Perturb_8908_KD_CCDC144NLAS1_SRP135858 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting CCDC144NLAS1 in human embryonic stem cells H14 cell line (Study accession: SRP135858) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_8908_KD_CCDC144NLAS1_SRP135858 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
DUSP5 dual specificity phosphatase 5 20.0
B3GNT7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 20.0
MYSM1 Myb-like, SWIRM and MPN domains 1 20.0
ETV5 ets variant 5 20.0
GRM4 glutamate receptor, metabotropic 4 20.0
THY1 Thy-1 cell surface antigen 20.0
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 20.0
HAS2 hyaluronan synthase 2 20.0
MT1G metallothionein 1G 20.0
MT1H metallothionein 1H 20.0
AK4 adenylate kinase 4 20.0
HMOX1 heme oxygenase 1 20.0
ARRDC3 arrestin domain containing 3 20.0
KAT7 K(lysine) acetyltransferase 7 20.0
KDR kinase insert domain receptor 20.0
GDF15 growth differentiation factor 15 20.0
ERRFI1 ERBB receptor feedback inhibitor 1 20.0
FOSL1 FOS-like antigen 1 20.0
ZNF90 zinc finger protein 90 20.0
SOX4 SRY (sex determining region Y)-box 4 20.0
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 20.0
EPS8L2 EPS8-like 2 20.0
SPRY4 sprouty homolog 4 (Drosophila) 20.0
CPT1A carnitine palmitoyltransferase 1A (liver) 20.0
TMEM63A transmembrane protein 63A 20.0
EDNRB endothelin receptor type B 20.0
RND3 Rho family GTPase 3 20.0
MCL1 myeloid cell leukemia 1 20.0
CTCFL CCCTC-binding factor (zinc finger protein)-like 20.0
NANOG Nanog homeobox 20.0
CLIC1 chloride intracellular channel 1 20.0
SKIL SKI-like proto-oncogene 20.0
COL1A2 collagen, type I, alpha 2 20.0
SHISA2 shisa family member 2 19.5229
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 19.3979
GDF3 growth differentiation factor 3 19.3979
GRPR gastrin-releasing peptide receptor 18.6778
IL17RD interleukin 17 receptor D 18.0458
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 17.9031
FAM102B family with sequence similarity 102, member B 17.8508
FBLIM1 filamin binding LIM protein 1 17.3468
TRIB2 tribbles pseudokinase 2 16.6657
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 16.4755
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 16.2838
CBR1 carbonyl reductase 1 16.2756
MCAM melanoma cell adhesion molecule 15.8758
PXN paxillin 15.7972
JADE1 jade family PHD finger 1 15.397
ERBB3 erb-b2 receptor tyrosine kinase 3 15.2781
WFDC2 WAP four-disulfide core domain 2 14.9601
PGPEP1 pyroglutamyl-peptidase I 14.9196
VENTX VENT homeobox 14.8927
COL14A1 collagen, type XIV, alpha 1 14.8154
ADD2 adducin 2 (beta) 14.8005
FDXR ferredoxin reductase 14.7667
DPPA4 developmental pluripotency associated 4 14.4221
DLL3 delta-like 3 (Drosophila) 14.312
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) 14.2434
FAM171B family with sequence similarity 171, member B 14.2
MKRN1 makorin ring finger protein 1 14.0595
CORO2A coronin, actin binding protein, 2A 13.5349
ITPKB inositol-trisphosphate 3-kinase B 13.4997
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 13.4172
APP amyloid beta (A4) precursor protein 12.9528
HSPA1B heat shock 70kDa protein 1B 12.9323
FN1 fibronectin 1 12.6883
GOLGA4 golgin A4 12.6244
METTL7A methyltransferase like 7A 12.6063
PGM1 phosphoglucomutase 1 12.3946
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 12.2682
TRIML2 tripartite motif family-like 2 12.1991
BTG2 BTG family, member 2 12.17
WDR60 WD repeat domain 60 12.1386
GAL galanin/GMAP prepropeptide 12.0379
NFE2L3 nuclear factor, erythroid 2-like 3 11.6931
ZNF770 zinc finger protein 770 11.6463
NANOGP8 Nanog homeobox pseudogene 8 11.6144
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 11.5933
TM7SF3 transmembrane 7 superfamily member 3 11.3867
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 11.2878
SULF1 sulfatase 1 11.2794
MAT2B methionine adenosyltransferase II, beta 11.2059
DPPA2 developmental pluripotency associated 2 11.1587
CARD11 caspase recruitment domain family, member 11 11.0508
SFN stratifin 11.0508
ETV1 ets variant 1 11.0508
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 11.0386
ARF4 ADP-ribosylation factor 4 10.9246
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 10.608
ODC1 ornithine decarboxylase 1 10.5832
ARRDC4 arrestin domain containing 4 10.5362
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 10.4801
SLC30A1 solute carrier family 30 (zinc transporter), member 1 10.4693
SQSTM1 sequestosome 1 10.4088
PTEN phosphatase and tensin homolog 10.4031
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 10.1396
HAS3 hyaluronan synthase 3 10.1396
RBM38 RNA binding motif protein 38 10.1212
ESYT2 extended synaptotagmin-like protein 2 9.98367
CDCA7L cell division cycle associated 7-like 9.94081

decreased expression

Symbol Name Standardized Value
C6ORF141 chromosome 6 open reading frame 141 -20.0
ALCAM activated leukocyte cell adhesion molecule -20.0
TPM1 tropomyosin 1 (alpha) -20.0
ATF4 activating transcription factor 4 -20.0
FGFR1 fibroblast growth factor receptor 1 -20.0
CHGA chromogranin A -20.0
RAB17 RAB17, member RAS oncogene family -20.0
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -20.0
PRICKLE1 prickle homolog 1 (Drosophila) -20.0
C1ORF21 chromosome 1 open reading frame 21 -20.0
CA11 carbonic anhydrase XI -20.0
GPRC5B G protein-coupled receptor, class C, group 5, member B -20.0
RCN2 reticulocalbin 2, EF-hand calcium binding domain -20.0
FLT1 fms-related tyrosine kinase 1 -20.0
ABRACL ABRA C-terminal like -20.0
ASS1 argininosuccinate synthase 1 -20.0
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -20.0
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -20.0
RRP1B ribosomal RNA processing 1B -20.0
ADM adrenomedullin -20.0
SKIDA1 SKI/DACH domain containing 1 -20.0
TEK TEK tyrosine kinase, endothelial -20.0
SMIM10L2A small integral membrane protein 10 like 2A -20.0
PODXL podocalyxin-like -20.0
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -20.0
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -20.0
METAP2 methionyl aminopeptidase 2 -20.0
VAT1L vesicle amine transport 1-like -20.0
DHFR dihydrofolate reductase -20.0
ZIC3 Zic family member 3 -20.0
HMCN2 hemicentin 2 -20.0
AJUBA ajuba LIM protein -20.0
PKDCC protein kinase domain containing, cytoplasmic -20.0
SOX3 SRY (sex determining region Y)-box 3 -20.0
SLFN13 schlafen family member 13 -20.0
GJA1 gap junction protein, alpha 1, 43kDa -20.0
ANOS1 anosmin 1 -20.0
ERBB2 erb-b2 receptor tyrosine kinase 2 -20.0
AHNAK AHNAK nucleoprotein -20.0
SESN3 sestrin 3 -20.0
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -20.0
SFRP1 secreted frizzled-related protein 1 -20.0
AUTS2 autism susceptibility candidate 2 -20.0
DCLK1 doublecortin-like kinase 1 -20.0
OLFML3 olfactomedin-like 3 -20.0
TMEM64 transmembrane protein 64 -20.0
APELA apelin receptor early endogenous ligand -20.0
TP53I11 tumor protein p53 inducible protein 11 -20.0
OBSL1 obscurin-like 1 -20.0
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -20.0
RHBDL3 rhomboid, veinlet-like 3 (Drosophila) -20.0
PLCL2 phospholipase C-like 2 -20.0
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 -20.0
RGS5 regulator of G-protein signaling 5 -20.0
GPC4 glypican 4 -20.0
GPC3 glypican 3 -20.0
DIAPH2 diaphanous-related formin 2 -20.0
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -20.0
CRABP2 cellular retinoic acid binding protein 2 -20.0
FZD7 frizzled class receptor 7 -20.0
FZD2 frizzled class receptor 2 -20.0
SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 -20.0
NAV2 neuron navigator 2 -20.0
GPR176 G protein-coupled receptor 176 -20.0
FAM3C family with sequence similarity 3, member C -20.0
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -20.0
OTX2 orthodenticle homeobox 2 -20.0
LITAF lipopolysaccharide-induced TNF factor -19.699
FGFR3 fibroblast growth factor receptor 3 -19.5229
TTYH1 tweety family member 1 -19.5229
DEGS1 delta(4)-desaturase, sphingolipid 1 -19.0969
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -18.8539
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -18.7696
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -18.7696
FRAS1 Fraser extracellular matrix complex subunit 1 -18.7447
CNTNAP2 contactin associated protein-like 2 -18.6021
PPP1R3B protein phosphatase 1, regulatory subunit 3B -18.5528
GLUL glutamate-ammonia ligase -18.3565
AMOTL2 angiomotin like 2 -18.1367
ARHGAP23 Rho GTPase activating protein 23 -17.767
CCNA2 cyclin A2 -17.6198
COL5A2 collagen, type V, alpha 2 -17.4737
IDO1 indoleamine 2,3-dioxygenase 1 -17.1662
LARP7 La ribonucleoprotein domain family, member 7 -17.1163
CDH1 cadherin 1, type 1, E-cadherin (epithelial) -17.0706
DCBLD2 discoidin, CUB and LCCL domain containing 2 -17.055
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -17.0292
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 -16.8684
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -16.7964
CADM4 cell adhesion molecule 4 -16.7755
GAS6 growth arrest-specific 6 -16.634
CACHD1 cache domain containing 1 -16.3938
ELL2 elongation factor, RNA polymerase II, 2 -16.3373
ARL4C ADP-ribosylation factor-like 4C -16.0062
GSN gelsolin -15.8716
TRIM2 tripartite motif containing 2 -15.8538
BLACAT1 bladder cancer associated transcript 1 (non-protein coding) -15.7001
DAZL deleted in azoospermia-like -15.6328
BCAT1 branched chain amino-acid transaminase 1, cytosolic -15.6238
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) -15.6038