Pexidartinib (hydrochloride)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.360552
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.140228
FN1 fibronectin 1 0.119367
APOB apolipoprotein B 0.115969
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.109472
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.107444
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0996711
ERRFI1 ERBB receptor feedback inhibitor 1 0.0978225
EEF2 eukaryotic translation elongation factor 2 0.07386
IGFBP1 insulin-like growth factor binding protein 1 0.0734586
FNDC3B fibronectin type III domain containing 3B 0.0727652
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0721932
TF transferrin 0.0705492
MAML2 mastermind-like 2 (Drosophila) 0.0685956
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0662693
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0565653
MRTFA myocardin related transcription factor A 0.0563042
FAT1 FAT atypical cadherin 1 0.0562557
SAMD4A sterile alpha motif domain containing 4A 0.0540257
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0539451
NRIP1 nuclear receptor interacting protein 1 0.0531013
NKD1 naked cuticle homolog 1 (Drosophila) 0.0528128
ARHGAP9 Rho GTPase activating protein 9 0.0507679
C3 complement component 3 0.05064
SLC38A2 solute carrier family 38, member 2 0.0492018
AFDN afadin, adherens junction formation factor 0.0479442
RPS12 ribosomal protein S12 0.0472444
JAG1 jagged 1 0.0469725
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0461165
AHR aryl hydrocarbon receptor 0.0456188
FBF1 Fas (TNFRSF6) binding factor 1 0.0447714
EHBP1 EH domain binding protein 1 0.0438238
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0434432
TNS1 tensin 1 0.0421887
ELL2 elongation factor, RNA polymerase II, 2 0.0417652
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0397649
LRMDA leucine rich melanocyte differentiation associated 0.0392969
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0389927
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0386892
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0383914
ABTB3 ankyrin repeat and BTB domain containing 3 0.0380378
PEG10 paternally expressed 10 0.0375343
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0366925
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0364861
SESTD1 SEC14 and spectrin domains 1 0.0360442
LCOR ligand dependent nuclear receptor corepressor 0.0353187
DLC1 DLC1 Rho GTPase activating protein 0.0349646
GPC6 glypican 6 0.0335811
CRLS1 cardiolipin synthase 1 0.0334575
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0324536
WDFY2 WD repeat and FYVE domain containing 2 0.0320374
MALRD1 MAM and LDL receptor class A domain containing 1 0.0310911
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0310304
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0306874
FRK fyn-related Src family tyrosine kinase 0.0303991
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0303469
SPATS2L spermatogenesis associated, serine-rich 2-like 0.030285
FLNB filamin B, beta 0.0299405
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0297548
KIF5B kinesin family member 5B 0.0293004
ATXN1 ataxin 1 0.0291318
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0275216
NFE2L1 nuclear factor, erythroid 2-like 1 0.0274857
PTPRM protein tyrosine phosphatase, receptor type, M 0.0274665
CFB complement factor B 0.0273014
KDM7A lysine (K)-specific demethylase 7A 0.0269084
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0268959
YAP1 Yes-associated protein 1 0.0263702
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0259851
HLF hepatic leukemia factor 0.0255762
PCBP1 poly(rC) binding protein 1 0.0251257
ZMIZ1 zinc finger, MIZ-type containing 1 0.0250001
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0249371
WNK1 WNK lysine deficient protein kinase 1 0.0246884
ARL5B ADP-ribosylation factor-like 5B 0.0241076
MTSS1 metastasis suppressor 1 0.0240059
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0238064
FOXO1 forkhead box O1 0.0237415
SLC35F5 solute carrier family 35, member F5 0.0237013
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0235954
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0230865
DOCK4 dedicator of cytokinesis 4 0.022949
CCL20 chemokine (C-C motif) ligand 20 0.0228763
ASXL1 additional sex combs like transcriptional regulator 1 0.0228248
NHSL1 NHS-like 1 0.0226949
JMJD1C jumonji domain containing 1C 0.0226598
MYH9 myosin, heavy chain 9, non-muscle 0.0225328
FILIP1L filamin A interacting protein 1-like 0.0224426
XRN2 5'-3' exoribonuclease 2 0.02171
IQSEC1 IQ motif and Sec7 domain 1 0.0216384
ZEB1 zinc finger E-box binding homeobox 1 0.0216072
EPS8 epidermal growth factor receptor pathway substrate 8 0.0212666
ICAM1 intercellular adhesion molecule 1 0.0212013
MBNL3 muscleblind-like splicing regulator 3 0.0211837
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.021178
SET SET nuclear proto-oncogene 0.0207688
GMDS GDP-mannose 4,6-dehydratase 0.0207042
WDR43 WD repeat domain 43 0.0206687
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.0206644
SPOPL speckle-type POZ protein-like 0.0204331

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201189
TPT1 tumor protein, translationally-controlled 1 -0.157011
APOA2 apolipoprotein A-II -0.129937
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.111577
RPS6 ribosomal protein S6 -0.10666
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.103352
ENO1 enolase 1, (alpha) -0.0992389
FTL ferritin, light polypeptide -0.0923501
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0787776
TM4SF1 transmembrane 4 L six family member 1 -0.0677396
RPS24 ribosomal protein S24 -0.0653527
H1-0 H1.0 linker histone -0.0636843
RPLP1 ribosomal protein, large, P1 -0.0570052
MT2A metallothionein 2A -0.0567852
RPL11 ribosomal protein L11 -0.0555315
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0546133
STAU1 staufen double-stranded RNA binding protein 1 -0.0545375
RPS8 ribosomal protein S8 -0.0538319
AKAP12 A kinase (PRKA) anchor protein 12 -0.0529296
RPLP0 ribosomal protein, large, P0 -0.0515222
RPL12 ribosomal protein L12 -0.048961
SDC4 syndecan 4 -0.0474161
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0474041
UBC ubiquitin C -0.0467763
TMSB10 thymosin beta 10 -0.0464037
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0461914
RPS27A ribosomal protein S27a -0.0453983
AHNAK AHNAK nucleoprotein -0.0452243
WDR45B WD repeat domain 45B -0.0440857
KDM3A lysine (K)-specific demethylase 3A -0.0434383
RPL34 ribosomal protein L34 -0.0428949
AMBP alpha-1-microglobulin/bikunin precursor -0.0427507
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0423411
RPS19 ribosomal protein S19 -0.0419094
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0410125
RPS21 ribosomal protein S21 -0.0405025
SOD2 superoxide dismutase 2, mitochondrial -0.0398485
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0392567
CP ceruloplasmin (ferroxidase) -0.0384447
RPS29 ribosomal protein S29 -0.0383885
AHSG alpha-2-HS-glycoprotein -0.0376864
RPS14 ribosomal protein S14 -0.036534
APOE apolipoprotein E -0.0363334
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0362004
RPS10 ribosomal protein S10 -0.0360108
GCC2 GRIP and coiled-coil domain containing 2 -0.0356542
PERP PERP, TP53 apoptosis effector -0.0354845
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0352464
RPL35A ribosomal protein L35a -0.0348471
LOC112694756 uncharaterized LOC112694756 -0.0342908
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0341893
RPL19 ribosomal protein L19 -0.0340626
PTMA prothymosin, alpha -0.0339363
RPS5 ribosomal protein S5 -0.0336315
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0336011
GPC3 glypican 3 -0.0335448
RPS23 ribosomal protein S23 -0.0335296
RPS13 ribosomal protein S13 -0.0321097
RRBP1 ribosome binding protein 1 -0.0319145
APOA1 apolipoprotein A-I -0.0319103
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0317925
VDAC1 voltage-dependent anion channel 1 -0.0316094
TPM4 tropomyosin 4 -0.0315907
S100A9 S100 calcium binding protein A9 -0.0313586
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0311911
RPL32 ribosomal protein L32 -0.0309792
BPTF bromodomain PHD finger transcription factor -0.0304441
RPS11 ribosomal protein S11 -0.030437
RPLP2 ribosomal protein, large, P2 -0.0299111
PDIA3 protein disulfide isomerase family A, member 3 -0.0292168
RPS16 ribosomal protein S16 -0.0291393
CANX calnexin -0.0290257
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0289767
PKM pyruvate kinase, muscle -0.0284475
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.028333
NDRG1 N-myc downstream regulated 1 -0.0282003
KRT18 keratin 18, type I -0.0281883
NPEPPS aminopeptidase puromycin sensitive -0.0281055
RPL28 ribosomal protein L28 -0.0280966
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0280062
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0273882
S100A10 S100 calcium binding protein A10 -0.0273118
INSIG2 insulin induced gene 2 -0.0267454
NAMPT nicotinamide phosphoribosyltransferase -0.02673
HDLBP high density lipoprotein binding protein -0.0266596
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0264035
RPL8 ribosomal protein L8 -0.0259931
P4HB prolyl 4-hydroxylase, beta polypeptide -0.025497
KMT2E lysine (K)-specific methyltransferase 2E -0.0254677
B2M beta-2-microglobulin -0.0253353
PTK2 protein tyrosine kinase 2 -0.0248692
IER3 immediate early response 3 -0.0247683
ZMYND8 zinc finger, MYND-type containing 8 -0.0237182
GNAS GNAS complex locus -0.0236922
LDHA lactate dehydrogenase A -0.0235462
YBX1 Y box binding protein 1 -0.0231999
RPS25 ribosomal protein S25 -0.0228042
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0226867
RPL38 ribosomal protein L38 -0.0226524
NBEAL1 neurobeachin-like 1 -0.0225826