| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.178011 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.160561 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.131043 |
| PRELID2 | PRELI domain containing 2 | 0.12617 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.12425 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.108695 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0937964 |
| TXNRD1 | thioredoxin reductase 1 | 0.083598 |
| ZNF292 | zinc finger protein 292 | 0.0789887 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0759404 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0721078 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0699156 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0671175 |
| GOLGA4 | golgin A4 | 0.066539 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0655873 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0630317 |
| YEATS2 | YEATS domain containing 2 | 0.0623411 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0608914 |
| LDHA | lactate dehydrogenase A | 0.0606586 |
| RAD51B | RAD51 paralog B | 0.0602177 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0600887 |
| NUP58 | nucleoporin 58 | 0.0600503 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.057069 |
| PCBP2 | poly(rC) binding protein 2 | 0.056812 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0567064 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0557023 |
| RPS2 | ribosomal protein S2 | 0.0555392 |
| TMF1 | TATA element modulatory factor 1 | 0.0539809 |
| TENM3 | teneurin transmembrane protein 3 | 0.053377 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.052277 |
| PGK1 | phosphoglycerate kinase 1 | 0.0522117 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0513361 |
| FTL | ferritin, light polypeptide | 0.0510412 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0505225 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0486 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0482647 |
| ZNF638 | zinc finger protein 638 | 0.0475524 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0470973 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0458679 |
| KIAA1217 | KIAA1217 | 0.0458636 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0456284 |
| NF1 | neurofibromin 1 | 0.0452342 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0450385 |
| OGA | O-GlcNAcase | 0.0440036 |
| NEBL | nebulette | 0.0433316 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0427738 |
| ATXN1 | ataxin 1 | 0.042752 |
| CDK19 | cyclin-dependent kinase 19 | 0.0424498 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0415518 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0409645 |
| KIF5B | kinesin family member 5B | 0.0409052 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0386273 |
| SFXN1 | sideroflexin 1 | 0.0384071 |
| ZNF654 | zinc finger protein 654 | 0.038051 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0376241 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0373086 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0371341 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0369866 |
| RBM39 | RNA binding motif protein 39 | 0.036605 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0362061 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0360295 |
| TPR | translocated promoter region, nuclear basket protein | 0.035721 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0356536 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0354461 |
| COG6 | component of oligomeric golgi complex 6 | 0.0351476 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0351227 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0350149 |
| SRP54 | signal recognition particle 54kDa | 0.0346328 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0344632 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0341902 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0341005 |
| HELZ | helicase with zinc finger | 0.0339359 |
| MATR3 | matrin 3 | 0.0336859 |
| PCM1 | pericentriolar material 1 | 0.0335425 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0334232 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0333633 |
| YTHDC1 | YTH domain containing 1 | 0.0330802 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0328845 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0328128 |
| BBX | bobby sox homolog (Drosophila) | 0.0325963 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0325953 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.0325934 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.032511 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0324624 |
| MYO9A | myosin IXA | 0.0324584 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.032186 |
| AFF4 | AF4/FMR2 family, member 4 | 0.032146 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0320398 |
| WWC2 | WW and C2 domain containing 2 | 0.0318939 |
| TMEM41B | transmembrane protein 41B | 0.0318121 |
| MED13L | mediator complex subunit 13-like | 0.0317593 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0315813 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0315659 |
| WDR26 | WD repeat domain 26 | 0.0311919 |
| SUCO | SUN domain containing ossification factor | 0.0311149 |
| NDRG1 | N-myc downstream regulated 1 | 0.0310226 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.03102 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0310016 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0307108 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.03069 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.311146 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.168542 |
| AHNAK | AHNAK nucleoprotein | -0.154632 |
| TMSB10 | thymosin beta 10 | -0.110156 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.106949 |
| RPS6 | ribosomal protein S6 | -0.0570049 |
| EGR1 | early growth response 1 | -0.0520093 |
| TUBA1B | tubulin, alpha 1b | -0.0505171 |
| S100A9 | S100 calcium binding protein A9 | -0.0430317 |
| RPS24 | ribosomal protein S24 | -0.0409198 |
| TPM4 | tropomyosin 4 | -0.040077 |
| ACTG1 | actin gamma 1 | -0.0367818 |
| HMGA2 | high mobility group AT-hook 2 | -0.0351828 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0338686 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0322547 |
| SERINC5 | serine incorporator 5 | -0.0321982 |
| HMGB1 | high mobility group box 1 | -0.0319595 |
| RPS13 | ribosomal protein S13 | -0.0314002 |
| H1-0 | H1.0 linker histone | -0.0304542 |
| RPLP2 | ribosomal protein, large, P2 | -0.0301581 |
| MT2A | metallothionein 2A | -0.0297067 |
| RPS15 | ribosomal protein S15 | -0.029702 |
| PKM | pyruvate kinase, muscle | -0.0290463 |
| RPS21 | ribosomal protein S21 | -0.0289809 |
| S100A6 | S100 calcium binding protein A6 | -0.0285949 |
| DEK | DEK proto-oncogene | -0.0279676 |
| SDC4 | syndecan 4 | -0.0272564 |
| RPS25 | ribosomal protein S25 | -0.0272453 |
| NOP56 | NOP56 ribonucleoprotein | -0.0261406 |
| KRT18 | keratin 18, type I | -0.0261028 |
| S100A10 | S100 calcium binding protein A10 | -0.0257127 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.025665 |
| INTS6 | integrator complex subunit 6 | -0.0255381 |
| LRRC23 | leucine rich repeat containing 23 | -0.0253095 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0250051 |
| POTEF | POTE ankyrin domain family, member F | -0.0246056 |
| CCND1 | cyclin D1 | -0.0242163 |
| RPL38 | ribosomal protein L38 | -0.023866 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0236126 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0232656 |
| CADPS | Ca++-dependent secretion activator | -0.0228906 |
| RPL19 | ribosomal protein L19 | -0.022773 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.022591 |
| UBC | ubiquitin C | -0.0223985 |
| RPL8 | ribosomal protein L8 | -0.0223543 |
| RPS11 | ribosomal protein S11 | -0.0219427 |
| RPS27A | ribosomal protein S27a | -0.0215919 |
| RPS8 | ribosomal protein S8 | -0.0213492 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0213126 |
| RAN | RAN, member RAS oncogene family | -0.0210376 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0207915 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0206962 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0206842 |
| FUS | FUS RNA binding protein | -0.0205834 |
| WWOX | WW domain containing oxidoreductase | -0.0204899 |
| RPL31 | ribosomal protein L31 | -0.0202448 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0199672 |
| RPL36A | ribosomal protein L36a | -0.0198409 |
| HLA-A | major histocompatibility complex, class I, A | -0.0198193 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0197786 |
| TGFB1 | transforming growth factor, beta 1 | -0.019738 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.019645 |
| MCL1 | myeloid cell leukemia 1 | -0.0189283 |
| RPL7A | ribosomal protein L7a | -0.0188987 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0186115 |
| GPC5 | glypican 5 | -0.0183045 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0182952 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0182158 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0181663 |
| RPS10 | ribosomal protein S10 | -0.0179525 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0178496 |
| RBMX | RNA binding motif protein, X-linked | -0.0178251 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0176404 |
| DIAPH2 | diaphanous-related formin 2 | -0.0175848 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0175706 |
| HELLS | helicase, lymphoid-specific | -0.0174162 |
| EGFR | epidermal growth factor receptor | -0.0173556 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0173495 |
| VCL | vinculin | -0.0173156 |
| RPL35A | ribosomal protein L35a | -0.0171889 |
| RPL32 | ribosomal protein L32 | -0.0171688 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0169929 |
| RPS29 | ribosomal protein S29 | -0.0169561 |
| MORC4 | MORC family CW-type zinc finger 4 | -0.0168879 |
| RCC1 | regulator of chromosome condensation 1 | -0.0168362 |
| VEGFA | vascular endothelial growth factor A | -0.0165201 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0164524 |
| MIDN | midnolin | -0.016292 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0161969 |
| AHI1 | Abelson helper integration site 1 | -0.0161453 |
| FAM107B | family with sequence similarity 107, member B | -0.0159687 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0159588 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0158801 |
| ASTN2 | astrotactin 2 | -0.0158414 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0158043 |
| UBB | ubiquitin B | -0.0157371 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0155533 |
| BRI3BP | BRI3 binding protein | -0.0155201 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0155113 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.015307 |
