Perturb_9957_KD_SNRNP200_SRP013565 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting SNRNP200 in K562 cell line (Study accession: SRP013565) (PerturbAtlas)
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Genes

153 genes differentially expressed following the Perturb_9957_KD_SNRNP200_SRP013565 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
KIAA0895 KIAA0895 4.12912
CTR9 CTR9, Paf1/RNA polymerase II complex component 3.81581
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 3.54604
RGMA repulsive guidance molecule family member a 3.41609
CTSB cathepsin B 2.90336
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 2.59655
SERINC4 serine incorporator 4 2.59655
LENG9 leukocyte receptor cluster (LRC) member 9 2.51348
PBLD phenazine biosynthesis-like protein domain containing 2.46062
ACTL6A actin-like 6A 2.29902
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.28275
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 2.18171
WRAP53 WD repeat containing, antisense to TP53 2.16872
ROM1 retinal outer segment membrane protein 1 2.13293
CNOT2 CCR4-NOT transcription complex, subunit 2 2.10511
SPC24 SPC24, NDC80 kinetochore complex component 2.10511
C12ORF73 chromosome 12 open reading frame 73 2.09274
ANGPTL3 angiopoietin-like 3 2.08759
SERP1 stress-associated endoplasmic reticulum protein 1 2.07592
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 2.0411
CRLF1 cytokine receptor-like factor 1 2.0386
RNF103-CHMP3 RNF103-CHMP3 readthrough 2.01667
NOP16 NOP16 nucleolar protein 1.94688
ZCCHC11 zinc finger, CCHC domain containing 11 1.94688
KIAA1644 KIAA1644 1.94602
RUVBL1 RuvB-like AAA ATPase 1 1.93565
TDRKH tudor and KH domain containing 1.93565
LENG1 leukocyte receptor cluster (LRC) member 1 1.93402
HDAC9 histone deacetylase 9 1.90242
CLN5 ceroid-lipofuscinosis, neuronal 5 1.88148
TECR trans-2,3-enoyl-CoA reductase 1.88148
HSBP1L1 heat shock factor binding protein 1-like 1 1.88148
SAR1B secretion associated, Ras related GTPase 1B 1.88148
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 1.87488
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 1.86146
PSTK phosphoseryl-tRNA kinase 1.7892
ZBTB48 zinc finger and BTB domain containing 48 1.71681
OR52D1 olfactory receptor, family 52, subfamily D, member 1 1.71208
SRRD SRR1 domain containing 1.71208
CCDC152 coiled-coil domain containing 152 1.64113
FAM118B family with sequence similarity 118, member B 1.63439
FICD FIC domain containing 1.62477
UBXN11 UBX domain protein 11 1.61704
ARHGAP9 Rho GTPase activating protein 9 1.60758
MARS methionyl-tRNA synthetase 1.58311
PNCK pregnancy up-regulated nonubiquitous CaM kinase 1.55347
TSSK3 testis-specific serine kinase 3 1.55293
SRPRB signal recognition particle receptor, B subunit 1.53563
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1 1.47294
TMEM165 transmembrane protein 165 1.47174
PMPCB peptidase (mitochondrial processing) beta 1.47121
CEP57 centrosomal protein 57kDa 1.47121
LRRC75A leucine rich repeat containing 75A 1.47014
RHOBTB2 Rho-related BTB domain containing 2 1.46813
MCTS1 malignant T cell amplified sequence 1 1.46813
ACADVL acyl-CoA dehydrogenase, very long chain 1.46813
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 1.46813
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 1.45614
MPDU1 mannose-P-dolichol utilization defect 1 1.44127
PRCC papillary renal cell carcinoma (translocation-associated) 1.42362
OSMR oncostatin M receptor 1.41379
CNTRL centriolin 1.40974
CDC42SE1 CDC42 small effector 1 1.35982
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 1.35625
PODNL1 podocan-like 1 1.3388
C19ORF44 chromosome 19 open reading frame 44 1.33625
IFT80 intraflagellar transport 80 1.33397
ZRANB3 zinc finger, RAN-binding domain containing 3 1.32188
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 1.32145
DNAH3 dynein, axonemal, heavy chain 3 1.31072

decreased expression

Symbol Name Standardized Value
MVK mevalonate kinase -4.12912
BCAN brevican -4.02446
C1ORF167 chromosome 1 open reading frame 167 -3.63325
ZACN zinc activated ligand-gated ion channel -3.25453
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) -2.92183
SNAP47 synaptosomal-associated protein, 47kDa -2.7167
YPEL1 yippee-like 1 (Drosophila) -2.6851
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.63532
PEX14 peroxisomal biogenesis factor 14 -2.59655
WDR33 WD repeat domain 33 -2.46062
TYMS thymidylate synthetase -2.10511
NAP1L1 nucleosome assembly protein 1-like 1 -2.10511
ZNF446 zinc finger protein 446 -2.10124
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -2.09274
ZFHX3 zinc finger homeobox 3 -2.04981
HEXIM1 hexamethylene bis-acetamide inducible 1 -2.03577
WDR73 WD repeat domain 73 -1.94451
CHAF1A chromatin assembly factor 1, subunit A (p150) -1.89381
EID1 EP300 interacting inhibitor of differentiation 1 -1.89105
HMGN2 high mobility group nucleosomal binding domain 2 -1.88148
LHX4 LIM homeobox 4 -1.88148
ARL8B ADP-ribosylation factor-like 8B -1.87208
VPS9D1 VPS9 domain containing 1 -1.86146
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -1.86146
SIGLEC10 sialic acid binding Ig-like lectin 10 -1.86146
NQO2 NAD(P)H dehydrogenase, quinone 2 -1.82669
GJD3 gap junction protein, delta 3, 31.9kDa -1.80812
FAM71E1 family with sequence similarity 71, member E1 -1.80385
SPRN shadow of prion protein homolog (zebrafish) -1.79261
GATA2 GATA binding protein 2 -1.77069
LIG1 ligase I, DNA, ATP-dependent -1.76977
C9ORF117 chromosome 9 open reading frame 117 -1.76632
MAP1B microtubule-associated protein 1B -1.76017
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -1.73719
WTAP Wilms tumor 1 associated protein -1.72968
SPTAN1 spectrin, alpha, non-erythrocytic 1 -1.72895
METAP2 methionyl aminopeptidase 2 -1.71681
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) -1.71289
BRD9 bromodomain containing 9 -1.70524
PLXNC1 plexin C1 -1.69902
HNRNPM heterogeneous nuclear ribonucleoprotein M -1.69732
C9ORF173 chromosome 9 open reading frame 173 -1.6659
PIEZO1 piezo-type mechanosensitive ion channel component 1 -1.64548
PMM2 phosphomannomutase 2 -1.63439
RCSD1 RCSD domain containing 1 -1.57492
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -1.54521
CLVS1 clavesin 1 -1.53563
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF -1.53563
RORA RAR-related orphan receptor A -1.53563
PABPN1 poly(A) binding protein, nuclear 1 -1.52962
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -1.51344
FLOT2 flotillin 2 -1.5134
OGFR opioid growth factor receptor -1.5059
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -1.49121
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -1.47544
CEMP1 cementum protein 1 -1.47014
LRRC39 leucine rich repeat containing 39 -1.44127
RSPH9 radial spoke head 9 homolog (Chlamydomonas) -1.41565
GLTSCR2 glioma tumor suppressor candidate region gene 2 -1.41379
EPB41 erythrocyte membrane protein band 4.1 -1.40974
ISPD isoprenoid synthase domain containing -1.40974
DCAF13 DDB1 and CUL4 associated factor 13 -1.40417
PMCH pro-melanin-concentrating hormone -1.37572
NUCB1 nucleobindin 1 -1.3712
SEPP1 selenoprotein P, plasma, 1 -1.36919
APC2 adenomatosis polyposis coli 2 -1.36919
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 -1.36919
CACTIN cactin, spliceosome C complex subunit -1.36919
FAR2 fatty acyl CoA reductase 2 -1.35625
RAPSN receptor-associated protein of the synapse -1.35522
CTTN cortactin -1.34678
BRICD5 BRICHOS domain containing 5 -1.3464
MATN1 matrilin 1, cartilage matrix protein -1.3457
SRPK3 SRSF protein kinase 3 -1.3457
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -1.34558
TMEM263 transmembrane protein 263 -1.3388
NUDC nudC nuclear distribution protein -1.33625
C1ORF226 chromosome 1 open reading frame 226 -1.33397
SRSF2 serine/arginine-rich splicing factor 2 -1.33397
ATP5J2-PTCD1 ATP5J2-PTCD1 readthrough -1.33397
MRPS27 mitochondrial ribosomal protein S27 -1.31771
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 -1.31258
TMCO1 transmembrane and coiled-coil domains 1 -1.30318