| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | 0.102139 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0938916 |
| DST | dystonin | 0.0740126 |
| PDGFC | platelet derived growth factor C | 0.0675832 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0664212 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0613532 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0595121 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.056715 |
| CLDN1 | claudin 1 | 0.0565637 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0553512 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.055348 |
| NEBL | nebulette | 0.054493 |
| TENM3 | teneurin transmembrane protein 3 | 0.0542505 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0530415 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0515027 |
| PCDH7 | protocadherin 7 | 0.0440008 |
| HMGA1 | high mobility group AT-hook 1 | 0.0373079 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0369204 |
| LDHA | lactate dehydrogenase A | 0.0349862 |
| PFN1 | profilin 1 | 0.0345969 |
| PCBP2 | poly(rC) binding protein 2 | 0.033911 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.032988 |
| ANXA1 | annexin A1 | 0.0327814 |
| EHBP1 | EH domain binding protein 1 | 0.031915 |
| PLK2 | polo-like kinase 2 | 0.030609 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0302696 |
| EPHA6 | EPH receptor A6 | 0.0292574 |
| PCBP1 | poly(rC) binding protein 1 | 0.0287419 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0284718 |
| DTNA | dystrobrevin, alpha | 0.0278729 |
| NUP58 | nucleoporin 58 | 0.0275242 |
| NHSL1 | NHS-like 1 | 0.0261631 |
| TBK1 | TANK-binding kinase 1 | 0.0260294 |
| KLF6 | Kruppel-like factor 6 | 0.0259676 |
| FAT1 | FAT atypical cadherin 1 | 0.0258046 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0257873 |
| FOXM1 | forkhead box M1 | 0.0247815 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0246995 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0244078 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0238431 |
| PEG10 | paternally expressed 10 | 0.023359 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0232064 |
| MTAP | methylthioadenosine phosphorylase | 0.0228317 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0224802 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0221497 |
| EDARADD | EDAR-associated death domain | 0.0220731 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0220485 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.0218915 |
| PRR16 | proline rich 16 | 0.0210905 |
| ECT2 | epithelial cell transforming 2 | 0.0210302 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0208454 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0206231 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0205217 |
| FLNA | filamin A, alpha | 0.0201045 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0198694 |
| PRELID2 | PRELI domain containing 2 | 0.0194966 |
| YEATS2 | YEATS domain containing 2 | 0.0194329 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0191006 |
| RAD51B | RAD51 paralog B | 0.0190657 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0185597 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0183355 |
| ZFP64 | ZFP64 zinc finger protein | 0.0179868 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0175428 |
| RACK1 | receptor for activated C kinase 1 | 0.0172689 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | 0.0171098 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0167028 |
| CCT2 | chaperonin containing TCP1, subunit 2 (beta) | 0.0166639 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0165141 |
| MAP1B | microtubule-associated protein 1B | 0.0163617 |
| BCHE | butyrylcholinesterase | 0.0163143 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0161822 |
| FSTL5 | follistatin-like 5 | 0.0160621 |
| WDR43 | WD repeat domain 43 | 0.0159777 |
| FASN | fatty acid synthase | 0.0159645 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0154974 |
| CLDND1 | claudin domain containing 1 | 0.0154703 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.0154068 |
| TMEM106B | transmembrane protein 106B | 0.015231 |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | 0.014692 |
| KSR2 | kinase suppressor of ras 2 | 0.0146778 |
| CCDC91 | coiled-coil domain containing 91 | 0.0146737 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.014648 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0145333 |
| CDV3 | CDV3 homolog (mouse) | 0.0144719 |
| ATXN2L | ataxin 2-like | 0.0143845 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0142168 |
| PGK1 | phosphoglycerate kinase 1 | 0.0141877 |
| ACTG1 | actin gamma 1 | 0.0141831 |
| HDAC9 | histone deacetylase 9 | 0.0141571 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0137857 |
| RBBP4 | retinoblastoma binding protein 4 | 0.0136823 |
| KIF18B | kinesin family member 18B | 0.0136791 |
| GOLT1A | golgi transport 1A | 0.0136535 |
| EXOC4 | exocyst complex component 4 | 0.0136394 |
| MED13L | mediator complex subunit 13-like | 0.0134358 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | 0.0133779 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0133208 |
| MTCL1 | microtubule crosslinking factor 1 | 0.013182 |
| YAP1 | Yes-associated protein 1 | 0.0131508 |
| TGM2 | transglutaminase 2 | 0.0130951 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.270431 |
| AREG | amphiregulin | -0.190155 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.132421 |
| PTMA | prothymosin, alpha | -0.130561 |
| TMSB10 | thymosin beta 10 | -0.0904009 |
| FTL | ferritin, light polypeptide | -0.0899946 |
| RPS6 | ribosomal protein S6 | -0.0861094 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.077302 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0714667 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0645656 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0615918 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0611969 |
| AHNAK | AHNAK nucleoprotein | -0.054768 |
| RPL19 | ribosomal protein L19 | -0.0529498 |
| RPL38 | ribosomal protein L38 | -0.0526878 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0526426 |
| RPS13 | ribosomal protein S13 | -0.0525687 |
| RPLP2 | ribosomal protein, large, P2 | -0.0510814 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0501867 |
| RPL8 | ribosomal protein L8 | -0.0496656 |
| RPS27A | ribosomal protein S27a | -0.0492559 |
| RPS21 | ribosomal protein S21 | -0.0480005 |
| CPOX | coproporphyrinogen oxidase | -0.0474146 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0467138 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0465271 |
| RPS23 | ribosomal protein S23 | -0.0462029 |
| RPS8 | ribosomal protein S8 | -0.0453281 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0445635 |
| SETD5 | SET domain containing 5 | -0.0433362 |
| RPS29 | ribosomal protein S29 | -0.0432496 |
| YBX3 | Y box binding protein 3 | -0.0422635 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0420266 |
| ASPH | aspartate beta-hydroxylase | -0.0416295 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0415343 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.041532 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.039866 |
| CANX | calnexin | -0.0394895 |
| MMP12 | matrix metallopeptidase 12 | -0.0384036 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.03812 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.038041 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0378908 |
| RPL12 | ribosomal protein L12 | -0.0375787 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0372514 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0371419 |
| RPS15 | ribosomal protein S15 | -0.0359255 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0358633 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0353768 |
| GOLGB1 | golgin B1 | -0.0349168 |
| H1-0 | H1.0 linker histone | -0.0346989 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0343187 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0343038 |
| RPL11 | ribosomal protein L11 | -0.0342297 |
| SQSTM1 | sequestosome 1 | -0.0339143 |
| RPLP1 | ribosomal protein, large, P1 | -0.0338586 |
| RPL36A | ribosomal protein L36a | -0.0336316 |
| RRM2 | ribonucleotide reductase M2 | -0.0334291 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.033278 |
| RPL31 | ribosomal protein L31 | -0.0330289 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0325416 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.03243 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0318649 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0314201 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0311087 |
| RPS25 | ribosomal protein S25 | -0.0309943 |
| RPS10 | ribosomal protein S10 | -0.0307352 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0299709 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0299208 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0295644 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0295369 |
| RPL34 | ribosomal protein L34 | -0.029428 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.029225 |
| OGA | O-GlcNAcase | -0.0292029 |
| HDLBP | high density lipoprotein binding protein | -0.0291447 |
| GOLGA4 | golgin A4 | -0.0290835 |
| RPL26 | ribosomal protein L26 | -0.0288098 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0286536 |
| RPS2 | ribosomal protein S2 | -0.028222 |
| RPS19 | ribosomal protein S19 | -0.028162 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0279385 |
| H3-3B | H3.3 histone B | -0.0278989 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0278795 |
| RSL24D1 | ribosomal L24 domain containing 1 | -0.0278623 |
| RAB10 | RAB10, member RAS oncogene family | -0.0276955 |
| RPL32 | ribosomal protein L32 | -0.0276271 |
| RPS24 | ribosomal protein S24 | -0.0274467 |
| RPS5 | ribosomal protein S5 | -0.026101 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.026089 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0256699 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0254904 |
| RPL9 | ribosomal protein L9 | -0.0251221 |
| TUBA1B | tubulin, alpha 1b | -0.025034 |
| RPL7 | ribosomal protein L7 | -0.0249418 |
| RPL36 | ribosomal protein L36 | -0.0248958 |
| IL6ST | interleukin 6 signal transducer | -0.0246571 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0246144 |
| UBC | ubiquitin C | -0.0245432 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0245236 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0243708 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0243172 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0243052 |
