| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting Epas1 in human umbilical vein endothelial cells cell line (Study accession: SRP049514) (PerturbAtlas) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Perturb_9132_KD_Epas1_SRP049514 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CALU | calumenin | 20.0 |
| MSRB3 | methionine sulfoxide reductase B3 | 20.0 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 18.585 |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 16.8567 |
| SRPR | signal recognition particle receptor (docking protein) | 15.3145 |
| BANF1 | barrier to autointegration factor 1 | 13.5323 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 13.1697 |
| H1FX | H1 histone family, member X | 12.0824 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 11.5364 |
| MCFD2 | multiple coagulation factor deficiency 2 | 11.5364 |
| SLC36A1 | solute carrier family 36 (proton/amino acid symporter), member 1 | 10.8982 |
| FAM49B | family with sequence similarity 49, member B | 10.3361 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 9.24436 |
| NGRN | neugrin, neurite outgrowth associated | 9.10912 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 8.89358 |
| CCND3 | cyclin D3 | 8.59382 |
| WDR1 | WD repeat domain 1 | 8.38759 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | 8.16341 |
| CALD1 | caldesmon 1 | 8.15152 |
| TAPT1 | transmembrane anterior posterior transformation 1 | 7.47103 |
| BOD1 | biorientation of chromosomes in cell division 1 | 7.46424 |
| NRBF2 | nuclear receptor binding factor 2 | 7.46424 |
| MBTPS1 | membrane-bound transcription factor peptidase, site 1 | 7.43844 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 7.42209 |
| SUSD1 | sushi domain containing 1 | 6.74398 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | 6.12774 |
| TMEM65 | transmembrane protein 65 | 6.01333 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 5.75245 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 5.72577 |
| GOPC | golgi-associated PDZ and coiled-coil motif containing | 5.61444 |
| FRMD6 | FERM domain containing 6 | 5.57538 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 5.55458 |
| RSL24D1 | ribosomal L24 domain containing 1 | 5.51855 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 5.50915 |
| ESYT2 | extended synaptotagmin-like protein 2 | 5.50391 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 5.31261 |
| RCAN3 | RCAN family member 3 | 5.10492 |
| MED21 | mediator complex subunit 21 | 5.0471 |
| TADA3 | transcriptional adaptor 3 | 5.02436 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 5.02218 |
| STX12 | syntaxin 12 | 5.01748 |
| TUBB2A | tubulin, beta 2A class IIa | 4.94476 |
| ARL4D | ADP-ribosylation factor-like 4D | 4.92174 |
| TCEB3 | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) | 4.72527 |
| FAM32A | family with sequence similarity 32, member A | 4.72337 |
| EEA1 | early endosome antigen 1 | 4.71379 |
| UNC45A | unc-45 homolog A (C. elegans) | 4.6996 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 4.59962 |
| GFRA1 | GDNF family receptor alpha 1 | 4.50999 |
| STAG2 | stromal antigen 2 | 4.45773 |
| STS | steroid sulfatase (microsomal), isozyme S | 4.45435 |
| LZTFL1 | leucine zipper transcription factor-like 1 | 4.45435 |
| PYGO2 | pygopus family PHD finger 2 | 4.44557 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 4.42615 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 4.3583 |
| GSDMC | gasdermin C | 4.34466 |
| PITX3 | paired-like homeodomain 3 | 4.27839 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | 4.1126 |
| C1D | C1D nuclear receptor corepressor | 4.06888 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 3.97643 |
| MGAT4A | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A | 3.94587 |
| RASA3 | RAS p21 protein activator 3 | 3.88956 |
| KLHL9 | kelch-like family member 9 | 3.86443 |
| PLS3 | plastin 3 | 3.72535 |
| CREB3L1 | cAMP responsive element binding protein 3-like 1 | 3.71681 |
| QDPR | quinoid dihydropteridine reductase | 3.70796 |
| UNC119B | unc-119 homolog B (C. elegans) | 3.70796 |
| MCRS1 | microspherule protein 1 | 3.68229 |
| AFAP1 | actin filament associated protein 1 | 3.65046 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | 3.65046 |
| PNMA2 | paraneoplastic Ma antigen 2 | 3.631 |
| IAH1 | isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) | 3.56507 |
| CPPED1 | calcineurin-like phosphoesterase domain containing 1 | 3.38333 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | 3.31311 |
| KSR1 | kinase suppressor of ras 1 | 3.30727 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 3.13765 |
| TSTA3 | tissue specific transplantation antigen P35B | 3.12768 |
| PCSK7 | proprotein convertase subtilisin/kexin type 7 | 3.12768 |
| RHOB | ras homolog family member B | 3.12768 |
| WWTR1 | WW domain containing transcription regulator 1 | 3.11232 |
| ZCCHC3 | zinc finger, CCHC domain containing 3 | 3.06943 |
| ZSWIM4 | zinc finger, SWIM-type containing 4 | 3.03785 |
| GPI | glucose-6-phosphate isomerase | 3.01208 |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | 2.95134 |
| PTPMT1 | protein tyrosine phosphatase, mitochondrial 1 | 2.94332 |
| KLF2 | Kruppel-like factor 2 | 2.87009 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 2.86759 |
| KCTD9 | potassium channel tetramerization domain containing 9 | 2.84303 |
| MCL1 | myeloid cell leukemia 1 | 2.84119 |
| C17ORF59 | chromosome 17 open reading frame 59 | 2.83443 |
| XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 | 2.83337 |
| KATNAL1 | katanin p60 subunit A-like 1 | 2.82153 |
| PSMC3 | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 2.81736 |
| ANKRD52 | ankyrin repeat domain 52 | 2.81301 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 2.80384 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 2.79978 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 2.79978 |
| SOCS5 | suppressor of cytokine signaling 5 | 2.7982 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 2.77253 |
| RABGGTB | Rab geranylgeranyltransferase, beta subunit | 2.76436 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EPAS1 | endothelial PAS domain protein 1 | -20.0 |
| C3ORF58 | chromosome 3 open reading frame 58 | -11.5364 |
| RPRD1B | regulation of nuclear pre-mRNA domain containing 1B | -8.24698 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | -8.13673 |
| TMEM64 | transmembrane protein 64 | -7.18748 |
| CLDND1 | claudin domain containing 1 | -6.58419 |
| FAM136A | family with sequence similarity 136, member A | -6.57929 |
| SLURP1 | secreted LY6/PLAUR domain containing 1 | -6.08702 |
| PHYHD1 | phytanoyl-CoA dioxygenase domain containing 1 | -5.92146 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | -5.60141 |
| FAM117B | family with sequence similarity 117, member B | -5.19079 |
| LIN52 | lin-52 DREAM MuvB core complex component | -4.92174 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -4.77228 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | -4.77228 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | -4.6996 |
| PYGM | phosphorylase, glycogen, muscle | -4.59962 |
| PPP1R16B | protein phosphatase 1, regulatory subunit 16B | -4.29666 |
| TSPAN13 | tetraspanin 13 | -4.29666 |
| PCNA | proliferating cell nuclear antigen | -4.18816 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -4.10828 |
| CEP68 | centrosomal protein 68kDa | -3.91984 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -3.86443 |
| NDUFC1 | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa | -3.75568 |
| EXOC3L2 | exocyst complex component 3-like 2 | -3.70796 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | -3.7053 |
| ISCA1 | iron-sulfur cluster assembly 1 | -3.65046 |
| CCDC138 | coiled-coil domain containing 138 | -3.63569 |
| TTC28 | tetratricopeptide repeat domain 28 | -3.631 |
| RNFT1 | ring finger protein, transmembrane 1 | -3.45668 |
| COPG1 | coatomer protein complex, subunit gamma 1 | -3.35704 |
| L3MBTL3 | l(3)mbt-like 3 (Drosophila) | -3.26056 |
| SLC25A40 | solute carrier family 25, member 40 | -3.18592 |
| GCK | glucokinase (hexokinase 4) | -3.15035 |
| WNT4 | wingless-type MMTV integration site family, member 4 | -3.10552 |
| MPZL3 | myelin protein zero-like 3 | -2.93376 |
| RMND5A | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | -2.90672 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -2.87009 |
| TFPI2 | tissue factor pathway inhibitor 2 | -2.86897 |
| QRFP | pyroglutamylated RFamide peptide | -2.82118 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -2.76646 |
| KIF16B | kinesin family member 16B | -2.76436 |
| ZNF25 | zinc finger protein 25 | -2.76436 |
| TMEM38B | transmembrane protein 38B | -2.74622 |
| ANKRD13A | ankyrin repeat domain 13A | -2.68302 |
| LUM | lumican | -2.6423 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -2.64106 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -2.61318 |
| VWA5A | von Willebrand factor A domain containing 5A | -2.56586 |
| PLCXD2 | phosphatidylinositol-specific phospholipase C, X domain containing 2 | -2.56131 |
| PEG10 | paternally expressed 10 | -2.5601 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -2.47899 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -2.47291 |
| EML1 | echinoderm microtubule associated protein like 1 | -2.45875 |
| MFAP3 | microfibrillar-associated protein 3 | -2.44399 |
| BPNT1 | 3'(2'), 5'-bisphosphate nucleotidase 1 | -2.44234 |
| ADCK3 | aarF domain containing kinase 3 | -2.42379 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -2.42135 |
| PPM1B | protein phosphatase, Mg2+/Mn2+ dependent, 1B | -2.37976 |
| ADAMTS4 | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | -2.33361 |
| MR1 | major histocompatibility complex, class I-related | -2.33033 |
| CCDC17 | coiled-coil domain containing 17 | -2.29064 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | -2.24897 |
| KLK2 | kallikrein-related peptidase 2 | -2.21657 |
| EML6 | echinoderm microtubule associated protein like 6 | -2.18273 |
| SCML2 | sex comb on midleg-like 2 (Drosophila) | -2.18273 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -2.18273 |
| LFNG | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -2.17102 |
| PTDSS1 | phosphatidylserine synthase 1 | -2.16295 |
| FBXO9 | F-box protein 9 | -2.12659 |
| ACRC | acidic repeat containing | -2.09226 |
| C19ORF35 | chromosome 19 open reading frame 35 | -2.09226 |
| ATP8B2 | ATPase, aminophospholipid transporter, class I, type 8B, member 2 | -2.09071 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -2.06048 |
| TBPL1 | TBP-like 1 | -1.97839 |
| ATP11A | ATPase, class VI, type 11A | -1.95584 |
| NOL4L | nucleolar protein 4-like | -1.94944 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -1.93575 |
| L3MBTL2 | l(3)mbt-like 2 (Drosophila) | -1.9147 |
| THNSL1 | threonine synthase-like 1 (S. cerevisiae) | -1.9147 |
| IL1RAP | interleukin 1 receptor accessory protein | -1.91275 |
| IMPAD1 | inositol monophosphatase domain containing 1 | -1.91136 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -1.90194 |
| MUC1 | mucin 1, cell surface associated | -1.88763 |
| SLC18B1 | solute carrier family 18, subfamily B, member 1 | -1.85137 |
| ULK2 | unc-51 like autophagy activating kinase 2 | -1.84626 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -1.84626 |
| NHSL2 | NHS-like 2 | -1.84347 |
| GPR180 | G protein-coupled receptor 180 | -1.81958 |
| INPP5B | inositol polyphosphate-5-phosphatase, 75kDa | -1.78664 |
| TOMM22 | translocase of outer mitochondrial membrane 22 homolog (yeast) | -1.78664 |
| TOX | thymocyte selection-associated high mobility group box | -1.78664 |
| PNPO | pyridoxamine 5'-phosphate oxidase | -1.77303 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | -1.77179 |
| CCDC169 | coiled-coil domain containing 169 | -1.7668 |
| RND1 | Rho family GTPase 1 | -1.74186 |
| NEMF | nuclear export mediator factor | -1.74186 |
| TAF4B | TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa | -1.74186 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -1.72559 |
| DESI1 | desumoylating isopeptidase 1 | -1.72332 |
| MEGF11 | multiple EGF-like-domains 11 | -1.72332 |
