Pexidartinib (hydrochloride)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.101196
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0700229
NRIP1 nuclear receptor interacting protein 1 0.069829
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0682125
ARHGAP26 Rho GTPase activating protein 26 0.0678584
PDE10A phosphodiesterase 10A 0.0597931
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0596963
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0576469
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0549286
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0537841
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0450486
CMIP c-Maf inducing protein 0.0407687
FNDC3B fibronectin type III domain containing 3B 0.0399229
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0394254
RNF213 ring finger protein 213 0.0381382
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0375986
SMAD3 SMAD family member 3 0.0375167
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0337738
TGM2 transglutaminase 2 0.0335416
PRELID2 PRELI domain containing 2 0.0311742
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0298369
EEF2 eukaryotic translation elongation factor 2 0.0258569
TBC1D22A TBC1 domain family, member 22A 0.0257376
EXOC6B exocyst complex component 6B 0.0243794
RBMS3 RNA binding motif, single stranded interacting protein 3 0.023973
GPRIN3 GPRIN family member 3 0.0237456
BIRC6 baculoviral IAP repeat containing 6 0.0237154
C1D C1D nuclear receptor corepressor 0.0235525
DGKD diacylglycerol kinase, delta 130kDa 0.0233997
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0232686
WWOX WW domain containing oxidoreductase 0.0228866
EGFR epidermal growth factor receptor 0.0227407
KDM4C lysine (K)-specific demethylase 4C 0.0226707
SMYD3 SET and MYND domain containing 3 0.0225132
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0223834
FLNA filamin A, alpha 0.0223711
PTPRJ protein tyrosine phosphatase, receptor type, J 0.022366
MSN moesin 0.0213862
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.021198
PRKCE protein kinase C, epsilon 0.021129
TBC1D5 TBC1 domain family, member 5 0.0210426
RIGI RNA sensor RIG-I 0.0210115
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0209003
TRIM25 tripartite motif containing 25 0.0203325
SP3 Sp3 transcription factor 0.0202996
RAD51B RAD51 paralog B 0.020267
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0193138
NFE2L1 nuclear factor, erythroid 2-like 1 0.0192369
KIAA1217 KIAA1217 0.0190282
DMXL2 Dmx-like 2 0.018761
GPC6 glypican 6 0.0186169
RPS2 ribosomal protein S2 0.0183928
PCBP2 poly(rC) binding protein 2 0.0182762
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.017758
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.017218
YEATS2 YEATS domain containing 2 0.0170164
RARB retinoic acid receptor, beta 0.0168735
PDZD8 PDZ domain containing 8 0.0166819
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0163159
SKAP2 src kinase associated phosphoprotein 2 0.016228
MYO1B myosin IB 0.0160958
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0159524
ANGPTL4 angiopoietin-like 4 0.0158168
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0156177
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0156004
LAMA5 laminin, alpha 5 0.0155529
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0154796
ETV6 ets variant 6 0.0154073
AKAP9 A kinase (PRKA) anchor protein 9 0.0150384
ADAM10 ADAM metallopeptidase domain 10 0.0150302
KDM7A lysine (K)-specific demethylase 7A 0.0147155
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.014477
TDRD7 tudor domain containing 7 0.014448
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0141239
RIN2 Ras and Rab interactor 2 0.0141076
NRG1 neuregulin 1 0.0140892
NAV2 neuron navigator 2 0.0140349
ADAM17 ADAM metallopeptidase domain 17 0.0139351
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0138093
HIPK2 homeodomain interacting protein kinase 2 0.0137746
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0136923
SBF2 SET binding factor 2 0.0136757
CD44 CD44 molecule (Indian blood group) 0.013671
CCNL1 cyclin L1 0.0136327
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0136034
SS18 synovial sarcoma translocation, chromosome 18 0.013544
HELB helicase (DNA) B 0.0135245
CHD9 chromodomain helicase DNA binding protein 9 0.0134271
BABAM2 BRISC and BRCA1 A complex member 2 0.0133521
NFIB nuclear factor I/B 0.0132836
TBK1 TANK-binding kinase 1 0.0131943
ANO6 anoctamin 6 0.0131881
MBD5 methyl-CpG binding domain protein 5 0.0131766
ITGB5 integrin, beta 5 0.0130402
SHB Src homology 2 domain containing adaptor protein B 0.0127004
CEP350 centrosomal protein 350kDa 0.0126481
GPATCH2L G patch domain containing 2-like 0.0126048
KIF16B kinesin family member 16B 0.0125709
DST dystonin 0.0124553
ACER3 alkaline ceramidase 3 0.0123462

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.325968
TMSB10 thymosin beta 10 -0.2512
AKAP12 A kinase (PRKA) anchor protein 12 -0.198702
FTL ferritin, light polypeptide -0.148666
VIM vimentin -0.123606
RPS6 ribosomal protein S6 -0.112382
KRT81 keratin 81, type II -0.10838
TPT1 tumor protein, translationally-controlled 1 -0.0970491
PTMA prothymosin, alpha -0.0951192
MT1X metallothionein 1X -0.09246
RPS19 ribosomal protein S19 -0.0915238
MT2A metallothionein 2A -0.0905491
TM4SF1 transmembrane 4 L six family member 1 -0.0888077
AHNAK AHNAK nucleoprotein -0.0797646
RPLP1 ribosomal protein, large, P1 -0.0774403
S100A6 S100 calcium binding protein A6 -0.0757106
ACTG1 actin gamma 1 -0.0733645
EIF1 eukaryotic translation initiation factor 1 -0.0695736
IGFBP4 insulin-like growth factor binding protein 4 -0.069528
ANXA2 annexin A2 -0.0692823
S100A10 S100 calcium binding protein A10 -0.065587
RPS16 ribosomal protein S16 -0.0651466
RPS24 ribosomal protein S24 -0.0636639
UBC ubiquitin C -0.0607908
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0607752
USP3 ubiquitin specific peptidase 3 -0.0579207
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0553119
AKR1C2 aldo-keto reductase family 1, member C2 -0.0543359
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0524398
RPL8 ribosomal protein L8 -0.0511755
RPL19 ribosomal protein L19 -0.0504473
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0499504
KCTD9 potassium channel tetramerization domain containing 9 -0.0496392
BASP1 brain abundant, membrane attached signal protein 1 -0.0494229
RPL12 ribosomal protein L12 -0.0484772
KRT7 keratin 7, type II -0.0474351
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0460717
RPS27A ribosomal protein S27a -0.0458307
RPS21 ribosomal protein S21 -0.0437911
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0435563
RPL32 ribosomal protein L32 -0.0424192
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0422433
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0421378
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0419143
RPL26 ribosomal protein L26 -0.0415594
RAB1A RAB1A, member RAS oncogene family -0.0413198
STC1 stanniocalcin 1 -0.0400582
NAP1L1 nucleosome assembly protein 1-like 1 -0.0398676
RPS11 ribosomal protein S11 -0.0393433
RPL23 ribosomal protein L23 -0.0375881
KRT18 keratin 18, type I -0.0375172
RPS5 ribosomal protein S5 -0.0374522
RPLP0 ribosomal protein, large, P0 -0.0369042
LMNA lamin A/C -0.0366121
RPS8 ribosomal protein S8 -0.0365703
RPS13 ribosomal protein S13 -0.0352432
PKM pyruvate kinase, muscle -0.034851
RPLP2 ribosomal protein, large, P2 -0.0340916
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0333657
KDM3A lysine (K)-specific demethylase 3A -0.0331722
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0326853
RPL34 ribosomal protein L34 -0.0323323
RPL7A ribosomal protein L7a -0.0322619
TMSB4X thymosin beta 4, X-linked -0.0319089
RSL1D1 ribosomal L1 domain containing 1 -0.0317685
RPL11 ribosomal protein L11 -0.0312612
NDRG1 N-myc downstream regulated 1 -0.031121
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0309302
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0309252
RPS14 ribosomal protein S14 -0.0304887
TKT transketolase -0.0304201
ASTN2 astrotactin 2 -0.0302959
CANX calnexin -0.0297408
RPS23 ribosomal protein S23 -0.029578
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0291705
ASPH aspartate beta-hydroxylase -0.0287241
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0284601
ZSWIM6 zinc finger, SWIM-type containing 6 -0.028454
KPNB1 karyopherin (importin) beta 1 -0.0283291
RPL36A ribosomal protein L36a -0.0281556
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0277063
H1-0 H1.0 linker histone -0.0276468
RPL35A ribosomal protein L35a -0.0266732
VCL vinculin -0.0265163
LOC112694756 uncharaterized LOC112694756 -0.0263209
IER3 immediate early response 3 -0.0262302
MCL1 myeloid cell leukemia 1 -0.0261954
ALCAM activated leukocyte cell adhesion molecule -0.0255844
RPL18 ribosomal protein L18 -0.0255727
TPM4 tropomyosin 4 -0.0254926
HDLBP high density lipoprotein binding protein -0.0250766
FBL fibrillarin -0.0247686
CD99 CD99 molecule -0.0245326
PGK1 phosphoglycerate kinase 1 -0.0244295
FTH1 ferritin, heavy polypeptide 1 -0.0243373
TPI1 triosephosphate isomerase 1 -0.0242899
KLF6 Kruppel-like factor 6 -0.0242768
ACBD3 acyl-CoA binding domain containing 3 -0.024249
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0241509
RRBP1 ribosome binding protein 1 -0.0241446