| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pexidartinib (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.22281 |
| FBN1 | fibrillin 1 | 0.105971 |
| LOX | lysyl oxidase | 0.0896513 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0838403 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0797837 |
| FNDC3B | fibronectin type III domain containing 3B | 0.075546 |
| LOXL2 | lysyl oxidase-like 2 | 0.0723153 |
| CD44 | CD44 molecule (Indian blood group) | 0.0677575 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0657504 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0656461 |
| THBS2 | thrombospondin 2 | 0.0607327 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.055718 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0551672 |
| FLNB | filamin B, beta | 0.0528989 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0504052 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.048309 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0448375 |
| GPC6 | glypican 6 | 0.0446449 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0443698 |
| ATP13A3 | ATPase type 13A3 | 0.0439673 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0426562 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0423881 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0417918 |
| STC1 | stanniocalcin 1 | 0.0406133 |
| DST | dystonin | 0.0390955 |
| SBF2 | SET binding factor 2 | 0.0385957 |
| C1D | C1D nuclear receptor corepressor | 0.0384658 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0382862 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0367901 |
| PRELID2 | PRELI domain containing 2 | 0.036512 |
| MYOF | myoferlin | 0.0363058 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0359416 |
| NDRG1 | N-myc downstream regulated 1 | 0.0357197 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.03423 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0330223 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0315313 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0310652 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0304637 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0302075 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0299155 |
| APP | amyloid beta (A4) precursor protein | 0.0296682 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.028921 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0288847 |
| ARRDC3 | arrestin domain containing 3 | 0.0288594 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0286403 |
| AUTS2 | autism susceptibility candidate 2 | 0.0278563 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0267786 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 0.026647 |
| YEATS2 | YEATS domain containing 2 | 0.0256342 |
| SEPTIN9 | septin 9 | 0.0247174 |
| TMOD1 | tropomodulin 1 | 0.0245122 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.024227 |
| COL3A1 | collagen, type III, alpha 1 | 0.0239222 |
| STK10 | serine/threonine kinase 10 | 0.0237887 |
| ZNF292 | zinc finger protein 292 | 0.0236778 |
| SP3 | Sp3 transcription factor | 0.0235045 |
| MXI1 | MAX interactor 1, dimerization protein | 0.023253 |
| MEF2A | myocyte enhancer factor 2A | 0.0231547 |
| OPTN | optineurin | 0.0226908 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.022681 |
| ANK2 | ankyrin 2, neuronal | 0.0226297 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0225961 |
| TDRD7 | tudor domain containing 7 | 0.0225544 |
| ATXN1 | ataxin 1 | 0.0224806 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0223974 |
| KLF6 | Kruppel-like factor 6 | 0.0221428 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0221356 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.022066 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0218032 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0215908 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.021514 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0213235 |
| RUNX1 | runt-related transcription factor 1 | 0.0212582 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0210848 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.020987 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0209847 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0209223 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0207931 |
| ANXA2 | annexin A2 | 0.0207823 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0207031 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0205778 |
| MB21D2 | Mab-21 domain containing 2 | 0.020574 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 0.0205033 |
| FNIP1 | folliculin interacting protein 1 | 0.0204157 |
| FLNA | filamin A, alpha | 0.0202109 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0200439 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0200245 |
| KIFAP3 | kinesin-associated protein 3 | 0.0198862 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0198078 |
| PCGF5 | polycomb group ring finger 5 | 0.0196971 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0195369 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0194183 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0193866 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0192516 |
| CD109 | CD109 molecule | 0.0192301 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0187649 |
| LDHA | lactate dehydrogenase A | 0.0185542 |
| SVIL | supervillin | 0.0184255 |
| RNF213 | ring finger protein 213 | 0.0182658 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0180424 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.167098 |
| TMSB10 | thymosin beta 10 | -0.145232 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.121596 |
| CDH13 | cadherin 13 | -0.103127 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.103086 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0884184 |
| FN1 | fibronectin 1 | -0.0874864 |
| AHNAK | AHNAK nucleoprotein | -0.076546 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0697411 |
| S100A10 | S100 calcium binding protein A10 | -0.06749 |
| LMNA | lamin A/C | -0.0642782 |
| COL5A1 | collagen, type V, alpha 1 | -0.0636495 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0616573 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0556015 |
| PTMA | prothymosin, alpha | -0.0539852 |
| MAP1B | microtubule-associated protein 1B | -0.0539088 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.052125 |
| POTEF | POTE ankyrin domain family, member F | -0.0519806 |
| CSTB | cystatin B (stefin B) | -0.047681 |
| S100A6 | S100 calcium binding protein A6 | -0.0468376 |
| CANX | calnexin | -0.0461831 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0428098 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0411719 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0409636 |
| TPM4 | tropomyosin 4 | -0.0371793 |
| ASPH | aspartate beta-hydroxylase | -0.0357764 |
| TAGLN2 | transgelin 2 | -0.0320838 |
| PRSS23 | protease, serine, 23 | -0.0315895 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0305148 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0303331 |
| FSTL1 | follistatin-like 1 | -0.0298164 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0295078 |
| PLAT | plasminogen activator, tissue | -0.0282109 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0278649 |
| IL7R | interleukin 7 receptor | -0.0277901 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0277702 |
| CYTH3 | cytohesin 3 | -0.0276005 |
| SUCNR1 | succinate receptor 1 | -0.0275226 |
| CAVIN1 | caveolae associated protein 1 | -0.0266257 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0262752 |
| TMSB4X | thymosin beta 4, X-linked | -0.0261798 |
| RRBP1 | ribosome binding protein 1 | -0.0253529 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0253362 |
| LRRC17 | leucine rich repeat containing 17 | -0.024718 |
| CCND1 | cyclin D1 | -0.0240845 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0238747 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0238706 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0237318 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0237087 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0234022 |
| PLXNA2 | plexin A2 | -0.0233318 |
| KRT81 | keratin 81, type II | -0.0232833 |
| MCL1 | myeloid cell leukemia 1 | -0.0232602 |
| FMN2 | formin 2 | -0.023112 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0230754 |
| SRPK2 | SRSF protein kinase 2 | -0.0226172 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0223581 |
| MT2A | metallothionein 2A | -0.0220562 |
| CALR | calreticulin | -0.0218778 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.021592 |
| SEC61G | Sec61 gamma subunit | -0.021212 |
| RIGI | RNA sensor RIG-I | -0.0211983 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0207763 |
| S100A4 | S100 calcium binding protein A4 | -0.0205126 |
| RASAL2 | RAS protein activator like 2 | -0.0204989 |
| PODXL | podocalyxin-like | -0.0203501 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0202769 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.0199021 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0195385 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0194244 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0182643 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.01821 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0179988 |
| PRRC2C | proline-rich coiled-coil 2C | -0.017983 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0179661 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0178371 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0176989 |
| COL1A1 | collagen, type I, alpha 1 | -0.0176324 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0175821 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0173069 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0171851 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0169947 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0168511 |
| MED13L | mediator complex subunit 13-like | -0.0168273 |
| S100A11 | S100 calcium binding protein A11 | -0.0166148 |
| CD99 | CD99 molecule | -0.0164992 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0164192 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0163575 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0163547 |
| TBCA | tubulin folding cofactor A | -0.0163267 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0162801 |
| ANKRD11 | ankyrin repeat domain 11 | -0.016231 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0161741 |
| B2M | beta-2-microglobulin | -0.0161625 |
| H3-3B | H3.3 histone B | -0.0159445 |
| TPM1 | tropomyosin 1 (alpha) | -0.0158617 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0157689 |
| EFNA5 | ephrin-A5 | -0.0157631 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0156473 |
| C12ORF75 | chromosome 12 open reading frame 75 | -0.0155899 |
