Perturb_9289_OE_KRAS_SRP172671 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description OE perturbation targeting KRAS in Immortalized BJ-hTERT cells cell line (Study accession: SRP172671) (PerturbAtlas)
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Genes

146 genes differentially expressed following the Perturb_9289_OE_KRAS_SRP172671 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
PHRF1 PHD and ring finger domains 1 20.0
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 10.2001
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 8.08156
HRAS Harvey rat sarcoma viral oncogene homolog 7.21283
CDC42SE1 CDC42 small effector 1 4.89272
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 4.80171
BCAN brevican 4.67444
BRD7 bromodomain containing 7 4.54781
C11ORF68 chromosome 11 open reading frame 68 4.54781
VTI1B vesicle transport through interaction with t-SNAREs 1B 3.98293
SPC24 SPC24, NDC80 kinetochore complex component 3.73121
CCDC85B coiled-coil domain containing 85B 3.24288
PRR29 proline rich 29 2.87704
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 2.70288
MALSU1 mitochondrial assembly of ribosomal large subunit 1 2.5449
C18ORF8 chromosome 18 open reading frame 8 2.42454
DPF3 D4, zinc and double PHD fingers, family 3 2.02026
ACSBG1 acyl-CoA synthetase bubblegum family member 1 2.00298
TATDN1 TatD DNase domain containing 1 1.98671
ATXN2 ataxin 2 1.96645
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 1.84406
FGFR1 fibroblast growth factor receptor 1 1.82528
ARL10 ADP-ribosylation factor-like 10 1.72909
ADA adenosine deaminase 1.70922
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 1.7079
FCHSD1 FCH and double SH3 domains 1 1.70662
THRA thyroid hormone receptor, alpha 1.6887
LOC122455342 testis-specific serine/proline-rich protein 1.60332
LHFPL5 lipoma HMGIC fusion partner-like 5 1.58295
COL5A1 collagen, type V, alpha 1 1.52987
FNDC8 fibronectin type III domain containing 8 1.52319
CEBPZOS CEBPZ opposite strand 1.50068
DNASE1 deoxyribonuclease I 1.4975
GLIPR1 GLI pathogenesis-related 1 1.46635
STK17A serine/threonine kinase 17a 1.46388
ASB14 ankyrin repeat and SOCS box containing 14 1.46388
CFLAR CASP8 and FADD-like apoptosis regulator 1.46388
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 1.45124
KLC1 kinesin light chain 1 1.45124
CCDC18 coiled-coil domain containing 18 1.40912
ERCC4 excision repair cross-complementation group 4 1.40053
FTSJ3 FtsJ homolog 3 (E. coli) 1.38725
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 1.38506
MXD3 MAX dimerization protein 3 1.38506
TSPAN31 tetraspanin 31 1.34407
NIT1 nitrilase 1 1.33411

decreased expression

Symbol Name Standardized Value
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -20.0
MOCS1 molybdenum cofactor synthesis 1 -20.0
PCSK7 proprotein convertase subtilisin/kexin type 7 -20.0
FSIP1 fibrous sheath interacting protein 1 -20.0
RBBP4 retinoblastoma binding protein 4 -19.301
SLC19A1 solute carrier family 19 (folate transporter), member 1 -13.9229
TCP1 t-complex 1 -13.7471
ZFP36L2 ZFP36 ring finger protein-like 2 -11.0011
CALD1 caldesmon 1 -11.0011
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -9.72867
SRFBP1 serum response factor binding protein 1 -8.72659
RANGAP1 Ran GTPase activating protein 1 -8.57624
CRYAB crystallin, alpha B -7.858
MBNL1 muscleblind-like splicing regulator 1 -7.60007
COL1A1 collagen, type I, alpha 1 -7.21283
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -6.25276
ZC3H14 zinc finger CCCH-type containing 14 -6.09113
FN1 fibronectin 1 -6.03491
SSTR1 somatostatin receptor 1 -5.79711
STK24 serine/threonine kinase 24 -5.5897
SLC46A1 solute carrier family 46 (folate transporter), member 1 -5.52139
TMEM255B transmembrane protein 255B -5.4542
MAPK7 mitogen-activated protein kinase 7 -5.41458
TBPL1 TBP-like 1 -5.19975
C14ORF166 chromosome 14 open reading frame 166 -4.65392
FEM1B fem-1 homolog b (C. elegans) -4.62503
AEBP1 AE binding protein 1 -4.61013
FMN2 formin 2 -4.49514
C16ORF70 chromosome 16 open reading frame 70 -4.40817
COL1A2 collagen, type I, alpha 2 -4.36983
ZNF135 zinc finger protein 135 -4.27133
CFAP44 cilia and flagella associated protein 44 -3.98141
MESDC2 mesoderm development candidate 2 -3.90083
AATK apoptosis-associated tyrosine kinase -3.8552
LMOD1 leiomodin 1 (smooth muscle) -3.74433
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -3.73864
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -3.72744
USP47 ubiquitin specific peptidase 47 -3.68961
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -3.61448
COL6A2 collagen, type VI, alpha 2 -3.43356
AFG3L2 AFG3-like AAA ATPase 2 -3.43228
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae) -3.22661
TSPAN18 tetraspanin 18 -3.03268
TSC2 tuberous sclerosis 2 -2.96943
PRSS23 protease, serine, 23 -2.94939
CDH23 cadherin-related 23 -2.93905
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -2.87704
COL6A1 collagen, type VI, alpha 1 -2.87096
LHX9 LIM homeobox 9 -2.66157
H2AFY H2A histone family, member Y -2.65774
THBS1 thrombospondin 1 -2.64479
LMO7 LIM domain 7 -2.57608
PAQR5 progestin and adipoQ receptor family member V -2.55955
LOC100652824 -2.54514
ACSS3 acyl-CoA synthetase short-chain family member 3 -2.49101
CERKL ceramide kinase-like -2.36533
CCNI cyclin I -2.35365
PDK2 pyruvate dehydrogenase kinase, isozyme 2 -2.34877
COL6A3 collagen, type VI, alpha 3 -2.29224
MMP24-AS1 MMP24 antisense RNA 1 -2.25282
ACKR4 atypical chemokine receptor 4 -2.24686
SAMD14 sterile alpha motif domain containing 14 -2.22334
PCED1B PC-esterase domain containing 1B -2.21129
BBIP1 BBSome interacting protein 1 -2.15775
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -2.15225
ZNF497 zinc finger protein 497 -2.11284
TREH trehalase (brush-border membrane glycoprotein) -2.0926
TMEM80 transmembrane protein 80 -2.08864
BAG2 BCL2-associated athanogene 2 -2.07178
MTERF4 mitochondrial transcription termination factor 4 -2.06803
C12ORF65 chromosome 12 open reading frame 65 -2.06744
TXNRD2 thioredoxin reductase 2 -2.05453
GJD3 gap junction protein, delta 3, 31.9kDa -2.03885
TPM2 tropomyosin 2 (beta) -1.96645
ZNF575 zinc finger protein 575 -1.90056
MYL9 myosin, light chain 9, regulatory -1.86519
ITGA9 integrin, alpha 9 -1.82811
FSTL1 follistatin-like 1 -1.72909
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 -1.70554
CD37 CD37 molecule -1.67593
CCDC80 coiled-coil domain containing 80 -1.65574
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 -1.65571
KANK2 KN motif and ankyrin repeat domains 2 -1.64044
CAPN12 calpain 12 -1.60427
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -1.59908
NBEA neurobeachin -1.5871
SERINC4 serine incorporator 4 -1.58201
C12ORF45 chromosome 12 open reading frame 45 -1.58201
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -1.57135
GTPBP1 GTP binding protein 1 -1.54939
MTCL1 microtubule crosslinking factor 1 -1.53719
STK25 serine/threonine kinase 25 -1.49824
HDDC2 HD domain containing 2 -1.49739
WDR33 WD repeat domain 33 -1.48358
SLC2A4RG SLC2A4 regulator -1.48304
NDEL1 nudE neurodevelopment protein 1-like 1 -1.47247
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -1.38506
CENPV centromere protein V -1.38163
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -1.37902
NEMF nuclear export mediator factor -1.37201