| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KO perturbation targeting RNASEH2B in IPSC-derived neural progenitor cells cell line (Study accession: SRP355094) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_9690_KO_RNASEH2B_SRP355094 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 17.9281 |
| MPPED2 | metallophosphoesterase domain containing 2 | 17.8633 |
| STRA6 | stimulated by retinoic acid 6 | 16.4032 |
| NMNAT2 | nicotinamide nucleotide adenylyltransferase 2 | 16.0006 |
| ZIC1 | Zic family member 1 | 13.0513 |
| TFAP2B | transcription factor AP-2 beta (activating enhancer binding protein 2 beta) | 11.4509 |
| ZIC5 | Zic family member 5 | 9.9249 |
| ZIC4 | Zic family member 4 | 9.88177 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | 9.57272 |
| BTBD17 | BTB (POZ) domain containing 17 | 9.45534 |
| EFCC1 | EF-hand and coiled-coil domain containing 1 | 8.62119 |
| FABP7 | fatty acid binding protein 7, brain | 8.42214 |
| ZNF93 | zinc finger protein 93 | 8.00288 |
| ACSS1 | acyl-CoA synthetase short-chain family member 1 | 7.87799 |
| GRB14 | growth factor receptor-bound protein 14 | 7.84921 |
| C11ORF87 | chromosome 11 open reading frame 87 | 7.63563 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 7.55858 |
| SCN1A | sodium channel, voltage gated, type I alpha subunit | 7.5514 |
| WSCD1 | WSC domain containing 1 | 7.16396 |
| DCLK1 | doublecortin-like kinase 1 | 6.97165 |
| CYYR1 | cysteine/tyrosine-rich 1 | 6.07875 |
| FAM189A1 | family with sequence similarity 189, member A1 | 5.99394 |
| RNF43 | ring finger protein 43 | 5.97009 |
| SLIT1 | slit homolog 1 (Drosophila) | 5.95503 |
| CA3 | carbonic anhydrase III | 5.95503 |
| FOXF2 | forkhead box F2 | 5.92242 |
| ERG | v-ets avian erythroblastosis virus E26 oncogene homolog | 5.80115 |
| MYBPC1 | myosin binding protein C, slow type | 5.75876 |
| GSG1L | GSG1-like | 5.72329 |
| IGDCC3 | immunoglobulin superfamily, DCC subclass, member 3 | 5.72329 |
| EGFL6 | EGF-like-domain, multiple 6 | 5.72329 |
| NWD2 | NACHT and WD repeat domain containing 2 | 5.66522 |
| NTRK3 | neurotrophic tyrosine kinase, receptor, type 3 | 5.36784 |
| FREM2 | FRAS1 related extracellular matrix protein 2 | 5.21741 |
| TTYH1 | tweety family member 1 | 5.15842 |
| SLC7A8 | solute carrier family 7 (amino acid transporter light chain, L system), member 8 | 5.01233 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 4.81033 |
| SLC30A8 | solute carrier family 30 (zinc transporter), member 8 | 4.77002 |
| DIRAS2 | DIRAS family, GTP-binding RAS-like 2 | 4.71766 |
| ZNF439 | zinc finger protein 439 | 4.69573 |
| CRB2 | crumbs family member 2 | 4.68542 |
| C7 | complement component 7 | 4.66662 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 4.66662 |
| PTCHD1 | patched domain containing 1 | 4.52053 |
| GDF10 | growth differentiation factor 10 | 4.50005 |
| GBX2 | gastrulation brain homeobox 2 | 4.40641 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 4.40637 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 4.38681 |
| CPAMD8 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | 4.36201 |
| VWDE | von Willebrand factor D and EGF domains | 4.31168 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 4.2838 |
| SLC8A3 | solute carrier family 8 (sodium/calcium exchanger), member 3 | 4.15183 |
| BMP7 | bone morphogenetic protein 7 | 4.12661 |
| ASPN | asporin | 4.02596 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 4.00554 |
| GPM6A | glycoprotein M6A | 3.98989 |
| CAMK1G | calcium/calmodulin-dependent protein kinase IG | 3.85016 |
| ADCY4 | adenylate cyclase 4 | 3.84613 |
| TMEM151B | transmembrane protein 151B | 3.8307 |
| ZIC2 | Zic family member 2 | 3.8307 |
| WDR86 | WD repeat domain 86 | 3.8103 |
| KIF1A | kinesin family member 1A | 3.64534 |
| FOXB1 | forkhead box B1 | 3.63893 |
| AFAP1L2 | actin filament associated protein 1-like 2 | 3.60979 |
| MMRN1 | multimerin 1 | 3.51367 |
| C1ORF226 | chromosome 1 open reading frame 226 | 3.50634 |
| FZD10 | frizzled class receptor 10 | 3.50257 |
| C1QTNF4 | C1q and tumor necrosis factor related protein 4 | 3.48061 |
| FBN3 | fibrillin 3 | 3.43268 |
| PGM5 | phosphoglucomutase 5 | 3.39629 |
| REPS2 | RALBP1 associated Eps domain containing 2 | 3.38166 |
| ARHGAP20 | Rho GTPase activating protein 20 | 3.38166 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 3.35928 |
| ISLR2 | immunoglobulin superfamily containing leucine-rich repeat 2 | 3.30939 |
| GAD1 | glutamate decarboxylase 1 (brain, 67kDa) | 3.29971 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 3.28204 |
| MAB21L2 | mab-21-like 2 (C. elegans) | 3.24224 |
| CPE | carboxypeptidase E | 3.22634 |
| C4ORF19 | chromosome 4 open reading frame 19 | 3.1857 |
| PHACTR3 | phosphatase and actin regulator 3 | 3.1824 |
| SEPP1 | selenoprotein P, plasma, 1 | 3.1824 |
| FMO1 | flavin containing monooxygenase 1 | 3.17535 |
| KIAA1644 | KIAA1644 | 3.16537 |
| ST6GALNAC5 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | 3.14852 |
| SLC22A23 | solute carrier family 22, member 23 | 3.12926 |
| IGSF3 | immunoglobulin superfamily, member 3 | 3.06251 |
| ZNF502 | zinc finger protein 502 | 3.02254 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 2.97629 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 2.94058 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 2.90234 |
| SLC40A1 | solute carrier family 40 (iron-regulated transporter), member 1 | 2.88916 |
| ADAM33 | ADAM metallopeptidase domain 33 | 2.87676 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 2.87591 |
| LGI4 | leucine-rich repeat LGI family, member 4 | 2.87044 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 2.86722 |
| ZIC3 | Zic family member 3 | 2.85613 |
| ITGB4 | integrin, beta 4 | 2.85613 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 2.8561 |
| FGFR2 | fibroblast growth factor receptor 2 | 2.8406 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 2.82003 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PKIB | protein kinase (cAMP-dependent, catalytic) inhibitor beta | -20.0 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -17.5258 |
| BDNF | brain-derived neurotrophic factor | -16.0178 |
| CD9 | CD9 molecule | -16.0006 |
| GFRA2 | GDNF family receptor alpha 2 | -15.5827 |
| GRIK3 | glutamate receptor, ionotropic, kainate 3 | -12.9497 |
| ARFGEF3 | ARFGEF family member 3 | -12.6826 |
| DSC2 | desmocollin 2 | -9.6588 |
| DLX3 | distal-less homeobox 3 | -9.57272 |
| GABBR2 | gamma-aminobutyric acid (GABA) B receptor, 2 | -8.69625 |
| PRDM8 | PR domain containing 8 | -8.56473 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -8.03417 |
| KCNA4 | potassium channel, voltage gated shaker related subfamily A, member 4 | -7.94374 |
| BDKRB2 | bradykinin receptor B2 | -7.91278 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -7.87799 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | -7.87799 |
| SNTG1 | syntrophin, gamma 1 | -7.84921 |
| SP6 | Sp6 transcription factor | -7.84921 |
| ISM1 | isthmin 1, angiogenesis inhibitor | -7.63563 |
| GRIA1 | glutamate receptor, ionotropic, AMPA 1 | -7.55858 |
| TUBA4A | tubulin, alpha 4a | -7.53861 |
| PALMD | palmdelphin | -7.30109 |
| VAT1L | vesicle amine transport 1-like | -7.30109 |
| GRIN3A | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | -6.7405 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -6.53968 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -6.48005 |
| COL9A1 | collagen, type IX, alpha 1 | -6.21859 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | -6.16651 |
| MTUS1 | microtubule associated tumor suppressor 1 | -5.56896 |
| FGFBP2 | fibroblast growth factor binding protein 2 | -5.55779 |
| NEGR1 | neuronal growth regulator 1 | -5.31385 |
| QPCT | glutaminyl-peptide cyclotransferase | -5.31385 |
| CNTN2 | contactin 2 (axonal) | -5.28746 |
| GABRR1 | gamma-aminobutyric acid (GABA) A receptor, rho 1 | -5.17865 |
| ANTXR2 | anthrax toxin receptor 2 | -5.15097 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -5.13792 |
| IFI16 | interferon, gamma-inducible protein 16 | -5.09751 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -4.95275 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -4.95275 |
| PGF | placental growth factor | -4.95143 |
| CADPS | Ca++-dependent secretion activator | -4.8865 |
| SNED1 | sushi, nidogen and EGF-like domains 1 | -4.54598 |
| ZNF662 | zinc finger protein 662 | -4.53142 |
| GBX1 | gastrulation brain homeobox 1 | -4.51708 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | -4.45958 |
| EDN3 | endothelin 3 | -4.45782 |
| HEPACAM | hepatic and glial cell adhesion molecule | -4.44169 |
| AMH | anti-Mullerian hormone | -4.25921 |
| GAB3 | GRB2-associated binding protein 3 | -4.25921 |
| CCDC85A | coiled-coil domain containing 85A | -4.13909 |
| N4BP3 | NEDD4 binding protein 3 | -4.13909 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | -4.08668 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -4.08085 |
| PRKCH | protein kinase C, eta | -4.05774 |
| TBX1 | T-box 1 | -3.995 |
| MGP | matrix Gla protein | -3.98989 |
| NTNG1 | netrin G1 | -3.8463 |
| RXRG | retinoid X receptor, gamma | -3.83888 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | -3.72961 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -3.65471 |
| GSTM1 | glutathione S-transferase mu 1 | -3.60979 |
| COL5A3 | collagen, type V, alpha 3 | -3.54516 |
| ACAN | aggrecan | -3.51998 |
| ITGA10 | integrin, alpha 10 | -3.51998 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -3.51998 |
| NPAS1 | neuronal PAS domain protein 1 | -3.51367 |
| GSC | goosecoid homeobox | -3.4624 |
| B3GAT2 | beta-1,3-glucuronyltransferase 2 | -3.42724 |
| GUCY1A2 | guanylate cyclase 1, soluble, alpha 2 | -3.42308 |
| ZNF486 | zinc finger protein 486 | -3.28204 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -3.27998 |
| SCARA3 | scavenger receptor class A, member 3 | -3.248 |
| FAM155A | family with sequence similarity 155, member A | -3.21895 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -3.21677 |
| GRIK4 | glutamate receptor, ionotropic, kainate 4 | -3.16599 |
| PRELP | proline/arginine-rich end leucine-rich repeat protein | -3.15632 |
| METTL7B | methyltransferase like 7B | -3.15632 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -3.14852 |
| PTGES | prostaglandin E synthase | -3.14627 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -3.12926 |
| KAZALD1 | Kazal-type serine peptidase inhibitor domain 1 | -3.05202 |
| C11ORF96 | chromosome 11 open reading frame 96 | -3.03877 |
| F2RL2 | coagulation factor II (thrombin) receptor-like 2 | -3.03125 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -3.00239 |
| NPAS3 | neuronal PAS domain protein 3 | -3.00018 |
| IL17D | interleukin 17D | -2.99413 |
| CAMK2N2 | calcium/calmodulin-dependent protein kinase II inhibitor 2 | -2.96695 |
| LANCL3 | LanC lantibiotic synthetase component C-like 3 (bacterial) | -2.94861 |
| DLK1 | delta-like 1 homolog (Drosophila) | -2.94515 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -2.90597 |
| KCNIP2 | Kv channel interacting protein 2 | -2.85713 |
| TMEM30B | transmembrane protein 30B | -2.85562 |
| MAMDC2 | MAM domain containing 2 | -2.84879 |
| CD1D | CD1d molecule | -2.8406 |
| STEAP4 | STEAP family member 4 | -2.7633 |
| SYNDIG1 | synapse differentiation inducing 1 | -2.76289 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -2.74954 |
| TMEM132E | transmembrane protein 132E | -2.7488 |
| KIAA1324 | KIAA1324 | -2.72906 |
| OGFRL1 | opioid growth factor receptor-like 1 | -2.7095 |
