Pexidartinib (hydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.135758
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0654761
PRELID2 PRELI domain containing 2 0.0536696
FLNA filamin A, alpha 0.0474131
MYH9 myosin, heavy chain 9, non-muscle 0.0406374
ITGB8 integrin, beta 8 0.0345323
NRIP1 nuclear receptor interacting protein 1 0.0306417
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0277479
MACROD2 MACRO domain containing 2 0.0251382
APP amyloid beta (A4) precursor protein 0.0245406
WWOX WW domain containing oxidoreductase 0.0235929
ZBTB20 zinc finger and BTB domain containing 20 0.0226856
HELZ helicase with zinc finger 0.0220928
ZNF292 zinc finger protein 292 0.0216238
MATR3 matrin 3 0.0205986
TBC1D5 TBC1 domain family, member 5 0.0198888
ANKRD36 ankyrin repeat domain 36 0.0195554
PCLO piccolo presynaptic cytomatrix protein 0.0194129
NFIB nuclear factor I/B 0.0194056
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.0184888
HLTF helicase-like transcription factor 0.0182689
NCKAP1 NCK-associated protein 1 0.0171122
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.017102
SLTM SAFB-like, transcription modulator 0.0170604
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0164111
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0163284
USP9X ubiquitin specific peptidase 9, X-linked 0.015707
SYNE2 spectrin repeat containing, nuclear envelope 2 0.015683
NUP58 nucleoporin 58 0.0154801
PAX8 paired box 8 0.0153161
ANLN anillin, actin binding protein 0.0152029
SINHCAF SIN3-HDAC complex associated factor 0.0152013
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0148046
YEATS2 YEATS domain containing 2 0.0146636
CEP95 centrosomal protein 95kDa 0.0146578
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0146073
WDFY3 WD repeat and FYVE domain containing 3 0.0143466
KIAA1328 KIAA1328 0.0143206
PHF3 PHD finger protein 3 0.013933
KAZN kazrin, periplakin interacting protein 0.0138361
CREBRF CREB3 regulatory factor 0.0135384
ATP13A3 ATPase type 13A3 0.013425
EEF2 eukaryotic translation elongation factor 2 0.0133931
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0131448
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0131053
STS steroid sulfatase (microsomal), isozyme S 0.0129482
SFPQ splicing factor proline/glutamine-rich 0.0129476
KDM6A lysine (K)-specific demethylase 6A 0.012852
BLTP1 bridge-like lipid transfer protein family member 1 0.0128129
TOP2B topoisomerase (DNA) II beta 180kDa 0.0127074
AZIN1 antizyme inhibitor 1 0.0126975
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0126814
MACC1 metastasis associated in colon cancer 1 0.0124921
CIP2A cellular inhibitor of PP2A 0.0124038
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0123403
NBAS neuroblastoma amplified sequence 0.0122769
LPP LIM domain containing preferred translocation partner in lipoma 0.0120479
RPN1 ribophorin I 0.0117273
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0115542
NFE2L1 nuclear factor, erythroid 2-like 1 0.0115342
MYEF2 myelin expression factor 2 0.0114235
AFDN afadin, adherens junction formation factor 0.0113366
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0112996
ANKRD36B ankyrin repeat domain 36B 0.0112641
SP3 Sp3 transcription factor 0.0111924
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.0111742
SMAD3 SMAD family member 3 0.0111137
SBF2 SET binding factor 2 0.0111102
TNRC6A trinucleotide repeat containing 6A 0.0111068
SUMF1 sulfatase modifying factor 1 0.011085
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0110069
TWF1 twinfilin actin binding protein 1 0.0110037
FAT1 FAT atypical cadherin 1 0.0109774
KIAA1958 KIAA1958 0.0109487
AXL AXL receptor tyrosine kinase 0.0108162
RPS2 ribosomal protein S2 0.010794
TMED2 transmembrane emp24 domain trafficking protein 2 0.0107602
PARD3B par-3 family cell polarity regulator beta 0.0107179
CAND1 cullin-associated and neddylation-dissociated 1 0.0106729
FTH1 ferritin, heavy polypeptide 1 0.0106239
ANXA3 annexin A3 0.0105718
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.010565
BIRC3 baculoviral IAP repeat containing 3 0.010558
SPRED1 sprouty-related, EVH1 domain containing 1 0.0105432
PCNX1 pecanex 1 0.0104623
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0104216
ICAM1 intercellular adhesion molecule 1 0.0104017
ADGRG6 adhesion G protein-coupled receptor G6 0.0103924
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0103501
SERINC1 serine incorporator 1 0.0103074
SLC35F5 solute carrier family 35, member F5 0.0102735
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0101698
KPNA5 karyopherin alpha 5 (importin alpha 6) 0.0100828
TXNRD1 thioredoxin reductase 1 0.0100557
ARRDC3 arrestin domain containing 3 0.0100265
SET SET nuclear proto-oncogene 0.0100055
PCM1 pericentriolar material 1 0.00983937
CAMTA1 calmodulin binding transcription activator 1 0.00983921
WNK1 WNK lysine deficient protein kinase 1 0.00983815
ZNF608 zinc finger protein 608 0.00983141

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228014
TMSB10 thymosin beta 10 -0.19625
MT2A metallothionein 2A -0.134565
PTMA prothymosin, alpha -0.122329
AHNAK AHNAK nucleoprotein -0.0941412
RPS6 ribosomal protein S6 -0.0941397
RPL35A ribosomal protein L35a -0.0912051
FTL ferritin, light polypeptide -0.0884895
TPT1 tumor protein, translationally-controlled 1 -0.0826745
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0771598
PKM pyruvate kinase, muscle -0.07066
RPL31 ribosomal protein L31 -0.0675275
NDRG1 N-myc downstream regulated 1 -0.0651198
RPS8 ribosomal protein S8 -0.0623934
TPM4 tropomyosin 4 -0.0597661
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0534406
RPL19 ribosomal protein L19 -0.0534141
IGFBP3 insulin-like growth factor binding protein 3 -0.0522289
RPL23 ribosomal protein L23 -0.0497496
S100A10 S100 calcium binding protein A10 -0.0494124
EIF1 eukaryotic translation initiation factor 1 -0.0478279
ACTG1 actin gamma 1 -0.0476138
RPS19 ribosomal protein S19 -0.0467653
ENO1 enolase 1, (alpha) -0.0447797
HMGA2 high mobility group AT-hook 2 -0.0446876
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0439283
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0435752
RPS29 ribosomal protein S29 -0.0431787
ANXA2 annexin A2 -0.0429774
KRT7 keratin 7, type II -0.0426567
RPS11 ribosomal protein S11 -0.0423955
ANKRD11 ankyrin repeat domain 11 -0.041707
RPS27A ribosomal protein S27a -0.0409667
RPL7A ribosomal protein L7a -0.04036
RPL34 ribosomal protein L34 -0.0399567
RPL37A ribosomal protein L37a -0.0395043
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.039233
RPLP2 ribosomal protein, large, P2 -0.038725
CD44 CD44 molecule (Indian blood group) -0.0382026
RPL9 ribosomal protein L9 -0.0382005
RPS14 ribosomal protein S14 -0.0380293
RPL12 ribosomal protein L12 -0.0377431
RPLP1 ribosomal protein, large, P1 -0.0374747
RPS24 ribosomal protein S24 -0.0367385
S100A6 S100 calcium binding protein A6 -0.0364071
RPL28 ribosomal protein L28 -0.0363618
MAP4 microtubule-associated protein 4 -0.0363245
RPS25 ribosomal protein S25 -0.0361347
RPS13 ribosomal protein S13 -0.0355768
LAMB3 laminin, beta 3 -0.0354051
RPL5 ribosomal protein L5 -0.0345601
POTEF POTE ankyrin domain family, member F -0.0340881
RPL38 ribosomal protein L38 -0.0340401
ALCAM activated leukocyte cell adhesion molecule -0.0335157
RPS23 ribosomal protein S23 -0.0334869
SH3KBP1 SH3-domain kinase binding protein 1 -0.0334368
RPS16 ribosomal protein S16 -0.0325905
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0323141
RPS10 ribosomal protein S10 -0.031714
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0314524
LAMA4 laminin, alpha 4 -0.0312748
RPS15 ribosomal protein S15 -0.0311632
RPL32 ribosomal protein L32 -0.0290366
CCND1 cyclin D1 -0.0289869
SETD5 SET domain containing 5 -0.0289371
AKAP12 A kinase (PRKA) anchor protein 12 -0.0289248
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0286191
ITGA6 integrin, alpha 6 -0.0285668
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0280454
VDAC1 voltage-dependent anion channel 1 -0.0270412
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0269739
RPL15 ribosomal protein L15 -0.02682
RPL11 ribosomal protein L11 -0.0266403
UPP1 uridine phosphorylase 1 -0.0265889
HMGA1 high mobility group AT-hook 1 -0.0263169
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0261823
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0257461
RPL35 ribosomal protein L35 -0.0257225
RPL8 ribosomal protein L8 -0.0256909
H1-0 H1.0 linker histone -0.0256537
ZNF609 zinc finger protein 609 -0.025532
RHOA ras homolog family member A -0.0251124
RPS17 ribosomal protein S17 -0.025086
DLC1 DLC1 Rho GTPase activating protein -0.0250602
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.024997
TPI1 triosephosphate isomerase 1 -0.0249065
HMGB1 high mobility group box 1 -0.0247086
RPS3 ribosomal protein S3 -0.024519
RPS21 ribosomal protein S21 -0.0245141
KRT19 keratin 19, type I -0.0243587
IARS1 isoleucyl-tRNA synthetase 1 -0.024254
NSD2 nuclear receptor binding SET domain protein 2 -0.0241212
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0238453
SVIL supervillin -0.0235643
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0232483
AFF1 AF4/FMR2 family, member 1 -0.0231948
WSB1 WD repeat and SOCS box containing 1 -0.023031
RPS27 ribosomal protein S27 -0.0229897
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.022954
GARS1 glycyl-tRNA synthetase 1 -0.022852