Pexidartinib (hydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.176249
FLNB filamin B, beta 0.134057
MUC17 mucin 17, cell surface associated 0.114721
EFNA5 ephrin-A5 0.0737239
ITGA6 integrin, alpha 6 0.069091
EGFR epidermal growth factor receptor 0.0603255
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0566025
VCAN versican 0.0547579
ESYT2 extended synaptotagmin-like protein 2 0.0499971
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0498434
PSD3 pleckstrin and Sec7 domain containing 3 0.0494844
RCOR1 REST corepressor 1 0.0452921
GRB10 growth factor receptor-bound protein 10 0.0447089
IGFBP3 insulin-like growth factor binding protein 3 0.0424617
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0391711
ERRFI1 ERBB receptor feedback inhibitor 1 0.0388372
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0359913
STK39 serine threonine kinase 39 0.0347697
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0342376
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0326565
SPTBN1 spectrin, beta, non-erythrocytic 1 0.032554
SLK STE20-like kinase 0.0320274
ITPRID2 ITPR interacting domain containing 2 0.0318875
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.031504
UBA6 ubiquitin-like modifier activating enzyme 6 0.0312446
TGM2 transglutaminase 2 0.0311436
CD59 CD59 molecule, complement regulatory protein 0.0305476
DOCK5 dedicator of cytokinesis 5 0.0301705
FNDC3B fibronectin type III domain containing 3B 0.0293703
GLS2 glutaminase 2 (liver, mitochondrial) 0.0289578
AKAP13 A kinase (PRKA) anchor protein 13 0.0289422
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0285784
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0282865
LDHA lactate dehydrogenase A 0.0277416
FAM13A family with sequence similarity 13, member A 0.0270467
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0266919
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0255327
PRELID2 PRELI domain containing 2 0.025459
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0250693
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0246562
PICALM phosphatidylinositol binding clathrin assembly protein 0.0244872
EEF2 eukaryotic translation elongation factor 2 0.0235445
MSN moesin 0.0234193
CAPRIN2 caprin family member 2 0.0233828
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0229158
PRSS3 protease, serine, 3 0.0228171
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0221337
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0220046
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0219609
PCBP2 poly(rC) binding protein 2 0.0216423
CTBP2 C-terminal binding protein 2 0.0216239
FOXO1 forkhead box O1 0.0214698
DSPP dentin sialophosphoprotein 0.0212642
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0209899
DIAPH2 diaphanous-related formin 2 0.0209188
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0207746
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0207012
ARRDC3 arrestin domain containing 3 0.0205624
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0205012
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0204943
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0204564
SULF2 sulfatase 2 0.0203967
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0203016
DPY19L1 dpy-19-like 1 (C. elegans) 0.0202891
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0200499
MYH9 myosin, heavy chain 9, non-muscle 0.0197046
MACF1 microtubule-actin crosslinking factor 1 0.019311
SLC38A2 solute carrier family 38, member 2 0.0192377
ARHGAP42 Rho GTPase activating protein 42 0.0191126
OXSR1 oxidative stress responsive 1 0.0191031
ERBIN erbb2 interacting protein 0.0188821
DPYSL2 dihydropyrimidinase-like 2 0.0188627
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0188371
NPAS2 neuronal PAS domain protein 2 0.0186148
SLC35F3 solute carrier family 35, member F3 0.0183258
KCMF1 potassium channel modulatory factor 1 0.0166177
FMNL2 formin-like 2 0.016346
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.016248
TRIB1 tribbles pseudokinase 1 0.0162286
RHOF ras homolog family member F (in filopodia) 0.0160005
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0156798
KIF16B kinesin family member 16B 0.0155534
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0152657
KIAA0040 KIAA0040 0.0152375
SLC35F5 solute carrier family 35, member F5 0.0152049
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0147505
LAMC2 laminin, gamma 2 0.0142014
NECTIN1 nectin cell adhesion molecule 1 0.0141882
OSMR oncostatin M receptor 0.0139889
EFNB2 ephrin-B2 0.0139592
FLNA filamin A, alpha 0.0138944
LAMA4 laminin, alpha 4 0.0135938
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0133872
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0133841
MPRIP myosin phosphatase Rho interacting protein 0.0133815
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0132955
FA2H fatty acid 2-hydroxylase 0.0131717
TSC22D2 TSC22 domain family, member 2 0.0131317
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.013127
MAML2 mastermind-like 2 (Drosophila) 0.0131025

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.207327
PTMA prothymosin, alpha -0.166175
TPT1 tumor protein, translationally-controlled 1 -0.122293
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0894578
AHNAK AHNAK nucleoprotein -0.0834549
VIM vimentin -0.073847
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0696196
S100A10 S100 calcium binding protein A10 -0.0689936
LAMB3 laminin, beta 3 -0.0620691
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0594725
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0570055
LMTK2 lemur tyrosine kinase 2 -0.054785
RPL12 ribosomal protein L12 -0.0524602
TM4SF1 transmembrane 4 L six family member 1 -0.0500541
ACTG1 actin gamma 1 -0.0493917
SQSTM1 sequestosome 1 -0.0486678
RPL8 ribosomal protein L8 -0.0478381
S100A6 S100 calcium binding protein A6 -0.0467556
RPS27A ribosomal protein S27a -0.0455951
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0440261
SDC4 syndecan 4 -0.043509
RAB1A RAB1A, member RAS oncogene family -0.0432764
RPS8 ribosomal protein S8 -0.0428741
FTL ferritin, light polypeptide -0.0425928
RPLP1 ribosomal protein, large, P1 -0.0422371
RPS21 ribosomal protein S21 -0.0406549
RPS6 ribosomal protein S6 -0.0402905
RPS13 ribosomal protein S13 -0.040285
RPL31 ribosomal protein L31 -0.0399825
RPS24 ribosomal protein S24 -0.0398118
TXNRD1 thioredoxin reductase 1 -0.0395401
RRBP1 ribosome binding protein 1 -0.0395135
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0394658
CANX calnexin -0.0392574
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0389563
KRT18 keratin 18, type I -0.038644
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0382205
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0380909
EIF1 eukaryotic translation initiation factor 1 -0.0372947
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0369245
TRA2A transformer 2 alpha homolog (Drosophila) -0.0364209
RAD21 RAD21 homolog (S. pombe) -0.0359973
RPLP2 ribosomal protein, large, P2 -0.0358366
RPL34 ribosomal protein L34 -0.0358162
S100A4 S100 calcium binding protein A4 -0.0352365
IER3 immediate early response 3 -0.0345259
ANXA2 annexin A2 -0.0341548
RPL37A ribosomal protein L37a -0.0335069
RPL35A ribosomal protein L35a -0.0330382
H1-0 H1.0 linker histone -0.0329105
GCC2 GRIP and coiled-coil domain containing 2 -0.0320527
RPL23 ribosomal protein L23 -0.0298941
NAP1L1 nucleosome assembly protein 1-like 1 -0.0292174
TMSB4X thymosin beta 4, X-linked -0.0287465
RSL1D1 ribosomal L1 domain containing 1 -0.0286295
RPL26 ribosomal protein L26 -0.0285657
TOP1 topoisomerase (DNA) I -0.0285571
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0284002
RPL36A ribosomal protein L36a -0.0282906
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0280686
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0280433
STAU1 staufen double-stranded RNA binding protein 1 -0.0280233
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0279618
RPS25 ribosomal protein S25 -0.027742
HDLBP high density lipoprotein binding protein -0.027665
EPCAM epithelial cell adhesion molecule -0.0275677
UBC ubiquitin C -0.02729
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0272188
KRT8 keratin 8, type II -0.0270843
RBM39 RNA binding motif protein 39 -0.0266222
MYL12B myosin, light chain 12B, regulatory -0.0263187
GNAS GNAS complex locus -0.0262556
NOP58 NOP58 ribonucleoprotein -0.0261915
RPL11 ribosomal protein L11 -0.0261206
RPL27A ribosomal protein L27a -0.0260039
KLK10 kallikrein-related peptidase 10 -0.0256635
OGA O-GlcNAcase -0.0256499
RPL7A ribosomal protein L7a -0.0251206
B2M beta-2-microglobulin -0.0249731
RPS14 ribosomal protein S14 -0.024894
RPS19 ribosomal protein S19 -0.024771
NAMPT nicotinamide phosphoribosyltransferase -0.0247604
BZW1 basic leucine zipper and W2 domains 1 -0.0245925
RPL9 ribosomal protein L9 -0.0245599
GARS1 glycyl-tRNA synthetase 1 -0.0244677
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0244314
GOLGA4 golgin A4 -0.0242528
WASF2 WAS protein family, member 2 -0.0242083
CD2AP CD2-associated protein -0.0241644
CELF1 CUGBP, Elav-like family member 1 -0.0239023
RPS23 ribosomal protein S23 -0.0233494
RPS20 ribosomal protein S20 -0.0230707
PRRC2C proline-rich coiled-coil 2C -0.0226538
RAB7A RAB7A, member RAS oncogene family -0.0224907
PTK2 protein tyrosine kinase 2 -0.0224869
ASPH aspartate beta-hydroxylase -0.0224868
RPL37 ribosomal protein L37 -0.0224486
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0224421
OLA1 Obg-like ATPase 1 -0.0220718
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0220558