 3 (S. cerevisiae) | 1.61418 |
| TSPO | translocator protein (18kDa) | 1.59266 |
| PRSS23 | protease, serine, 23 | 1.59118 |
| SNX32 | sorting nexin 32 | 1.58792 |
| TMEM80 | transmembrane protein 80 | 1.58138 |
| BIRC6 | baculoviral IAP repeat containing 6 | 1.57015 |
| PRR19 | proline rich 19 | 1.56807 |
| MFSD11 | major facilitator superfamily domain containing 11 | 1.56761 |
| CENPT | centromere protein T | 1.52389 |
| EMC10 | ER membrane protein complex subunit 10 | 1.47908 |
| MMP24 | matrix metallopeptidase 24 (membrane-inserted) | 1.47121 |
| CIITA | class II, major histocompatibility complex, transactivator | 1.45326 |
| MED12L | mediator complex subunit 12-like | 1.42264 |
| SYCP3 | synaptonemal complex protein 3 | 1.41993 |
| NOP16 | NOP16 nucleolar protein | 1.40103 |
| C11ORF48 | 1.38777 | |
| ALDH6A1 | aldehyde dehydrogenase 6 family, member A1 | 1.37033 |
| EDF1 | endothelial differentiation-related factor 1 | 1.3688 |
| ZNF517 | zinc finger protein 517 | 1.34919 |
| BLCAP | bladder cancer associated protein | 1.33841 |
| SNX22 | sorting nexin 22 | 1.32869 |
| HMHA1 | histocompatibility (minor) HA-1 | 1.3219 |
| ADRM1 | adhesion regulating molecule 1 | 1.32183 |
| HSD17B1 | hydroxysteroid (17-beta) dehydrogenase 1 | 1.31896 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 1.31896 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GLS | glutaminase | -16.0582 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | -10.2183 |
| CLDN22 | claudin 22 | -9.34092 |
| NRAP | nebulin-related anchoring protein | -9.23001 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | -7.12076 |
| SPATA1 | spermatogenesis associated 1 | -7.12076 |
| CERKL | ceramide kinase-like | -6.7784 |
| VPS37A | vacuolar protein sorting 37 homolog A (S. cerevisiae) | -6.19006 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | -5.87106 |
| PDE6B | phosphodiesterase 6B, cGMP-specific, rod, beta | -4.67263 |
| RGL4 | ral guanine nucleotide dissociation stimulator-like 4 | -4.22712 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | -4.06761 |
| TSPEAR | thrombospondin-type laminin G domain and EAR repeats | -3.94019 |
| GYG1 | glycogenin 1 | -3.65858 |
| TSTD2 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 | -3.52922 |
| IQCK | IQ motif containing K | -3.33409 |
| NPHS1 | nephrosis 1, congenital, Finnish type (nephrin) | -3.31521 |
| HOXB3 | homeobox B3 | -3.00299 |
| UBXN6 | UBX domain protein 6 | -2.95399 |
| BAG2 | BCL2-associated athanogene 2 | -2.85354 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -2.80237 |
| IL7 | interleukin 7 | -2.77878 |
| FRMD4A | FERM domain containing 4A | -2.73656 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -2.67675 |
| ACOT13 | acyl-CoA thioesterase 13 | -2.64587 |
| EPN2 | epsin 2 | -2.58493 |
| CCDC154 | coiled-coil domain containing 154 | -2.54506 |
| PDCD6 | programmed cell death 6 | -2.46533 |
| SARM1 | sterile alpha and TIR motif containing 1 | -2.46076 |
| ENG | endoglin | -2.40863 |
| CCDC78 | coiled-coil domain containing 78 | -2.40863 |
| C11ORF57 | chromosome 11 open reading frame 57 | -2.40863 |
| PSMA3 | proteasome (prosome, macropain) subunit, alpha type, 3 | -2.32978 |
| VIL1 | villin 1 | -2.32685 |
| IFNLR1 | interferon, lambda receptor 1 | -2.32461 |
| ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | -2.29999 |
| NEFM | neurofilament, medium polypeptide | -2.27596 |
| PKD2L2 | polycystic kidney disease 2-like 2 | -2.22776 |
| APP | amyloid beta (A4) precursor protein | -2.17056 |
| GCA | grancalcin, EF-hand calcium binding protein | -2.14376 |
| NECAB1 | N-terminal EF-hand calcium binding protein 1 | -2.09862 |
| STAG3 | stromal antigen 3 | -2.09221 |
| IL21R | interleukin 21 receptor | -2.08066 |
| ZNF562 | zinc finger protein 562 | -2.04713 |
| ZSWIM8 | zinc finger, SWIM-type containing 8 | -2.02943 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -2.01027 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -1.95868 |
| AKTIP | AKT interacting protein | -1.95092 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -1.92668 |
| SNED1 | sushi, nidogen and EGF-like domains 1 | -1.9126 |
| COPG2 | coatomer protein complex, subunit gamma 2 | -1.91164 |
| ARSG | arylsulfatase G | -1.91164 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -1.91164 |
| C16ORF54 | chromosome 16 open reading frame 54 | -1.91164 |
| KHSRP | KH-type splicing regulatory protein | -1.90916 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | -1.90531 |
| SIAH1 | siah E3 ubiquitin protein ligase 1 | -1.89205 |
| FAM120B | family with sequence similarity 120B | -1.84806 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -1.81851 |
| FAM92A1 | family with sequence similarity 92, member A1 | -1.81698 |
| USP34 | ubiquitin specific peptidase 34 | -1.8155 |
| ZNF814 | zinc finger protein 814 | -1.79105 |
| CD37 | CD37 molecule | -1.737 |
| DDHD2 | DDHD domain containing 2 | -1.71054 |
| ABI2 | abl-interactor 2 | -1.71054 |
| SOX11 | SRY (sex determining region Y)-box 11 | -1.67789 |
| PLCE1 | phospholipase C, epsilon 1 | -1.65984 |
| MEIS1 | Meis homeobox 1 | -1.65582 |
| CCNH | cyclin H | -1.65472 |
| ACAP1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 | -1.63485 |
| NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae) | -1.62412 |
| DIMT1 | DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) | -1.62412 |
| MTFR1 | mitochondrial fission regulator 1 | -1.5755 |
| ABR | active BCR-related | -1.56955 |
| COX20 | COX20 cytochrome c oxidase assembly factor | -1.52389 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | -1.52389 |
| BSN | bassoon presynaptic cytomatrix protein | -1.50968 |
| ZNF394 | zinc finger protein 394 | -1.50623 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -1.50582 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -1.50464 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -1.48674 |
| FAM109A | family with sequence similarity 109, member A | -1.47485 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | -1.46621 |
| LHX4 | LIM homeobox 4 | -1.46621 |
| YIF1A | Yip1 interacting factor homolog A (S. cerevisiae) | -1.4491 |
| ZC3H14 | zinc finger CCCH-type containing 14 | -1.44425 |
| PTGR2 | prostaglandin reductase 2 | -1.42685 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | -1.41036 |
| ERMARD | ER membrane-associated RNA degradation | -1.40487 |
| PCDHA10 | protocadherin alpha 10 | -1.40487 |
| ATG14 | autophagy related 14 | -1.40175 |
| ZNF175 | zinc finger protein 175 | -1.38777 |
| SLC7A6OS | solute carrier family 7, member 6 opposite strand | -1.37682 |
| SLC29A4 | solute carrier family 29 (equilibrative nucleoside transporter), member 4 | -1.3703 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | -1.36829 |
| CCDC39 | coiled-coil domain containing 39 | -1.36284 |
| LUC7L | LUC7-like (S. cerevisiae) | -1.36146 |
| IPP | intracisternal A particle-promoted polypeptide | -1.35304 |
| MESDC2 | mesoderm development candidate 2 | -1.35304 |
| SLC15A3 | solute carrier family 15 (oligopeptide transporter), member 3 | -1.35139 |
