| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.114284 |
| RUNX1 | runt-related transcription factor 1 | 0.102192 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0790384 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0728907 |
| RNF43 | ring finger protein 43 | 0.0699429 |
| PRELID2 | PRELI domain containing 2 | 0.0614365 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0612435 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0602813 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0577288 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0570722 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.0528519 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0526307 |
| IFNGR1 | interferon gamma receptor 1 | 0.051259 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.048741 |
| EFNB2 | ephrin-B2 | 0.0483822 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0465251 |
| RAD51B | RAD51 paralog B | 0.04331 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0430643 |
| MEIS2 | Meis homeobox 2 | 0.0424874 |
| FAT1 | FAT atypical cadherin 1 | 0.0408994 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0404515 |
| WWOX | WW domain containing oxidoreductase | 0.0400675 |
| NDRG1 | N-myc downstream regulated 1 | 0.0399248 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0393625 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0391899 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0382029 |
| ASPH | aspartate beta-hydroxylase | 0.0377177 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0371053 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0358631 |
| YAP1 | Yes-associated protein 1 | 0.035309 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0352927 |
| ABHD2 | abhydrolase domain containing 2 | 0.0348723 |
| EHF | ets homologous factor | 0.0348292 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0337423 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0335549 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.03281 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.0312643 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0307683 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0307212 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0303092 |
| TC2N | tandem C2 domains, nuclear | 0.029835 |
| FRK | fyn-related Src family tyrosine kinase | 0.0289876 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0282951 |
| KIF16B | kinesin family member 16B | 0.028139 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0277631 |
| PADI1 | peptidyl arginine deiminase, type I | 0.0276576 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | 0.0276194 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0267899 |
| NCKAP5 | NCK-associated protein 5 | 0.0266838 |
| STK24 | serine/threonine kinase 24 | 0.0266691 |
| DENND4C | DENN/MADD domain containing 4C | 0.0264229 |
| DSPP | dentin sialophosphoprotein | 0.0261231 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0260768 |
| FOXP1 | forkhead box P1 | 0.0251353 |
| CCNL1 | cyclin L1 | 0.0247569 |
| TRIM2 | tripartite motif containing 2 | 0.0246891 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0244503 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0235581 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0235233 |
| RASSF6 | Ras association (RalGDS/AF-6) domain family member 6 | 0.0234974 |
| FHL2 | four and a half LIM domains 2 | 0.0233562 |
| SP3 | Sp3 transcription factor | 0.023185 |
| ARRDC3 | arrestin domain containing 3 | 0.0228493 |
| STK39 | serine threonine kinase 39 | 0.0227487 |
| DST | dystonin | 0.0227454 |
| TMEM51 | transmembrane protein 51 | 0.0223989 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.0220885 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0220764 |
| HDAC4 | histone deacetylase 4 | 0.0219381 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0218386 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0213914 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0210681 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0210512 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0209593 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0209501 |
| VCL | vinculin | 0.020917 |
| SLC37A1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | 0.0209112 |
| ETV6 | ets variant 6 | 0.0208892 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | 0.0203961 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0203038 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.020058 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0193039 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0189395 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0189247 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0188324 |
| MKI67 | marker of proliferation Ki-67 | 0.0188031 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0187529 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0186356 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.0185992 |
| AOPEP | aminopeptidase O (putative) | 0.0185761 |
| ALPK1 | alpha-kinase 1 | 0.0184099 |
| UBAC2 | UBA domain containing 2 | 0.0183804 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.018352 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0182925 |
| TBK1 | TANK-binding kinase 1 | 0.0182629 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0182406 |
| LMO7 | LIM domain 7 | 0.0181473 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0179009 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0176295 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0175969 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.229868 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.136655 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.126836 |
| PTMA | prothymosin, alpha | -0.115439 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.110412 |
| SQSTM1 | sequestosome 1 | -0.104138 |
| B2M | beta-2-microglobulin | -0.102293 |
| LYZ | lysozyme | -0.0989257 |
| XAF1 | XIAP associated factor 1 | -0.0903967 |
| EGR1 | early growth response 1 | -0.0822192 |
| RIGI | RNA sensor RIG-I | -0.0751701 |
| HLA-B | major histocompatibility complex, class I, B | -0.0743828 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0732346 |
| RPS6 | ribosomal protein S6 | -0.0708218 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0704784 |
| EZR | ezrin | -0.0685274 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0652934 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0648686 |
| RNF213 | ring finger protein 213 | -0.0614907 |
| SP100 | SP100 nuclear antigen | -0.0610912 |
| H1-0 | H1.0 linker histone | -0.0598622 |
| RRBP1 | ribosome binding protein 1 | -0.0594315 |
| RPL35A | ribosomal protein L35a | -0.0588165 |
| AHI1 | Abelson helper integration site 1 | -0.058006 |
| MX2 | MX dynamin-like GTPase 2 | -0.0569045 |
| RPL34 | ribosomal protein L34 | -0.0556411 |
| PERP | PERP, TP53 apoptosis effector | -0.0555673 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0552269 |
| GOLGB1 | golgin B1 | -0.0537441 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0526788 |
| FTL | ferritin, light polypeptide | -0.0525314 |
| TMSB10 | thymosin beta 10 | -0.0506869 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0489838 |
| AHNAK | AHNAK nucleoprotein | -0.0483885 |
| TMC5 | transmembrane channel-like 5 | -0.0478752 |
| JUN | jun proto-oncogene | -0.047554 |
| CANX | calnexin | -0.0453979 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0449342 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | -0.0438155 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.043371 |
| RPL19 | ribosomal protein L19 | -0.0433589 |
| RPL23 | ribosomal protein L23 | -0.0424764 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0421171 |
| UBC | ubiquitin C | -0.0416448 |
| HLA-C | major histocompatibility complex, class I, C | -0.0416221 |
| LCN2 | lipocalin 2 | -0.0406951 |
| RPLP1 | ribosomal protein, large, P1 | -0.0404611 |
| RPS8 | ribosomal protein S8 | -0.0394452 |
| RPS24 | ribosomal protein S24 | -0.0394309 |
| IRF1 | interferon regulatory factor 1 | -0.039209 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0391884 |
| SDC4 | syndecan 4 | -0.0391151 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0387908 |
| CSTB | cystatin B (stefin B) | -0.0383482 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0379662 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0379479 |
| MAP7 | microtubule-associated protein 7 | -0.0375092 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0372454 |
| EPCAM | epithelial cell adhesion molecule | -0.0368418 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0367344 |
| RPL26 | ribosomal protein L26 | -0.0360644 |
| INTS6 | integrator complex subunit 6 | -0.0360628 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0359609 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0356158 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0351908 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0351876 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0347509 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0343819 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.0338126 |
| MPHOSPH8 | M-phase phosphoprotein 8 | -0.0336745 |
| RPL12 | ribosomal protein L12 | -0.0333307 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0333235 |
| PKM | pyruvate kinase, muscle | -0.0333056 |
| HLA-E | major histocompatibility complex, class I, E | -0.0332414 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0332205 |
| RPL31 | ribosomal protein L31 | -0.0329598 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0329588 |
| RPL11 | ribosomal protein L11 | -0.0327638 |
| SERF2 | small EDRK-rich factor 2 | -0.0325078 |
| TFRC | transferrin receptor | -0.0324934 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0324834 |
| PMP22 | peripheral myelin protein 22 | -0.0323406 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0319149 |
| RPLP0 | ribosomal protein, large, P0 | -0.031792 |
| S100A6 | S100 calcium binding protein A6 | -0.0317221 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0317073 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0315723 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0314638 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0312976 |
| MUC20 | mucin 20, cell surface associated | -0.0312301 |
| S100A9 | S100 calcium binding protein A9 | -0.0310662 |
| NPSR1 | neuropeptide S receptor 1 | -0.0310433 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0310301 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0308734 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0307805 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0307695 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.030477 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0298265 |
| SPATA13 | spermatogenesis associated 13 | -0.0297198 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0296395 |
