Pexidartinib (hydrochloride)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.177706
F3 coagulation factor III (thromboplastin, tissue factor) 0.136574
LAMB3 laminin, beta 3 0.134322
IGFBP3 insulin-like growth factor binding protein 3 0.132723
NDRG1 N-myc downstream regulated 1 0.125128
CXCL8 chemokine (C-X-C motif) ligand 8 0.10633
ACTG1 actin gamma 1 0.103877
LAMC2 laminin, gamma 2 0.0873616
DTNA dystrobrevin, alpha 0.0777122
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.076094
DST dystonin 0.0743029
FTH1 ferritin, heavy polypeptide 1 0.0726665
NAMPT nicotinamide phosphoribosyltransferase 0.0725103
PGK1 phosphoglycerate kinase 1 0.0724215
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0709762
TRIO trio Rho guanine nucleotide exchange factor 0.0690755
FAM13A family with sequence similarity 13, member A 0.0681093
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0593894
MAP1B microtubule-associated protein 1B 0.0578802
BIRC3 baculoviral IAP repeat containing 3 0.056621
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0550836
MAML2 mastermind-like 2 (Drosophila) 0.0549834
LAMA4 laminin, alpha 4 0.0549482
MEF2A myocyte enhancer factor 2A 0.0522038
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0518576
KLF6 Kruppel-like factor 6 0.050389
MMP7 matrix metallopeptidase 7 0.0499045
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0493557
RPS2 ribosomal protein S2 0.0489159
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0476212
ESYT2 extended synaptotagmin-like protein 2 0.0473628
KMT2C lysine (K)-specific methyltransferase 2C 0.0466259
HMGA1 high mobility group AT-hook 1 0.0461904
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.045167
UBA6 ubiquitin-like modifier activating enzyme 6 0.0440112
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0439305
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0439187
BACE2 beta-site APP-cleaving enzyme 2 0.0435371
RAD51B RAD51 paralog B 0.0423085
ERRFI1 ERBB receptor feedback inhibitor 1 0.04027
EHBP1 EH domain binding protein 1 0.0398415
KRT19 keratin 19, type I 0.0395655
LPP LIM domain containing preferred translocation partner in lipoma 0.0395556
GRB10 growth factor receptor-bound protein 10 0.0389426
BZW1 basic leucine zipper and W2 domains 1 0.0386615
ASPH aspartate beta-hydroxylase 0.035683
DDIT4 DNA-damage-inducible transcript 4 0.0356219
FNDC3B fibronectin type III domain containing 3B 0.0355395
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0353764
MXI1 MAX interactor 1, dimerization protein 0.0352233
MACC1 metastasis associated in colon cancer 1 0.0351005
TMSB4X thymosin beta 4, X-linked 0.0337069
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0336951
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0332054
NCKAP5 NCK-associated protein 5 0.0329451
ALCAM activated leukocyte cell adhesion molecule 0.032486
MKI67 marker of proliferation Ki-67 0.0320684
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0319648
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0313834
SPAG9 sperm associated antigen 9 0.031019
PLAU plasminogen activator, urokinase 0.0307269
PICALM phosphatidylinositol binding clathrin assembly protein 0.0306714
MACF1 microtubule-actin crosslinking factor 1 0.0304306
CLTC clathrin, heavy chain (Hc) 0.0293586
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0289859
RACK1 receptor for activated C kinase 1 0.028867
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0284027
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0277066
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0268518
YEATS2 YEATS domain containing 2 0.026554
RIN2 Ras and Rab interactor 2 0.0265351
MBNL1 muscleblind-like splicing regulator 1 0.0263703
POTEF POTE ankyrin domain family, member F 0.0263002
ELL2 elongation factor, RNA polymerase II, 2 0.0262054
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0260231
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0259973
STC2 stanniocalcin 2 0.0258667
S100A6 S100 calcium binding protein A6 0.0257749
FLNB filamin B, beta 0.0257257
JUP junction plakoglobin 0.0255536
EZR ezrin 0.0252047
AKAP9 A kinase (PRKA) anchor protein 9 0.024993
SLTM SAFB-like, transcription modulator 0.0245999
NFE2L1 nuclear factor, erythroid 2-like 1 0.0244075
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0243616
FAT1 FAT atypical cadherin 1 0.0242388
PDZD8 PDZ domain containing 8 0.024137
CDC73 cell division cycle 73 0.0240792
LDHA lactate dehydrogenase A 0.0238219
HELZ helicase with zinc finger 0.0236626
DSPP dentin sialophosphoprotein 0.0236471
ANXA1 annexin A1 0.0236154
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0235776
KIF5B kinesin family member 5B 0.0232585
FLNA filamin A, alpha 0.0230738
KMT2E lysine (K)-specific methyltransferase 2E 0.022783
KLF5 Kruppel-like factor 5 (intestinal) 0.0227377
DEPP1 DEPP autophagy regulator 1 0.022648
RAB8B RAB8B, member RAS oncogene family 0.0225883
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0225461

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.225176
UBC ubiquitin C -0.207358
PTMA prothymosin, alpha -0.172645
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.121965
AHNAK AHNAK nucleoprotein -0.116275
TMSB10 thymosin beta 10 -0.104525
MT2A metallothionein 2A -0.0869041
HLA-B major histocompatibility complex, class I, B -0.0847092
TPT1 tumor protein, translationally-controlled 1 -0.0787893
RPS27A ribosomal protein S27a -0.0666407
RPL23 ribosomal protein L23 -0.0619351
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0586524
RPL19 ribosomal protein L19 -0.0549976
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0458476
RPS29 ribosomal protein S29 -0.04546
TM4SF1 transmembrane 4 L six family member 1 -0.0447692
RPS21 ribosomal protein S21 -0.0427127
S100A10 S100 calcium binding protein A10 -0.042353
RPS23 ribosomal protein S23 -0.0399586
UBE2H ubiquitin-conjugating enzyme E2H -0.0399023
PDIA4 protein disulfide isomerase family A, member 4 -0.0397368
MCL1 myeloid cell leukemia 1 -0.0396734
OGA O-GlcNAcase -0.036815
RPS24 ribosomal protein S24 -0.0357053
APOL1 apolipoprotein L, 1 -0.0345451
SDC4 syndecan 4 -0.0336511
FAM3C family with sequence similarity 3, member C -0.0324115
RPS25 ribosomal protein S25 -0.0324056
ANKRD11 ankyrin repeat domain 11 -0.032177
JUN jun proto-oncogene -0.0313212
FTL ferritin, light polypeptide -0.0310286
TXNIP thioredoxin interacting protein -0.0307617
RPL34 ribosomal protein L34 -0.0300574
RPL9 ribosomal protein L9 -0.029868
RPL28 ribosomal protein L28 -0.0294767
RPLP2 ribosomal protein, large, P2 -0.0292877
CANX calnexin -0.0290535
PPARD peroxisome proliferator-activated receptor delta -0.0286435
PCBP2 poly(rC) binding protein 2 -0.0283979
RPS6 ribosomal protein S6 -0.0283496
RPL31 ribosomal protein L31 -0.0282543
RPS11 ribosomal protein S11 -0.027905
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0276149
BRD2 bromodomain containing 2 -0.0273267
FUS FUS RNA binding protein -0.0267688
IER3 immediate early response 3 -0.0254674
EIF1 eukaryotic translation initiation factor 1 -0.0247672
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0243163
NOP58 NOP58 ribonucleoprotein -0.0239079
TOP1 topoisomerase (DNA) I -0.0238426
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0238189
AREG amphiregulin -0.0236819
DENND4A DENN/MADD domain containing 4A -0.023661
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0236551
CDK12 cyclin-dependent kinase 12 -0.0234225
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0234132
VMP1 vacuole membrane protein 1 -0.0234095
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0233174
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0231578
RPL36A ribosomal protein L36a -0.0227029
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.02269
RPLP1 ribosomal protein, large, P1 -0.0223199
RPL8 ribosomal protein L8 -0.0223027
NRG3 neuregulin 3 -0.0216014
MT1X metallothionein 1X -0.0214952
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0214664
RPS13 ribosomal protein S13 -0.0214033
RPS15 ribosomal protein S15 -0.0211416
RPS5 ribosomal protein S5 -0.0209239
MDK midkine (neurite growth-promoting factor 2) -0.020915
SP100 SP100 nuclear antigen -0.0206908
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.020353
RPS8 ribosomal protein S8 -0.0202164
RHEB Ras homolog enriched in brain -0.0201945
RPS10 ribosomal protein S10 -0.0199616
RAB1A RAB1A, member RAS oncogene family -0.0197539
TAOK3 TAO kinase 3 -0.01969
DSCAM Down syndrome cell adhesion molecule -0.0194298
TPM1 tropomyosin 1 (alpha) -0.0191401
APOL2 apolipoprotein L, 2 -0.019061
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.019003
ISG15 ISG15 ubiquitin-like modifier -0.0188902
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0186091
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0183976
H3-3B H3.3 histone B -0.0182777
ANXA11 annexin A11 -0.0182542
NT5C2 5'-nucleotidase, cytosolic II -0.0182184
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0181206
GCC2 GRIP and coiled-coil domain containing 2 -0.0180668
RPS16 ribosomal protein S16 -0.0180117
GOLGB1 golgin B1 -0.0179975
CFLAR CASP8 and FADD-like apoptosis regulator -0.0179909
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0178375
C15ORF48 chromosome 15 open reading frame 48 -0.0177675
HLA-A major histocompatibility complex, class I, A -0.0174405
BCL2L1 BCL2-like 1 -0.017283
TUFT1 tuftelin 1 -0.0170583
ATP5F1B ATP synthase F1 subunit beta -0.0167547
CLIC4 chloride intracellular channel 4 -0.0167206
RBM39 RNA binding motif protein 39 -0.0166184