| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting RAD21 in IMR5/75 neuroblastoma cells cell line (Study accession: SRP071219) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_9393_KD_RAD21_SRP071219 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 20.0 |
| ITPKB | inositol-trisphosphate 3-kinase B | 20.0 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 20.0 |
| STAG1 | stromal antigen 1 | 19.2218 |
| TP53INP1 | tumor protein p53 inducible nuclear protein 1 | 13.9983 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 12.1352 |
| TLE4 | transducin-like enhancer of split 4 | 12.0915 |
| MXD4 | MAX dimerization protein 4 | 11.9154 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 11.6324 |
| KCTD8 | potassium channel tetramerization domain containing 8 | 11.2728 |
| COL3A1 | collagen, type III, alpha 1 | 10.3544 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | 10.3544 |
| BTG2 | BTG family, member 2 | 10.2143 |
| BCAN | brevican | 10.0219 |
| NRIP1 | nuclear receptor interacting protein 1 | 10.0193 |
| CCNG2 | cyclin G2 | 9.01891 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 9.01612 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 8.49037 |
| SYN2 | synapsin II | 8.48392 |
| SLCO5A1 | solute carrier organic anion transporter family, member 5A1 | 8.46309 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 8.33808 |
| SYT11 | synaptotagmin XI | 7.71753 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 7.53814 |
| CELF3 | CUGBP, Elav-like family member 3 | 7.3909 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 7.15378 |
| PLK3 | polo-like kinase 3 | 7.07343 |
| SPOPL | speckle-type POZ protein-like | 7.07343 |
| ALCAM | activated leukocyte cell adhesion molecule | 6.87008 |
| RNF11 | ring finger protein 11 | 6.69663 |
| DUSP6 | dual specificity phosphatase 6 | 6.66948 |
| SESN1 | sestrin 1 | 6.65943 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 6.61789 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 6.51146 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 6.51062 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 6.33224 |
| LEPR | leptin receptor | 6.29194 |
| DYRK1B | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B | 6.20472 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 6.17337 |
| ACER2 | alkaline ceramidase 2 | 5.90277 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 5.87812 |
| C10ORF10 | chromosome 10 open reading frame 10 | 5.84439 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | 5.81091 |
| ICK | intestinal cell (MAK-like) kinase | 5.7406 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 5.71422 |
| PAFAH2 | platelet-activating factor acetylhydrolase 2, 40kDa | 5.6884 |
| FAM214B | family with sequence similarity 214, member B | 5.50118 |
| STK38L | serine/threonine kinase 38 like | 5.48981 |
| SCARB2 | scavenger receptor class B, member 2 | 5.45985 |
| FAM98C | family with sequence similarity 98, member C | 5.43179 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 5.30348 |
| STK17A | serine/threonine kinase 17a | 5.26541 |
| HSPA4L | heat shock 70kDa protein 4-like | 5.21304 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 5.16317 |
| REEP3 | receptor accessory protein 3 | 5.1187 |
| MEX3B | mex-3 RNA binding family member B | 5.07536 |
| SERINC1 | serine incorporator 1 | 5.03404 |
| KLHL24 | kelch-like family member 24 | 5.02291 |
| CHODL | chondrolectin | 5.02291 |
| LIMCH1 | LIM and calponin homology domains 1 | 4.92983 |
| NELFCD | negative elongation factor complex member C/D | 4.92477 |
| FAM160B1 | family with sequence similarity 160, member B1 | 4.92351 |
| SYTL3 | synaptotagmin-like 3 | 4.87869 |
| NBR1 | neighbor of BRCA1 gene 1 | 4.87869 |
| NHLH2 | nescient helix loop helix 2 | 4.87782 |
| CSRNP3 | cysteine-serine-rich nuclear protein 3 | 4.87534 |
| CPE | carboxypeptidase E | 4.87106 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 4.83137 |
| METTL7A | methyltransferase like 7A | 4.76211 |
| YPEL5 | yippee-like 5 (Drosophila) | 4.74625 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 4.7047 |
| SMAD6 | SMAD family member 6 | 4.6925 |
| RRAGB | Ras-related GTP binding B | 4.68194 |
| SPATA18 | spermatogenesis associated 18 | 4.67126 |
| SESN2 | sestrin 2 | 4.64839 |
| OLFML3 | olfactomedin-like 3 | 4.64759 |
| RNF38 | ring finger protein 38 | 4.60247 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 4.54813 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 4.51799 |
| CCND1 | cyclin D1 | 4.50006 |
| MTMR9 | myotubularin related protein 9 | 4.45962 |
| ANKRD50 | ankyrin repeat domain 50 | 4.43113 |
| PLK2 | polo-like kinase 2 | 4.42388 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 4.42329 |
| EDA2R | ectodysplasin A2 receptor | 4.39435 |
| SPRY2 | sprouty homolog 2 (Drosophila) | 4.30419 |
| KLHL28 | kelch-like family member 28 | 4.25785 |
| SATB1 | SATB homeobox 1 | 4.24371 |
| MVB12B | multivesicular body subunit 12B | 4.21279 |
| AK4 | adenylate kinase 4 | 4.14695 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 4.12464 |
| EBF1 | early B-cell factor 1 | 4.10973 |
| HBP1 | HMG-box transcription factor 1 | 4.03769 |
| GPC1 | glypican 1 | 3.95187 |
| TSPYL2 | TSPY-like 2 | 3.91447 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 3.90035 |
| LRRC4 | leucine rich repeat containing 4 | 3.87522 |
| TSPAN17 | tetraspanin 17 | 3.82175 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | 3.82175 |
| XPC | xeroderma pigmentosum, complementation group C | 3.80959 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 3.77903 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RAD21 | RAD21 homolog (S. pombe) | -20.0 |
| SNRPA1 | small nuclear ribonucleoprotein polypeptide A' | -20.0 |
| ALX4 | ALX homeobox 4 | -20.0 |
| KIF21B | kinesin family member 21B | -20.0 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | -17.2175 |
| RTN4 | reticulon 4 | -17.1733 |
| EHD2 | EH-domain containing 2 | -16.9851 |
| NTRK1 | neurotrophic tyrosine kinase, receptor, type 1 | -16.7565 |
| PHOX2A | paired-like homeobox 2a | -15.9057 |
| NAV1 | neuron navigator 1 | -14.7751 |
| SPCS3 | signal peptidase complex subunit 3 homolog (S. cerevisiae) | -14.7222 |
| RAB31 | RAB31, member RAS oncogene family | -14.636 |
| KCNG1 | potassium channel, voltage gated modifier subfamily G, member 1 | -14.5496 |
| TNIK | TRAF2 and NCK interacting kinase | -13.6 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | -13.43 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -12.9334 |
| PLXND1 | plexin D1 | -12.8726 |
| STC1 | stanniocalcin 1 | -12.7855 |
| OLFM1 | olfactomedin 1 | -11.9154 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -11.7445 |
| ARHGAP36 | Rho GTPase activating protein 36 | -11.3482 |
| ADRA2A | adrenoceptor alpha 2A | -10.7923 |
| SLC18A3 | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | -10.5415 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | -10.3443 |
| CD9 | CD9 molecule | -10.3132 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -9.81136 |
| KANK4 | KN motif and ankyrin repeat domains 4 | -9.75978 |
| TNC | tenascin C | -9.75978 |
| LIG1 | ligase I, DNA, ATP-dependent | -9.71271 |
| ARL4D | ADP-ribosylation factor-like 4D | -9.68922 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -9.68922 |
| FKBP5 | FK506 binding protein 5 | -9.58822 |
| SLITRK5 | SLIT and NTRK-like family, member 5 | -9.14257 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -8.61283 |
| AURKB | aurora kinase B | -8.46309 |
| DBH | dopamine beta-hydroxylase (dopamine beta-monooxygenase) | -7.75259 |
| KCNC1 | potassium channel, voltage gated Shaw related subfamily C, member 1 | -7.75259 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -7.75259 |
| SHMT1 | serine hydroxymethyltransferase 1 (soluble) | -7.7021 |
| MCM3 | minichromosome maintenance complex component 3 | -7.66489 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -7.61485 |
| MCM4 | minichromosome maintenance complex component 4 | -7.40617 |
| THSD7B | thrombospondin, type I, domain containing 7B | -7.32051 |
| ZNF395 | zinc finger protein 395 | -7.29067 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | -7.15437 |
| MRC2 | mannose receptor, C type 2 | -7.08596 |
| MKI67 | marker of proliferation Ki-67 | -6.93258 |
| RELN | reelin | -6.93258 |
| NCAPH | non-SMC condensin I complex, subunit H | -6.74165 |
| FAM65A | family with sequence similarity 65, member A | -6.67266 |
| ADCY9 | adenylate cyclase 9 | -6.62672 |
| LFNG | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -6.44844 |
| FASN | fatty acid synthase | -6.43491 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | -6.43491 |
| PCOLCE | procollagen C-endopeptidase enhancer | -6.40209 |
| TNFSF13B | tumor necrosis factor (ligand) superfamily, member 13b | -6.34824 |
| MEST | mesoderm specific transcript | -6.25872 |
| CDC25B | cell division cycle 25B | -6.24628 |
| CNTFR | ciliary neurotrophic factor receptor | -6.13569 |
| ISOC1 | isochorismatase domain containing 1 | -6.08347 |
| PLSCR1 | phospholipid scramblase 1 | -6.00916 |
| AHCYL1 | adenosylhomocysteinase-like 1 | -5.92171 |
| SNAI2 | snail family zinc finger 2 | -5.83869 |
| TK1 | thymidine kinase 1, soluble | -5.83869 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -5.79209 |
| CCNG1 | cyclin G1 | -5.76787 |
| TRIM9 | tripartite motif containing 9 | -5.75153 |
| FGFR2 | fibroblast growth factor receptor 2 | -5.7406 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -5.7406 |
| CRABP2 | cellular retinoic acid binding protein 2 | -5.7406 |
| H1F0 | H1 histone family, member 0 | -5.70143 |
| ARHGAP22 | Rho GTPase activating protein 22 | -5.69751 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | -5.69751 |
| PTGFR | prostaglandin F receptor (FP) | -5.69751 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -5.69751 |
| VWA1 | von Willebrand factor A domain containing 1 | -5.6884 |
| ATP13A2 | ATPase type 13A2 | -5.68216 |
| GPM6B | glycoprotein M6B | -5.65171 |
| EGFLAM | EGF-like, fibronectin type III and laminin G domains | -5.64275 |
| ZNF385D | zinc finger protein 385D | -5.54544 |
| IER5 | immediate early response 5 | -5.51553 |
| PDZD4 | PDZ domain containing 4 | -5.46335 |
| ANXA6 | annexin A6 | -5.42327 |
| FLNB | filamin B, beta | -5.42001 |
| SSTR2 | somatostatin receptor 2 | -5.38689 |
| FTSJ1 | FtsJ RNA methyltransferase homolog 1 (E. coli) | -5.23094 |
| FLNA | filamin A, alpha | -5.17352 |
| CDC45 | cell division cycle 45 | -5.17173 |
| GRIK3 | glutamate receptor, ionotropic, kainate 3 | -5.1187 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -5.1187 |
| LONP1 | lon peptidase 1, mitochondrial | -5.08974 |
| HTR3A | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | -5.07587 |
| DPYD | dihydropyrimidine dehydrogenase | -5.04896 |
| ARHGAP29 | Rho GTPase activating protein 29 | -5.04896 |
| TLN1 | talin 1 | -5.02254 |
| MCM2 | minichromosome maintenance complex component 2 | -5.00436 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -4.99776 |
| FOXM1 | forkhead box M1 | -4.97601 |
| ADAM11 | ADAM metallopeptidase domain 11 | -4.962 |
| PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1 | -4.93739 |
