| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MEST | mesoderm specific transcript | 0.284085 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0984346 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0928332 |
| RPS2 | ribosomal protein S2 | 0.0838275 |
| VIM | vimentin | 0.0786918 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.063236 |
| LDHA | lactate dehydrogenase A | 0.0618195 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0598461 |
| SET | SET nuclear proto-oncogene | 0.057333 |
| RACK1 | receptor for activated C kinase 1 | 0.0566274 |
| PEG10 | paternally expressed 10 | 0.0528718 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0514173 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0512971 |
| VEGFA | vascular endothelial growth factor A | 0.0507666 |
| ZNF292 | zinc finger protein 292 | 0.0483362 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.045723 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0451621 |
| RPS12 | ribosomal protein S12 | 0.0451439 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0432891 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0428002 |
| PCBP2 | poly(rC) binding protein 2 | 0.0423328 |
| RPL37A | ribosomal protein L37a | 0.0419407 |
| RPS3 | ribosomal protein S3 | 0.0416683 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0356774 |
| CALR | calreticulin | 0.0353054 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0347524 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0340814 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0336717 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0334729 |
| PKM | pyruvate kinase, muscle | 0.0330434 |
| IGF2 | insulin-like growth factor 2 | 0.0329672 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0307654 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0297803 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.0279577 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.027657 |
| CENPF | centromere protein F, 350/400kDa | 0.0275577 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 0.0275341 |
| NUP58 | nucleoporin 58 | 0.027434 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0274321 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 0.0274306 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0271447 |
| RPS17 | ribosomal protein S17 | 0.0271025 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0270486 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0269898 |
| KPNA5 | karyopherin alpha 5 (importin alpha 6) | 0.0265521 |
| NUCB2 | nucleobindin 2 | 0.0263193 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0261324 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0258351 |
| RPS8 | ribosomal protein S8 | 0.0257605 |
| CBX3 | chromobox homolog 3 | 0.0256176 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0255549 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0252369 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0250372 |
| NFIB | nuclear factor I/B | 0.0249046 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0247847 |
| EGFR | epidermal growth factor receptor | 0.0244695 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0243916 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0238968 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0238262 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0237633 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0234049 |
| LNPK | lunapark, ER junction formation factor | 0.0233284 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0229584 |
| KIF5B | kinesin family member 5B | 0.0227419 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0227181 |
| TAC4 | tachykinin 4 (hemokinin) | 0.022703 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0226502 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0226397 |
| RPL37 | ribosomal protein L37 | 0.0223981 |
| RBBP4 | retinoblastoma binding protein 4 | 0.022045 |
| KLF10 | Kruppel-like factor 10 | 0.0220444 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0219872 |
| RPLP1 | ribosomal protein, large, P1 | 0.0217514 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0215504 |
| SSR1 | signal sequence receptor, alpha | 0.021514 |
| PFN1 | profilin 1 | 0.0214458 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0212584 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0209383 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0209205 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0207133 |
| NDRG1 | N-myc downstream regulated 1 | 0.0206279 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0205897 |
| MATR3 | matrin 3 | 0.020586 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.0203232 |
| HYOU1 | hypoxia up-regulated 1 | 0.02031 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0202363 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.0201746 |
| PRELID2 | PRELI domain containing 2 | 0.0199174 |
| YBX1 | Y box binding protein 1 | 0.0198472 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0196765 |
| RPL13A | ribosomal protein L13a | 0.0194888 |
| TCERG1 | transcription elongation regulator 1 | 0.0194061 |
| PRKD1 | protein kinase D1 | 0.0193245 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.0193234 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0190709 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0190355 |
| FTL | ferritin, light polypeptide | 0.018945 |
| MKI67 | marker of proliferation Ki-67 | 0.0189145 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0188451 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.0188293 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0839612 |
| JMJD1C | jumonji domain containing 1C | -0.0679447 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0635833 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0634133 |
| HMGA2 | high mobility group AT-hook 2 | -0.0614246 |
| RPS24 | ribosomal protein S24 | -0.0595907 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.0505794 |
| COL1A2 | collagen, type I, alpha 2 | -0.0479934 |
| CADM2 | cell adhesion molecule 2 | -0.0418829 |
| SRPK2 | SRSF protein kinase 2 | -0.0413835 |
| CUX1 | cut-like homeobox 1 | -0.0404023 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0396518 |
| AHNAK | AHNAK nucleoprotein | -0.0390217 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0386058 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0341226 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.033843 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0336485 |
| CANX | calnexin | -0.0329496 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0327603 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0327031 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0324138 |
| RHEB | Ras homolog enriched in brain | -0.0314972 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0301516 |
| IER3 | immediate early response 3 | -0.0298857 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | -0.0298216 |
| MEOX2 | mesenchyme homeobox 2 | -0.0297955 |
| VCL | vinculin | -0.0296538 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0296064 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.0295836 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0286176 |
| PTK2 | protein tyrosine kinase 2 | -0.0281655 |
| TULP4 | tubby like protein 4 | -0.0276319 |
| FOXC1 | forkhead box C1 | -0.0272092 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0269195 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0267248 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0266562 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.0265846 |
| OGA | O-GlcNAcase | -0.0265435 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.026521 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0258983 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0252884 |
| PRRC2B | proline-rich coiled-coil 2B | -0.025179 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0250775 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.0249552 |
| RANBP17 | RAN binding protein 17 | -0.0246417 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0245231 |
| DIAPH3 | diaphanous-related formin 3 | -0.0243817 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0243706 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | -0.0239925 |
| RNF38 | ring finger protein 38 | -0.0239016 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | -0.0236693 |
| HDAC8 | histone deacetylase 8 | -0.0236548 |
| MTAP | methylthioadenosine phosphorylase | -0.0232404 |
| PTMA | prothymosin, alpha | -0.0229973 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0227789 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0227587 |
| USP34 | ubiquitin specific peptidase 34 | -0.0226234 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0225859 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0224937 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0224171 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0223128 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0223092 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.0221747 |
| RPS6 | ribosomal protein S6 | -0.0220209 |
| STIL | SCL/TAL1 interrupting locus | -0.0217771 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0216499 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0216366 |
| CTBP2 | C-terminal binding protein 2 | -0.0216207 |
| RPLP0 | ribosomal protein, large, P0 | -0.0216036 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.02148 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0213639 |
| RPS27A | ribosomal protein S27a | -0.02111 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0209666 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | -0.0209271 |
| TUBB | tubulin, beta class I | -0.0207374 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0205791 |
| PAXBP1 | PAX3 and PAX7 binding protein 1 | -0.0205113 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0204515 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0204072 |
| DENND5A | DENN/MADD domain containing 5A | -0.0203718 |
| MED13 | mediator complex subunit 13 | -0.0202974 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0202919 |
| HIP1 | huntingtin interacting protein 1 | -0.0201458 |
| GOLGB1 | golgin B1 | -0.0199988 |
| KIAA0232 | KIAA0232 | -0.0199587 |
| GATAD2A | GATA zinc finger domain containing 2A | -0.0199483 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0199262 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0199029 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | -0.0198894 |
| CD2AP | CD2-associated protein | -0.0198666 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0198185 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.0198123 |
| TCF12 | transcription factor 12 | -0.0197692 |
| DEK | DEK proto-oncogene | -0.0196149 |
| KLHL7 | kelch-like family member 7 | -0.0195962 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0195927 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0195247 |
| VPS13D | vacuolar protein sorting 13 homolog D (S. cerevisiae) | -0.0194509 |
| SLMAP | sarcolemma associated protein | -0.0194232 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0193296 |
