Pexidartinib (hydrochloride)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEMIP cell migration inducing protein, hyaluronan binding 0.0749348
ANKRD36C ankyrin repeat domain 36C 0.043546
ASPH aspartate beta-hydroxylase 0.0382549
THSD4 thrombospondin, type I, domain containing 4 0.0298743
ITGB6 integrin, beta 6 0.0291742
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0263303
FTH1 ferritin, heavy polypeptide 1 0.0234929
CATSPERB catsper channel auxiliary subunit beta 0.0207263
OSMR oncostatin M receptor 0.0199867
KDM7A lysine (K)-specific demethylase 7A 0.019417
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0189184
LPP LIM domain containing preferred translocation partner in lipoma 0.0189037
YPEL2 yippee-like 2 (Drosophila) 0.0187052
TNIK TRAF2 and NCK interacting kinase 0.0182443
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0177913
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0174967
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0172513
CD24 CD24 molecule 0.0171165
TRPS1 trichorhinophalangeal syndrome I 0.017073
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0170088
TENM2 teneurin transmembrane protein 2 0.0163727
GRB10 growth factor receptor-bound protein 10 0.0161074
SRCIN1 SRC kinase signaling inhibitor 1 0.016106
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0157826
SLC22A23 solute carrier family 22, member 23 0.0157498
TOM1L1 target of myb1 (chicken)-like 1 0.0157118
ERBB2 erb-b2 receptor tyrosine kinase 2 0.0157094
MBNL2 muscleblind-like splicing regulator 2 0.0156288
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 0.0152438
KIAA1217 KIAA1217 0.0147602
CEP250 centrosomal protein 250kDa 0.0146228
VAV3 vav 3 guanine nucleotide exchange factor 0.0143353
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0141395
EEF2 eukaryotic translation elongation factor 2 0.0139283
LIMCH1 LIM and calponin homology domains 1 0.0133491
EGFR epidermal growth factor receptor 0.0125191
FASN fatty acid synthase 0.0124734
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0122612
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.012241
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0122256
PIAS2 protein inhibitor of activated STAT, 2 0.0120869
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.012086
CCNL1 cyclin L1 0.0119516
FNDC3A fibronectin type III domain containing 3A 0.0118236
PLK2 polo-like kinase 2 0.0117373
DUSP16 dual specificity phosphatase 16 0.0117312
DTNA dystrobrevin, alpha 0.0116448
AHR aryl hydrocarbon receptor 0.0113668
SAMD5 sterile alpha motif domain containing 5 0.0112696
EPPK1 epiplakin 1 0.0109153
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0108535
NAMPT nicotinamide phosphoribosyltransferase 0.0106622
CXCL8 chemokine (C-X-C motif) ligand 8 0.0106497
ELOVL5 ELOVL fatty acid elongase 5 0.0105855
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0104914
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0104563
ABHD17C abhydrolase domain containing 17C 0.0104015
USP53 ubiquitin specific peptidase 53 0.0103705
TC2N tandem C2 domains, nuclear 0.0103034
AMPD3 adenosine monophosphate deaminase 3 0.010296
SET SET nuclear proto-oncogene 0.0102176
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0101554
PRELID2 PRELI domain containing 2 0.0101237
ZBTB20 zinc finger and BTB domain containing 20 0.0101144
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.0100656
CLMN calmin (calponin-like, transmembrane) 0.0100304
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.00998283
SHROOM3 shroom family member 3 0.00989746
FNDC3B fibronectin type III domain containing 3B 0.00975289
INSR insulin receptor 0.00972284
UBA6 ubiquitin-like modifier activating enzyme 6 0.00971824
FRMD6 FERM domain containing 6 0.00962038
MYO1B myosin IB 0.0095228
RAB22A RAB22A, member RAS oncogene family 0.00947479
TMEM45B transmembrane protein 45B 0.00930199
RUNX2 runt-related transcription factor 2 0.00928263
CFB complement factor B 0.00925875
RREB1 ras responsive element binding protein 1 0.00906273
SOS2 son of sevenless homolog 2 (Drosophila) 0.00904956
TMC5 transmembrane channel-like 5 0.00896985
ARID5B AT rich interactive domain 5B (MRF1-like) 0.00895905
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.00888987
PTEN phosphatase and tensin homolog 0.0088482
ICAM1 intercellular adhesion molecule 1 0.00875696
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.00872254
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00865253
MTSS1 metastasis suppressor 1 0.00863251
HSPA8 heat shock 70kDa protein 8 0.00851373
ADGRG6 adhesion G protein-coupled receptor G6 0.00832595
ZNF292 zinc finger protein 292 0.00827512
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.00827356
RPS2 ribosomal protein S2 0.00827046
METTL15 methyltransferase like 15 0.00821071
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00819371
FAM13A family with sequence similarity 13, member A 0.00818915
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.00817448
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.00809811
LCOR ligand dependent nuclear receptor corepressor 0.00808027
GSK3B glycogen synthase kinase 3 beta 0.0078519
MYO10 myosin X 0.00779169

decreased expression

Symbol Name Standardized Value
RPL19 ribosomal protein L19 -0.373085
RPL23 ribosomal protein L23 -0.372587
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.127219
PTMA prothymosin, alpha -0.118592
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.103977
CDK12 cyclin-dependent kinase 12 -0.0995734
MT2A metallothionein 2A -0.0968392
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0813117
TPT1 tumor protein, translationally-controlled 1 -0.0789721
TMSB10 thymosin beta 10 -0.0780716
RPS3 ribosomal protein S3 -0.0632161
ACTG1 actin gamma 1 -0.0628901
RPL35A ribosomal protein L35a -0.0625921
RPL12 ribosomal protein L12 -0.0588463
RPS19 ribosomal protein S19 -0.0538383
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.051852
LASP1 LIM and SH3 protein 1 -0.0486222
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0469705
RPS6 ribosomal protein S6 -0.0455609
FBXL20 F-box and leucine-rich repeat protein 20 -0.045193
RPLP1 ribosomal protein, large, P1 -0.0439745
RPS29 ribosomal protein S29 -0.0430709
MYL12B myosin, light chain 12B, regulatory -0.0421472
PRRC2C proline-rich coiled-coil 2C -0.0406028
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0403713
S100A9 S100 calcium binding protein A9 -0.0401275
B2M beta-2-microglobulin -0.0398526
IFI6 interferon, alpha-inducible protein 6 -0.0396649
PFDN4 prefoldin subunit 4 -0.0395619
RPS8 ribosomal protein S8 -0.0387793
LMNA lamin A/C -0.0377659
RPS24 ribosomal protein S24 -0.0375117
RPL8 ribosomal protein L8 -0.0371873
RPL37A ribosomal protein L37a -0.0366888
GRB7 growth factor receptor-bound protein 7 -0.0366088
RPL31 ribosomal protein L31 -0.0359666
S100A8 S100 calcium binding protein A8 -0.0357864
RPL34 ribosomal protein L34 -0.0353682
RPL37 ribosomal protein L37 -0.0351542
SLC38A1 solute carrier family 38, member 1 -0.0349056
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0348062
CCNI cyclin I -0.034769
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -0.0344965
GNAS GNAS complex locus -0.0338442
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0336178
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0334874
WSB1 WD repeat and SOCS box containing 1 -0.0333207
HLA-B major histocompatibility complex, class I, B -0.0331068
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0329378
TMSB4X thymosin beta 4, X-linked -0.0329343
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -0.0324981
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0320921
RPL35 ribosomal protein L35 -0.03205
RPS13 ribosomal protein S13 -0.0316565
RPL7A ribosomal protein L7a -0.0313493
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0313392
ENO1 enolase 1, (alpha) -0.0312003
LOC102724023 ES1 protein homolog, mitochondrial -0.0309816
DYNLRB1 dynein, light chain, roadblock-type 1 -0.030962
HLA-C major histocompatibility complex, class I, C -0.0303449
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0300958
RPLP0 ribosomal protein, large, P0 -0.0292379
RRBP1 ribosome binding protein 1 -0.0283201
RPL32 ribosomal protein L32 -0.0282145
FTL ferritin, light polypeptide -0.0281628
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0280546
RPL9 ribosomal protein L9 -0.0277539
AHNAK AHNAK nucleoprotein -0.0276144
MCL1 myeloid cell leukemia 1 -0.026362
RPL36 ribosomal protein L36 -0.026211
STAU1 staufen double-stranded RNA binding protein 1 -0.0261687
RPL5 ribosomal protein L5 -0.0259741
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0255651
VCP valosin containing protein -0.0253571
PRRC2B proline-rich coiled-coil 2B -0.0251399
EIF5B eukaryotic translation initiation factor 5B -0.0251149
MDK midkine (neurite growth-promoting factor 2) -0.0250003
RPL30 ribosomal protein L30 -0.0247341
EIF1 eukaryotic translation initiation factor 1 -0.0246871
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0246197
UBC ubiquitin C -0.0245911
RPL27A ribosomal protein L27a -0.0244459
MTDH metadherin -0.0243049
RPS27A ribosomal protein S27a -0.0239581
RPL26 ribosomal protein L26 -0.0239321
RPS16 ribosomal protein S16 -0.0237991
RPS17 ribosomal protein S17 -0.023693
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0229418
MIEN1 migration and invasion enhancer 1 -0.0229217
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0228823
S100A14 S100 calcium binding protein A14 -0.0226919
HMGB1 high mobility group box 1 -0.0223484
RPS21 ribosomal protein S21 -0.0220469
RPS15 ribosomal protein S15 -0.0220441
SERF2 small EDRK-rich factor 2 -0.0217888
RPS14 ribosomal protein S14 -0.0217034
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0215981
RAB7A RAB7A, member RAS oncogene family -0.0215749
RPL28 ribosomal protein L28 -0.02154
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0215336