| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pexidartinib (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.150792 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.138315 |
| NDRG1 | N-myc downstream regulated 1 | 0.131084 |
| EGFR | epidermal growth factor receptor | 0.105247 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0843914 |
| STC1 | stanniocalcin 1 | 0.0686125 |
| LOX | lysyl oxidase | 0.0639887 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0512624 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0510685 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0482708 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0469326 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0436761 |
| CD44 | CD44 molecule (Indian blood group) | 0.0428438 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0413849 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0413671 |
| RPS2 | ribosomal protein S2 | 0.0408917 |
| ZNF841 | zinc finger protein 841 | 0.0390683 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0388095 |
| ASPH | aspartate beta-hydroxylase | 0.0382628 |
| SBF2 | SET binding factor 2 | 0.0376236 |
| HDAC9 | histone deacetylase 9 | 0.0371681 |
| FLNA | filamin A, alpha | 0.0368948 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0363521 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0361029 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0342352 |
| RACK1 | receptor for activated C kinase 1 | 0.034001 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0339574 |
| METTL15 | methyltransferase like 15 | 0.033077 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0327003 |
| FNIP1 | folliculin interacting protein 1 | 0.0326741 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0324341 |
| COL5A1 | collagen, type V, alpha 1 | 0.0323349 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0315768 |
| SMAD3 | SMAD family member 3 | 0.0313875 |
| YEATS2 | YEATS domain containing 2 | 0.0313489 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0312855 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0311473 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0310007 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0304529 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0300472 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0299079 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0294475 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | 0.0290189 |
| PYGL | phosphorylase, glycogen, liver | 0.0288938 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0286829 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0281253 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0271642 |
| COG5 | component of oligomeric golgi complex 5 | 0.0267861 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0266919 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0266049 |
| PGK1 | phosphoglycerate kinase 1 | 0.0262582 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.026123 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0254014 |
| RASA2 | RAS p21 protein activator 2 | 0.0252984 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0252778 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0248438 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.024422 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0243444 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0237845 |
| CALD1 | caldesmon 1 | 0.0235615 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0234309 |
| MKI67 | marker of proliferation Ki-67 | 0.0227261 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0227203 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0227102 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0225106 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.022509 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0223313 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0223225 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0222826 |
| RPL37A | ribosomal protein L37a | 0.0221985 |
| PRELID2 | PRELI domain containing 2 | 0.0220945 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0220672 |
| NOTCH2 | notch 2 | 0.0219131 |
| GPATCH2L | G patch domain containing 2-like | 0.0218067 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.02156 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0214866 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0214138 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0210562 |
| SMYD3 | SET and MYND domain containing 3 | 0.0210204 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0209684 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0209252 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.020767 |
| CDK14 | cyclin-dependent kinase 14 | 0.0206914 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0206696 |
| LOXL2 | lysyl oxidase-like 2 | 0.0206624 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0206581 |
| WDR26 | WD repeat domain 26 | 0.0206099 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | 0.0205484 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0205168 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0204769 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0202589 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.020135 |
| NAV1 | neuron navigator 1 | 0.0198872 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0197844 |
| CDK13 | cyclin-dependent kinase 13 | 0.0197789 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0197228 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.019717 |
| RNF216 | ring finger protein 216 | 0.0196865 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0196426 |
| FLNB | filamin B, beta | 0.0196272 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.413499 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.192623 |
| FTL | ferritin, light polypeptide | -0.191919 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.119891 |
| PTMA | prothymosin, alpha | -0.0920299 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0740267 |
| RPS6 | ribosomal protein S6 | -0.061249 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0540883 |
| EGR1 | early growth response 1 | -0.0534423 |
| CANX | calnexin | -0.0532659 |
| ADM | adrenomedullin | -0.0477282 |
| POTEF | POTE ankyrin domain family, member F | -0.0420069 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0402861 |
| RLF | rearranged L-myc fusion | -0.0379299 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0378484 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0373948 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0370035 |
| MAP1B | microtubule-associated protein 1B | -0.0364365 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0362227 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0346023 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0343398 |
| S100A10 | S100 calcium binding protein A10 | -0.0339109 |
| TPM4 | tropomyosin 4 | -0.0336711 |
| TPI1 | triosephosphate isomerase 1 | -0.0331507 |
| UBC | ubiquitin C | -0.0331007 |
| ANXA2 | annexin A2 | -0.0329587 |
| TXNRD1 | thioredoxin reductase 1 | -0.0327843 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0326446 |
| PKM | pyruvate kinase, muscle | -0.0316973 |
| B2M | beta-2-microglobulin | -0.0310034 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0307601 |
| AHNAK | AHNAK nucleoprotein | -0.030444 |
| YBX1 | Y box binding protein 1 | -0.0299205 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.029192 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0290924 |
| RPLP2 | ribosomal protein, large, P2 | -0.0289102 |
| RPS25 | ribosomal protein S25 | -0.0287912 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0286783 |
| RPLP0 | ribosomal protein, large, P0 | -0.0277378 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0276731 |
| TUBA1B | tubulin, alpha 1b | -0.0265696 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0265466 |
| USP3 | ubiquitin specific peptidase 3 | -0.0260415 |
| SETD5 | SET domain containing 5 | -0.025991 |
| SQSTM1 | sequestosome 1 | -0.025967 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0257133 |
| H3-3B | H3.3 histone B | -0.0256514 |
| RPL19 | ribosomal protein L19 | -0.0254254 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0252517 |
| RPS23 | ribosomal protein S23 | -0.0250126 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0249731 |
| RPS11 | ribosomal protein S11 | -0.0246754 |
| RHEB | Ras homolog enriched in brain | -0.0245361 |
| RPS13 | ribosomal protein S13 | -0.024331 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.02432 |
| TXNIP | thioredoxin interacting protein | -0.0239493 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0239154 |
| MSN | moesin | -0.0237111 |
| JUN | jun proto-oncogene | -0.0236342 |
| VEGFA | vascular endothelial growth factor A | -0.0233684 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0233113 |
| RPS8 | ribosomal protein S8 | -0.0222805 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0222503 |
| RPL28 | ribosomal protein L28 | -0.0221224 |
| MCL1 | myeloid cell leukemia 1 | -0.022011 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0219822 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.021946 |
| HLA-A | major histocompatibility complex, class I, A | -0.0215848 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0214083 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0213315 |
| BBX | bobby sox homolog (Drosophila) | -0.021284 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0212488 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0211409 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0211394 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0210501 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0209387 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0208734 |
| RPS24 | ribosomal protein S24 | -0.0207426 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0203887 |
| QKI | QKI, KH domain containing, RNA binding | -0.020167 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.020154 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.020108 |
| GDF15 | growth differentiation factor 15 | -0.0198881 |
| CCNI | cyclin I | -0.0198774 |
| TMSB10 | thymosin beta 10 | -0.0196632 |
| ZNF207 | zinc finger protein 207 | -0.0196365 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0195855 |
| BRD4 | bromodomain containing 4 | -0.0195363 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.019485 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0194416 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0191956 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0190759 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -0.0190288 |
| CD99 | CD99 molecule | -0.0190119 |
| SDC4 | syndecan 4 | -0.0187706 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0187608 |
| MTDH | metadherin | -0.0187588 |
| VCL | vinculin | -0.0186925 |
| CCNL1 | cyclin L1 | -0.018524 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0183959 |
