| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.298623 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.241654 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.15069 |
| COL6A3 | collagen, type VI, alpha 3 | 0.128791 |
| NDRG1 | N-myc downstream regulated 1 | 0.122224 |
| VIM | vimentin | 0.111376 |
| LOX | lysyl oxidase | 0.0881946 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0778182 |
| CD44 | CD44 molecule (Indian blood group) | 0.0596519 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0593156 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0586355 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0562918 |
| LOXL2 | lysyl oxidase-like 2 | 0.0535792 |
| MT2A | metallothionein 2A | 0.0506121 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0465769 |
| PRELID2 | PRELI domain containing 2 | 0.0448892 |
| VCAN | versican | 0.0427268 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0423639 |
| ACTG1 | actin gamma 1 | 0.041301 |
| FLNA | filamin A, alpha | 0.0391921 |
| ATP13A3 | ATPase type 13A3 | 0.0382434 |
| EGFR | epidermal growth factor receptor | 0.0381128 |
| STC1 | stanniocalcin 1 | 0.0378622 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0375556 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.036945 |
| RPS12 | ribosomal protein S12 | 0.0366299 |
| PDE10A | phosphodiesterase 10A | 0.0365152 |
| CALR | calreticulin | 0.0364234 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.035991 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0339177 |
| NAV1 | neuron navigator 1 | 0.0325827 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0321891 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.031832 |
| TMSB10 | thymosin beta 10 | 0.0314075 |
| COL5A1 | collagen, type V, alpha 1 | 0.0310335 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0298969 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0283647 |
| AXL | AXL receptor tyrosine kinase | 0.0280867 |
| RPS2 | ribosomal protein S2 | 0.0276891 |
| RACK1 | receptor for activated C kinase 1 | 0.027674 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0270865 |
| KLF6 | Kruppel-like factor 6 | 0.0269334 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0253904 |
| RPL35A | ribosomal protein L35a | 0.0243484 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0241053 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0237081 |
| STC2 | stanniocalcin 2 | 0.0236636 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0233971 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0233819 |
| NAV2 | neuron navigator 2 | 0.0229852 |
| PFN1 | profilin 1 | 0.0225645 |
| VEGFA | vascular endothelial growth factor A | 0.0224699 |
| CDH13 | cadherin 13 | 0.0219642 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0219221 |
| HMGA1 | high mobility group AT-hook 1 | 0.0218145 |
| CMIP | c-Maf inducing protein | 0.0209781 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0209045 |
| ATXN1 | ataxin 1 | 0.0201512 |
| RPS3 | ribosomal protein S3 | 0.0201507 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0200698 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0200639 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0200483 |
| RPL37A | ribosomal protein L37a | 0.0192156 |
| CDC27 | cell division cycle 27 | 0.0191919 |
| RASA2 | RAS p21 protein activator 2 | 0.0187712 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0187249 |
| EPHB1 | EPH receptor B1 | 0.0186982 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0186624 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 0.0185937 |
| PGM3 | phosphoglucomutase 3 | 0.0185745 |
| RPS17 | ribosomal protein S17 | 0.0181146 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0180001 |
| RPS19 | ribosomal protein S19 | 0.0179271 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0179225 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0179167 |
| MKI67 | marker of proliferation Ki-67 | 0.0178868 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0176488 |
| FAT1 | FAT atypical cadherin 1 | 0.0175794 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0174903 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0174323 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0171941 |
| CLMP | CXADR-like membrane protein | 0.0168744 |
| ARRDC3 | arrestin domain containing 3 | 0.0168741 |
| FLNC | filamin C, gamma | 0.0165543 |
| EGR1 | early growth response 1 | 0.0163669 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0162433 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0162166 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0160595 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0159946 |
| FOSL1 | FOS-like antigen 1 | 0.0159392 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0158303 |
| ANGPTL4 | angiopoietin-like 4 | 0.0156962 |
| MTSS1 | metastasis suppressor 1 | 0.015683 |
| KAZN | kazrin, periplakin interacting protein | 0.0155967 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0155167 |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | 0.0154853 |
| KLF10 | Kruppel-like factor 10 | 0.0154246 |
| RPL23 | ribosomal protein L23 | 0.0153768 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0153292 |
| NUCB2 | nucleobindin 2 | 0.0153291 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.44115 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.253831 |
| COL1A1 | collagen, type I, alpha 1 | -0.197012 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.124107 |
| FN1 | fibronectin 1 | -0.0854482 |
| AHNAK | AHNAK nucleoprotein | -0.0760764 |
| PTMA | prothymosin, alpha | -0.0731965 |
| CANX | calnexin | -0.0727909 |
| IER3 | immediate early response 3 | -0.0612186 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0500557 |
| RPS6 | ribosomal protein S6 | -0.0476841 |
| IL6ST | interleukin 6 signal transducer | -0.0457127 |
| UBC | ubiquitin C | -0.0434726 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0404184 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0382614 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0380221 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0367518 |
| HDLBP | high density lipoprotein binding protein | -0.0362828 |
| H1-0 | H1.0 linker histone | -0.0357 |
| ASPH | aspartate beta-hydroxylase | -0.0350345 |
| RPL8 | ribosomal protein L8 | -0.0349965 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0339408 |
| RLF | rearranged L-myc fusion | -0.0332112 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.032488 |
| COL1A2 | collagen, type I, alpha 2 | -0.0322306 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0318055 |
| S100A10 | S100 calcium binding protein A10 | -0.0312691 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.030753 |
| MAP4 | microtubule-associated protein 4 | -0.0293073 |
| RHEB | Ras homolog enriched in brain | -0.0280877 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0280756 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0275746 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0268807 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0266366 |
| ANXA2 | annexin A2 | -0.0265202 |
| RBM39 | RNA binding motif protein 39 | -0.0264839 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0262652 |
| OGA | O-GlcNAcase | -0.026048 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0256881 |
| THY1 | Thy-1 cell surface antigen | -0.0251788 |
| SDC4 | syndecan 4 | -0.02495 |
| RRBP1 | ribosome binding protein 1 | -0.0248792 |
| RPS24 | ribosomal protein S24 | -0.0248594 |
| QKI | QKI, KH domain containing, RNA binding | -0.024204 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0241869 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0240221 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0239876 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0237808 |
| DSTN | destrin (actin depolymerizing factor) | -0.0235085 |
| RYBP | RING1 and YY1 binding protein | -0.023189 |
| CAVIN1 | caveolae associated protein 1 | -0.022931 |
| MT1X | metallothionein 1X | -0.0228102 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0223495 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0222374 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0215571 |
| TMSB4X | thymosin beta 4, X-linked | -0.0212253 |
| S100A9 | S100 calcium binding protein A9 | -0.0209714 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0204295 |
| SP100 | SP100 nuclear antigen | -0.0203909 |
| USP3 | ubiquitin specific peptidase 3 | -0.0202162 |
| RPL19 | ribosomal protein L19 | -0.0202044 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0201439 |
| COL3A1 | collagen, type III, alpha 1 | -0.0198093 |
| IRF1 | interferon regulatory factor 1 | -0.0195032 |
| RPS15 | ribosomal protein S15 | -0.019032 |
| FSTL1 | follistatin-like 1 | -0.0186836 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0186795 |
| RPL14 | ribosomal protein L14 | -0.0186262 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0182475 |
| PTK2 | protein tyrosine kinase 2 | -0.0178542 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0178239 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0176075 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0175079 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0174049 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0173313 |
| RPS21 | ribosomal protein S21 | -0.0172237 |
| GLG1 | golgi glycoprotein 1 | -0.0171482 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.016856 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0167881 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0166541 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0166108 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0166042 |
| RPS23 | ribosomal protein S23 | -0.0164908 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.016343 |
| WASF2 | WAS protein family, member 2 | -0.0163132 |
| DEK | DEK proto-oncogene | -0.0161756 |
| RPS11 | ribosomal protein S11 | -0.0159658 |
| TMEM263 | transmembrane protein 263 | -0.0159354 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0158632 |
| RHOA | ras homolog family member A | -0.0157967 |
| IER3IP1 | immediate early response 3 interacting protein 1 | -0.0157913 |
| RPL32 | ribosomal protein L32 | -0.0157524 |
| COL4A1 | collagen, type IV, alpha 1 | -0.0156354 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0156323 |
| MX2 | MX dynamin-like GTPase 2 | -0.0156164 |
| HMGB1 | high mobility group box 1 | -0.015591 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0155657 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0154775 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0154773 |
| GNG12 | guanine nucleotide binding protein (G protein), gamma 12 | -0.0154153 |
