| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.186686 |
| TXNRD1 | thioredoxin reductase 1 | 0.105486 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0831065 |
| ATXN1 | ataxin 1 | 0.0814072 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0736407 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0699172 |
| RPS12 | ribosomal protein S12 | 0.0697677 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0681249 |
| RPS2 | ribosomal protein S2 | 0.0667871 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0556568 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0553998 |
| FRY | furry homolog (Drosophila) | 0.0537566 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0522377 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0515275 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0484797 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.044254 |
| PRELID2 | PRELI domain containing 2 | 0.0431884 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.0428445 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0426075 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0421352 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0420548 |
| STK24 | serine/threonine kinase 24 | 0.0415356 |
| PDZD8 | PDZ domain containing 8 | 0.0413686 |
| RBM47 | RNA binding motif protein 47 | 0.0393621 |
| ERBIN | erbb2 interacting protein | 0.0379229 |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | 0.037802 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0374695 |
| LPIN2 | lipin 2 | 0.0372627 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0365681 |
| RIGI | RNA sensor RIG-I | 0.0365493 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0364364 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0363967 |
| PTPRH | protein tyrosine phosphatase, receptor type, H | 0.0363468 |
| TMEM45B | transmembrane protein 45B | 0.0359641 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0354094 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0352819 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.0341853 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0335016 |
| NUP58 | nucleoporin 58 | 0.0333099 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0332957 |
| LAMB3 | laminin, beta 3 | 0.0327924 |
| NEK7 | NIMA-related kinase 7 | 0.0312655 |
| NCKAP1 | NCK-associated protein 1 | 0.0311753 |
| MKI67 | marker of proliferation Ki-67 | 0.0309418 |
| RPS3 | ribosomal protein S3 | 0.0301518 |
| FOXO1 | forkhead box O1 | 0.030039 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0299517 |
| S100P | S100 calcium binding protein P | 0.0298041 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0292907 |
| RPS17 | ribosomal protein S17 | 0.0291537 |
| RPL4 | ribosomal protein L4 | 0.0282685 |
| ANXA3 | annexin A3 | 0.0273127 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0272789 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0266083 |
| LDHA | lactate dehydrogenase A | 0.0264122 |
| RPL37A | ribosomal protein L37a | 0.0262449 |
| KIF5B | kinesin family member 5B | 0.0260989 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0257659 |
| JMJD1C | jumonji domain containing 1C | 0.0256161 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0252107 |
| TRIB3 | tribbles pseudokinase 3 | 0.0251035 |
| HKDC1 | hexokinase domain containing 1 | 0.0250443 |
| TMEM41B | transmembrane protein 41B | 0.0247237 |
| RACK1 | receptor for activated C kinase 1 | 0.0238137 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0237772 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.023696 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0236401 |
| JUP | junction plakoglobin | 0.0235068 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0234473 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0233645 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0231854 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0231707 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.023167 |
| HOXB6 | homeobox B6 | 0.0230864 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.02308 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0230198 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0229977 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0227535 |
| MYO6 | myosin VI | 0.0227421 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0226874 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0224694 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0223991 |
| HYOU1 | hypoxia up-regulated 1 | 0.0223495 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.0222352 |
| CLDN4 | claudin 4 | 0.0220739 |
| RPL13A | ribosomal protein L13a | 0.0219754 |
| RTN4 | reticulon 4 | 0.021856 |
| LRATD2 | LRAT domain containing 2 | 0.0216657 |
| ADIPOR2 | adiponectin receptor 2 | 0.0214159 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0213038 |
| EHF | ets homologous factor | 0.0212308 |
| TRIB1 | tribbles pseudokinase 1 | 0.0209099 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0208126 |
| EFR3A | EFR3 homolog A (S. cerevisiae) | 0.0206694 |
| BCL3 | B-cell CLL/lymphoma 3 | 0.0206312 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0206168 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0204486 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0204259 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.020103 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0200746 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.22312 |
| AHNAK | AHNAK nucleoprotein | -0.171141 |
| PTMA | prothymosin, alpha | -0.14798 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.127097 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.112682 |
| RPS6 | ribosomal protein S6 | -0.101422 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.100964 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.089812 |
| S100A10 | S100 calcium binding protein A10 | -0.0733067 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0721591 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0720328 |
| UBC | ubiquitin C | -0.0714104 |
| KRT8 | keratin 8, type II | -0.0677883 |
| INTS6 | integrator complex subunit 6 | -0.0653649 |
| RPS24 | ribosomal protein S24 | -0.0581554 |
| RPS11 | ribosomal protein S11 | -0.057958 |
| KRT18 | keratin 18, type I | -0.0544736 |
| PKM | pyruvate kinase, muscle | -0.0536588 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0534321 |
| RPLP2 | ribosomal protein, large, P2 | -0.0527273 |
| RPL21 | ribosomal protein L21 | -0.0521366 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0512059 |
| CANX | calnexin | -0.0507668 |
| RPL8 | ribosomal protein L8 | -0.0502868 |
| RPS21 | ribosomal protein S21 | -0.048902 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0468111 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0463119 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0460127 |
| EZR | ezrin | -0.0449701 |
| HMGB1 | high mobility group box 1 | -0.0436724 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0433312 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0429631 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0425349 |
| PERP | PERP, TP53 apoptosis effector | -0.0422688 |
| DEK | DEK proto-oncogene | -0.0419074 |
| TMSB10 | thymosin beta 10 | -0.0410712 |
| LYZ | lysozyme | -0.0404443 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0401494 |
| MCL1 | myeloid cell leukemia 1 | -0.0398198 |
| RPS27A | ribosomal protein S27a | -0.0397704 |
| RPLP0 | ribosomal protein, large, P0 | -0.0397286 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.039579 |
| RHEB | Ras homolog enriched in brain | -0.0395688 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0395246 |
| JUN | jun proto-oncogene | -0.0385557 |
| DIAPH2 | diaphanous-related formin 2 | -0.0383803 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0380685 |
| AGR2 | anterior gradient 2 | -0.0379257 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0376982 |
| RPL28 | ribosomal protein L28 | -0.0376108 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0376062 |
| RPS5 | ribosomal protein S5 | -0.0373295 |
| POTEF | POTE ankyrin domain family, member F | -0.0363974 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0361753 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0359348 |
| LAMA4 | laminin, alpha 4 | -0.0356529 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0345821 |
| RPS13 | ribosomal protein S13 | -0.0340981 |
| FUS | FUS RNA binding protein | -0.0337944 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0334188 |
| CCNI | cyclin I | -0.0332798 |
| KRT19 | keratin 19, type I | -0.0331137 |
| ASPH | aspartate beta-hydroxylase | -0.0330519 |
| ASTN2 | astrotactin 2 | -0.0328563 |
| RPS23 | ribosomal protein S23 | -0.0328539 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0322402 |
| CTTN | cortactin | -0.0321946 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0317973 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0317081 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0316921 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.031184 |
| HDLBP | high density lipoprotein binding protein | -0.0310141 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0309709 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0300707 |
| RPL19 | ribosomal protein L19 | -0.0298158 |
| POF1B | premature ovarian failure, 1B | -0.0296898 |
| NBEAL1 | neurobeachin-like 1 | -0.0296658 |
| TPI1 | triosephosphate isomerase 1 | -0.0296204 |
| MYO10 | myosin X | -0.0294575 |
| VCL | vinculin | -0.0294028 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0293417 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0293374 |
| PARD3 | par-3 family cell polarity regulator | -0.0293243 |
| VIM | vimentin | -0.0291752 |
| EGR1 | early growth response 1 | -0.0288106 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0284081 |
| WASF2 | WAS protein family, member 2 | -0.0283638 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0276468 |
| CTBP2 | C-terminal binding protein 2 | -0.0274702 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0274589 |
| RPS15 | ribosomal protein S15 | -0.0273991 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0273705 |
| H1-0 | H1.0 linker histone | -0.0270151 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0269562 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.026936 |
| GOLGB1 | golgin B1 | -0.0268609 |
| DSTN | destrin (actin depolymerizing factor) | -0.0267823 |
| PCBP2 | poly(rC) binding protein 2 | -0.026723 |
| MYADM | myeloid-associated differentiation marker | -0.0266048 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0265606 |
