| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.29772 |
| ASPH | aspartate beta-hydroxylase | 0.237668 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.188489 |
| TXNRD1 | thioredoxin reductase 1 | 0.135549 |
| NRP2 | neuropilin 2 | 0.107306 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.106264 |
| CD44 | CD44 molecule (Indian blood group) | 0.0936054 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0836584 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0800436 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.075232 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0712783 |
| RPS2 | ribosomal protein S2 | 0.0699679 |
| GPC6 | glypican 6 | 0.0671135 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0669303 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0654561 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0652316 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.062788 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0622749 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0607546 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.0602994 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0598468 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0594931 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0585919 |
| GLIS3 | GLIS family zinc finger 3 | 0.0584221 |
| FAT1 | FAT atypical cadherin 1 | 0.0583643 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0576786 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0576362 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0574143 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0540818 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0536124 |
| PLK2 | polo-like kinase 2 | 0.0519726 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0502675 |
| LDHA | lactate dehydrogenase A | 0.0494518 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0472749 |
| TGFB2 | transforming growth factor, beta 2 | 0.0472329 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0457135 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0454369 |
| FLNA | filamin A, alpha | 0.0448265 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0446447 |
| NFIB | nuclear factor I/B | 0.0442561 |
| RNF213 | ring finger protein 213 | 0.0435228 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0433398 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0430878 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0430327 |
| SMAD3 | SMAD family member 3 | 0.0426765 |
| SET | SET nuclear proto-oncogene | 0.0425084 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0424451 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0423995 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0403572 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0398537 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0396018 |
| DST | dystonin | 0.0392406 |
| VCAN | versican | 0.039114 |
| ETV6 | ets variant 6 | 0.0389606 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0358389 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0353607 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0352024 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0347109 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0346094 |
| KYNU | kynureninase | 0.0344419 |
| ANLN | anillin, actin binding protein | 0.0342963 |
| RAI14 | retinoic acid induced 14 | 0.0338681 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0333488 |
| APP | amyloid beta (A4) precursor protein | 0.0333194 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.03329 |
| MYOF | myoferlin | 0.0325181 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0324986 |
| HMGB2 | high mobility group box 2 | 0.0318506 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.031703 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0316366 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0315456 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0313562 |
| ANXA1 | annexin A1 | 0.0311379 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.030992 |
| RIGI | RNA sensor RIG-I | 0.0307661 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0303391 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0300812 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0299942 |
| SLTM | SAFB-like, transcription modulator | 0.0298481 |
| TUSC3 | tumor suppressor candidate 3 | 0.0296876 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0286563 |
| ARRDC3 | arrestin domain containing 3 | 0.028226 |
| RACK1 | receptor for activated C kinase 1 | 0.0282227 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0279953 |
| NCKAP1 | NCK-associated protein 1 | 0.0278852 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0278826 |
| RPS4X | ribosomal protein S4, X-linked | 0.0277803 |
| MKI67 | marker of proliferation Ki-67 | 0.0277112 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0276726 |
| ERBIN | erbb2 interacting protein | 0.0275277 |
| TNS3 | tensin 3 | 0.0275175 |
| ATXN10 | ataxin 10 | 0.0270375 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0270317 |
| JAK1 | Janus kinase 1 | 0.0269162 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0267787 |
| ANXA2 | annexin A2 | 0.0266512 |
| TGFA | transforming growth factor, alpha | 0.0265987 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0259906 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0259815 |
| TKT | transketolase | 0.0256416 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.186005 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.129265 |
| TMSB10 | thymosin beta 10 | -0.110557 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0872997 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0655523 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0543334 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0510511 |
| APOL1 | apolipoprotein L, 1 | -0.047361 |
| CTSD | cathepsin D | -0.0468034 |
| RPS6 | ribosomal protein S6 | -0.0435279 |
| B2M | beta-2-microglobulin | -0.0426705 |
| PLIN2 | perilipin 2 | -0.0418139 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.04108 |
| FRMD4A | FERM domain containing 4A | -0.0409255 |
| FRMD5 | FERM domain containing 5 | -0.0406063 |
| UBC | ubiquitin C | -0.0395039 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0385187 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0380717 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0375566 |
| HLA-B | major histocompatibility complex, class I, B | -0.0361701 |
| SCFD2 | sec1 family domain containing 2 | -0.0359152 |
| CUX1 | cut-like homeobox 1 | -0.035675 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0349483 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0336987 |
| NDRG1 | N-myc downstream regulated 1 | -0.0325418 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0312464 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0306632 |
| HM13 | histocompatibility (minor) 13 | -0.0302286 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0295447 |
| S100A6 | S100 calcium binding protein A6 | -0.0294745 |
| RPS21 | ribosomal protein S21 | -0.0294176 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0293801 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0292896 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0292 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0289452 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0277329 |
| PRKCA | protein kinase C, alpha | -0.0273363 |
| ADM | adrenomedullin | -0.0271099 |
| CP | ceruloplasmin (ferroxidase) | -0.0269829 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0263932 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0260759 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0259116 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0256312 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0255231 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -0.0253495 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0251785 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0245481 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0244883 |
| RPS24 | ribosomal protein S24 | -0.02446 |
| HLA-C | major histocompatibility complex, class I, C | -0.0242895 |
| RPL35A | ribosomal protein L35a | -0.0237867 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0235358 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | -0.0233998 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0233642 |
| S100A9 | S100 calcium binding protein A9 | -0.0230662 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.0228936 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | -0.0224923 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | -0.02242 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0223624 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0223461 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0219283 |
| RPS13 | ribosomal protein S13 | -0.0218932 |
| SQLE | squalene epoxidase | -0.0218078 |
| PTMA | prothymosin, alpha | -0.0216479 |
| COG6 | component of oligomeric golgi complex 6 | -0.0214647 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0214588 |
| CD63 | CD63 molecule | -0.0214046 |
| FTL | ferritin, light polypeptide | -0.0211678 |
| S100A11 | S100 calcium binding protein A11 | -0.0210713 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0210181 |
| TUBA1B | tubulin, alpha 1b | -0.0207645 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0205822 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0204704 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0203519 |
| RPS15 | ribosomal protein S15 | -0.0202288 |
| CLMP | CXADR-like membrane protein | -0.0199485 |
| TPM1 | tropomyosin 1 (alpha) | -0.0198505 |
| SLC35E1 | solute carrier family 35, member E1 | -0.0191851 |
| VEGFA | vascular endothelial growth factor A | -0.0189084 |
| RNASET2 | ribonuclease T2 | -0.0188861 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0188252 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0188239 |
| RPS11 | ribosomal protein S11 | -0.0188103 |
| RPL12 | ribosomal protein L12 | -0.0187224 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | -0.0186794 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -0.0185919 |
| SERF2 | small EDRK-rich factor 2 | -0.0183816 |
| RPS23 | ribosomal protein S23 | -0.0183665 |
| S100A10 | S100 calcium binding protein A10 | -0.0182658 |
| ACLY | ATP citrate lyase | -0.0182395 |
| RPL28 | ribosomal protein L28 | -0.0182366 |
| HLA-A | major histocompatibility complex, class I, A | -0.0181695 |
| UBAP2 | ubiquitin associated protein 2 | -0.0180992 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0179162 |
| NAV2 | neuron navigator 2 | -0.0178137 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.017766 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0177615 |
| AHNAK | AHNAK nucleoprotein | -0.0177541 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) | -0.0177481 |
| MYADM | myeloid-associated differentiation marker | -0.0177467 |
