Pexidartinib (hydrochloride)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.154576
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.134639
MEIS2 Meis homeobox 2 0.113677
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.10641
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0919768
SOS1 son of sevenless homolog 1 (Drosophila) 0.0824487
FAM13A family with sequence similarity 13, member A 0.0807628
MAP1B microtubule-associated protein 1B 0.0728227
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0695439
HELZ helicase with zinc finger 0.0489737
MEF2A myocyte enhancer factor 2A 0.0481218
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0473152
CD36 CD36 molecule (thrombospondin receptor) 0.0455998
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0444814
ZNF292 zinc finger protein 292 0.0440474
ANGPT1 angiopoietin 1 0.0439249
EEF2 eukaryotic translation elongation factor 2 0.0416912
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0406444
MBNL2 muscleblind-like splicing regulator 2 0.0390581
LINGO2 leucine rich repeat and Ig domain containing 2 0.0385187
TRIO trio Rho guanine nucleotide exchange factor 0.0347722
YEATS2 YEATS domain containing 2 0.0343165
DST dystonin 0.0341341
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0334338
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0320565
LIMCH1 LIM and calponin homology domains 1 0.0320215
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0309358
FNDC3B fibronectin type III domain containing 3B 0.0300814
SLITRK6 SLIT and NTRK-like family, member 6 0.0300707
PTPRD protein tyrosine phosphatase, receptor type, D 0.029999
NFE2L1 nuclear factor, erythroid 2-like 1 0.0298177
ADGRG6 adhesion G protein-coupled receptor G6 0.0296769
PDE4D phosphodiesterase 4D, cAMP-specific 0.0295223
ZNF148 zinc finger protein 148 0.0294046
KCTD3 potassium channel tetramerization domain containing 3 0.0283844
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0282172
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0276889
PIAS2 protein inhibitor of activated STAT, 2 0.0276425
KMT2E lysine (K)-specific methyltransferase 2E 0.027544
ARHGAP9 Rho GTPase activating protein 9 0.0274887
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0274404
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.027256
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0270008
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.0269941
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0265921
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0264749
RFX7 regulatory factor X, 7 0.0264739
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0264587
PTEN phosphatase and tensin homolog 0.0259067
BBX bobby sox homolog (Drosophila) 0.0254728
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0251654
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0248902
ESYT2 extended synaptotagmin-like protein 2 0.0247053
FNBP1 formin binding protein 1 0.0245609
PCBP2 poly(rC) binding protein 2 0.0244931
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0242236
PSD3 pleckstrin and Sec7 domain containing 3 0.0239824
CENPF centromere protein F, 350/400kDa 0.0237716
DTNA dystrobrevin, alpha 0.023716
MXI1 MAX interactor 1, dimerization protein 0.0234731
DDIT4 DNA-damage-inducible transcript 4 0.0232435
TMEM131 transmembrane protein 131 0.0228862
FRMD6 FERM domain containing 6 0.022401
HMBOX1 homeobox containing 1 0.0220346
UBA6 ubiquitin-like modifier activating enzyme 6 0.0218039
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0217416
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0216958
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0216258
NDRG1 N-myc downstream regulated 1 0.0215252
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0214792
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0212101
ASPH aspartate beta-hydroxylase 0.021033
PCDH9 protocadherin 9 0.0210073
PCM1 pericentriolar material 1 0.0207727
ZMIZ1 zinc finger, MIZ-type containing 1 0.0206018
NAMPT nicotinamide phosphoribosyltransferase 0.0205666
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0205508
CD46 CD46 molecule, complement regulatory protein 0.020175
NGLY1 N-glycanase 1 0.0200943
ITPRID2 ITPR interacting domain containing 2 0.0197132
NEK7 NIMA-related kinase 7 0.0196288
RALYL RALY RNA binding protein-like 0.0195957
NCAM2 neural cell adhesion molecule 2 0.0195625
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0190741
RTN4 reticulon 4 0.018936
SCARB2 scavenger receptor class B, member 2 0.0188688
EPHA3 EPH receptor A3 0.0188291
SET SET nuclear proto-oncogene 0.0187367
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0186998
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0186302
TET2 tet methylcytosine dioxygenase 2 0.018609
SDK1 sidekick cell adhesion molecule 1 0.0186008
WDR43 WD repeat domain 43 0.0185821
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0184637
SOX9 SRY (sex determining region Y)-box 9 0.0181064
RAB30 RAB30, member RAS oncogene family 0.0179808
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0178681
SYT1 synaptotagmin I 0.0176693
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0176628
TRIM9 tripartite motif containing 9 0.0175214

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.223142
VCL vinculin -0.181964
PTMA prothymosin, alpha -0.148697
TPT1 tumor protein, translationally-controlled 1 -0.0984389
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0889257
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.08601
RPL38 ribosomal protein L38 -0.0845836
RPL34 ribosomal protein L34 -0.0831079
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0795723
EXT1 exostosin glycosyltransferase 1 -0.0790465
RPL19 ribosomal protein L19 -0.0779471
LSAMP limbic system-associated membrane protein -0.0766841
RPS6 ribosomal protein S6 -0.07629
RPLP1 ribosomal protein, large, P1 -0.07615
RPL23 ribosomal protein L23 -0.076021
RPL35A ribosomal protein L35a -0.0694062
TPM1 tropomyosin 1 (alpha) -0.0663757
ACTG1 actin gamma 1 -0.0632433
EGR1 early growth response 1 -0.0630151
TMSB10 thymosin beta 10 -0.0585254
RPS24 ribosomal protein S24 -0.0578623
COL1A1 collagen, type I, alpha 1 -0.052824
FMN1 formin 1 -0.0523843
RPL31 ribosomal protein L31 -0.0512818
IER3 immediate early response 3 -0.0512641
NALF1 NALCN channel auxiliary factor 1 -0.0495321
THSD4 thrombospondin, type I, domain containing 4 -0.0474912
EIF1 eukaryotic translation initiation factor 1 -0.0467325
RPS19 ribosomal protein S19 -0.0465858
TLE4 transducin-like enhancer of split 4 -0.0459263
GLCCI1 glucocorticoid induced 1 -0.0457204
CUX1 cut-like homeobox 1 -0.0449504
VMP1 vacuole membrane protein 1 -0.0443752
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0410449
RPL32 ribosomal protein L32 -0.0408463
BCAS3 breast carcinoma amplified sequence 3 -0.0406662
RPL12 ribosomal protein L12 -0.0402583
RPL26 ribosomal protein L26 -0.0399677
TPM4 tropomyosin 4 -0.0398451
H3-3B H3.3 histone B -0.0396618
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0388732
DNAH14 dynein, axonemal, heavy chain 14 -0.0384231
S100A9 S100 calcium binding protein A9 -0.037652
RPL37A ribosomal protein L37a -0.0371445
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0371381
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0360148
RPS27A ribosomal protein S27a -0.0354715
RPS23 ribosomal protein S23 -0.0352621
MCL1 myeloid cell leukemia 1 -0.0351868
FNDC3A fibronectin type III domain containing 3A -0.0350596
CCDC47 coiled-coil domain containing 47 -0.0350248
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0349741
BPTF bromodomain PHD finger transcription factor -0.0347244
RPS11 ribosomal protein S11 -0.0342632
VIM vimentin -0.0342136
RPL7A ribosomal protein L7a -0.0339642
STK38L serine/threonine kinase 38 like -0.033921
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0333998
FTL ferritin, light polypeptide -0.0332738
NPAS2 neuronal PAS domain protein 2 -0.0331866
RPS21 ribosomal protein S21 -0.032977
RPL36A ribosomal protein L36a -0.0324563
PRKCA protein kinase C, alpha -0.0322681
B2M beta-2-microglobulin -0.031776
INTS6 integrator complex subunit 6 -0.0315586
MED13 mediator complex subunit 13 -0.0315366
NAP1L1 nucleosome assembly protein 1-like 1 -0.0314186
CANX calnexin -0.0314093
SLIT2 slit homolog 2 (Drosophila) -0.0309778
RPS15 ribosomal protein S15 -0.0300798
FERMT2 fermitin family member 2 -0.0300753
AKAP12 A kinase (PRKA) anchor protein 12 -0.0296284
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0294542
HIP1 huntingtin interacting protein 1 -0.0292922
RPLP0 ribosomal protein, large, P0 -0.0288551
RPS29 ribosomal protein S29 -0.0285344
GREM2 gremlin 2, DAN family BMP antagonist -0.0284923
RPL36 ribosomal protein L36 -0.0283608
P4HB prolyl 4-hydroxylase, beta polypeptide -0.028077
GPATCH8 G patch domain containing 8 -0.0277817
PLAT plasminogen activator, tissue -0.0275654
RPS3 ribosomal protein S3 -0.0273571
RPS25 ribosomal protein S25 -0.0265206
RSL1D1 ribosomal L1 domain containing 1 -0.0263519
RPL11 ribosomal protein L11 -0.0261954
RIGI RNA sensor RIG-I -0.026078
PCNX4 pecanex 4 -0.0258
SP100 SP100 nuclear antigen -0.0257433
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0253609
SIK2 salt-inducible kinase 2 -0.0253443
THBS1 thrombospondin 1 -0.0253198
RPS27 ribosomal protein S27 -0.0252233
SOX4 SRY (sex determining region Y)-box 4 -0.024977
PDLIM5 PDZ and LIM domain 5 -0.02485
AHNAK AHNAK nucleoprotein -0.0248169
MYO1E myosin IE -0.0244699
RPL7 ribosomal protein L7 -0.0244358
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0244048
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0243223
ZNF609 zinc finger protein 609 -0.0242513