| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.207273 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.178724 |
| FTL | ferritin, light polypeptide | 0.116866 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.107556 |
| NDRG1 | N-myc downstream regulated 1 | 0.0899573 |
| SET | SET nuclear proto-oncogene | 0.0840821 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0831353 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0808983 |
| HLA-B | major histocompatibility complex, class I, B | 0.0761166 |
| SLC12A8 | solute carrier family 12, member 8 | 0.0723224 |
| LDHA | lactate dehydrogenase A | 0.0684572 |
| FLNA | filamin A, alpha | 0.0659347 |
| B2M | beta-2-microglobulin | 0.0628998 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0602782 |
| ENO1 | enolase 1, (alpha) | 0.0592827 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0589402 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0575756 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0562499 |
| PKM | pyruvate kinase, muscle | 0.0530894 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0525284 |
| CD44 | CD44 molecule (Indian blood group) | 0.0518294 |
| HEG1 | heart development protein with EGF-like domains 1 | 0.0512055 |
| FLNB | filamin B, beta | 0.0477923 |
| CALR | calreticulin | 0.0476615 |
| FOSL1 | FOS-like antigen 1 | 0.0444634 |
| TXNRD1 | thioredoxin reductase 1 | 0.0436808 |
| SULF1 | sulfatase 1 | 0.0425874 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0418235 |
| ZNF841 | zinc finger protein 841 | 0.0416313 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0415051 |
| L1CAM | L1 cell adhesion molecule | 0.0404955 |
| PODXL | podocalyxin-like | 0.0402656 |
| DST | dystonin | 0.0399149 |
| STC2 | stanniocalcin 2 | 0.038979 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0383669 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0375714 |
| HLA-A | major histocompatibility complex, class I, A | 0.0375579 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0366354 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0355454 |
| PDE10A | phosphodiesterase 10A | 0.0354315 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0353543 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0340693 |
| NAV2 | neuron navigator 2 | 0.0332101 |
| AFAP1 | actin filament associated protein 1 | 0.033024 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0326556 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0321661 |
| PLIN2 | perilipin 2 | 0.0320662 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0319909 |
| POTEF | POTE ankyrin domain family, member F | 0.0318132 |
| CENPF | centromere protein F, 350/400kDa | 0.0314289 |
| ADM | adrenomedullin | 0.0311924 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0305937 |
| ACTG1 | actin gamma 1 | 0.0300366 |
| TENM3 | teneurin transmembrane protein 3 | 0.029788 |
| PLK2 | polo-like kinase 2 | 0.0297526 |
| MKI67 | marker of proliferation Ki-67 | 0.0294968 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.029331 |
| PGK1 | phosphoglycerate kinase 1 | 0.0281221 |
| RPS2 | ribosomal protein S2 | 0.0277932 |
| MYOF | myoferlin | 0.0272957 |
| MSN | moesin | 0.026969 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0269286 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0269091 |
| KIF5B | kinesin family member 5B | 0.0267895 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0267878 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0267821 |
| PCBP2 | poly(rC) binding protein 2 | 0.0262099 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0258342 |
| RACK1 | receptor for activated C kinase 1 | 0.0258251 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0257638 |
| NUP58 | nucleoporin 58 | 0.0257596 |
| RPS3 | ribosomal protein S3 | 0.0255441 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.025485 |
| GATA2 | GATA binding protein 2 | 0.0253136 |
| COL5A1 | collagen, type V, alpha 1 | 0.0252049 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.0247619 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0245031 |
| SQSTM1 | sequestosome 1 | 0.0238517 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0237683 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0235887 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0235581 |
| RNF213 | ring finger protein 213 | 0.023495 |
| RPL35A | ribosomal protein L35a | 0.0234779 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0233398 |
| HPS3 | Hermansky-Pudlak syndrome 3 | 0.0232703 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0230093 |
| KRT8 | keratin 8, type II | 0.0229978 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0229348 |
| KLF10 | Kruppel-like factor 10 | 0.0228383 |
| ANXA1 | annexin A1 | 0.0227444 |
| RPS8 | ribosomal protein S8 | 0.0226865 |
| EGFR | epidermal growth factor receptor | 0.0226644 |
| ATXN1 | ataxin 1 | 0.0226041 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0224688 |
| TPR | translocated promoter region, nuclear basket protein | 0.0224687 |
| YEATS2 | YEATS domain containing 2 | 0.0224221 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0224139 |
| KRT7 | keratin 7, type II | 0.0220805 |
| TPM3 | tropomyosin 3 | 0.0219756 |
| LOXL2 | lysyl oxidase-like 2 | 0.0218414 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AHNAK | AHNAK nucleoprotein | -0.0767782 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0685223 |
| MT1X | metallothionein 1X | -0.0664807 |
| FN1 | fibronectin 1 | -0.0601698 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0562774 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0544207 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0472995 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0471643 |
| GLIS3 | GLIS family zinc finger 3 | -0.0400407 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.03831 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0271017 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0270466 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0266126 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.025856 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0249708 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0226468 |
| TMSB10 | thymosin beta 10 | -0.0223157 |
| GOLGA3 | golgin A3 | -0.0208646 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0208575 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0202863 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0195035 |
| SDC4 | syndecan 4 | -0.0188981 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0185962 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0179221 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0178798 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0176938 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0175766 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0170852 |
| ZXDC | ZXD family zinc finger C | -0.017031 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0166724 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0166094 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0165662 |
| RHOA | ras homolog family member A | -0.0164066 |
| CTTN | cortactin | -0.0163553 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0161888 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) | -0.0158947 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0158929 |
| TAOK3 | TAO kinase 3 | -0.0158856 |
| WNT5B | wingless-type MMTV integration site family, member 5B | -0.0158377 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0158223 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.015475 |
| COPA | coatomer protein complex, subunit alpha | -0.0154403 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.015414 |
| CDK13 | cyclin-dependent kinase 13 | -0.0153684 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0151718 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0151703 |
| ZNF804A | zinc finger protein 804A | -0.0150663 |
| SETD5 | SET domain containing 5 | -0.0150276 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0149371 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0149212 |
| ERBIN | erbb2 interacting protein | -0.0148316 |
| CSTF3 | cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa | -0.0147903 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0147422 |
| CALD1 | caldesmon 1 | -0.0146631 |
| ATG7 | autophagy related 7 | -0.0146224 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0144634 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0144072 |
| HLA-C | major histocompatibility complex, class I, C | -0.0142697 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0142681 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | -0.0142458 |
| TAOK1 | TAO kinase 1 | -0.0138859 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0138664 |
| CUL4A | cullin 4A | -0.0138001 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0137169 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0136244 |
| CCDC80 | coiled-coil domain containing 80 | -0.0134737 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0134209 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0133348 |
| GLG1 | golgi glycoprotein 1 | -0.0133032 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0131537 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0131066 |
| RANBP17 | RAN binding protein 17 | -0.0130173 |
| MGLL | monoglyceride lipase | -0.0129494 |
| SCFD2 | sec1 family domain containing 2 | -0.0129441 |
| TOP1 | topoisomerase (DNA) I | -0.012863 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0128472 |
| COG5 | component of oligomeric golgi complex 5 | -0.0128063 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0127703 |
| SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | -0.0127552 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0126449 |
| DEK | DEK proto-oncogene | -0.0126297 |
| CLINT1 | clathrin interactor 1 | -0.0126186 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0125475 |
| NLK | nemo-like kinase | -0.0125264 |
| RBM6 | RNA binding motif protein 6 | -0.0124844 |
| TSC22D2 | TSC22 domain family, member 2 | -0.01239 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0123392 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0123075 |
| CDK12 | cyclin-dependent kinase 12 | -0.0122957 |
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | -0.0121712 |
| TMEM165 | transmembrane protein 165 | -0.0120692 |
| TMEM263 | transmembrane protein 263 | -0.0120551 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0120531 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | -0.0120507 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.012011 |
| MB21D2 | Mab-21 domain containing 2 | -0.0120066 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0119158 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0118922 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0118543 |
| SRSF6 | serine/arginine-rich splicing factor 6 | -0.0117597 |
