| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.347097 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.180386 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.144596 |
| DPYD | dihydropyrimidine dehydrogenase | 0.137587 |
| LMO7 | LIM domain 7 | 0.0840011 |
| CD44 | CD44 molecule (Indian blood group) | 0.0813659 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.078812 |
| MYOF | myoferlin | 0.0782436 |
| MTSS1 | metastasis suppressor 1 | 0.0754992 |
| RASAL2 | RAS protein activator like 2 | 0.0740463 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0738547 |
| RIGI | RNA sensor RIG-I | 0.0725134 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0647145 |
| FLNB | filamin B, beta | 0.0645159 |
| TMSB4X | thymosin beta 4, X-linked | 0.0638272 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0637364 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0630907 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0622667 |
| PRELID2 | PRELI domain containing 2 | 0.0621471 |
| SULF1 | sulfatase 1 | 0.0616349 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0613516 |
| ANXA2 | annexin A2 | 0.0604513 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0599106 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0575604 |
| LDHA | lactate dehydrogenase A | 0.0574357 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0572692 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0555481 |
| ENO1 | enolase 1, (alpha) | 0.0525768 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0523692 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0519737 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0513472 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0513373 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0507469 |
| HMGA2 | high mobility group AT-hook 2 | 0.0490343 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0489771 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0488371 |
| KRT6A | keratin 6A, type II | 0.0487379 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0483463 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0479405 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0467542 |
| PGK1 | phosphoglycerate kinase 1 | 0.0461969 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.046075 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0458714 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0457334 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0455034 |
| DST | dystonin | 0.0449669 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0442739 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0434932 |
| ANXA1 | annexin A1 | 0.0421283 |
| GNAS | GNAS complex locus | 0.0420818 |
| RIN2 | Ras and Rab interactor 2 | 0.0413792 |
| CDK6 | cyclin-dependent kinase 6 | 0.0410602 |
| ITGA6 | integrin, alpha 6 | 0.0407777 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0406511 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0403309 |
| MEF2A | myocyte enhancer factor 2A | 0.0400013 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0395047 |
| IGF2 | insulin-like growth factor 2 | 0.039114 |
| PTK2 | protein tyrosine kinase 2 | 0.0390305 |
| IFI44 | interferon-induced protein 44 | 0.0385277 |
| MXRA5 | matrix-remodelling associated 5 | 0.0380899 |
| RAD51B | RAD51 paralog B | 0.0379357 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.037665 |
| LAMC2 | laminin, gamma 2 | 0.0375354 |
| MECOM | MDS1 and EVI1 complex locus | 0.0374677 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0374464 |
| OSMR | oncostatin M receptor | 0.0371845 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0361094 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0354601 |
| ASPH | aspartate beta-hydroxylase | 0.0353451 |
| EMP1 | epithelial membrane protein 1 | 0.034725 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0346734 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0345091 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.034405 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0343881 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0338625 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0335984 |
| NFIB | nuclear factor I/B | 0.0335521 |
| AMOTL1 | angiomotin like 1 | 0.0333295 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0326431 |
| LMNA | lamin A/C | 0.0326253 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0324672 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0322925 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0321692 |
| SET | SET nuclear proto-oncogene | 0.0321556 |
| FLNA | filamin A, alpha | 0.0319252 |
| ACTG1 | actin gamma 1 | 0.0318546 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0318027 |
| PLK2 | polo-like kinase 2 | 0.0317316 |
| PRSS23 | protease, serine, 23 | 0.0313579 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0313258 |
| RAI14 | retinoic acid induced 14 | 0.0307823 |
| UTRN | utrophin | 0.0303328 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0295603 |
| VCL | vinculin | 0.0294605 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0287256 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | 0.0287076 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0284058 |
| TPM3 | tropomyosin 3 | 0.0280187 |
| PLS3 | plastin 3 | 0.0279269 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0885345 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0605014 |
| RPS13 | ribosomal protein S13 | -0.0564951 |
| CLU | clusterin | -0.0543372 |
| FTL | ferritin, light polypeptide | -0.0511724 |
| FOXO1 | forkhead box O1 | -0.0458519 |
| RPLP2 | ribosomal protein, large, P2 | -0.0444704 |
| RPS23 | ribosomal protein S23 | -0.0418751 |
| RPS25 | ribosomal protein S25 | -0.0402664 |
| RPS21 | ribosomal protein S21 | -0.0390725 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0378057 |
| RPS29 | ribosomal protein S29 | -0.0370077 |
| MT1E | metallothionein 1E | -0.0368049 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0366976 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0359273 |
| PTMA | prothymosin, alpha | -0.0350085 |
| RPS6 | ribosomal protein S6 | -0.0349596 |
| OGA | O-GlcNAcase | -0.0329151 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0325847 |
| MT2A | metallothionein 2A | -0.0316428 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0313974 |
| HM13 | histocompatibility (minor) 13 | -0.0313574 |
| RPS11 | ribosomal protein S11 | -0.030959 |
| RPL31 | ribosomal protein L31 | -0.029022 |
| S100A10 | S100 calcium binding protein A10 | -0.0290031 |
| ADIRF | adipogenesis regulatory factor | -0.0287744 |
| RPS8 | ribosomal protein S8 | -0.028048 |
| HLA-B | major histocompatibility complex, class I, B | -0.0279634 |
| SQSTM1 | sequestosome 1 | -0.0275558 |
| INTS6 | integrator complex subunit 6 | -0.026679 |
| SETD5 | SET domain containing 5 | -0.0257266 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.023562 |
| RPL37A | ribosomal protein L37a | -0.0231978 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | -0.0228481 |
| RPL28 | ribosomal protein L28 | -0.0227502 |
| RPS27 | ribosomal protein S27 | -0.0219715 |
| EFHD2 | EF-hand domain family, member D2 | -0.02195 |
| RPLP1 | ribosomal protein, large, P1 | -0.0217281 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0216814 |
| RPS15 | ribosomal protein S15 | -0.0211959 |
| RPL19 | ribosomal protein L19 | -0.0210129 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | -0.021006 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0208474 |
| PLIN2 | perilipin 2 | -0.0206688 |
| RHEB | Ras homolog enriched in brain | -0.0204954 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0204293 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0204208 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0203891 |
| RPL38 | ribosomal protein L38 | -0.02028 |
| SCFD1 | sec1 family domain containing 1 | -0.020057 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0196509 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0196078 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0194567 |
| UBC | ubiquitin C | -0.0194083 |
| RPL11 | ribosomal protein L11 | -0.0192133 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0191253 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0189761 |
| SLC45A4 | solute carrier family 45, member 4 | -0.0188881 |
| RPS24 | ribosomal protein S24 | -0.0188154 |
| RPL23 | ribosomal protein L23 | -0.0187994 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0183058 |
| GUK1 | guanylate kinase 1 | -0.0181295 |
| PLTP | phospholipid transfer protein | -0.0180295 |
| UPP1 | uridine phosphorylase 1 | -0.0179442 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0177234 |
| RPL35A | ribosomal protein L35a | -0.0174238 |
| DENND4C | DENN/MADD domain containing 4C | -0.0171936 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.01672 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0163721 |
| RPL21 | ribosomal protein L21 | -0.0163307 |
| RPS14 | ribosomal protein S14 | -0.0159775 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.0158582 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0157862 |
| PTEN | phosphatase and tensin homolog | -0.0156554 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | -0.0154159 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0153786 |
| CAPRIN2 | caprin family member 2 | -0.0153593 |
| ADRM1 | adhesion regulating molecule 1 | -0.0152447 |
| SH3PXD2A | SH3 and PX domains 2A | -0.0149899 |
| ATP5MK | ATP synthase membrane subunit k | -0.0149592 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0148136 |
| RPL9 | ribosomal protein L9 | -0.0147978 |
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase | -0.0147705 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0147342 |
| WASF2 | WAS protein family, member 2 | -0.0146992 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0146708 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0145989 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0144417 |
| RPL36A | ribosomal protein L36a | -0.0144087 |
| GLG1 | golgi glycoprotein 1 | -0.0142842 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0142384 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.01413 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0140193 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | -0.0139057 |
| RPL8 | ribosomal protein L8 | -0.0137438 |
| USP34 | ubiquitin specific peptidase 34 | -0.0137381 |
| MAGT1 | magnesium transporter 1 | -0.0136857 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0136777 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0136473 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | -0.0136233 |
