| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.133766 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.102963 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0717809 |
| CD44 | CD44 molecule (Indian blood group) | 0.0634806 |
| COL5A1 | collagen, type V, alpha 1 | 0.0560196 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0556487 |
| IGF2 | insulin-like growth factor 2 | 0.0511645 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0486375 |
| HMGA2 | high mobility group AT-hook 2 | 0.0467698 |
| LAMB3 | laminin, beta 3 | 0.0462531 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0461155 |
| LOX | lysyl oxidase | 0.0445534 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0392203 |
| PRELID2 | PRELI domain containing 2 | 0.0389218 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0388876 |
| FLNA | filamin A, alpha | 0.0383956 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0346391 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0329886 |
| NAV2 | neuron navigator 2 | 0.031787 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0311997 |
| EFNA5 | ephrin-A5 | 0.0301039 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0299603 |
| EXT1 | exostosin glycosyltransferase 1 | 0.029887 |
| DTNA | dystrobrevin, alpha | 0.0293083 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0291395 |
| NAV1 | neuron navigator 1 | 0.0287942 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0285002 |
| ACTG1 | actin gamma 1 | 0.0284424 |
| FLNB | filamin B, beta | 0.0283645 |
| HPCAL1 | hippocalcin-like 1 | 0.0280171 |
| SEPTIN9 | septin 9 | 0.0273786 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0264316 |
| RPL37A | ribosomal protein L37a | 0.0255718 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0255193 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0254461 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0253061 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0249057 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0247277 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0246054 |
| EPN2 | epsin 2 | 0.0245627 |
| RPS12 | ribosomal protein S12 | 0.0243972 |
| YEATS2 | YEATS domain containing 2 | 0.0242415 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.02289 |
| CDH13 | cadherin 13 | 0.0222932 |
| RPS2 | ribosomal protein S2 | 0.022021 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0218728 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0218336 |
| PLEC | plectin | 0.021654 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0215401 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0210642 |
| KLF6 | Kruppel-like factor 6 | 0.0204764 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0203132 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0202618 |
| PCBP3 | poly(rC) binding protein 3 | 0.0202493 |
| MYO10 | myosin X | 0.02014 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0199222 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0196512 |
| NDRG1 | N-myc downstream regulated 1 | 0.0190876 |
| PDE10A | phosphodiesterase 10A | 0.0188209 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0187996 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0184452 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0181766 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0178389 |
| RPS3 | ribosomal protein S3 | 0.0177807 |
| RASA3 | RAS p21 protein activator 3 | 0.0176118 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0171 |
| FNIP1 | folliculin interacting protein 1 | 0.0168658 |
| L1CAM | L1 cell adhesion molecule | 0.0163567 |
| FMNL2 | formin-like 2 | 0.0158785 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0158294 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0157696 |
| RUNX1 | runt-related transcription factor 1 | 0.0155468 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0155299 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0155021 |
| RPL30 | ribosomal protein L30 | 0.0154947 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0151562 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0150712 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0149268 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0146454 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0145418 |
| FMN1 | formin 1 | 0.0143619 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0142723 |
| SMAD3 | SMAD family member 3 | 0.0140658 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0139657 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0139083 |
| SBF2 | SET binding factor 2 | 0.0138706 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.0135886 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0135368 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0135167 |
| TNS1 | tensin 1 | 0.0134149 |
| CEP350 | centrosomal protein 350kDa | 0.0133281 |
| PRKCA | protein kinase C, alpha | 0.0133262 |
| LOXL2 | lysyl oxidase-like 2 | 0.0132505 |
| MLPH | melanophilin | 0.0130019 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0127925 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0127021 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0126785 |
| SMYD3 | SET and MYND domain containing 3 | 0.0124352 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0124207 |
| CLIC1 | chloride intracellular channel 1 | 0.0122873 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.477794 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.156236 |
| PTMA | prothymosin, alpha | -0.0786022 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0760959 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0701057 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0612806 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0545073 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0542501 |
| EGR1 | early growth response 1 | -0.0521829 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0498857 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0460584 |
| RPS6 | ribosomal protein S6 | -0.0449968 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0417803 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0406574 |
| AHNAK | AHNAK nucleoprotein | -0.0389054 |
| IER3 | immediate early response 3 | -0.0365765 |
| MAP1B | microtubule-associated protein 1B | -0.0364681 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0351029 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0326557 |
| UBC | ubiquitin C | -0.0300254 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0299716 |
| USP3 | ubiquitin specific peptidase 3 | -0.0297264 |
| SETD5 | SET domain containing 5 | -0.0293612 |
| FTL | ferritin, light polypeptide | -0.0293003 |
| ASPH | aspartate beta-hydroxylase | -0.0289315 |
| FN1 | fibronectin 1 | -0.0288423 |
| CANX | calnexin | -0.0287083 |
| S100A10 | S100 calcium binding protein A10 | -0.0283741 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0276198 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0262938 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0252654 |
| SYAP1 | synapse associated protein 1 | -0.0245301 |
| CLIC4 | chloride intracellular channel 4 | -0.0237786 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0236102 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0235183 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0230048 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0226128 |
| TXNRD1 | thioredoxin reductase 1 | -0.0225329 |
| RLF | rearranged L-myc fusion | -0.022377 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0223403 |
| MT2A | metallothionein 2A | -0.0220998 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0219704 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0216434 |
| DST | dystonin | -0.0215956 |
| YBX1 | Y box binding protein 1 | -0.0214783 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0209391 |
| CENPF | centromere protein F, 350/400kDa | -0.0206867 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0201369 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.0200386 |
| MCL1 | myeloid cell leukemia 1 | -0.0196895 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.019668 |
| TFRC | transferrin receptor | -0.0196296 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0195292 |
| RPL8 | ribosomal protein L8 | -0.019446 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0190895 |
| TPI1 | triosephosphate isomerase 1 | -0.0187352 |
| ASTN2 | astrotactin 2 | -0.0186842 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0184605 |
| G0S2 | G0/G1 switch 2 | -0.0184277 |
| RTN4 | reticulon 4 | -0.0181521 |
| PKM | pyruvate kinase, muscle | -0.0179574 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0179223 |
| TXNIP | thioredoxin interacting protein | -0.0177965 |
| RYBP | RING1 and YY1 binding protein | -0.0176824 |
| QKI | QKI, KH domain containing, RNA binding | -0.0175461 |
| RPLP0 | ribosomal protein, large, P0 | -0.0174422 |
| ADM | adrenomedullin | -0.0172648 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0169842 |
| CCNI | cyclin I | -0.0169347 |
| DEK | DEK proto-oncogene | -0.0165294 |
| COL1A1 | collagen, type I, alpha 1 | -0.0162741 |
| JUN | jun proto-oncogene | -0.0161922 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.016106 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0160054 |
| TPM4 | tropomyosin 4 | -0.0159623 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0159417 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0157374 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0156522 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0152005 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0151871 |
| CDCP1 | CUB domain containing protein 1 | -0.0150971 |
| STC1 | stanniocalcin 1 | -0.015075 |
| FAM162A | family with sequence similarity 162, member A | -0.0150256 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0146127 |
| POTEF | POTE ankyrin domain family, member F | -0.0145839 |
| RBM39 | RNA binding motif protein 39 | -0.0145781 |
| CCND1 | cyclin D1 | -0.0145559 |
| LMNA | lamin A/C | -0.0145146 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0144133 |
| GOLGB1 | golgin B1 | -0.0143992 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0143695 |
| B2M | beta-2-microglobulin | -0.014266 |
| KIF14 | kinesin family member 14 | -0.0142186 |
| MT1X | metallothionein 1X | -0.0142002 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0139732 |
| TUBA1B | tubulin, alpha 1b | -0.0136817 |
| H3-3B | H3.3 histone B | -0.0135368 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.013358 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0133572 |
| XPO1 | exportin 1 | -0.0132236 |
