Perturb_8905_KD_VTCN1_SRP406765 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting VTCN1 in Human embryonic stem cell cell line (Study accession: SRP406765) (PerturbAtlas)
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Genes

128 genes differentially expressed following the Perturb_8905_KD_VTCN1_SRP406765 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
IFIH1 interferon induced with helicase C domain 1 20.0
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 20.0
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 20.0
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 20.0
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 20.0
APOL6 apolipoprotein L, 6 20.0
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 20.0
MX1 MX dynamin-like GTPase 1 19.699
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 18.1487
PARP12 poly (ADP-ribose) polymerase family, member 12 17.9788
PARP14 poly (ADP-ribose) polymerase family, member 14 17.0565
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 16.9646
SAMD9 sterile alpha motif domain containing 9 16.4609
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 16.0408
USP18 ubiquitin specific peptidase 18 15.8364
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 15.5398
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 14.9644
SP100 SP100 nuclear antigen 14.0878
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 13.0876
IFI27 interferon, alpha-inducible protein 27 13.0141
IFITM1 interferon induced transmembrane protein 1 13.0141
SAMHD1 SAM domain and HD domain 1 12.4578
RSAD2 radical S-adenosyl methionine domain containing 2 11.194
PARP9 poly (ADP-ribose) polymerase family, member 9 11.0426
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 10.7621
BST2 bone marrow stromal cell antigen 2 10.1188
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 9.84989
NLRC5 NLR family, CARD domain containing 5 9.65611
TRIM14 tripartite motif containing 14 9.49572
BATF2 basic leucine zipper transcription factor, ATF-like 2 9.28115
PMP22 peripheral myelin protein 22 9.00016
CCL5 chemokine (C-C motif) ligand 5 8.97229
ISG15 ISG15 ubiquitin-like modifier 8.77417
IFI6 interferon, alpha-inducible protein 6 8.66527
DTX3L deltex 3 like, E3 ubiquitin ligase 8.25048
C19ORF66 chromosome 19 open reading frame 66 8.20311
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 8.12134
GBP1 guanylate binding protein 1, interferon-inducible 8.12134
HELZ2 helicase with zinc finger 2, transcriptional coactivator 7.5903
ZNFX1 zinc finger, NFX1-type containing 1 7.57785
LAMP3 lysosomal-associated membrane protein 3 7.56957
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 7.3214
ETV7 ets variant 7 7.25402
PARP10 poly (ADP-ribose) polymerase family, member 10 6.94214
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 6.90902
APOL1 apolipoprotein L, 1 6.64165
STAT1 signal transducer and activator of transcription 1, 91kDa 6.57202
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.21502
UBE2L6 ubiquitin-conjugating enzyme E2L 6 6.19061
UBA7 ubiquitin-like modifier activating enzyme 7 6.12836
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 5.96843
EPSTI1 epithelial stromal interaction 1 (breast) 5.81341
ATP10A ATPase, class V, type 10A 5.28148
IFI35 interferon-induced protein 35 5.17654
RGAG1 retrotransposon gag domain containing 1 5.00061
TDRD7 tudor domain containing 7 5.00061
TRIM22 tripartite motif containing 22 4.93384
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 4.8747
IRF7 interferon regulatory factor 7 4.69881
ERAP2 endoplasmic reticulum aminopeptidase 2 4.67998
MYO1C myosin IC 4.59849
IFI16 interferon, gamma-inducible protein 16 4.43438
APOL2 apolipoprotein L, 2 4.04682
ZC3HAV1 zinc finger CCCH-type, antiviral 1 3.86218
IRF1 interferon regulatory factor 1 3.77155
SP140L SP140 nuclear body protein-like 3.65563
ISG20 interferon stimulated exonuclease gene 20kDa 3.42491
PLSCR1 phospholipid scramblase 1 3.38137
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 3.06956
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 2.96772
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.92248
NEK7 NIMA-related kinase 7 2.85298
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 2.84584
HLA-F major histocompatibility complex, class I, F 2.70212
PNPT1 polyribonucleotide nucleotidyltransferase 1 2.67193
PML promyelocytic leukemia 2.54267
CXCR4 chemokine (C-X-C motif) receptor 4 2.4623
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 2.32277
ZMAT3 zinc finger, matrin-type 3 2.23104
TRIM25 tripartite motif containing 25 2.09782
RABGAP1L RAB GTPase activating protein 1-like 2.08311
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 1.99962
TLR3 toll-like receptor 3 1.9611
BTN3A1 butyrophilin, subfamily 3, member A1 1.88412
CCR1 chemokine (C-C motif) receptor 1 1.8577
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 1.4323
IL1RAP interleukin 1 receptor accessory protein 1.4323
F13A1 coagulation factor XIII, A1 polypeptide 1.4323
TRIM38 tripartite motif containing 38 1.41072

decreased expression

Symbol Name Standardized Value
VTCN1 V-set domain containing T cell activation inhibitor 1 -13.3381
SNN stannin -8.91779
LAGE3 L antigen family, member 3 -6.8947
BCAT1 branched chain amino-acid transaminase 1, cytosolic -4.42987
CBY1 chibby homolog 1 (Drosophila) -4.35808
ARL2 ADP-ribosylation factor-like 2 -4.27917
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 -4.27738
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.27522
DCDC2 doublecortin domain containing 2 -2.93774
PRR11 proline rich 11 -2.93373
CDC123 cell division cycle 123 -2.84584
INIP INTS3 and NABP interacting protein -2.68046
PIEZO2 piezo-type mechanosensitive ion channel component 2 -2.61338
RNMT RNA (guanine-7-) methyltransferase -2.54429
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 -2.45202
TMEM45A transmembrane protein 45A -2.32277
LCLAT1 lysocardiolipin acyltransferase 1 -2.27692
MAN2B1 mannosidase, alpha, class 2B, member 1 -2.1787
TRIQK triple QxxK/R motif containing -2.16883
HAS3 hyaluronan synthase 3 -2.14356
ANLN anillin, actin binding protein -2.03136
CCND1 cyclin D1 -1.9611
APIP APAF1 interacting protein -1.9611
PFKM phosphofructokinase, muscle -1.91592
LRRC3B leucine rich repeat containing 3B -1.90564
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -1.82774
ITPK1 inositol-tetrakisphosphate 1-kinase -1.82303
CERS2 ceramide synthase 2 -1.76309
FRY furry homolog (Drosophila) -1.67255
AKT3 v-akt murine thymoma viral oncogene homolog 3 -1.6229
CASP6 caspase 6, apoptosis-related cysteine peptidase -1.58271
GRIA4 glutamate receptor, ionotropic, AMPA 4 -1.53505
SLC16A9 solute carrier family 16, member 9 -1.49754
RPL27A ribosomal protein L27a -1.48731
SYNGR2 synaptogyrin 2 -1.48582
IGSF9 immunoglobulin superfamily, member 9 -1.47637
AURKA aurora kinase A -1.44362
FOXE3 forkhead box E3 -1.3754
SPARCL1 SPARC-like 1 (hevin) -1.32749